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Sarah Nelson, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentRadiology
Address1700 4th Street
San Francisco CA 94158
Phone415-476-6383
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    Academy of Radiology Research 2014Distinguished Investigator
    ISMRM, Salt Lake City2013Outstanding Teacher Award
    Academy of Radiology Research2013Distinguished Investigator
    University of California, San Francisco Graduate Division Alumni Association2012Outstanding Faculty Mentorship Award
    San Francisco Business Times2012Most Influential Bay Area Women Award
    AACR2010Expert Speaker
    Surbeck Laboratory of Advanced Imaging2004Margaret Hart Surbeck Distinguished Professorship in Advanced Imaging
    International Society of Magnetic Resonance in Medicine1998Fellow

    Collapse Overview 
    Collapse Overview
    Sarah J. Nelson, PhD, is a Professor of Radiology and Biomedical Imaging with secondary appointment in the Department of Neurology. She is the Margaret Hart Surbeck Distinguished Professor of Advanced Imaging, Director of the Surbeck Laboratory, and Director of the Brain Research Interest Group at the University of California, San Francisco. She completed her BSc in Mathematics at the University of Manchester in England, and obtained her PhD in Biomathematics at the University of Heidelberg, Department of Mathematics in West Germany. She completed a postdoctoral fellowship in Biostatics at Fox Chase Institute for Cancer Research in Philadelphia, Pennsylvania.

    As Director of the Surbeck Laboratory, Dr. Nelson is responsible for managing the recharge operations for three research MR scanners, the 3T system at the Center of Molecular and Functional Imaging, and the 3T and 7T systems at the Institute for Quantitative Biosciences (QB3) at UCSF Byers Hall Mission Bay Campus. Her research program is focused on the development of techniques for acquisition, reconstruction, and quantitative analysis of magnetic resonance (MR) imaging and spectral data with the goal of improving the sensitivity and specificity of the data obtained for characterizing human diseases, selecting therapies, and monitoring novel treatment paradigms.

    Dr. Nelson has served as Principal Investigator and Co-Principal Investigator for numerous NIH grants, and she has published over 200 research articles.

    Expertise:
    Bioengineering, Mathematics

    Specialty:
    Magnetic resonance imaging and spectroscopy

    Professional Interests:
    Magnetic resonance imaging and spectroscopy, image reconstruction, signal processing, algorithm development, quantitative analysis, imaging biomarker discovery, neurological diseases, evaluation of therapy, brain cancer, prostate cancer, multiple sclerosis

    Education and Training:
    • Bachelor of Science: University of Manchester, England - Mathematics
    • Doctor of Philosophy: University of Heidelberg Department of Mathematics, West Germany - Biomathematics
    • Postdoctoral Fellowship: Fox Chase Institute for Cancer Research, Philadelphia, Pennsylvania - Biostatistics


    Collapse Research 
    Collapse Research Activities and Funding
    RESPONSE TO THERAPY FOR PATIENTS WITH GLIOMA USING HYPERPOLARIZED C-13 PYRUVATE
    NIH/NCI R21CA170148Jul 23, 2012 - Jun 30, 2014
    Role: Principal Investigator
    MR Metabolic Imaging of Response to Targeted Therapies in GBM
    NIH/NCI R01CA154915Sep 8, 2011 - Jun 30, 2016
    Role: Co-Principal Investigator
    Hyperpolarized MRI Technology Resource Center
    NIH/NIBIB P41EB013598Jul 1, 2011 - May 31, 2021
    Role: Co-Investigator
    Impact of molecular phenotype on glioma metabolism and growth
    NIH/NCI R01CA159869Apr 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Upgrading a 7T Scanner to Study Cancer, Neurological and Musculoskeletal Diseases
    NIH/NCRR S10RR026845Jun 10, 2010 - Jun 9, 2011
    Role: Principal Investigator
    3T MR Scanner for Translational Research using MRI and MRSI
    NIH/NCRR S10RR029570Jun 3, 2010 - Jun 2, 2012
    Role: Principal Investigator
    MR Metabolic Markers for Evaluation of Patients with Recurrent Glioma
    NIH/NCI R01CA127612Apr 1, 2007 - May 31, 2018
    Role: Principal Investigator
    Imaging and Tissue Correlates to Optimize Management of Glioblastoma
    NIH/NCI P01CA118816Dec 1, 2005 - Jul 31, 2018
    Role: Co-Principal Investigator
    Tools for Improved Radiation Treatment Using MRSI
    NIH/NCI R21CA110171Aug 6, 2004 - Jul 31, 2006
    Role: Principal Investigator
    SPORE: Brain Tumore SPORE Grant
    NIH/NCI P50CA097257Sep 20, 2002 - Aug 31, 2018
    Role: Co-Investigator
    EVALUATION OF GLIOMAS USING MRI AND MRS
    NIH/NCI R01CA079719Dec 23, 1998 - Nov 30, 2003
    Role: Principal Investigator
    PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    NIH/NCI U01CA062561May 18, 1995 - Feb 28, 2001
    Role: Principal Investigator
    Response to Fractionated radiation Therapy by MRSI
    NIH/NCI R01CA059880May 15, 1993 - May 31, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Nelson S, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. Sci Transl Med. 2013 Aug 14; 5(198):198ra108. PMID: 23946197; PMCID: PMC4201045.
    2. Barajas RF, Hess CP, Phillips JJ, Von Morze CJ, Yu JP, Chang SM, Nelson S, McDermott MW, Berger MS, Cha S. Super-resolution track density imaging of glioblastoma: histopathologic correlation. AJNR Am J Neuroradiol. 2013 Jul; 34(7):1319-25. PMID: 23413250; PMCID: PMC4017075.
    3. Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson S, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014 Jan; 71(1):1-11. PMID: 23412881; PMCID: PMC3659200.
    4. Nelson S, Ozhinsky E, Li Y, Park Iw, Crane J. Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging. J Magn Reson. 2013 Apr; 229:187-97. PMID: 23453759; PMCID: PMC3808990.
    5. Lupo JM, Essock-Burns E, Molinaro AM, Cha S, Chang SM, Butowski N, Nelson S. Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme. Neuro Oncol. 2013 Apr; 15(4):480-9. PMID: 23393208; PMCID: PMC3607266.
    6. Li Y, Lupo JM, Parvataneni R, Lamborn KR, Cha S, Chang SM, Nelson S. Survival analysis in patients with newly diagnosed glioblastoma using pre- and postradiotherapy MR spectroscopic imaging. Neuro Oncol. 2013 May; 15(5):607-17. PMID: 23393206; PMCID: PMC3635514.
    7. Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson S, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Sep; 38(3):701-13. PMID: 23293097; PMCID: PMC3759833.
    8. Essock-Burns E, Phillips JJ, Molinaro AM, Lupo JM, Cha S, Chang SM, Nelson S. Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM. J Magn Reson Imaging. 2013 Aug; 38(2):388-400. PMID: 23281184; PMCID: PMC3711964.
    9. Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson S, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013 May; 31(4):490-6. PMID: 23107275; PMCID: PMC3625683.
    10. Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson S. Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging. Magn Reson Med. 2013 Jul; 70(1):33-9. PMID: 22851374; PMCID: PMC3630274.
    11. Barajas RF, Phillips JJ, Parvataneni R, Molinaro A, Essock-Burns E, Bourne G, Parsa AT, Aghi MK, McDermott MW, Berger MS, Cha S, Chang SM, Nelson S. Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. Neuro Oncol. 2012 Jul; 14(7):942-54. PMID: 22711606; PMCID: PMC3379808.
    12. Ozhinsky E, Vigneron DB, Chang SM, Nelson S. Automated prescription of oblique brain 3D magnetic resonance spectroscopic imaging. Magn Reson Med. 2013 Apr; 69(4):920-30. PMID: 22692829; PMCID: PMC3443494.
    13. Bian W, Harter K, Hammond-Rosenbluth KE, Lupo JM, Xu D, Kelley DA, Vigneron DB, Nelson S, Pelletier D. A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis. Mult Scler. 2013 Jan; 19(1):69-75. PMID: 22641301.
      View in: PubMed
    14. Constantin A, Elkhaled A, Jalbert L, Srinivasan R, Cha S, Chang SM, Bajcsy R, Nelson S. Identifying malignant transformations in recurrent low grade gliomas using high resolution magic angle spinning spectroscopy. Artif Intell Med. 2012 May; 55(1):61-70. PMID: 22387185; PMCID: PMC3314104.
    15. Ozturk-Isik E, Pirzkall A, Lamborn KR, Cha S, Chang SM, Nelson S. Spatial characteristics of newly diagnosed grade 3 glioma assessed by magnetic resonance metabolic and diffusion tensor imaging. Transl Oncol. 2012 Feb; 5(1):10-8. PMID: 22348171; PMCID: PMC3281410.
    16. Wu B, Zhang X, Wang C, Li Y, Pang Y, Lu J, Xu D, Majumdar S, Nelson S, Vigneron DB. Flexible transceiver array for ultrahigh field human MR imaging. Magn Reson Med. 2012 Oct; 68(4):1332-8. PMID: 22246803; PMCID: PMC3350759.
    17. Elkhaled A, Jalbert LE, Phillips JJ, Yoshihara HA, Parvataneni R, Srinivasan R, Bourne G, Berger MS, Chang SM, Cha S, Nelson S. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas. Sci Transl Med. 2012 Jan 11; 4(116):116ra5. PMID: 22238333; PMCID: PMC3772177.
    18. Lupo JM, Li Y, Hess CP, Nelson S. Advances in ultra-high field MRI for the clinical management of patients with brain tumors. Curr Opin Neurol. 2011 Dec; 24(6):605-15. PMID: 22045220.
      View in: PubMed
    19. Pang Y, Xie Z, Xu D, Kelley DA, Nelson S, Vigneron DB, Zhang X. A dual-tuned quadrature volume coil with mixed ?/2 and ?/4 microstrip resonators for multinuclear MRSI at 7 T. Magn Reson Imaging. 2012 Feb; 30(2):290-8. PMID: 22055851; PMCID: PMC3254778.
    20. Wang C, Li Y, Wu B, Xu D, Nelson S, Vigneron DB, Zhang X. A practical multinuclear transceiver volume coil for in vivo MRI/MRS at 7 T. Magn Reson Imaging. 2012 Jan; 30(1):78-84. PMID: 22055858; PMCID: PMC3277811.
    21. Lupo JM, Chuang CF, Chang SM, Barani IJ, Jimenez B, Hess CP, Nelson S. 7-Tesla susceptibility-weighted imaging to assess the effects of radiotherapy on normal-appearing brain in patients with glioma. Int J Radiat Oncol Biol Phys. 2012 Mar 01; 82(3):e493-500. PMID: 22000750; PMCID: PMC3268881.
    22. Wu B, Wang C, Lu J, Pang Y, Nelson S, Vigneron DB, Zhang X. Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans. IEEE Trans Med Imaging. 2012 Feb; 31(2):183-91. PMID: 21878410; PMCID: PMC3277810.
    23. Khayal IS, Vandenberg SR, Smith KJ, Cloyd CP, Chang SM, Cha S, Nelson S, McKnight TR. MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas. Neuro Oncol. 2011 Nov; 13(11):1192-201. PMID: 21865401; PMCID: PMC3199150.
    24. Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson S, Ronen SM. Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. Neuroimage. 2012 Jan 02; 59(1):193-201. PMID: 21807103; PMCID: PMC3196046.
    25. Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson S, Kurhanewicz J, Vigneron DB, Goga A. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 2011 Jul 06; 14(1):131-42. PMID: 21723511; PMCID: PMC3858338.
    26. Nelson S. Assessment of therapeutic response and treatment planning for brain tumors using metabolic and physiological MRI. NMR Biomed. 2011 Jul; 24(6):734-49. PMID: 21538632; PMCID: PMC3772179.
    27. Ozhinsky E, Vigneron DB, Nelson S. Improved spatial coverage for brain 3D PRESS MRSI by automatic placement of outer-volume suppression saturation bands. J Magn Reson Imaging. 2011 Apr; 33(4):792-802. PMID: 21448942; PMCID: PMC3071575.
    28. Li Y, Lupo JM, Polley MY, Crane JC, Bian W, Cha S, Chang S, Nelson S. Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme. Neuro Oncol. 2011 May; 13(5):546-57. PMID: 21297128; PMCID: PMC3093330.
    29. Essock-Burns E, Lupo JM, Cha S, Polley MY, Butowski NA, Chang SM, Nelson S. Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma. Neuro Oncol. 2011 Jan; 13(1):119-31. PMID: 21036812; PMCID: PMC3018901.
    30. Kerchner GA, Hess CP, Hammond-Rosenbluth KE, Xu D, Rabinovici GD, Kelley DA, Vigneron DB, Nelson S, Miller BL. Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI. Neurology. 2010 Oct 12; 75(15):1381-7. PMID: 20938031; PMCID: PMC3013485.
    31. Larson PE, Hu S, Lustig M, Kerr AB, Nelson S, Kurhanewicz J, Pauly JM, Vigneron DB. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011 Mar; 65(3):610-9. PMID: 20939089; PMCID: PMC3021589.
    32. Baranzini SE, Srinivasan R, Khankhanian P, Okuda DT, Nelson S, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain. 2010 Sep; 133(9):2603-11. PMID: 20802204; PMCID: PMC2929334.
    33. Park I, Chen AP, Zierhut ML, Ozturk-Isik E, Vigneron DB, Nelson S. Implementation of 3 T lactate-edited 3D 1H MR spectroscopic imaging with flyback echo-planar readout for gliomas patients. Ann Biomed Eng. 2011 Jan; 39(1):193-204. PMID: 20652745; PMCID: PMC3010202.
    34. Srinivasan R, Phillips JJ, Vandenberg SR, Polley MY, Bourne G, Au A, Pirzkall A, Cha S, Chang SM, Nelson S. Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM. Neuro Oncol. 2010 Nov; 12(11):1152-61. PMID: 20647244; PMCID: PMC3098023.
    35. Khayal IS, Polley MY, Jalbert L, Elkhaled A, Chang SM, Cha S, Butowski NA, Nelson S. Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme. Neuro Oncol. 2010 Sep; 12(9):908-16. PMID: 20501631; PMCID: PMC2940691.
    36. Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson S, Macdonald JM, Vigneron DB, Kurhanewicz J. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7. PMID: 20478721; PMCID: PMC2885774.
    37. Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson S, Pauly JM, Kurhanewicz J, Vigneron DB. Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med. 2010 Mar; 63(3):582-91. PMID: 20187172; PMCID: PMC2844437.
    38. Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson S, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM. Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res. 2010 Feb 15; 70(4):1296-305. PMID: 20145128; PMCID: PMC2822895.
    39. Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson S, Goga A, Pauly JM, Vigneron DB. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb; 63(2):312-21. PMID: 20017160; PMCID: PMC2829256.
    40. Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson S. Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol. 2010 Feb; 12(2):133-44. PMID: 20150380; PMCID: PMC2940577.
    41. Xu D, Lee MC, Carballido-Gamio J, Barkovich M, Majumdar S, Vigneron DB, Nelson S. Quantitative analysis of spatial distortions of diffusion techniques at 3T. Magn Reson Imaging. 2010 Apr; 28(3):451-4. PMID: 20096524; PMCID: PMC2842007.
    42. Bian W, Khayal IS, Lupo JM, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson S. Multiparametric characterization of grade 2 glioma subtypes using magnetic resonance spectroscopic, perfusion, and diffusion imaging. Transl Oncol. 2009 Dec; 2(4):271-80. PMID: 19956389; PMCID: PMC2781083.
    43. Pirzkall A, McGue C, Saraswathy S, Cha S, Liu R, Vandenberg S, Lamborn KR, Berger MS, Chang SM, Nelson S. Tumor regrowth between surgery and initiation of adjuvant therapy in patients with newly diagnosed glioblastoma. Neuro Oncol. 2009 Dec; 11(6):842-52. PMID: 19229057; PMCID: PMC2802404.
    44. Zierhut ML, Yen YF, Chen AP, Bok R, Albers MJ, Zhang V, Tropp J, Park I, Vigneron DB, Kurhanewicz J, Hurd RE, Nelson S. Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J Magn Reson. 2010 Jan; 202(1):85-92. PMID: 19884027; PMCID: PMC2833325.
    45. Wu B, Wang C, Kelley DA, Xu D, Vigneron DB, Nelson S, Zhang X. Shielded microstrip array for 7T human MR imaging. IEEE Trans Med Imaging. 2010 Jan; 29(1):179-84. PMID: 19822470; PMCID: PMC2834268.
    46. Ozturk-Isik E, Chen AP, Crane JC, Bian W, Xu D, Han ET, Chang SM, Vigneron DB, Nelson S. 3D sensitivity encoded ellipsoidal MR spectroscopic imaging of gliomas at 3T. Magn Reson Imaging. 2009 Nov; 27(9):1249-57. PMID: 19766422; PMCID: PMC3022436.
    47. Zierhut ML, Ozturk-Isik E, Chen AP, Park I, Vigneron DB, Nelson S. (1)H spectroscopic imaging of human brain at 3 Tesla: comparison of fast three-dimensional magnetic resonance spectroscopic imaging techniques. J Magn Reson Imaging. 2009 Sep; 30(3):473-80. PMID: 19711396; PMCID: PMC3037114.
    48. Wu B, Wang C, Krug R, Kelley DA, Xu D, Pang Y, Banerjee S, Vigneron DB, Nelson S, Majumdar S, Zhang X. 7T human spine imaging arrays with adjustable inductive decoupling. IEEE Trans Biomed Eng. 2010 Feb; 57(2):397-403. PMID: 19709956; PMCID: PMC2834655.
    49. Srinivasan R, Ratiney H, Hammond-Rosenbluth KE, Pelletier D, Nelson S. MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis. Magn Reson Imaging. 2010 Feb; 28(2):163-70. PMID: 19695821.
      View in: PubMed
    50. Lupo JM, Chen AP, Zierhut ML, Bok RA, Cunningham CH, Kurhanewicz J, Vigneron DB, Nelson S. Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer. Magn Reson Imaging. 2010 Feb; 28(2):153-62. PMID: 19695815; PMCID: PMC3075841.
    51. Banerjee S, Ozturk-Isik E, Nelson S, Majumdar S. Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T. Magn Reson Imaging. 2009 Dec; 27(10):1319-25. PMID: 19577396.
      View in: PubMed
    52. Khayal IS, Nelson S. Characterization of low-grade gliomas using RGB color maps derived from ADC histograms. J Magn Reson Imaging. 2009 Jul; 30(1):209-13. PMID: 19557741.
      View in: PubMed
    53. Yen YF, Kohler SJ, Chen AP, Tropp J, Bok R, Wolber J, Albers MJ, Gram KA, Zierhut ML, Park I, Zhang V, Hu S, Nelson S, Vigneron DB, Kurhanewicz J, Dirven HA, Hurd RE. Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate. Magn Reson Med. 2009 Jul; 62(1):1-10. PMID: 19319902; PMCID: PMC2782538.
    54. Hu S, Chen AP, Zierhut ML, Bok R, Yen YF, Schroeder MA, Hurd RE, Nelson S, Kurhanewicz J, Vigneron DB. In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol Imaging Biol. 2009 Nov-Dec; 11(6):399-407. PMID: 19424761; PMCID: PMC2763080.
    55. Khayal IS, McKnight TR, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson S. Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomas. NMR Biomed. 2009 May; 22(4):449-55. PMID: 19125391; PMCID: PMC3772178.
    56. Wilson DM, Hurd RE, Keshari K, Van Criekinge M, Chen AP, Nelson S, Vigneron DB, Kurhanewicz J. Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5503-7. PMID: 19276112; PMCID: PMC2654026.
    57. Osorio JA, Xu D, Cunningham CH, Chen A, Kerr AB, Pauly JM, Vigneron DB, Nelson S. Design of cosine modulated very selective suppression pulses for MR spectroscopic imaging at 3T. Magn Reson Med. 2009 Mar; 61(3):533-40. PMID: 19097232; PMCID: PMC2690719.
    58. Metcalf M, Xu D, Okuda DT, Carvajal L, Srinivasan R, Kelley DA, Mukherjee P, Nelson S, Vigneron DB, Pelletier D. High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patients. J Neuroimaging. 2010 Apr; 20(2):141-7. PMID: 19187478; PMCID: PMC2874605.
    59. Hammond KE, Metcalf M, Carvajal L, Okuda DT, Srinivasan R, Vigneron D, Nelson S, Pelletier D. Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol. 2008 Dec; 64(6):707-13. PMID: 19107998.
      View in: PubMed
    60. Okuda DT, Srinivasan R, Oksenberg JR, Goodin DS, Baranzini SE, Beheshtian A, Waubant E, Zamvil SS, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson S, Cree BA, Hauser SL, Pelletier D. Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain. 2009 Jan; 132(Pt 1):250-9. PMID: 19022862; PMCID: PMC2638695.
    61. Crawford FW, Khayal IS, McGue C, Saraswathy S, Pirzkall A, Cha S, Lamborn KR, Chang SM, Berger MS, Nelson S. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM. J Neurooncol. 2009 Feb; 91(3):337-51. PMID: 19009235; PMCID: PMC3022444.
    62. Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, Kohler SJ, Tropp J, Hurd RE, Yen YF, Nelson S, Vigneron DB, Kurhanewicz J. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res. 2008 Oct 15; 68(20):8607-15. PMID: 18922937; PMCID: PMC2829248.
    63. Lupo JM, Banerjee S, Hammond KE, Kelley DA, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson S. GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T. Magn Reson Imaging. 2009 May; 27(4):480-8. PMID: 18823730; PMCID: PMC4905599.
    64. Saraswathy S, Crawford FW, Lamborn KR, Pirzkall A, Chang S, Cha S, Nelson S. Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy. J Neurooncol. 2009 Jan; 91(1):69-81. PMID: 18810326; PMCID: PMC3022437.
    65. Tessem MB, Swanson MG, Keshari KR, Albers MJ, Joun D, Tabatabai ZL, Simko JP, Shinohara K, Nelson S, Vigneron DB, Gribbestad IS, Kurhanewicz J. Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues. Magn Reson Med. 2008 Sep; 60(3):510-6. PMID: 18727052; PMCID: PMC2613807.
    66. Li Y, Srinivasan R, Ratiney H, Lu Y, Chang SM, Nelson S. Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T. J Magn Reson Imaging. 2008 Aug; 28(2):342-50. PMID: 18666155; PMCID: PMC3033227.
    67. Xu D, Cunningham CH, Chen AP, Li Y, Kelley DA, Mukherjee P, Pauly JM, Nelson S, Vigneron DB. Phased array 3D MR spectroscopic imaging of the brain at 7 T. Magn Reson Imaging. 2008 Nov; 26(9):1201-6. PMID: 18486386; PMCID: PMC2821191.
    68. Chen AP, Kurhanewicz J, Bok R, Xu D, Joun D, Zhang V, Nelson S, Hurd RE, Vigneron DB. Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies. Magn Reson Imaging. 2008 Jul; 26(6):721-6. PMID: 18479878; PMCID: PMC2577896.
    69. Lee MC, Nelson S. Supervised pattern recognition for the prediction of contrast-enhancement appearance in brain tumors from multivariate magnetic resonance imaging and spectroscopy. Artif Intell Med. 2008 May; 43(1):61-74. PMID: 18448318; PMCID: PMC3755619.
    70. Khayal IS, Crawford FW, Saraswathy S, Lamborn KR, Chang SM, Cha S, McKnight TR, Nelson S. Relationship between choline and apparent diffusion coefficient in patients with gliomas. J Magn Reson Imaging. 2008 Apr; 27(4):718-25. PMID: 18383265; PMCID: PMC3030277.
    71. Cunningham CH, Chen AP, Lustig M, Hargreaves BA, Lupo J, Xu D, Kurhanewicz J, Hurd RE, Pauly JM, Nelson S, Vigneron DB. Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products. J Magn Reson. 2008 Jul; 193(1):139-46. PMID: 18424203; PMCID: PMC3051833.
    72. Hu S, Lustig M, Chen AP, Crane J, Kerr A, Kelley DA, Hurd R, Kurhanewicz J, Nelson S, Pauly JM, Vigneron DB. Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI. J Magn Reson. 2008 Jun; 192(2):258-64. PMID: 18367420; PMCID: PMC2475338.
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    75. Hammond KE, Lupo JM, Xu D, Metcalf M, Kelley DA, Pelletier D, Chang SM, Mukherjee P, Vigneron DB, Nelson S. Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases. Neuroimage. 2008 Feb 15; 39(4):1682-92. PMID: 18096412; PMCID: PMC2377156.
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    79. Osorio JA, Ozturk-Isik E, Xu D, Cha S, Chang S, Berger MS, Vigneron DB, Nelson S. 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil. J Magn Reson Imaging. 2007 Jul; 26(1):23-30. PMID: 17659562.
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    80. Ratiney H, Noworolski SM, Sdika M, Srinivasan R, Henry RG, Nelson S, Pelletier D. Estimation of metabolite T1 relaxation times using tissue specific analysis, signal averaging and bootstrapping from magnetic resonance spectroscopic imaging data. MAGMA. 2007 Jun; 20(3):143-55. PMID: 17602253; PMCID: PMC2798973.
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    82. Cha S, Lupo JM, Chen MH, Lamborn KR, McDermott MW, Berger MS, Nelson S, Dillon WP. Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. AJNR Am J Neuroradiol. 2007 Jun-Jul; 28(6):1078-84. PMID: 17569962.
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    83. Chen AP, Cunningham CH, Ozturk-Isik E, Xu D, Hurd RE, Kelley DA, Pauly JM, Kurhanewicz J, Nelson S, Vigneron DB. High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding. J Magn Reson Imaging. 2007 Jun; 25(6):1288-92. PMID: 17520729.
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    84. Park I, Tamai G, Lee MC, Chuang CF, Chang SM, Berger MS, Nelson S, Pirzkall A. Patterns of recurrence analysis in newly diagnosed glioblastoma multiforme after three-dimensional conformal radiation therapy with respect to pre-radiation therapy magnetic resonance spectroscopic findings. Int J Radiat Oncol Biol Phys. 2007 Oct 01; 69(2):381-9. PMID: 17513061; PMCID: PMC2377157.
    85. Catalaa I, Henry R, Dillon WP, Graves EE, McKnight TR, Lu Y, Vigneron DB, Nelson S. Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas. NMR Biomed. 2006 Jun; 19(4):463-75. PMID: 16763973.
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    86. Lupo JM, Banerjee S, Kelley D, Xu D, Vigneron DB, Majumdar S, Nelson S. Partially-parallel, susceptibility-weighted MR imaging of brain vasculature at 7 Tesla using sensitivity encoding and an autocalibrating parallel technique. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:747-50. PMID: 17945996.
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    87. Banerjee S, Ozturk-Isik E, Nelson S, Majumdar S. Fast magnetic resonance spectroscopic imaging at 3 Tesla using autocalibrating parallel technique. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:1866-9. PMID: 17945677.
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    88. Cunningham CH, Vigneron DB, Chen AP, Xu D, Nelson S, Hurd RE, Kelley DA, Pauly JM. Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging. Magn Reson Med. 2005 Nov; 54(5):1286-9. PMID: 16187273.
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    89. Hurd R, Sailasuta N, Srinivasan R, Vigneron DB, Pelletier D, Nelson S. Measurement of brain glutamate using TE-averaged PRESS at 3T. Magn Reson Med. 2004 Mar; 51(3):435-40. PMID: 15004781.
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