Shawn Sorrells, PhD

TitleAssociate Specialist
InstitutionUniversity of California San Francisco
DepartmentNeurological Surgery
Address35 Medical Center Way
San Francisco CA 94143
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    Collapse Research 
    Collapse Research Activities and Funding
    Modification of amygdala circuit function with inhibitory interneuron transplants
    NIH/NIMH F32MH103003May 1, 2014 - Apr 30, 2017
    Role: Principal Investigator
    The role of glucocorticoid signaling in immune cells during excitotoxicity.
    NIH/NINDS F31NS063491Apr 1, 2009 - Mar 31, 2011
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sorrells S, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15; 555(7696):377-381. PMID: 29513649.
      View in: PubMed
    2. Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells S, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC. Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb Cortex. 2017 Apr 26; 1-13. PMID: 28449024.
      View in: PubMed
    3. Paredes MF, Sorrells S, Garcia-Verdugo JM, Alvarez-Buylla A. Brain size and limits to adult neurogenesis. J Comp Neurol. 2016 Feb 15; 524(3):646-64. PMID: 26417888.
      View in: PubMed
    4. Vogt D, Wu PR, Sorrells S, Arnold C, Alvarez-Buylla A, Rubenstein JL. Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. J Vis Exp. 2015 Apr 23; (98). PMID: 25938985; PMCID: PMC4541591.
    5. Sorrells S, Munhoz CD, Manley NC, Yen S, Sapolsky RM. Glucocorticoids increase excitotoxic injury and inflammation in the hippocampus of adult male rats. Neuroendocrinology. 2014; 100(2-3):129-40. PMID: 25228100; PMCID: PMC4304880.
    6. Krieger S, Sorrells S, Nickerson M, Pace TW. Mechanistic insights into corticosteroids in multiple sclerosis: war horse or chameleon?. Clin Neurol Neurosurg. 2014 Apr; 119:6-16. PMID: 24635918.
      View in: PubMed
    7. Sorrells S, Caso JR, Munhoz CD, Hu CK, Tran KV, Miguel ZD, Chien BY, Sapolsky RM. Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation. J Neurosci. 2013 May 01; 33(18):7877-89. PMID: 23637179; PMCID: PMC3691990.
    8. Manley NC, Caso JR, Works MG, Cutler AB, Zemlyak I, Sun G, Munhoz CD, Chang S, Sorrells S, Ermini FV, Decker JH, Bertrand AA, Dinkel KM, Steinberg GK, Sapolsky RM. Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat. PLoS One. 2013; 8(4):e61789. PMID: 23613937; PMCID: PMC3627911.
    9. Munhoz CD, Sorrells S, Caso JR, Scavone C, Sapolsky RM. Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner. J Neurosci. 2010 Oct 13; 30(41):13690-8. PMID: 20943909; PMCID: PMC3842494.
    10. Sorrells S, Caso JR, Munhoz CD, Sapolsky RM. The stressed CNS: when glucocorticoids aggravate inflammation. Neuron. 2009 Oct 15; 64(1):33-9. PMID: 19840546; PMCID: PMC4782919.
    11. Sorrells S, Sapolsky RM. Glucocorticoids can arm macrophages for innate immune battle. Brain Behav Immun. 2010 Jan; 24(1):17-8. PMID: 19822202; PMCID: PMC4782920.
    12. Sorrells S, Sapolsky RM. An inflammatory review of glucocorticoid actions in the CNS. Brain Behav Immun. 2007 Mar; 21(3):259-72. PMID: 17194565; PMCID: PMC1997278.