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Shaun Fontaine, PhD

Title(s)ProLynx, Inc.-Scientist, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th Street
San Francisco CA 94158
Phone415-514-1367
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A very long-acting Poly(ADP-ribose) polymerase inhibitor suppresses cancer cell growth in DNA repair-deficient tumor models. Cancer Res. 2020 Dec 15. Fontaine SD, Ashley GW, Houghton PJ, Kurmasheva RT, Diolaiti M, Ashworth A, Peer CJ, Nguyen R, Figg WD, Beckford-Vera DR, Santi DV. PMID: 33323380.
      View in: PubMed   Mentions:    Fields:    
    2. Prospective use of the single-mouse experimental design for the evaluation of PLX038A. Cancer Chemother Pharmacol. 2020 02; 85(2):251-263. Ghilu S, Li Q, Fontaine SD, Santi DV, Kurmasheva RT, Zheng S, Houghton PJ. PMID: 31927611.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89. . 2020 02; 19(2):673-679. Beckford Vera DR, Fontaine SD, VanBrocklin HF, Hearn BR, Reid R, Ashley GW, Santi DV. PMID: 31744896.
      View in: PubMed   Mentions:
    4. PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity. Cancer Chemother Pharmacol. 2020 01; 85(1):225-229. Fontaine SD, Santi AD, Reid R, Smith PC, Ashley GW, Santi DV. PMID: 31707444.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft. Cancer Chemother Pharmacol. 2019 10; 84(4):729-738. Fontaine SD, Hann B, Reid R, Ashley GW, Santi DV. PMID: 31321449.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system. J Control Release. 2018 05 28; 278:74-79. Hearn BR, Fontaine SD, Pfaff SJ, Schneider EL, Henise J, Ashley GW, Santi DV. PMID: 29577950.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. J Med Chem. 2016 12 22; 59(24):11161-11170. Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR. PMID: 27936709.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake. Bioconjug Chem. 2016 Oct 19; 27(10):2534-2539. Schneider EL, Hearn BR, Pfaff SJ, Fontaine SD, Reid R, Ashley GW, Grabulovski S, Strassberger V, Vogt L, Jung T, Santi DV. PMID: 27657443.
      View in: PubMed   Mentions: 2     Fields:    
    9. A reactivity-based probe of the intracellular labile ferrous iron pool. Nat Chem Biol. 2016 09; 12(9):680-5. Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. PMID: 27376690.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    10. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. PMID: 26789650.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. ACS Med Chem Lett. 2015 Nov 12; 6(11):1145-9. Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. PMID: 26617969.
      View in: PubMed   Mentions:
    12. High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations. Sci Rep. 2015 Sep 25; 5:13891. Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ. PMID: 26403635.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    13. Long-term stabilization of maleimide-thiol conjugates. Bioconjug Chem. 2015 Jan 21; 26(1):145-52. PMID: 25494821.
      View in: PubMed   Mentions: 35     Fields:    
    14. Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery. Org Lett. 2014 Nov 07; 16(21):5776-9. PMID: 25331549.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Drug delivery to the malaria parasite using an arterolane-like scaffold. ChemMedChem. 2015 Jan; 10(1):47-51. PMID: 25314098.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Synthetic studies on the mycolactone core. Org Biomol Chem. 2010 Nov 21; 8(22):5159-65. Ko KS, Alexander MD, Fontaine SD, Biggs-Houck JE, La Clair JJ, Burkart MD. PMID: 20844795.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    17. Synthesis of the mycolactone core by ring-closing metathesis. Chem Commun (Camb). 2006 Nov 28; (44):4602-4. Alexander MD, Fontaine SD, La Clair JJ, Dipasquale AG, Rheingold AL, Burkart MD. PMID: 17082856.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
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