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Satish Pillai, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address270 Masonic Ave
San Francisco CA 94118
Phone415-513-4461
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    Despite nearly three decades of focused research since the discovery of HIV-1, to date there is no cure or effective prophylactic vaccine for HIV-1 infection. Although the advent of Highly Active Antiretroviral Therapy (HAART) has dramatically decreased the morbidity and mortality associated with HIV-1 infection, there is a pronounced demand for alternative clinical management strategies due to frequent evolution of antiretroviral resistance, toxicity, and access constraints in resource-limited settings. My research is focused on identifying and characterizing novel host factors that act against HIV-1, by investigating the molecular determinants underlying the anti-HIV-1 activity of the antiviral cytokine interferon-alpha (IFN-a) in vivo. These host factors may serve as the foundations of future prophylactic, therapeutic and eradication strategies for HIV-1 infection.

    Induction of IFN-a expression is a critical first step in the defense against a range of viral infections. The antiretroviral activity of the IFN-a cytokine was demonstrated in vitro almost immediately after the discovery of HIV-1, and includes inhibition of HIV-1 reverse transcription, viral assembly and virion release. Several clinical studies including our own report that IFN-a treatment acts against HIV-1 in vivo, and potently suppresses HIV-1 viremia in chronically-infected individuals. The precise molecular mechanisms underlying this suppressive activity in vivo, however, remain to be elucidated.

    My laboratory uses a systems biology approach to decipher the antiretroviral effects of IFN-a in vivo, by studying host gene expression, viral production and viral evolution in HIV-1-infected individuals undergoing IFN-a therapy. Recent data generated by our group strongly suggest that IFN-a suppresses HIV-1 replication in chronically infected individuals by inducing intrinsic cellular inhibitors of retroviral replication known as host restriction factors. One of these factors, the cytidine deaminase APOBEC3, blocks HIV-1 infection by hypermutating the viral genome so it no longer encodes functional proteins that are necessary for viral replication. Another factor, the type 2 integral membrane protein BST-2/tetherin, blocks HIV-1 infection by restricting the release of fully formed progeny virions from infected cells. Our data warrant investigation into therapeutic strategies that specifically enhance the expression of these intrinsic immune factors in HIV-1-infected individuals. For a concise explanation of my latest research and its implications, please visit this new UCSF press release:

    http://www.ucsf.edu/news/2012/02/11598/fighting-infections-old-drug-reveals-new-tricks

    In addition to the my principal research projects involving IFN-a and host restriction factors, I participate as a bioinformaticist and phylogeneticist in a number of HIV/AIDS collaborations with researchers at the San Francisco VA Medical Center (SFVAMC), San Francisco General Hospital (SFGH) and the Gladstone Institute of Virology and Immunology (GIVI).

    Collapse Research 
    Collapse Research Activities and Funding
    Effects of Human Galectin-9 on the CNS HIV Reservoir
    NIH/NIMH R01MH112457Sep 22, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Effects of Cell-Intrinsic Immunity on Establishment and Reversal of HIV Latency
    NIH/NIAID R01AI150449Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Effects of Cell-Intrinsic Immunity on Establishment and Reversal of HIV Latency
    NIH/NIGMS R01GM117901Sep 1, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Characterization of the HIV-1 Latent Reservoir in CCR5-Delta 32 Heterozygotes
    NIH/NIAID R21AI108503Aug 15, 2013 - Jul 31, 2015
    Role: Principal Investigator
    High throughput measurement of envelope gene diversity for an HIV incidence assay
    NIH/NIAID R21AI102791Jan 18, 2013 - Jun 30, 2013
    Role: Principal Investigator
    Antiviral Role of APOBEC3 in HIV/HCV Coinfected Patients
    NIH/NIDA K01DA024654May 1, 2008 - Jun 30, 2013
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood. Nat Commun. 2020 09 17; 11(1):4698. Ng DL, Goldgof GM, Shy BR, Levine AG, Balcerek J, Bapat SP, Prostko J, Rodgers M, Coller K, Pearce S, Franz S, Du L, Stone M, Pillai SK, Sotomayor-Gonzalez A, Servellita V, Martin CSS, Granados A, Glasner DR, Han LM, Truong K, Akagi N, Nguyen DN, Neumann NM, Qazi D, Hsu E, Gu W, Santos YA, Custer B, Green V, Williamson P, Hills NK, Lu CM, Whitman JD, Stramer SL, Wang C, Reyes K, Hakim JMC, Sujishi K, Alazzeh F, Pham L, Thornborrow E, Oon CY, Miller S, Kurtz T, Simmons G, Hackett J, Busch MP, Chiu CY. PMID: 32943630.
      View in: PubMed   Mentions:    Fields:    
    2. µ-Lat: A mouse model to evaluate human immunodeficiency virus eradication strategies. FASEB J. 2020 Sep 09. Sperber HS, Togarrati PP, Raymond KA, Bouzidi MS, Gilfanova R, Gutierrez AG, Muench MO, Pillai SK. PMID: 32901981.
      View in: PubMed   Mentions:    Fields:    
    3. Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States. PLoS One. 2020; 15(9):e0238342. Burke RM, Balter S, Barnes E, Barry V, Bartlett K, Beer KD, Benowitz I, Biggs HM, Bruce H, Bryant-Genevier J, Cates J, Chatham-Stephens K, Chea N, Chiou H, Christiansen D, Chu VT, Clark S, Cody SH, Cohen M, Conners EE, Dasari V, Dawson P, DeSalvo T, Donahue M, Dratch A, Duca L, Duchin J, Dyal JW, Feldstein LR, Fenstersheib M, Fischer M, Fisher R, Foo C, Freeman-Ponder B, Fry AM, Gant J, Gautom R, Ghinai I, Gounder P, Grigg CT, Gunzenhauser J, Hall AJ, Han GS, Haupt T, Holshue M, Hunter J, Ibrahim MB, Jacobs MW, Jarashow MC, Joshi K, Kamali T, Kawakami V, Kim M, Kirking HL, Kita-Yarbro A, Klos R, Kobayashi M, Kocharian A, Lang M, Layden J, Leidman E, Lindquist S, Lindstrom S, Link-Gelles R, Marlow M, Mattison CP, McClung N, McPherson TD, Mello L, Midgley CM, Novosad S, Patel MT, Pettrone K, Pillai SK, Pray IW, Reese HE, Rhodes H, Robinson S, Rolfes M, Routh J, Rubin R, Rudman SL, Russell D, Scott S, Shetty V, Smith-Jeffcoat SE, Soda EA, Spitters C, Stierman B, Sunenshine R, Terashita D, Traub E, Vahey GM, Verani JR, Wallace M, Westercamp M, Wortham J, Xie A, Yousaf A, Zahn M. PMID: 32877446.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    4. Seminal Plasma-Derived Extracellular-Vesicle Fractions from HIV-Infected Men Exhibit Unique MicroRNA Signatures and Induce a Proinflammatory Response in Cells Isolated from the Female Reproductive Tract. J Virol. 2020 Jul 30; 94(16). Marques de Menezes EG, Jang K, George AF, Nyegaard M, Neidleman J, Inglis HC, Danesh A, Deng X, Afshari A, Kim YH, Billaud JN, Marson K, Pilcher CD, Pillai SK, Norris PJ, Roan NR. PMID: 32434889.
      View in: PubMed   Mentions:    Fields:    
    5. FOXO1 promotes HIV latency by suppressing ER stress in T cells. Nat Microbiol. 2020 Sep; 5(9):1144-1157. Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA, Walter M, Habrylo I, Cruz A, Deeks S, Pillai S, Verdin E, Ott M. PMID: 32541947.
      View in: PubMed   Mentions: 1     Fields:    
    6. SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area. medRxiv. 2020 May 25. Ng D, Goldgof G, Shy B, Levine A, Balcerek J, Bapat SP, Prostko J, Rodgers M, Coller K, Pearce S, Franz S, Du L, Stone M, Pillai S, Sotomayor-Gonzalez A, Servellita V, Sanchez-San Martin C, Granados A, Glasner DR, Han LM, Truong K, Akagi N, Nguyen DN, Neumann N, Qazi D, Hsu E, Gu W, Santos YA, Custer B, Green V, Williamson P, Hills NK, Lu CM, Whitman JD, Stramer S, Wang C, Reyes K, Hakim J, Sujishi K, Alazzeh F, Pharm L, Oon CY, Miller S, Kurtz T, Hackett J, Simmons G, Busch MP, Chiu CY. PMID: 32511477.
      View in: PubMed   Mentions:
    7. Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency. PLoS Pathog. 2019 01; 15(1):e1007498. Li Z, Wu J, Chavez L, Hoh R, Deeks SG, Pillai SK, Zhou Q. PMID: 30645648.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals. J Neurovirol. 2019 04; 25(2):150-161. Premeaux TA, D'Antoni ML, Abdel-Mohsen M, Pillai SK, Kallianpur KJ, Nakamoto BK, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Gisslén M, Price RW, Valcour V, Ndhlovu LC. PMID: 30478799.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function. Nat Commun. 2018 08 30; 9(1):3525. Laustsen A, Bak RO, Krapp C, Kjær L, Egedahl JH, Petersen CC, Pillai S, Tang HQ, Uldbjerg N, Porteus M, Roan NR, Nyegaard M, Denton PW, Jakobsen MR. PMID: 30166549.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients. Front Immunol. 2018; 9:956. Danesh A, Inglis HC, Abdel-Mohsen M, Deng X, Adelman A, Schechtman KB, Heitman JW, Vilardi R, Shah A, Keating SM, Cohen MJ, Jacobs ES, Pillai SK, Lacroix J, Spinella PC, Norris PJ. PMID: 29867942.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells. Elife. 2018 05 01; 7. Battivelli E, Dahabieh MS, Abdel-Mohsen M, Svensson JP, Tojal Da Silva I, Cohn LB, Gramatica A, Deeks S, Greene WC, Pillai SK, Verdin E. PMID: 29714165.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    12. D-106 Chromatin Functional States Correlate with the Reversal of Latently HIV-1 Infected Primary CD4+ T cells. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2018 Apr 1; 77(&NA;):40. Emilie Battivelli, Matthew S. Dahabieh, Mohamed Abdel-Mohsen, J. Peter Svensson, Israel Tojal Da Silva, Lilian B. Cohn, Andrea Gramatica, Steven Deeks, Warner Greene, Satish K. Pillai, Eric Verdin. .
      View in: Publisher Site   Mentions:
    13. Absence of neurocognitive disadvantage associated with paediatric HIV subtype A infection in children on antiretroviral therapy. J Int AIDS Soc. 2017 10; 20(2). Bangirana P, Ruel TD, Boivin MJ, Pillai SK, Giron LB, Sikorskii A, Banik A, Achan J. PMID: 29052340.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon. Mucosal Immunol. 2018 03; 11(2):449-461. Krarup AR, Abdel-Mohsen M, Schleimann MH, Vibholm L, Engen PA, Dige A, Wittig B, Schmidt M, Green SJ, Naqib A, Keshavarzian A, Deng X, Olesen R, Petersen AM, Benfield T, Østergaard L, Rasmussen TA, Agnholt J, Nyengaard JR, Landay A, Søgaard OS, Pillai SK, Tolstrup M, Denton PW. PMID: 28766555.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsCTClinical Trials
    15. HIV Antibody Level as a Marker of HIV Persistence and Low-Level Viral Replication. J Infect Dis. 2017 07 01; 216(1):72-81. Keating SM, Pilcher CD, Jain V, Lebedeva M, Hampton D, Abdel-Mohsen M, Deng X, Murphy G, Welte A, Facente SN, Hecht F, Deeks SG, Pillai SK, Busch MP. PMID: 28498985.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 Jun 15; 64(12):1686-1695. Vibholm L, Schleimann MH, Højen JF, Benfield T, Offersen R, Rasmussen K, Olesen R, Dige A, Agnholt J, Grau J, Buzon M, Wittig B, Lichterfeld M, Petersen AM, Deng X, Abdel-Mohsen M, Pillai SK, Rutsaert S, Trypsteen W, De Spiegelaere W, Vandekerchove L, Østergaard L, Rasmussen TA, Denton PW, Tolstrup M, Søgaard OS. PMID: 28329286.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCellsCTClinical Trials
    17. Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands. Sci Rep. 2017 06 14; 7(1):3484. Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO. PMID: 28615711.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Signature of the Sleeper Cell: A Biomarker of HIV Latency Revealed. Trends Immunol. 2017 07; 38(7):457-458. Pillai SK, Deeks SG. PMID: 28511815.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Measuring the Size of the Latent Human Immunodeficiency Virus Reservoir: The Present and Future of Evaluating Eradication Strategies. J Infect Dis. 2017 03 15; 215(suppl_3):S134-S141. Henrich TJ, Deeks SG, Pillai SK. PMID: 28520968.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression. J Virol. 2017 03 15; 91(6). Jacobs ES, Keating SM, Abdel-Mohsen M, Gibb SL, Heitman JW, Inglis HC, Martin JN, Zhang J, Kaidarova Z, Deng X, Wu S, Anastos K, Crystal H, Villacres MC, Young M, Greenblatt RM, Landay AL, Gange SJ, Deeks SG, Golub ET, Pillai SK, Norris PJ. PMID: 28053103.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. PLoS Pathog. 2016 06; 12(6):e1005677. Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK. PMID: 27253379.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. TIMP3 Attenuates the Loss of Neural Stem Cells, Mature Neurons and Neurocognitive Dysfunction in Traumatic Brain Injury. Stem Cells. 2015 Dec; 33(12):3530-44. Gibb SL, Zhao Y, Potter D, Hylin MJ, Bruhn R, Baimukanova G, Zhao J, Xue H, Abdel-Mohsen M, Pillai SK, Moore AN, Johnson EM, Cox CS, Dash PK, Pati S. PMID: 26299440.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    23. Antiviral gene expression in psoriasis. J Eur Acad Dermatol Venereol. 2015 Oct; 29(10):1951-7. Raposo RA, Gupta R, Abdel-Mohsen M, Dimon M, Debbaneh M, Jiang W, York VA, Leadabrand KS, Brown G, Malakouti M, Arron S, Kuebler PJ, Wu JJ, Pillai SK, Nixon DF, Liao W. PMID: 25809693.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    24. Select host restriction factors are associated with HIV persistence during antiretroviral therapy. AIDS. 2015 Feb 20; 29(4):411-20. Abdel-Mohsen M, Wang C, Strain MC, Lada SM, Deng X, Cockerham LR, Pilcher CD, Hecht FM, Liegler T, Richman DD, Deeks SG, Pillai SK. PMID: 25602681.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    25. Role of microRNA modulation in the interferon-a/ribavirin suppression of HIV-1 in vivo. PLoS One. 2014; 9(10):e109220. Abdel-Mohsen M, Deng X, Danesh A, Liegler T, Jacobs ES, Rauch A, Ledergerber B, Norris PJ, Günthard HF, Wong JK, Pillai SK. PMID: 25275557.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Evolutionary History of the Proviruses HERV-K 113 and HERV-K 115. eLS. 2014 Sep 15. Keith E Garrison, Douglas F Nixon, Satish K Pillai, Aashish R Jha. .
      View in: Publisher Site   Mentions:
    27. Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo. J Virol. 2014 Oct; 88(19):11624-9. Raposo RA, Abdel-Mohsen M, Deng X, Hecht FM, Pilcher CD, Pillai SK, Nixon DF. PMID: 25031350.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    28. Decreased HIV type 1 transcription in CCR5-?32 heterozygotes during suppressive antiretroviral therapy. J Infect Dis. 2014 Dec 01; 210(11):1838-43. Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher CD, Hecht FM, Sinclair E, Liegler T, Richman DD, Deeks SG, Pillai SK. PMID: 24935955.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo. J Virol. 2014 Jan; 88(1):763-7. Abdel-Mohsen M, Deng X, Liegler T, Guatelli JC, Salama MS, Ghanem Hel-D, Rauch A, Ledergerber B, Deeks SG, Günthard HF, Wong JK, Pillai SK. PMID: 24155399.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    30. Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology. 2013 Oct 16; 10:106. Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK. PMID: 24131498.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    31. Hematopoietic cell transplantation and HIV cure: where we are and what next? Blood. 2013 Oct 31; 122(18):3111-5. Zou S, Glynn S, Kuritzkes D, Shah M, Cook N, Berliner N. PMID: 24009230.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    32. Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells. J Virol. 2013 Nov; 87(21):11924-9. Raposo RA, Abdel-Mohsen M, Bilska M, Montefiori DC, Nixon DF, Pillai SK. PMID: 23966394.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    33. Increased expression of intrinsic antiviral genes in HLA-B*57-positive individuals. J Leukoc Biol. 2013 Nov; 94(5):1051-9. Raposo RA, Abdel-Mohsen M, Holditch SJ, Kuebler PJ, Cheng RG, Eriksson EM, Liao W, Pillai SK, Nixon DF. PMID: 23929683.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 2013; 9(5):e1003347. Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG. PMID: 23671416.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCellsCTClinical Trials
    35. Role of retroviral restriction factors in the interferon-a-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK. PMID: 22315404.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    36. Human endogenous retrovirus K106 (HERV-K106) was infectious after the emergence of anatomically modern humans. PLoS One. 2011; 6(5):e20234. Jha AR, Nixon DF, Rosenberg MG, Martin JN, Deeks SG, Hudson RR, Garrison KE, Pillai SK. PMID: 21633511.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    37. BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action. Virology. 2011 Mar 01; 411(1):65-77. Skasko M, Tokarev A, Chen CC, Fischer WB, Pillai SK, Guatelli J. PMID: 21237475.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    38. Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS. 2010 Jun 19; 24(10):1415-23. Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L. PMID: 20495440.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    39. In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. PLoS Pathog. 2010 Jan 29; 6(1):e1000748. Wong JK, Strain MC, Porrata R, Reay E, Sankaran-Walters S, Ignacio CC, Russell T, Pillai SK, Looney DJ, Dandekar S. PMID: 20126442.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    40. Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure. AIDS. 2010 Jan 28; 24(3):411-6. Manosuthi W, Butler DM, Pérez-Santiago J, Poon AF, Pillai SK, Mehta SR, Pacold ME, Richman DD, Pond SK, Smith DM. PMID: 20009919.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    41. Cross-sectional dating of novel haplotypes of HERV-K 113 and HERV-K 115 indicate these proviruses originated in Africa before Homo sapiens. Mol Biol Evol. 2009 Nov; 26(11):2617-26. Jha AR, Pillai SK, York VA, Sharp ER, Storm EC, Wachter DJ, Martin JN, Deeks SG, Rosenberg MG, Nixon DF, Garrison KE. PMID: 19666991.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    42. Association between specific HIV-1 Env traits and virologic control in vivo. Infect Genet Evol. 2010 Apr; 10(3):365-72. Joos B, Rieder P, Fischer M, Kuster H, Rusert P, Trkola A, Pillai SK, Wong JK, Weber R, Günthard HF. PMID: 19524069.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    43. Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity. Virology. 2009 Apr 25; 387(1):98-108. Yukl S, Pillai S, Li P, Chang K, Pasutti W, Ahlgren C, Havlir D, Strain M, Günthard H, Richman D, Rice AP, Daar E, Little S, Wong JK. PMID: 19268337.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    44. Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations. Virology. 2009 Mar 01; 385(1):204-8. Smith DM, Zárate S, Shao H, Pillai SK, Letendre SL, Wong JK, Richman DD, Frost SD, Ellis RJ. PMID: 19100592.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    45. HIV rebounds from latently infected cells, rather than from continuing low-level replication. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16725-30. Joos B, Fischer M, Kuster H, Pillai SK, Wong JK, Böni J, Hirschel B, Weber R, Trkola A, Günthard HF. PMID: 18936487.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    46. Estimating selection pressures on HIV-1 using phylogenetic likelihood models. Stat Med. 2008 Oct 15; 27(23):4779-89. Kosakovsky Pond SL, Poon AF, Zárate S, Smith DM, Little SJ, Pillai SK, Ellis RJ, Wong JK, Leigh Brown AJ, Richman DD, Frost SD. PMID: 18381707.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    47. Inferring HIV transmission dynamics from phylogenetic sequence relationships. PLoS Med. 2008 Mar 18; 5(3):e69. Pilcher CD, Wong JK, Pillai SK. PMID: 18351799.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. Turning up the volume on mutational pressure: is more of a good thing always better? (A case study of HIV-1 Vif and APOBEC3). Retrovirology. 2008 Mar 13; 5:26. Pillai SK, Wong JK, Barbour JD. PMID: 18339206.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    49. Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates. AIDS. 2007 Sep 12; 21(14):F17-24. Low AJ, Dong W, Chan D, Sing T, Swanstrom R, Jensen M, Pillai S, Good B, Harrigan PR. PMID: 17721088.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    50. Rational peptide selection to detect human immunodeficiency virus type 1-specific T-cell responses under resource-limited conditions. Clin Vaccine Immunol. 2007 Jun; 14(6):785-8. Willberg CB, Pillai SK, Sharp ER, Rosenberg MG, Agudelo JD, Barbour JD, Nixon DF. PMID: 17409221.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    51. Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1. J Virol. 2007 May; 81(9):4776-86. Noviello CM, Pond SL, Lewis MJ, Richman DD, Pillai SK, Yang OO, Little SJ, Smith DM, Guatelli JC. PMID: 17329339.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    52. Lack of neutralizing antibody response to HIV-1 predisposes to superinfection. Virology. 2006 Nov 10; 355(1):1-5. Smith DM, Strain MC, Frost SD, Pillai SK, Wong JK, Wrin T, Liu Y, Petropolous CJ, Daar ES, Little SJ, Richman DD. PMID: 16962152.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    53. Genetic attributes of cerebrospinal fluid-derived HIV-1 env. Brain. 2006 Jul; 129(Pt 7):1872-83. Pillai SK, Pond SL, Liu Y, Good BM, Strain MC, Ellis RJ, Letendre S, Smith DM, Günthard HF, Grant I, Marcotte TD, McCutchan JA, Richman DD, Wong JK. PMID: 16735456.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    54. Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif. J Virol. 2006 Feb; 80(4):1837-49. Coleman SH, Madrid R, Van Damme N, Mitchell RS, Bouchet J, Servant C, Pillai S, Benichou S, Guatelli JC. PMID: 16439540.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. Codon volatility does not reflect selective pressure on the HIV-1 genome. Virology. 2005 Jun 05; 336(2):137-43. Pillai SK, Kosakovsky Pond SL, Woelk CH, Richman DD, Smith DM. PMID: 15892955.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    56. Semen-specific genetic characteristics of human immunodeficiency virus type 1 env. J Virol. 2005 Feb; 79(3):1734-42. Pillai SK, Good B, Pond SK, Wong JK, Strain MC, Richman DD, Smith DM. PMID: 15650198.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    57. Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy. J Virol. 2005 Feb; 79(3):1772-88. Strain MC, Letendre S, Pillai SK, Russell T, Ignacio CC, Günthard HF, Good B, Smith DM, Wolinsky SM, Furtado M, Marquie-Beck J, Durelle J, Grant I, Richman DD, Marcotte T, McCutchan JA, Ellis RJ, Wong JK. PMID: 15650202.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    58. Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome. Nat Struct Mol Biol. 2004 May; 11(5):435-42. Yu Q, König R, Pillai S, Chiles K, Kearney M, Palmer S, Richman D, Coffin JM, Landau NR. PMID: 15098018.
      View in: PubMed   Mentions: 315     Fields:    Translation:Cells
    59. Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea. J Virol. 2003 Nov; 77(22):12310-8. Kunstman KJ, Puffer B, Korber BT, Kuiken C, Smith UR, Kunstman J, Stanton J, Agy M, Shibata R, Yoder AD, Pillai S, Doms RW, Marx P, Wolinsky SM. PMID: 14581567.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    60. Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations. J Immunol. 2003 Oct 15; 171(8):3999-4005. Ali A, Pillai S, Ng H, Lubong R, Richman DD, Jamieson BD, Ding Y, McElrath MJ, Guatelli JC, Yang OO. PMID: 14530319.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    61. Sequence Note: A New Perspective on V3 Phenotype Prediction. AIDS Research and Human Retroviruses. 2003 Apr 1; 19(4):347-347. Satish Pillai, Benjamin Good, Douglas Richman, Jacques Corbeil. .
      View in: Publisher Site   Mentions:
    62. A new perspective on V3 phenotype prediction. AIDS Res Hum Retroviruses. 2003 Feb; 19(2):145-9. Pillai S, Good B, Richman D, Corbeil J. PMID: 12643277.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    63. The sequential introduction of HIV-1 subtype B and CRF01AE in Singapore by sexual transmission: accelerated V3 region evolution in a subpopulation of Asian CRF01 viruses. Virology. 2002 Dec 20; 304(2):311-29. Kalish ML, Korber BT, Pillai S, Robbins KE, Leo YS, Saekhou A, Verghese I, Gerrish P, Goh CL, Lupo D, Tan BH, Brown TM, Chan R. PMID: 12504572.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
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