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Saptarsi Haldar, MD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1650 Owens
San Francisco CA 94107
Phone415-734-4058
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    Collapse Biography 
    Collapse Education and Training
    Cornell UniversityB.S.1995
    Johns Hopkins UniversityM.D.2000
    Johns Hopkins UniversityOlser Medical Residency2003Internal Medicine
    Brigham and Women's Hospital, Harvard Medical SchoolFellowship in Cardiovascular Medicine2006
    Collapse Awards and Honors
    1998Sarnoff Fellowship
    2009Jeremiah Stamler Distinguished Young Investigator Award, Northwestern Univ. YI Competition
    2012ASCI Best Research Poster Award
    2013Hartwell Foundation Biomedical Research Award
    2014Science Translational Medicine, Associate Scientific Advisory Board

    Collapse Overview 
    Collapse Overview
    Clinical: I am a cardiologist specializing in general adult cardiology.

    Research: I am a principal investigator at the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco. My scientific focus is to understand gene-regulatory and epigenetic mechanisms governing cell state transitions in the cardiovascular system and in skeletal muscle with an ultimate goal of finding novel therapeutic strategies to prevent and treat heart failure, cardiometabolic, and myopathic diseases.

    A major focus of our team is in the pathobiology of heart failure, a devastating disease for which morbidity and mortality remain extremely high despite current standards of medical care. As a practicing physician-scientist that recognizes this major unmet need, one of my laboratory’s central goals is to discover novel mechanisms underlying heart failure pathogenesis and to develop new therapeutic strategies for this extremely common and lethal condition. We have a deep interest in the very nascent area of cardiovascular epigenetics and seek to unravel how chromatin-dependent signal transduction drives cardiovascular plasticity during physiological and pathophysiological states. As epigenetic regulators and chromatin-associated proteins are often tractable drug targets, we actively seek to translate our findings into novel transcriptionally-active cardiovascular therapeutics.


    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Chromatin Signaling in Heart Failure by BET Bromodomain Proteins
    NIH/NHLBI R01HL127240Apr 1, 2015 - Mar 31, 2019
    Role: Co-Principal Investigator
    KLF15 and Transcriptional Control of Muscle Metabolism
    NIH/NIDDK R01DK093821Jun 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Kruppel-like Factor 15 (KLF15) as a Regulator of Cardiac Hypertrophy
    NIH/NHLBI K08HL086614May 7, 2007 - Apr 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar S. BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Sci Transl Med. 2017 May 17; 9(390). PMID: 28515341.
      View in: PubMed
    2. Haldar S, Srivastava D. Sarcomeres and Cardiac Growth: Tension in the Relationship. Trends Mol Med. 2016 Jul; 22(7):530-3. PMID: 27237981.
      View in: PubMed
    3. Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar S. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci U S A. 2015 Dec 8; 112(49):E6780-9. PMID: 26598680.
      View in: PubMed
    4. Tandler B, Fujioka H, Hoppel CL, Haldar S, Jain MK. Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) Mouse. Ultrastruct Pathol. 2015 Sep; 39(5):336-9. PMID: 26111268.
      View in: PubMed
    5. Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar S, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI. Differential role of an NF-?B transcriptional response element in endothelial versus intimal cell VCAM-1 expression. Circ Res. 2015 Jul 3; 117(2):166-77. PMID: 26034041.
      View in: PubMed
    6. Duan Q, Madan ND, Wu J, Kalisz J, Doshi KY, Haldar S, Liu L, Pierre SV. Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning. J Mol Cell Cardiol. 2015 Mar; 80:114-25. PMID: 25575882.
      View in: PubMed
    7. Padmanabhan A, Haldar S. Neuroprotection in ischemic stroke: AhR we making progress? Circulation. 2014 Dec 2; 130(23):2002-4. PMID: 25359167.
      View in: PubMed
    8. Haldar S, McKinsey TA. BET-ting on chromatin-based therapeutics for heart failure. J Mol Cell Cardiol. 2014 Sep; 74:98-102. PMID: 24838003; PMCID: PMC4115033.
      View in: PubMed, PubMed Central
    9. Prosdocimo DA, Anand P, Liao X, Zhu H, Shelkay S, Artero-Calderon P, Zhang L, Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J, Fujioka H, Tuschl T, Bai X, Schulze PC, Hoppel CL, Jain MK, Haldar S. Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism. J Biol Chem. 2014 Feb 28; 289(9):5914-24. PMID: 24407292; PMCID: PMC3937660.
      View in: PubMed, PubMed Central
    10. Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar S. BET bromodomains mediate transcriptional pause release in heart failure. Cell. 2013 Aug 1; 154(3):569-82. PMID: 23911322; PMCID: PMC4090947.
      View in: PubMed, PubMed Central
    11. Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar S, Gerber AN. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry. Mol Cell Biol. 2013 Jun; 33(11):2104-15. PMID: 23508109; PMCID: PMC3648070.
      View in: PubMed, PubMed Central
    12. Haldar S, Stamler JS. S-nitrosylation: integrator of cardiovascular performance and oxygen delivery. J Clin Invest. 2013 Jan; 123(1):101-10. PMID: 23281416; PMCID: PMC3533273.
      View in: PubMed, PubMed Central
    13. Fujioka H, Tandler B, Haldar S, Jain MK, Hoppel CL. String mitochondria in mouse soleus muscle. Microsc Res Tech. 2013 Mar; 76(3):237-41. PMID: 23174930.
      View in: PubMed
    14. Haldar S, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6739-44. PMID: 22493257; PMCID: PMC3340075.
      View in: PubMed, PubMed Central
    15. Jeyaraj D, Scheer FA, Ripperger JA, Haldar S, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 2012 Mar 7; 15(3):311-23. PMID: 22405069; PMCID: PMC3299986.
      View in: PubMed, PubMed Central
    16. Jeyaraj D, Haldar S, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Mar 1; 483(7387):96-9. PMID: 22367544; PMCID: PMC3297978.
      View in: PubMed, PubMed Central
    17. Haldar S, Stamler JS. S-Nitrosylation at the interface of autophagy and disease. Mol Cell. 2011 Jul 8; 43(1):1-3. PMID: 21726803.
      View in: PubMed
    18. Mahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy R, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar S, Atkins GB, Wong HR, Lingrel JB, Jain MK. The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity. 2011 May 27; 34(5):715-28. PMID: 21565532; PMCID: PMC3103656.
      View in: PubMed, PubMed Central
    19. Masuno K, Haldar S, Jeyaraj D, Mailloux CM, Huang X, Panettieri RA, Jain MK, Gerber AN. Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):642-9. PMID: 21257922; PMCID: PMC3175579.
      View in: PubMed, PubMed Central
    20. Lu Y, Haldar S, Croce K, Wang Y, Sakuma M, Morooka T, Wang B, Jeyaraj D, Gray SJ, Simon DI, Jain MK. Kruppel-like factor 15 regulates smooth muscle response to vascular injury--brief report. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1550-2. PMID: 20508206; PMCID: PMC2937185.
      View in: PubMed, PubMed Central
    21. Liao X, Haldar S, Lu Y, Jeyaraj D, Paruchuri K, Nahori M, Cui Y, Kaestner KH, Jain MK. Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy. J Mol Cell Cardiol. 2010 Aug; 49(2):334-8. PMID: 20433848; PMCID: PMC2885477.
      View in: PubMed, PubMed Central
    22. Haldar S, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med. 2010 Apr 7; 2(26):26ra26. PMID: 20375365; PMCID: PMC3003709.
      View in: PubMed, PubMed Central
    23. Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar S, Maemura K, Lamanna JC, Jain MK. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J Biol Chem. 2009 Jul 31; 284(31):20522-30. PMID: 19491109; PMCID: PMC2742816.
      View in: PubMed, PubMed Central
    24. Wang B, Haldar S, Lu Y, Ibrahim OA, Fisch S, Gray S, Leask A, Jain MK. The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J Mol Cell Cardiol. 2008 Aug; 45(2):193-7. PMID: 18586263; PMCID: PMC2566509.
      View in: PubMed, PubMed Central
    25. Haldar S, Ibrahim OA, Jain MK. Kruppel-like Factors (KLFs) in muscle biology. J Mol Cell Cardiol. 2007 Jul; 43(1):1-10. PMID: 17531262; PMCID: PMC2743293.
      View in: PubMed, PubMed Central
    26. Fisch S, Gray S, Heymans S, Haldar S, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Pinto Y, Liao R, Jain MK. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7074-9. PMID: 17438289; PMCID: PMC1855421.
      View in: PubMed, PubMed Central
    27. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab. 2007 Apr; 5(4):305-12. PMID: 17403374; PMCID: PMC1892530.
      View in: PubMed, PubMed Central
    28. Haldar S, O'Gara PT. Infective endocarditis: diagnosis and management. Nat Clin Pract Cardiovasc Med. 2006 Jun; 3(6):310-7. PMID: 16729009.
      View in: PubMed
    29. Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, Kass DA. Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. Circulation. 2003 Dec 2; 108(22):2790-7. PMID: 14638552.
      View in: PubMed
    30. Bernier SG, Haldar S, Michel T. Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase. J Biol Chem. 2000 Sep 29; 275(39):30707-15. PMID: 10899167.
      View in: PubMed
    31. Haldar S, Beatty C, Tsujimoto Y, Croce CM. The bcl-2 gene encodes a novel G protein. Nature. 1989 Nov 9; 342(6246):195-8. PMID: 2478890.
      View in: PubMed
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