Saptarsi Haldar, MD

Title(s)Clinical Professor, Medicine
SchoolSchool of Medicine
Address1650 Owens
San Francisco CA 94107
Phone415-734-4058
ORCID ORCID Icon0000-0001-7968-9696 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Cornell UniversityB.S.1995
    Johns Hopkins UniversityM.D.2000
    Johns Hopkins UniversityOlser Medical Residency2003Internal Medicine
    Brigham and Women's Hospital, Harvard Medical SchoolFellowship in Cardiovascular Medicine2006
    Collapse Awards and Honors
    1998Sarnoff Fellowship
    2009Jeremiah Stamler Distinguished Young Investigator Award, Northwestern Univ. YI Competition
    2012ASCI Best Research Poster Award
    2013Hartwell Foundation Biomedical Research Award
    2014Science Translational Medicine, Associate Scientific Advisory Board
    AHA Council on Basic Cardiovascular Science (BCVS)2018Fellow of the American Heart Association
    2018American Society for Clinical Investigation (ASCI)

    Collapse Overview 
    Collapse Overview
    Clinical: I am a cardiologist specializing in general adult cardiology.

    Primary Appointment: In 2018, I was recruited to be a Vice President of Research at Amgen, based in South San Francisco. I am the head of Cardiometabolic Research at Amgen, where I lead multidisciplinary efforts in drug discovery and development for a wide range of cardiovascular and metabolic diseases. I have maintained visiting faculty appointments at UCSF and Gladstone Institutes, where I continue to participate in mentorship, original research, volunteer clinical service and other academic activities.

    Research: I am a Visiting Investigator at the Gladstone Institute of Cardiovascular Disease and a Visiting Professor the University of California, San Francisco. My scientific focus is to understand gene-regulatory and epigenetic mechanisms governing cell state transitions in the cardiovascular system and in skeletal muscle with an ultimate goal of finding novel therapeutic strategies to prevent and treat heart failure, cardiometabolic, and myopathic diseases.

    A major focus of our team is in the pathobiology of heart failure, a devastating disease for which morbidity and mortality remain extremely high despite current standards of medical care. As a practicing physician-scientist that recognizes this major unmet need, one of my laboratory’s central goals is to discover novel mechanisms underlying heart failure pathogenesis and to develop new therapeutic strategies for this extremely common and lethal condition. We have a deep interest in the very nascent area of cardiovascular epigenetics and seek to unravel how chromatin-dependent signal transduction drives cardiovascular plasticity during physiological and pathophysiological states. As epigenetic regulators and chromatin-associated proteins are often tractable drug targets, we actively seek to translate our findings into novel transcriptionally-active cardiovascular therapeutics.

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Chromatin Signaling in Heart Failure by the BRD4 Bromodomain Protein.
    NIH R01HL127240Apr 1, 2015 - Jun 30, 2023
    Role: Co-Principal Investigator
    KLF15 and Transcriptional Control of Muscle Metabolism
    NIH R01DK093821Jun 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Kruppel-like Factor 15 (KLF15) as a Regulator of Cardiac Hypertrophy
    NIH K08HL086614May 7, 2007 - Apr 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A transcriptional switch governs fibroblast activation in heart disease. Nature. 2021 Jul; 595(7867):438-443. Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. PMID: 34163071.
      View in: PubMed   Mentions:    Fields:    
    2. Abstract 17168: Myocardial Natriuretic Peptide Expression in Heart Failure With Preserved Ejection Fraction. Circulation. 2020 Nov 17; 142(Suppl_3). Virginia S Hahn, Hildur Knutsdottir, Kenneth C Bedi, Kenneth B Margulies, Saptarsi M Haldar, Marina Stolina, Joel S Bader, David A Kass, Kavita Sharma. .
      View in: Publisher Site   Mentions:
    3. Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction. Circulation. 2021 Jan 12; 143(2):120-134. Hahn VS, Knutsdottir H, Luo X, Bedi K, Margulies KB, Haldar SM, Stolina M, Yin J, Khakoo AY, Vaishnav J, Bader JS, Kass DA, Sharma K. PMID: 33118835.
      View in: PubMed   Mentions: 8     Fields:    
    4. BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation. 2020 Dec 15; 142(24):2338-2355. Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D. PMID: 33094644.
      View in: PubMed   Mentions: 4     Fields:    
    5. Distinct Myocardial Gene Expression Signatures in Heart Failure with Preserved Ejection Fraction. Journal of Cardiac Failure. 2020 Oct 1; 26(10):s8-s9. Virginia S. Hahn, Hildur Knutsdottir, Aditi Madan, Xin Luo, Kenneth Bedi, Kenneth B. Margulies, Saptarsi M. Haldar, Marina Stolina, Jun Yin, Aarif Y. Khahoo, Joban Vaishnav, Anthony Cammarato, Joel S. Bader, David A. Kass, Kavita Sharma. .
      View in: Publisher Site   Mentions:
    6. BETs that cover the spread from acquired to heritable heart failure. J Clin Invest. 2020 09 01; 130(9):4536-4539. Alexanian M, Haldar SM. PMID: 32773407.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    7. BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy. JCI Insight. 2020 08 06; 5(15). Antolic A, Wakimoto H, Jiao Z, Gorham JM, DePalma SR, Lemieux ME, Conner DA, Lee DY, Qi J, Seidman JG, Bradner JE, Brown JD, Haldar SM, Seidman CE, Burke MA. PMID: 32603312.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    8. A New Therapeutic Framework for Atrial Fibrillation Drug Development. Circ Res. 2020 06 19; 127(1):184-201. Ang YS, Rajamani S, Haldar SM, Hüser J. PMID: 32717173.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    9. Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. J Clin Invest. 2020 06 01; 130(6):2966-2977. Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM. PMID: 32106109.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming. JCI Insight. 2019 12 19; 4(24). Quattrocelli M, Zelikovich AS, Jiang Z, Peek CB, Demonbreun AR, Kuntz NL, Barish GD, Haldar SM, Bass J, McNally EM. PMID: 31852847.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    11. Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. Development. 2019 12 09; 146(23). George MR, Duan Q, Nagle A, Kathiriya IS, Huang Y, Rao K, Haldar SM, Bruneau BG. PMID: 31784461.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    12. Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation. Circ Res. 2019 09 13; 125(7):662-677. Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA. PMID: 31409188.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    13. Drugging transcription in heart failure. J Physiol. 2020 07; 598(14):3005-3014. Padmanabhan A, Haldar SM. PMID: 30927446.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Epigenetic therapies in heart failure. J Mol Cell Cardiol. 2019 05; 130:197-204. Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM. PMID: 30991033.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Unusual transcription factor protects against heart failure. Science. 2018 12 21; 362(6421):1359-1360. Padmanabhan A, Haldar SM. PMID: 30573617.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. The Cardiac Myofibroblast. Circ Res. 2018 12 07; 123(12):1258-1260. Alexanian M, Haldar SM. PMID: 30566054.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Epigenomic Control of Cardiac Fibrosis by Bet Bromodomain Proteins in Dilated Cardiomyopathy. Journal of Cardiac Failure. 2018 Aug 1; 24(8):s2. Michael A. Burke, Hiroko Wakimoto, Zhe Jiao, Joshua M. Gorham, Steven R. DePalma, David A. Conner, Jun Qi, Jonathan G. Seidman, James E. Bradner, Jonathan D. Brown, Saptarsi M. Haldar, Christine E. Seidman. .
      View in: Publisher Site   Mentions:
    18. Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice. EBioMedicine. 2018 May; 31:226-242. Walter LM, Deguise MO, Meijboom KE, Betts CA, Ahlskog N, van Westering TLE, Hazell G, McFall E, Kordala A, Hammond SM, Abendroth F, Murray LM, Shorrock HK, Prosdocimo DA, Haldar SM, Jain MK, Gillingwater TH, Claus P, Kothary R, Wood MJA, Bowerman M. PMID: 29735415.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    19. BET bromodomain proteins regulate enhancer function during adipogenesis. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2144-2149. Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE. PMID: 29444854.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    20. Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform. Circ Heart Fail. 2018 02; 11(2):e004793. Padmanabhan A, Haldar SM. PMID: 29438983.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Probing the Pathogenesis of Duchenne Muscular Dystrophy Using Mouse Models. Methods Mol Biol. 2018; 1687:107-119. Morrison-Nozik A, Haldar SM. PMID: 29067659.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    22. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metab. 2017 Sep 05; 26(3):547-557.e8. Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. PMID: 28877458.
      View in: PubMed   Mentions: 80     Fields:    Translation:Animals
    23. BRD4 inhibition for the treatment of pathological organ fibrosis. F1000Res. 2017; 6. Stratton MS, Haldar SM, McKinsey TA. PMID: 28721198.
      View in: PubMed   Mentions: 13     Fields:    
    24. BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Sci Transl Med. 2017 05 17; 9(390). Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM. PMID: 28515341.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    25. Abstract 417: BET Bromodomain Inhibition Blunts Heart Failure Progression and Fibrosis in Genetic Cardiomyopathy. Circulation Research. 2016 Jul 22; 119(suppl_1). Michael A Burke, Hiroko Wakimoto, Joshua M Gorham, David A Conner, Jonathan G Seidman, James E Bradner, Saptarsi M Haldar, Jonathan D Brown, Christine E Seidman. .
      View in: Publisher Site   Mentions:
    26. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 08 02; 16(5):1366-1378. Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. PMID: 27425608.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    27. Sarcomeres and Cardiac Growth: Tension in the Relationship. Trends Mol Med. 2016 07; 22(7):530-533. Haldar SM, Srivastava D. PMID: 27237981.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    28. BET Bromodomains and P-TEFb in Cardiac Transcription and Heart Failure Pathogenesis. Epigenetics in Cardiac Disease. 2016 Jan 1; 283-296. Priti Anand, Amir Munir, Saptarsi M. Haldar. .
      View in: Publisher Site   Mentions:
    29. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6780-9. Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. PMID: 26598680.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    30. Abstract 131: A microRNA Targets the Epigenetic Reader BRD4 to Suppress Transcription Elongation in the Heart. Circulation Research. 2015 Jul 17; 117(suppl_1). Matthew S Stratton, Bradley S Ferguson, Charles Y Lin, Priti Anand, Sean T Wickers, Philip D Tatman, James E Bradner, Saptarsi M Haldar, Timothy A McKinsey. .
      View in: Publisher Site   Mentions:
    31. Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) Mouse. Ultrastruct Pathol. 2015; 39(5):336-9. Tandler B, Fujioka H, Hoppel CL, Haldar SM, Jain MK. PMID: 26111268.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    32. Differential role of an NF-?B transcriptional response element in endothelial versus intimal cell VCAM-1 expression. Circ Res. 2015 Jul 03; 117(2):166-77. Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI. PMID: 26034041.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    33. A change of heart for phosphodiesterase signaling. Science Translational Medicine. 2015 Apr 1; 7(281):281ec52-281ec52. Saptarsi M. Haldar. .
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    34. A mighty "MyD" guardian of heart function. Science Translational Medicine. 2015 Feb 18; 7(275):275ec28-275ec28. Saptarsi M. Haldar. .
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    35. Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning. J Mol Cell Cardiol. 2015 Mar; 80:114-25. Duan Q, Madan ND, Wu J, Kalisz J, Doshi KY, Haldar SM, Liu L, Pierre SV. PMID: 25575882.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. Abstract 15863: Macrophage Foxp1 is a Regulator of Pathologic Cardiac Hypertrophy. Circulation. 2014 Nov 25; 130(suppl_2). Shuichi Yoneda, Saptarsi M Haldar, Jessica Jenkins, Yunmei Wang, Teruo Inoue, Mukesh K Jain, Can Shi, Daniel I Simon. .
      View in: Publisher Site   Mentions:
    37. Neuroprotection in ischemic stroke: AhR we making progress? Circulation. 2014 Dec 02; 130(23):2002-4. Padmanabhan A, Haldar SM. PMID: 25359167.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    38. Epigenetic mechanisms in heart failure pathogenesis. Circ Heart Fail. 2014 Sep; 7(5):850-863. Di Salvo TG, Haldar SM. PMID: 25228320.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    39. Fishing for Drugs That Mitigate Metabolic Syndrome. Science Translational Medicine. 2014 Jul 16; 6(245):245ec121-245ec121. Saptarsi M. Haldar. .
      View in: Publisher Site   Mentions:
    40. BET-ting on chromatin-based therapeutics for heart failure. J Mol Cell Cardiol. 2014 Sep; 74:98-102. Haldar SM, McKinsey TA. PMID: 24838003.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    41. Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism. J Biol Chem. 2014 Feb 28; 289(9):5914-24. Prosdocimo DA, Anand P, Liao X, Zhu H, Shelkay S, Artero-Calderon P, Zhang L, Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J, Fujioka H, Tuschl T, Bai X, Schulze PC, Hoppel CL, Jain MK, Haldar SM. PMID: 24407292.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    42. BET bromodomains mediate transcriptional pause release in heart failure. Cell. 2013 Aug 01; 154(3):569-82. Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM. PMID: 23911322.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    43. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry. Mol Cell Biol. 2013 Jun; 33(11):2104-15. Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar SM, Gerber AN. PMID: 23508109.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    44. S-nitrosylation: integrator of cardiovascular performance and oxygen delivery. J Clin Invest. 2013 Jan; 123(1):101-10. Haldar SM, Stamler JS. PMID: 23281416.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    45. String mitochondria in mouse soleus muscle. Microsc Res Tech. 2013 Mar; 76(3):237-41. Fujioka H, Tandler B, Haldar SM, Jain MK, Hoppel CL. PMID: 23174930.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    46. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6739-44. Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. PMID: 22493257.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    47. Induction of Klf15 by glucocorticoids in the lung regulates downstream transcriptional effects on mitochondrial function and metabolism. The FASEB Journal. 2012 Apr 1; 26:1151.3-1151.3. Anthony Nicholas Gerber, Sarah Sasse, Saptarsi Haldar, Mukesh Jain. .
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    48. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 2012 Mar 07; 15(3):311-23. Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. PMID: 22405069.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    49. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22; 483(7387):96-9. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. PMID: 22367544.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    50. S-Nitrosylation at the interface of autophagy and disease. Mol Cell. 2011 Jul 08; 43(1):1-3. Haldar SM, Stamler JS. PMID: 21726803.
      View in: PubMed   Mentions: 10     Fields:    
    51. The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock. Immunity. 2011 Jul 1; 35(1):146. Ganapati H. Mahabeleshwar, Daiji Kawanami, Nikunj Sharma, Yoichi Takami, Guangjin Zhou, Hong Shi, Lalitha Nayak, Darwin Jeyaraj, Robert Grealy, Mary White, Ross McManus, Thomas Ryan, Patrick Leahy, Zhiyong Lin, Saptarsi M. Haldar, G. Brandon Atkins, Hector R. Wong, Jerry B. Lingrel, Mukesh K. Jain. .
      View in: Publisher Site   Mentions:
    52. The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity. 2011 May 27; 34(5):715-28. Mahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy R, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, Jain MK. PMID: 21565532.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    53. Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):642-9. Masuno K, Haldar SM, Jeyaraj D, Mailloux CM, Huang X, Panettieri RA, Jain MK, Gerber AN. PMID: 21257922.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    54. Kruppel-like factor 15 regulates smooth muscle response to vascular injury--brief report. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1550-2. Lu Y, Haldar S, Croce K, Wang Y, Sakuma M, Morooka T, Wang B, Jeyaraj D, Gray SJ, Simon DI, Jain MK. PMID: 20508206.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    55. Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy. J Mol Cell Cardiol. 2010 Aug; 49(2):334-8. Liao X, Haldar SM, Lu Y, Jeyaraj D, Paruchuri K, Nahori M, Cui Y, Kaestner KH, Jain MK. PMID: 20433848.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    56. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med. 2010 Apr 07; 2(26):26ra26. Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK. PMID: 20375365.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    57. Role of Connective Tissue Growth Factor in Cardiac Fibrosis. CCN Proteins in Health and Disease. 2010 Jan 1; 121-132. Daiji Kawanami, Saptarsi M. Haldar, Mukesh K. Jain. .
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    58. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J Biol Chem. 2009 Jul 31; 284(31):20522-30. Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, Lamanna JC, Jain MK. PMID: 19491109.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    59. Kruppel Like Factor 15 is a Critical Regulator of Angiotensin II Mediated Vascular Remodeling. The FASEB Journal. 2009 Apr 1; 23:637.7-637.7. Yuan Lu, Saptarsi Haldar, Caili Hao, Yingjie Cui, Yongqiu Doughman, Michiko Watanabe, Mukesh K Jain. .
      View in: Publisher Site   Mentions:
    60. Krüppel-like Factors in the Heart. The Biology of Krüppel-like Factors. 2009 Jan 1; 159-171. Daiji Kawanami, Saptarsi M. Haldar, Mukesh K. Jain. .
      View in: Publisher Site   Mentions:
    61. Abstract 5275: Kruppel-Like Factor 15 Regulates the Cardiovascular Response to Angiotensin II. Circulation. 2008 Oct 28; 118(suppl_18). Saptarsi M Haldar, Yuan Lu, Yingjie Cui, Darwin Jeyaraj, Osama A Ibrahim, Manjusri Das, Caili Hao, Sam J Eapen, Daiji Kawanami, Yong Qiu Doughman, Michiko Watanabe, Junichi Sadoshima, Mukesh K Jain. .
      View in: Publisher Site   Mentions:
    62. Abstract 5440: Klf2 Inhibits Hif-1a Expression and Function in the Endothelium. Circulation. 2008 Oct 28; 118(suppl_18). Daiji Kawanami, Zhiyong Lin, Ganapati Mahabaleshwar, G. B Atkins, Anne Hamik, Saptarsi Haldar, Koji Maemura, Jerry Lingrel, Mukesh Jain. .
      View in: Publisher Site   Mentions:
    63. The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J Mol Cell Cardiol. 2008 Aug; 45(2):193-7. Wang B, Haldar SM, Lu Y, Ibrahim OA, Fisch S, Gray S, Leask A, Jain MK. PMID: 18586263.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    64. Kruppel-like Factors (KLFs) in muscle biology. J Mol Cell Cardiol. 2007 Jul; 43(1):1-10. Haldar SM, Ibrahim OA, Jain MK. PMID: 17531262.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    65. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7074-9. Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Pinto Y, Liao R, Jain MK. PMID: 17438289.
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    66. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab. 2007 Apr; 5(4):305-12. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. PMID: 17403374.
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    67. KRUPPEL-LIKE FACTOR 15 IS A NOVEL REGULATOR OF CARDIOMYOCYTE HYPERTROPHY.: 38. Journal of Investigative Medicine. 2007 Mar 1; 55(2):s354. S. Fisch, S. Gray, S. Heymans, S. Haldar, B. Wang, Y. Zhu, R. Liao, Y. M. Pinto, M. K. Jain. .
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    69. Infective endocarditis: diagnosis and management. Nat Clin Pract Cardiovasc Med. 2006 Jun; 3(6):310-7. Haldar SM, O'Gara PT. PMID: 16729009.
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    70. Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. Circulation. 2003 Dec 02; 108(22):2790-7. Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, Kass DA. PMID: 14638552.
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    71. Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium. Hypertension. 2003 Feb; 41(2):378-81. Peng X, Haldar S, Deshpande S, Irani K, Kass DA. PMID: 12574111.
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