Saptarsi Haldar, MD

Title(s)Clinical Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Cornell UniversityB.S.1995
    Johns Hopkins UniversityM.D.2000
    Johns Hopkins UniversityOlser Medical Residency2003Internal Medicine
    Brigham and Women's Hospital, Harvard Medical SchoolFellowship in Cardiovascular Medicine2006
    Collapse Awards and Honors
    1998Sarnoff Fellowship
    2009Jeremiah Stamler Distinguished Young Investigator Award, Northwestern Univ. YI Competition
    2012ASCI Best Research Poster Award
    2013Hartwell Foundation Biomedical Research Award
    2014Science Translational Medicine, Associate Scientific Advisory Board

    Collapse Overview 
    Collapse Overview
    Clinical: I am a cardiologist specializing in general adult cardiology.

    Research: I am a principal investigator at the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco. My scientific focus is to understand gene-regulatory and epigenetic mechanisms governing cell state transitions in the cardiovascular system and in skeletal muscle with an ultimate goal of finding novel therapeutic strategies to prevent and treat heart failure, cardiometabolic, and myopathic diseases.

    A major focus of our team is in the pathobiology of heart failure, a devastating disease for which morbidity and mortality remain extremely high despite current standards of medical care. As a practicing physician-scientist that recognizes this major unmet need, one of my laboratory’s central goals is to discover novel mechanisms underlying heart failure pathogenesis and to develop new therapeutic strategies for this extremely common and lethal condition. We have a deep interest in the very nascent area of cardiovascular epigenetics and seek to unravel how chromatin-dependent signal transduction drives cardiovascular plasticity during physiological and pathophysiological states. As epigenetic regulators and chromatin-associated proteins are often tractable drug targets, we actively seek to translate our findings into novel transcriptionally-active cardiovascular therapeutics.

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Chromatin Signaling in Heart Failure by BET Bromodomain Proteins
    NIH/NHLBI R01HL127240Apr 1, 2015 - Mar 31, 2019
    Role: Co-Principal Investigator
    KLF15 and Transcriptional Control of Muscle Metabolism
    NIH/NIDDK R01DK093821Jun 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Kruppel-like Factor 15 (KLF15) as a Regulator of Cardiac Hypertrophy
    NIH/NHLBI K08HL086614May 7, 2007 - Apr 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Padmanabhan A, Haldar SM. Unusual transcription factor protects against heart failure. Science. 2018 12 21; 362(6421):1359-1360. PMID: 30573617.
      View in: PubMed
    2. Alexanian M, Haldar SM. The Cardiac Myofibroblast. Circ Res. 2018 Dec 07; 123(12):1258-1260. PMID: 30566054.
      View in: PubMed
    3. Walter LM, Deguise MO, Meijboom KE, Betts CA, Ahlskog N, van Westering TLE, Hazell G, McFall E, Kordala A, Hammond SM, Abendroth F, Murray LM, Shorrock HK, Prosdocimo DA, Haldar SM, Jain MK, Gillingwater TH, Claus P, Kothary R, Wood MJA, Bowerman M. Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice. EBioMedicine. 2018 May; 31:226-242. PMID: 29735415.
      View in: PubMed
    4. Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE. BET bromodomain proteins regulate enhancer function during adipogenesis. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2144-2149. PMID: 29444854.
      View in: PubMed
    5. Padmanabhan A, Haldar SM. Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform. Circ Heart Fail. 2018 Feb; 11(2):e004793. PMID: 29438983.
      View in: PubMed
    6. Morrison-Nozik A, Haldar SM. Probing the Pathogenesis of Duchenne Muscular Dystrophy Using Mouse Models. Methods Mol Biol. 2018; 1687:107-119. PMID: 29067659.
      View in: PubMed
    7. Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metab. 2017 Sep 05; 26(3):547-557.e8. PMID: 28877458.
      View in: PubMed
    8. Stratton MS, Haldar SM, McKinsey TA. BRD4 inhibition for the treatment of pathological organ fibrosis. F1000Res. 2017; 6. PMID: 28721198.
      View in: PubMed
    9. Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM. BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Sci Transl Med. 2017 05 17; 9(390). PMID: 28515341.
      View in: PubMed
    10. Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 08 02; 16(5):1366-1378. PMID: 27425608.
      View in: PubMed
    11. Haldar SM, Srivastava D. Sarcomeres and Cardiac Growth: Tension in the Relationship. Trends Mol Med. 2016 07; 22(7):530-533. PMID: 27237981.
      View in: PubMed
    12. Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6780-9. PMID: 26598680; PMCID: PMC4679037.
    13. Tandler B, Fujioka H, Hoppel CL, Haldar SM, Jain MK. Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) Mouse. Ultrastruct Pathol. 2015; 39(5):336-9. PMID: 26111268; PMCID: PMC4827860.
    14. Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI. Differential role of an NF-?B transcriptional response element in endothelial versus intimal cell VCAM-1 expression. Circ Res. 2015 Jul 03; 117(2):166-77. PMID: 26034041; PMCID: PMC4758452.
    15. Duan Q, Madan ND, Wu J, Kalisz J, Doshi KY, Haldar SM, Liu L, Pierre SV. Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning. J Mol Cell Cardiol. 2015 Mar; 80:114-25. PMID: 25575882; PMCID: PMC4827870.
    16. Padmanabhan A, Haldar SM. Neuroprotection in ischemic stroke: AhR we making progress? Circulation. 2014 Dec 02; 130(23):2002-4. PMID: 25359167.
      View in: PubMed
    17. Di Salvo TG, Haldar SM. Epigenetic mechanisms in heart failure pathogenesis. Circ Heart Fail. 2014 Sep; 7(5):850-863. PMID: 25228320; PMCID: PMC4169025.
    18. Haldar SM, McKinsey TA. BET-ting on chromatin-based therapeutics for heart failure. J Mol Cell Cardiol. 2014 Sep; 74:98-102. PMID: 24838003; PMCID: PMC4115033.
    19. Prosdocimo DA, Anand P, Liao X, Zhu H, Shelkay S, Artero-Calderon P, Zhang L, Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J, Fujioka H, Tuschl T, Bai X, Schulze PC, Hoppel CL, Jain MK, Haldar SM. Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism. J Biol Chem. 2014 Feb 28; 289(9):5914-24. PMID: 24407292; PMCID: PMC3937660.
    20. Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM. BET bromodomains mediate transcriptional pause release in heart failure. Cell. 2013 Aug 01; 154(3):569-82. PMID: 23911322; PMCID: PMC4090947.
    21. Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar SM, Gerber AN. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry. Mol Cell Biol. 2013 Jun; 33(11):2104-15. PMID: 23508109; PMCID: PMC3648070.
    22. Haldar SM, Stamler JS. S-nitrosylation: integrator of cardiovascular performance and oxygen delivery. J Clin Invest. 2013 Jan; 123(1):101-10. PMID: 23281416; PMCID: PMC3533273.
    23. Fujioka H, Tandler B, Haldar SM, Jain MK, Hoppel CL. String mitochondria in mouse soleus muscle. Microsc Res Tech. 2013 Mar; 76(3):237-41. PMID: 23174930.
      View in: PubMed
    24. Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6739-44. PMID: 22493257; PMCID: PMC3340075.
    25. Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 2012 Mar 07; 15(3):311-23. PMID: 22405069; PMCID: PMC3299986.
    26. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22; 483(7387):96-9. PMID: 22367544.
      View in: PubMed
    27. Haldar SM, Stamler JS. S-Nitrosylation at the interface of autophagy and disease. Mol Cell. 2011 Jul 08; 43(1):1-3. PMID: 21726803.
      View in: PubMed
    28. Mahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy R, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, Jain MK. The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity. 2011 May 27; 34(5):715-28. PMID: 21565532; PMCID: PMC3103656.
    29. Masuno K, Haldar SM, Jeyaraj D, Mailloux CM, Huang X, Panettieri RA, Jain MK, Gerber AN. Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):642-9. PMID: 21257922; PMCID: PMC3175579.
    30. Lu Y, Haldar S, Croce K, Wang Y, Sakuma M, Morooka T, Wang B, Jeyaraj D, Gray SJ, Simon DI, Jain MK. Kruppel-like factor 15 regulates smooth muscle response to vascular injury--brief report. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1550-2. PMID: 20508206; PMCID: PMC2937185.
    31. Liao X, Haldar SM, Lu Y, Jeyaraj D, Paruchuri K, Nahori M, Cui Y, Kaestner KH, Jain MK. Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy. J Mol Cell Cardiol. 2010 Aug; 49(2):334-8. PMID: 20433848; PMCID: PMC2885477.
    32. Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med. 2010 Apr 07; 2(26):26ra26. PMID: 20375365; PMCID: PMC3003709.
    33. Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, Lamanna JC, Jain MK. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J Biol Chem. 2009 Jul 31; 284(31):20522-30. PMID: 19491109; PMCID: PMC2742816.
    34. Wang B, Haldar SM, Lu Y, Ibrahim OA, Fisch S, Gray S, Leask A, Jain MK. The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J Mol Cell Cardiol. 2008 Aug; 45(2):193-7. PMID: 18586263; PMCID: PMC2566509.
    35. Haldar SM, Ibrahim OA, Jain MK. Kruppel-like Factors (KLFs) in muscle biology. J Mol Cell Cardiol. 2007 Jul; 43(1):1-10. PMID: 17531262; PMCID: PMC2743293.
    36. Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Pinto Y, Liao R, Jain MK. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7074-9. PMID: 17438289; PMCID: PMC1855421.
    37. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab. 2007 Apr; 5(4):305-12. PMID: 17403374.
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    38. Haldar SM, O'Gara PT. Infective endocarditis: diagnosis and management. Nat Clin Pract Cardiovasc Med. 2006 Jun; 3(6):310-7. PMID: 16729009.
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    39. Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, Kass DA. Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. Circulation. 2003 Dec 02; 108(22):2790-7. PMID: 14638552.
      View in: PubMed