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Scott Kogan, MD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-514-0815
ORCID ORCID Icon0000-0002-2395-8479 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Residency School of Medicine
    University of California, San FranciscoM.D.1991 School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Impact of low IL-10 levels at birth and leukemia risk
    NIH/NCI R01CA185058Jun 1, 2014 - May 31, 2019
    Role: Co-Principal Investigator
    Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia
    NIH/NCI R21CA173028Feb 1, 2013 - Jan 31, 2015
    Role: Co-Principal Investigator
    Center for Integrative Research on Childhood Leukemia and the Environment
    NIH P50ES018172Sep 25, 2009 - Jun 30, 2019
    Role: Co-Investigator
    Molecular Mechanisms of Leukemogenesis by PMLRAR alpha
    NIH/NCI R01CA095274Apr 1, 2002 - Mar 31, 2008
    Role: Principal Investigator
    PATHOGENESIS AND THERAPY OF ACUTE PROMYELOCYTIC LEUKEMIA
    NIH/NCI K08CA075986Feb 19, 1999 - Jan 31, 2004
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 Nov 05; 5(21). Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. PMID: 32990679.
      View in: PubMed   Mentions:    Fields:    
    2. Trends in Acute Lymphoblastic Leukemia Incidence in the US from 2000-2016: an Increased Risk in Latinos Across All Age Groups. Am J Epidemiol. 2020 Oct 09. Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL. PMID: 33034340.
      View in: PubMed   Mentions:    Fields:    
    3. History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System. Am J Epidemiol. 2020 10 01; 189(10):1076-1085. Morimoto LM, Kwan ML, Deosaransingh K, Munneke JR, Kang AY, Quesenberry C, Kogan S, de Smith AJ, Metayer C, Wiemels JL. PMID: 32322901.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 Oct; 90:65-71.e1. Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. PMID: 32946981.
      View in: PubMed   Mentions:    Fields:    
    5. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. 2020 05 14; 135(20):1772-1782. Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. PMID: 32219446.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 08; 34(8):2025-2037. Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K. PMID: 32066867.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology. Haematologica. 2019 11; 104(11):e514-e516. Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL. PMID: 30923090.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias. Blood. 2019 03 28; 133(13):1495-1506. Esnault C, Rahmé R, Rice KL, Berthier C, Gaillard C, Quentin S, Maubert AL, Kogan S, de Thé H. PMID: 30674471.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    9. Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia. Blood Adv. 2018 10 09; 2(19):2462-2466. Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC. PMID: 30266821.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. Dilute Russell viper venom time interpretation and clinical correlation: A two-year retrospective institutional review. Int J Lab Hematol. 2019 Feb; 41(1):80-86. Jacquot C, Wool GD, Kogan SC. PMID: 30194751.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. TCEA1 regulates the proliferative potential of mouse myeloid cells. Exp Cell Res. 2018 09 15; 370(2):551-560. Yang T, Cui H, Wen M, Zuber J, Kogan SC, Wei G. PMID: 30009791.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin. Cell Mol Gastroenterol Hepatol. 2018; 6(4):405-427. Fuqua BK, Lu Y, Frazer DM, Darshan D, Wilkins SJ, Dunn L, Loguinov AV, Kogan SC, Matak P, Chen H, Dunaief JL, Vulpe CD, Anderson GJ. PMID: 30182051.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes. Mol Ther. 2018 07 05; 26(7):1685-1693. An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML. PMID: 29914756.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia. Nat Commun. 2018 05 24; 9(1):2047. Lehmann-Che J, Bally C, Letouzé E, Berthier C, Yuan H, Jollivet F, Ades L, Cassinat B, Hirsch P, Pigneux A, Mozziconacci MJ, Kogan S, Fenaux P, de Thé H. PMID: 29795382.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    15. Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice. Blood. 2018 02 08; 131(6):636-648. Voisset E, Moravcsik E, Stratford EW, Jaye A, Palgrave CJ, Hills RK, Salomoni P, Kogan SC, Solomon E, Grimwade D. PMID: 29191918.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation? Cancer Genet. 2017 Oct; 216-217:74-78. Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN. PMID: 29025598.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood. 2017 03 23; 129(12):1680-1684. Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. PMID: 27979823.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    18. Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression. Blood. 2016 Dec 2; 128(22):753-753. Anica M. Wandler, Benjamin Huang, Alessandro Scacchetti, Jeff Craig, Hannah Yan, Gabriela Monsalve, Qing Li, Monique Dail, Jasmine C. Wong, Joy Nakitandwe, Olga Weinberg, Robert P. Hasserjian, Scott C. Kogan, Deepak Sampath, James R. Downing, Keith Yamamoto, Barry S. Taylor, Jon C. Aster, Jinghui Zhang, Kevin Shannon. .
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    19. Dilute Russell Viper Venom Time Interpretation and Clinical Correlation: A Two-Year Retrospective Institutional Review. Blood. 2016 Dec 2; 128(22):2609-2609. Cyril Jacquot, Geoffrey D. Wool, Scott C. Kogan. .
      View in: Publisher Site   Mentions:
    20. Identification of IRF8 As a Potent Tumor Suppressor in Murine Acute Promyelocytic Leukemia. Blood. 2016 Dec 2; 128(22):1518-1518. Sangeetha Surianarayanan, Coline M Gaillard, Trevor Bentley, Matthew R. Warr, Briana Fitch, Huimin Geng, Emmanuelle Passegue, Hugues de Thé, Scott C. Kogan. .
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    21. Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways. Blood. 2016 Dec 2; 128(22):742-742. Edwige Voisset, Eva Moravcsik, Eva W Stratford, Amie Jaye, Christopher J Palgrave, Robert K Hills, Paolo Salomoni, Scott C. Kogan, Ellen Solomon, David Grimwade. .
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    22. Mechanism of IL-10 Protective Effect in Development of Childhood B Cell Acute Lymphoblastic Leukemia. Blood. 2016 Dec 2; 128(22):4075-4075. Briana Fitch, Michelle L. Hermiston, Joseph L. Wiemels, Scott C. Kogan. .
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    23. Genetic Subtypes of Human Pediatric ALLs Show Gene Expression Differences That Parallel Those Observed in Mouse B1 and B2 Progenitors, Suggesting Divergent Developmental Origins. Blood. 2016 Dec 2; 128(22):1741-1741. Scott C. Kogan, Huimin Geng, Ritu Roy, Encarnacion Montecino-Rodriguez, Coline M Gaillard, Kamir Hiam, Henrik Bengtsson, David Casero, Adam B Olshen, Kenneth Dorshkind. .
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    24. Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPa as a common target of TRIB1 and PML/RARA. Haematologica. 2016 10; 101(10):1228-1236. Keeshan K, Vieugué P, Chaudhury S, Rishi L, Gaillard C, Liang L, Garcia E, Nakamura T, Omidvar N, Kogan SC. PMID: 27390356.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    25. DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia. Cancer Discov. 2016 05; 6(5):501-15. Meyer SE, Qin T, Muench DE, Masuda K, Venkatasubramanian M, Orr E, Suarez L, Gore SD, Delwel R, Paietta E, Tallman MS, Fernandez H, Melnick A, Le Beau MM, Kogan S, Salomonis N, Figueroa ME, Grimes HL. PMID: 27016502.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    26. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2016 Jan; 126(1):404. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. PMID: 26727232.
      View in: PubMed   Mentions: 1     Fields:    
    27. Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Elife. 2015 Jul 20; 4. Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K. PMID: 26193121.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation. Haematologica. 2015 Aug; 100(8):1064-75. Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC. PMID: 26088929.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    29. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015 Jul; 16(7):766-774. Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M. PMID: 25985233.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    30. Direct and indirect targeting of MYC to treat acute myeloid leukemia. Cancer Chemother Pharmacol. 2015 Jul; 76(1):35-46. Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC. PMID: 25956709.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    31. Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet. 2015 May; 47(5):539-43. Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. PMID: 25822087.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    32. Preclinical Efficacy of MEK Inhibition in Nras Mutant Acute Myeloid Leukemia. Blood. 2014 Dec 6; 124(21):3753-3753. Michael R. Burgess, Eugene Hwang, Ari J Firestone, Tannie Huang, Jin Xu, Johannes Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis, Scott W. Lowe, Kevin Shannon, Qing Li. .
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    33. Aberrant Hematopoietic Stem Cell Function in Mice Haploinsufficient for a 2 Mb Deletion of Chromosome 5A3 Syntenic to a Region of Human 7q22 Frequently Deleted in Myelodysplastic Syndromes. Blood. 2014 Dec 6; 124(21):3247-3247. Jasmine C. Wong, Kelley Weinfurtner, Pilar Alzamora, Scott C. Kogan, Michael R. Burgess, Yan Zhang, Joy Nakitandwe, Jing Ma, Jinjun Cheng, Shann-Ching Chen, Johanna Flach, Damien Reynaud, Emmanuelle Passegue, James R Downing, Kevin Shannon. .
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    34. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 2014 Dec 18; 124(26):3947-55. Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. PMID: 25361812.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    35. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 2014 May 12; 25(5):652-65. Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW. PMID: 24794707.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    36. Crenolanib is a selective type I pan-FLT3 inhibitor. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5319-24. Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP. PMID: 24623852.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    37. CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res. 2014 Jan 15; 74(2):520-31. Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, LaBarge MA, You L, Kogan SC, Gray JW, Mao JH, Wei G. PMID: 24305877.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    38. The Challenge Of Russell’s Viper Venom Time Interpretation For Lupus Anticoagulant Diagnosis: A Two-Year Retrospective Institutional Review. Blood. 2013 Nov 15; 122(21):1131-1131. Geoffrey D. Wool, Scott C. Kogan. .
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    39. Disruption Of PML Nuclear Bodies Cooperates In The Pathogenesis Of Acute Promyelocytic Leukemia. Blood. 2013 Nov 15; 122(21):3721-3721. Eva Moravcsik, Melanie Joannides, Edwige Voisset, Eva Wessel Stratford, Bernd B. Zeisig, Jo Morris, Ruth Densham, Chris Palgrave, Gordon Stamp, Emma Nye, Robert K. Hills, Paolo Salomoni, Chi Wai Eric So, Scott C. Kogan, Ellen Solomon, David Grimwade. .
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    40. Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization. J Exp Med. 2013 Oct 21; 210(11):2337-49. Tesio M, Oser GM, Baccelli I, Blanco-Bose W, Wu H, Göthert JR, Kogan SC, Trumpp A. PMID: 24127490.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    41. The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia. Cancer Cell. 2013 Mar 18; 23(3):376-89. Arteaga MF, Mikesch JH, Qiu J, Christensen J, Helin K, Kogan SC, Dong S, So CW. PMID: 23518351.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    42. Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations. Leukemia. 2013 Jul; 27(7):1570-3. Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegué E, Kogan SC. PMID: 23443342.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    43. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2013 Jan; 123(1):335-9. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. PMID: 23221337.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    44. PML-RARa Deregulates an Unexpectedly Small Number of Genes in Pre-Leukemic Promyelocytes. Blood. 2012 Nov 16; 120(21):3526-3526. Coline M Gaillard, Taku A Tokuyasu, Emmanuelle Passegue´, Scott C. Kogan. .
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    45. Crenolanib (CP-868,596) Is a Potent and Selective Type I FLT3 Inhibitor That Retains Activity Against AC220 Resistance-Causing FLT3 Kinase Domain Mutants. Blood. 2012 Nov 16; 120(21):141-141. Catherine C Smith, Elisabeth Lasater, Melissa Mccreery, Kimberly Lin, Whitney Stewart, Lauren E Damon, Alexander E Perl, Grace R Jeschke, Mayumi Sugita, Martin Carroll, Scott C. Kogan, Neil Shah. .
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    46. Evaluation of Patients with Bleeding Symptoms Using a Novel Perfusion Chamber Assay (PCA). Blood. 2012 Nov 16; 120(21):3295-3295. Matthew F. Gorman, Scott C. Kogan, James Huang, Gillian Stephens. .
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    47. PML-RARa co-operates with Sox4 in acute myeloid leukemia development in mice. Haematologica. 2013 Mar; 98(3):424-7. Omidvar N, Maunakea ML, Jones L, Sevcikova S, Yin B, Himmel KL, Tennant TR, Le Beau MM, Largaespada DA, Kogan SC. PMID: 23144197.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    48. A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis. PLoS Genet. 2012; 8(11):e1003034. Bagley BN, Keane TM, Maklakova VI, Marshall JG, Lester RA, Cancel MM, Paulsen AR, Bendzick LE, Been RA, Kogan SC, Cormier RT, Kendziorski C, Adams DJ, Collier LS. PMID: 23133403.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    49. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. PMID: 23071067.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    50. An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood. 2012 May 10; 119(19):4512-23. Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, Lowe SW, O'Sullivan MG, Kogan SC, Adams DJ, Largaespada DA. PMID: 22427200.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    51. Heterozygous Germ Line Deletion of a 2Mb Interval in Mice That Models Loss of 7q22 in Human Myeloid Malignancies Results in Defective Hematopoietic Stem Cell Function Reminiscent of Premature Aging. Blood. 2011 Nov 18; 118(21):2340-2340. Jasmine C. Wong, Kelley Weinfurtner, Yan Zhang, Pilar Alzamora, Eugene Hwang, Scott C. Kogan, Kevin M. Shannon. .
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    52. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev. 2011 Oct 15; 25(20):2125-36. Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW. PMID: 21979375.
      View in: PubMed   Mentions: 232     Fields:    Translation:HumansAnimalsCells
    53. PML-RARa enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy. 2011 Oct; 7(10):1132-44. Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ. PMID: 21673516.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    54. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14; 3(100):100ra90. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. PMID: 21918107.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    55. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011 Aug 03; 478(7370):524-8. Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR. PMID: 21814200.
      View in: PubMed   Mentions: 764     Fields:    Translation:HumansAnimalsCells
    56. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 2011 Aug 01; 25(15):1628-40. Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Fellman C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, Lowe SW. PMID: 21828272.
      View in: PubMed   Mentions: 115     Fields:    Translation:Animals
    57. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell. 2011 Apr 01; 145(1):145-58. Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW. PMID: 21458673.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    58. Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model. Genes Cancer. 2011 Feb; 2(2):160-5. Scaglioni PP, Cai LF, Majid SM, Yung TM, Socci ND, Kogan SC, Kopelovich L, Pandolfi PP. PMID: 21779489.
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    59. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 01; 71(1):106-15. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. PMID: 21199799.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    60. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. PMID: 21163920.
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    61. Mutant BCL2 Co-Operates with CBFß/PEBP2ß-MYH11 to Promote Expansion of Leukemia Initiating Cells with a Predominantly Pro-Apoptotic Mechanism Via Recruitment of Ras-GTP In a Mouse Model of Progressive Acute Myeloid Leukemia. Blood. 2010 Nov 19; 116(21):1050-1050. Nader Omidvar, Carole Le Pogam, Stephanie Beurlet, Maria-Elena Noguera, Ann Janin, Scott C. Kogan, Irving L. Weissman, Marika Pla, Christine Chomienne, Rose Ann Padua. .
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    62. ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2- Mediated Acute Myeloid Leukemia Progression with Increased Survival. Blood. 2010 Nov 19; 116(21):3308-3308. Rose Ann Padua, Stephanie Beurlet, Patricia Krief, Nader Omidvar, Carole Le Pogam, Didier Auboeuf, Pierre de la Grange, Annie Soulie, Anne Janin, Maria-Elena Noguera, Pascal Merlet, Laure Sarda-Mantel, Pierre Fenaux, Marina Konopleva, Michael Andreeff, Andrea Tu, Phoebe Yang, Alice C. Fan, Scott C. Kogan, Irving L. Weissman, Dean W. Felsher, Marika Pla, Robert West, Christine Chomienne. .
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    63. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med. 2010 Nov 22; 207(12):2581-94. Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, Le Beau MM, Kogan SC. PMID: 21059853.
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    64. PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res. 2010 Nov 01; 70(21):8792-801. Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R. PMID: 20861188.
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    65. p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev. 2010 Jul 01; 24(13):1389-402. Zhao Z, Zuber J, Diaz-Flores E, Lintault L, Kogan SC, Shannon K, Lowe SW. PMID: 20595231.
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    66. Medicine. Poisonous contacts. Science. 2010 Apr 09; 328(5975):184-5. Kogan SC. PMID: 20378808.
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    67. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood. 2010 Jun 03; 115(22):4524-32. Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K. PMID: 20233966.
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    68. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. PMID: 20194733.
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    69. An Insertional Mutagenesis Screen for Genes That Cooperate with Mll-AF9 in Leukemogenesis. Blood. 2009 Nov 20; 114(22):3962-3962. Rachel Joy Bergerson, Lara S Collier, Sanne Lugthart, Raha Allaei, Molly J Nixon, Kevin A.T. Silverstein, Aaron Sarver, Danhua Flora Fan, Anne-Francoise J Lamblin, Linda Wolff, John H. Kersey, M. Gerard O'Sullivan, Ruud Delwel, Scott C. Kogan, David J Adams, David Largaespada. .
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    70. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature. 2009 Sep 17; 461(7262):411-4. Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K. PMID: 19727076.
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    71. Mouse models of human AML accurately predict chemotherapy response. Genes Dev. 2009 Apr 01; 23(7):877-89. Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, Lowe SW. PMID: 19339691.
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    72. Curing APL: differentiation or destruction? Cancer Cell. 2009 Jan 06; 15(1):7-8. Kogan SC. PMID: 19111876.
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    73. ABT-737 Targets Intrinsic Apoptosis during Cooperation of BCL-2 and Oncogenic NRAS in An in Vivo Progression Model of Myelodysplasia/Acute Myeloid Leukaemia. Blood. 2008 Nov 16; 112(11):848-848. Nader Omidvar, Stephanie Beurlet, Carole Le Pogam, Anne Janin, Christophe Leboeuf, Annie Soulie, Niclas Setterblad, Maria-Elena Noguera, Laure Sarda-Mantel, Pascal Merlet, Marika Pla, Scott C. Kogan, Irving L Weissman, Marina Konopleva, William Bormann, Michael Andreeff, Christine Chomienne, Rose Ann Padua. .
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    74. Myc Drives Chromosomal Gain in Acute Myeloid Leukemia. Blood. 2008 Nov 16; 112(11):792-792. Letetia Jones, Sabina Sevcikova, Vernon Phan, Sachi Jain, Angell Shieh, Joshua Dubansky, Min Li, Mei Lin Maunakea, George Zhu, Thelma R Tennant, Scott Lowe, Michelle M. Le, Scott C. Kogan. .
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    75. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell. 2008 Oct 09; 3(4):416-28. Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J. PMID: 18940733.
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    76. Fractionated Cranial Irradiation Induces a Distinctive Pattern of Second Malignant Neoplasms in Nf1 Mutant Mice. International Journal of Radiation Oncology • Biology • Physics. 2008 Sep 1; 72(1):s83. J.L. Nakamura, C. Phong, S. Kogan, S. Vandenberg, R.O. Pieper, K. Shannon. .
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    77. mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10853-8. Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J. PMID: 18664580.
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    78. Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure. Mutagenesis. 2008 Sep; 23(5):341-6. Nagasubramanian R, Hansen RJ, Delaney SM, Cherian MM, Samson LD, Kogan SC, Dolan ME. PMID: 18477655.
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    79. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade. J Hum Hypertens. 2008 Jul; 22(7):512-5. Kelley-Hedgepeth A, Peter I, Kip K, Montefusco M, Kogan S, Cox D, Ordovas J, Levy D, Reis S, Mendelsohn M, Housman D, Huggins G. PMID: 18418400.
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    80. BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia. Cancer Res. 2007 Dec 15; 67(24):11657-67. Omidvar N, Kogan S, Beurlet S, le Pogam C, Janin A, West R, Noguera ME, Reboul M, Soulie A, Leboeuf C, Setterblad N, Felsher D, Lagasse E, Mohamedali A, Thomas NS, Fenaux P, Fontenay M, Pla M, Mufti GJ, Weissman I, Chomienne C, Padua RA. PMID: 18089795.
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    81. Novel Mll-AF9 Cooperating Genes Identified in a Leukemogenesis Screen Using Retroviral Mutagenesis. Blood. 2007 Nov 16; 110(11):825-825. Rachel J. Bergerson, Lara S. Collier, Raha Allaei, Kevin A. Silverstein, Anne-Francoise F. Lamblin, Linda Wolff, Scott C. Kogan, John H. Kersey, David J. Adams, David A. Largaespada. .
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    82. Expressing N-RasG12D from the Endogenous Promoter Induces Myeloproliferative Disease (MPD) and Cooperates with Retroviral Insertional Mutagenesis (RIM) To Generate Acute Myeloid Leukemia (AML). Blood. 2007 Nov 16; 110(11):1616-1616. Qing Li, Kevin Haigis, Andrew McDaniel, Benjamin Huang, Michelle Miller, Angell Shieh, Scott Kogan, Lynda Wolff, Tyler Jacks, Kevin Shannon. .
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    83. PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL. . 2007 Dec; 6(12):1967-77. Tabe Y, Konopleva M, Kondo Y, Contractor R, Tsao T, Konoplev S, Shi Y, Ling X, Watt JC, Tsutsumi-Ishii Y, Ohsaka A, Nagaoka I, Issa JP, Kogan SC, Andreeff M. PMID: 18075297.
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    85. Mouse models of acute promyelocytic leukemia. Curr Top Microbiol Immunol. 2007; 313:3-29. Kogan SC. PMID: 17217036.
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    86. Dual treatment with FLT3 inhibitor SU11657 and doxorubicin increases survival of leukemic mice. Leuk Res. 2007 Aug; 31(8):1131-4. Lee BD, Sevcikova S, Kogan SC. PMID: 17184839.
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    87. SU11657 Cooperates with Doxorubicin To Increase Survival of Leukemic Mice. Blood. 2006 Nov 16; 108(11):4572-4572. Sabina Sevcikova, Brian D. Lee, Scott C. Kogan. .
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    89. Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood. 2007 Feb 15; 109(4):1687-91. Kim A, Morgan K, Hasz DE, Wiesner SM, Lauchle JO, Geurts JL, Diers MD, Le DT, Kogan SC, Parada LF, Shannon K, Largaespada DA. PMID: 17090653.
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    90. Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. Cancer Res. 2006 Aug 01; 66(15):7639-46. Wendel HG, Malina A, Zhao Z, Zender L, Kogan SC, Cordon-Cardo C, Pelletier J, Lowe SW. PMID: 16885364.
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    91. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Cell. 2006 Jul 28; 126(2):415-26. Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E. PMID: 16873070.
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    92. CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities. Blood. 2006 Oct 01; 108(7):2416-9. Lee YJ, Jones LC, Timchenko NA, Perrotti D, Tenen DG, Kogan SC. PMID: 16788101.
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    93. Loss of p53 impedes the antileukemic response to BCR-ABL inhibition. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7444-9. Wendel HG, de Stanchina E, Cepero E, Ray S, Emig M, Fridman JS, Veach DR, Bornmann WG, Clarkson B, McCombie WR, Kogan SC, Hochhaus A, Lowe SW. PMID: 16651519.
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    94. Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia. Exp Hematol. 2006 May; 34(5):631-41. Yin B, Kogan SC, Dickins RA, Lowe SW, Largaespada DA. PMID: 16647569.
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    95. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene. 2006 Mar 23; 25(13):1974-9. Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP. PMID: 16331271.
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    96. Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. J Biol Chem. 2006 Apr 21; 281(16):10745-51. Zhuang D, Qiu Y, Kogan SC, Dong F. PMID: 16500901.
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    97. Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. Cancer Cell. 2006 Feb; 9(2):81-94. Sternsdorf T, Phan VT, Maunakea ML, Ocampo CB, Sohal J, Silletto A, Galimi F, Le Beau MM, Evans RM, Kogan SC. PMID: 16473276.
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    98. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell. 2006 Jan; 9(1):57-68. Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP, Le Beau MM, Kogan SC, Castilla LH. PMID: 16413472.
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    99. Investigation of Hematopoietic Stem Cell and Progenitor Populations: Implication for Cell Fate Determination and Lineage Commitment. Blood. 2005 Nov 16; 106(11):801-801. Emmanuelle Passegue, Camilla Forsberg, Thomas Serwold, Scott Kogan, Irving L. Weissman. .
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    100. Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. Br J Haematol. 2005 Nov; 131(4):495-507. Yamashita N, Osato M, Huang L, Yanagida M, Kogan SC, Iwasaki M, Nakamura T, Shigesada K, Asou N, Ito Y. PMID: 16281942.
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    101. Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia. Nat Rev Cancer. 2005 10; 5(10):821-7. Lallemand-Breitenbach V, Zhu J, Kogan S, Chen Z, de Thé H. PMID: 16175176.
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    102. Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell. 2005 Oct; 8(4):337-48. Chao RC, Pyzel U, Fridlyand J, Kuo YM, Teel L, Haaga J, Borowsky A, Horvai A, Kogan SC, Bonifas J, Huey B, Jacks TE, Albertson DG, Shannon KM. PMID: 16226708.
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    103. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood. 2006 Jan 15; 107(2):698-707. Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ. PMID: 16166593.
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    104. Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities. J Pharmacol Exp Ther. 2005 Dec; 315(3):1247-55. Hansen RJ, Nagasubramanian R, Delaney SM, Cherian MM, Lin S, Kogan SC, Dolan ME. PMID: 16126841.
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    105. Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation. Molecular and Cellular Biology. 2005 Jul 1; 25(13):5787-5787. Vernon T. Phan, David B. Shultz, Bao-Tran H. Truong, Timothy J. Blake, Anna L. Brown, Thomas J. Gonda, Michelle M. Le Beau, Scott C. Kogan. .
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    107. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005 Jan 26; 24(2):368-81. Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ. PMID: 15635450.
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    108. O-14 A reversible two-step model ofMDS/preleukemia: Transgenic mice expressing inducible BCL2 and mutant NRAS. Leukemia Research. 2005 Jan 1; 29:s5. R.A. Padua, N. Omidvar, S. Kogan, T.-H. Phan, R. West, D. Felsher, I. Weissmann, S. Thomas, J. Whittaker, A. Janin, M. Pla, G. Muftis, J.M. Bishop, C. Chomienne. .
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    109. Discovery of Genes Involved in Experimental Pre-Leukemia to Leukemia Transition in Mice Using Expression Arrays. Blood. 2004 Nov 16; 104(11):1109-1109. Igor A. Entin, Scott C. Kogan. .
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    110. Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice. Blood. 2004 Nov 16; 104(11):543-543. Ya-Huei Kuo, Susan Heilman, Amy Chen, Pu P. Liu, Rachel Gernstein, Scott Kogan, Lucio H. Castilla. .
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    111. Identification of Cooperating Genetic Alterations in RUNX Leukemia Using the Mouse Model for the Human Familial Leukemia, FPD/AML. Blood. 2004 Nov 16; 104(11):3383-3383. Motomi Osato, Namiko Yamashita, Masatoshi Yanagida, Liqun Huang, Scott Kogan, Masayuki Iwasaki, Takuro Nakamura, Katsuya Shigesada, Norio Asou, Yoshiaki Ito. .
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    112. Increased DNA Damage and Error-Prone Repair in MPD/MDS Mice with Disease Progression: Key Indicators for Increased Genomic Instability. Blood. 2004 Nov 16; 104(11):200-200. Feyruz V. Rassool, Terry J. Gaymes, Nicola Brady, Nicholas Lea, Marika Pla, Thi Hai Phan, Scott Kogan, Christine Chomienne, Nicholas S. Thomas, Ghulam J. Mafti, Rose Ann Padua. .
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    113. Cooperative Pathways to Acute Myeloid Leukemia Include the Combining of Transcription Factor Alterations: PML-RARa Cooperates with SOX4. Blood. 2004 Nov 16; 104(11):3385-3385. Scott C. Kogan, Mei Lin Maunakea, Karen L. Himmel, Bin Yin, Michelle M. Le Beau, David A. Largaespada. .
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    114. Homodimerization of Retinoic Acid Receptor alpha through its Fusion Partners Underlies Pathogenesis of Acute Promyelocytic Leukemia. Blood. 2004 Nov 16; 104(11):546-546. Scott C. Kogan, Vernon T. Phan, Thomas Sternsdorf, Mei Lin Maunakea, Jastinder Sohal, Angela Silletto, Francesco Galimi, Ronald M. Evans. .
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    115. HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood. 2005 Feb 15; 105(4):1456-66. Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ. PMID: 15522959.
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    116. Myeloid Malignancies. Mouse Models of Human Cancer. 2004 Oct 15. Scott C. Kogan. .
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    117. Mouse models of human cancers (part 3). Comp Med. 2004 Jun; 54(3):258-70. Borowsky AD, Munn RJ, Galvez JJ, Cardiff RD, Ward JM, Morse HC, Kogan SC, Aldape KD, Louis DN, Bosenberg MW. PMID: 15253271.
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    118. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature. 2004 Mar 18; 428(6980):332-7. Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW. PMID: 15029198.
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    119. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood. 2004 Jun 01; 103(11):4243-50. Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM. PMID: 14982883.
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    120. The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res. 2004 Jan 15; 64(2):581-9. Verschuren EW, Hodgson JG, Gray JW, Kogan S, Jones N, Evan GI. PMID: 14744772.
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    121. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):597-602. Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM. PMID: 14699048.
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    122. PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia. Nat Med. 2003 Nov; 9(11):1413-7. Padua RA, Larghero J, Robin M, le Pogam C, Schlageter MH, Muszlak S, Fric J, West R, Rousselot P, Phan TH, Mudde L, Teisserenc H, Carpentier AF, Kogan S, Degos L, Pla M, Bishop JM, Stevenson F, Charron D, Chomienne C. PMID: 14566333.
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    123. A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis. Cancer Res. 2003 Sep 01; 63(17):5257-65. Hansen LA, Brown D, Virador V, Tanaka T, Andreola F, Strain K, Dancheck B, Riley R, Arbeit JM, De Luca LM, Kogan S, Yuspa SH. PMID: 14500356.
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    124. Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation. Mol Cell Biol. 2003 Jul; 23(13):4573-85. Phan VT, Shultz DB, Truong BT, Blake TJ, Brown AL, Gonda TJ, Le Beau MM, Kogan SC. PMID: 12808098.
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    125. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia. Blood. 2003 Aug 01; 102(3):1072-4. Le Beau MM, Davis EM, Patel B, Phan VT, Sohal J, Kogan SC. PMID: 12689927.
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    126. A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657. Blood. 2003 Apr 15; 101(8):3188-97. Sohal J, Phan VT, Chan PV, Davis EM, Patel B, Kelly LM, Abrams TJ, O'Farrell AM, Gilliland DG, Le Beau MM, Kogan SC. PMID: 12515727.
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    127. In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia. J Exp Med. 2002 Nov 18; 196(10):1373-80. Guillemin MC, Raffoux E, Vitoux D, Kogan S, Soilihi H, Lallemand-Breitenbach V, Zhu J, Janin A, Daniel MT, Gourmel B, Degos L, Dombret H, Lanotte M, De Thé H. PMID: 12438428.
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    128. CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood. 2003 Feb 01; 101(3):1141-8. Truong BT, Lee YJ, Lodie TA, Park DJ, Perrotti D, Watanabe N, Koeffler HP, Nakajima H, Tenen DG, Kogan SC. PMID: 12393450.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    129. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002 Jul 01; 100(1):238-45. Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC. PMID: 12070033.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimals
    130. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood. 2002 Jul 01; 100(1):246-58. Morse HC, Anver MR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Jaffe ES, Kogan SC, MacLennan IC, Pattengale PK, Ward JM. PMID: 12070034.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    131. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia. Blood. 2002 Apr 15; 99(8):2985-91. Le Beau MM, Bitts S, Davis EM, Kogan SC. PMID: 11929790.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    132. Characteristics of consumer terminology for health information retrieval. Methods Inf Med. 2002; 41(4):289-98. Zeng Q, Kogan S, Ash N, Greenes RA, Boxwala AA. PMID: 12425240.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    133. Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia. J Virol. 2001 Oct; 75(19):9427-34. Blaydes SM, Kogan SC, Truong BT, Gilbert DJ, Jenkins NA, Copeland NG, Largaespada DA, Brannan CI. PMID: 11533205.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    134. Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi. Cancer Res. 2001 Apr 15; 61(8):3472-9. Gum JR, Hicks JW, Gillespie AM, Rius JL, Treseler PA, Kogan SC, Carlson EJ, Epstein CJ, Kim YS. PMID: 11309310.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    135. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia. J Exp Med. 2001 Feb 19; 193(4):531-43. Kogan SC, Brown DE, Shultz DB, Truong BT, Lallemand-Breitenbach V, Guillemin MC, Lagasse E, Weissman IL, Bishop JM. PMID: 11181704.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    136. Patient and clinician vocabulary: how different are they? Stud Health Technol Inform. 2001; 84(Pt 1):399-403. Zeng Q, Kogan S, Ash N, Greenes RA. PMID: 11604772.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    137. Problems and challenges in patient information retrieval: a descriptive study. Proc AMIA Symp. 2001; 329-33. Kogan S, Zeng Q, Ash N, Greenes RA. PMID: 11825205.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    138. Acute promyelocytic leukemia: a view from a mouse. Blood Cells Mol Dis. 2000 Dec; 26(6):620-5. Kogan SC. PMID: 11358354.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    139. Leukemia initiated by PMLRARalpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable. Blood. 2000 Mar 01; 95(5):1541-50. Kogan SC, Hong SH, Shultz DB, Privalsky ML, Bishop JM. PMID: 10688806.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    140. Acute promyelocytic leukemia: from treatment to genetics and back. Oncogene. 1999 Sep 20; 18(38):5261-7. Kogan SC, Bishop JM. PMID: 10498878.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    141. Images in clinical medicine. Indinavir crystalluria. N Engl J Med. 1999 Apr 29; 340(17):1329. Tsao JW, Kogan SC. PMID: 10219068.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    142. Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia. J Exp Med. 1999 Apr 05; 189(7):1043-52. Lallemand-Breitenbach V, Guillemin MC, Janin A, Daniel MT, Degos L, Kogan SC, Bishop JM, de Thé H. PMID: 10190895.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    143. The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11863-8. Kogan SC, Lagasse E, Atwater S, Bae SC, Weissman I, Ito Y, Bishop JM. PMID: 9751756.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    144. A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2551-6. Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, Atwater S, Bishop JM. PMID: 9122233.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    145. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J. 1995 Feb 01; 14(3):461-72. Haas-Kogan DA, Kogan SC, Levi D, Dazin P, T'Ang A, Fung YK, Israel MA. PMID: 7859736.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    146. Genitourinary malformations associated with agenesis of the corpus callosum. J Urol. 1993 May; 149(5):1119-21. Franco I, Kogan S, Fisher J, Rifkinson-Mann S, Reda E, Levitt S, Roseman B. PMID: 8483226.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    147. Amino acid substitutions in conserved domains of factor VIII and related proteins: study of patients with mild and moderately severe hemophilia A. Hum Mutat. 1992; 1(3):248-57. Diamond C, Kogan S, Levinson B, Gitschier J. PMID: 1301932.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    148. Genetic basis of hemophilia A. Thromb Haemost. 1991 Jul 12; 66(1):37-9. Gitschier J, Kogan S, Diamond C, Levinson B. PMID: 1926049.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    149. Mutations and a polymorphism in the factor VIII gene discovered by denaturing gradient gel electrophoresis. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2092-6. Kogan S, Gitschier J. PMID: 2107542.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    150. 35 GENETIC PREDICTION OF HEMOPHILIA A. PCR Protocols. 1990 Jan 1; 288-299. Scott C. Kogan, Jane Gitschier. .
      View in: Publisher Site   Mentions:
    151. Accurate prenatal diagnosis with novel polymerase chain reaction primers in a family with sporadic hemophilia A. Obstet Gynecol. 1989 Sep; 74(3 Pt 1):414-7. Sarkar G, Evans MI, Kogan S, Lusher J, Sommer SS. PMID: 2569705.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    152. Functional dissection and sequence of yeast HAP1 activator. Cell. 1989 Jan 27; 56(2):291-301. Pfeifer K, Kim KS, Kogan S, Guarente L. PMID: 2643482.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    153. Mutations of factor VIII cleavage sites in hemophilia A. Blood. 1988 Sep; 72(3):1022-8. Gitschier J, Kogan S, Levinson B, Tuddenham EG. PMID: 3137981.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    154. Mutations of factor VIII cleavage sites in hemophilia A. Blood. 1988 Sep 1; 72(3):1022-1028. J Gitschier, S Kogan, B Levinson, EG Tuddenham. .
      View in: Publisher Site   Mentions:
    155. An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences. Obstetrical & Gynecological Survey. 1988 Apr 1; 43(4):236-238. SCOTT C. KOGAN, MARIE DOHERTY, JANE GITSCHIER. .
      View in: Publisher Site   Mentions:
    156. An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences. Obstetrical & Gynecological Survey. 1988 Apr 1; 43(4):236-238. SCOTT C. KOGAN, MARIE DOHERTY, JANE GITSCHIER. .
      View in: Publisher Site   Mentions:
    157. An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A. N Engl J Med. 1987 Oct 15; 317(16):985-90. Kogan SC, Doherty M, Gitschier J. PMID: 3657865.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansCells
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