Loading...

Shingo Kajimura, PhD

Title(s)Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
AddressLocation Required
Varies CA 00000
Phone415-476-9644
EmailShingo.Kajimura@ucsf.edu
ORCID ORCID Icon0000-0003-0672-5910 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    Japan Society for the Promotion of Science2018JSPS Prize
    Edward Mallinckrodt, Jr. Foundation2017Mallinckrodt Scholar Award
    Helmholtz Zentrum München and Nature Medicine2014The Helmholtz Young Investigator in Diabetes Award
    Baker IDI 2014Baker IDI Metabolism & Inflammation Distinguished Lecture
    The White House2013The Presidential Early Career Awards for Scientists and Engineers (PECASE)
    The Pew Charitable Trusts2013Pew Scholar
    NIDDK2010NIH Pathway to Independence K99/R00
    American Heart Association2009Scientist Development Award

    Collapse Overview 
    Collapse Overview
    Obesity is a major risk factor for metabolic disorders such as type-2 diabetes and cardiovascular disease. A fundamental concept in understanding obesity is energy balance; obesity develops when energy intake (i.e., feeding) chronically exceeds total energy expenditure.

    Adipose tissue serves as a central regulator of energy balance. Two types of adipose tissue, white and brown, are found in mammals: white adipose tissue (WAT) functions exclusively in the storage of excess energy, while brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat through a process called non-shivering thermogenesis. Due to its remarkable oxidative capacity to dissipate excess chemical energy, brown fat function is tightly linked to the development of obesity and metabolic disorders in rodents and humans. The main focus of our lab is to uncover the molecular circuits that control brown and white fat cell development and their roles in energy metabolism.

    Over the last several years, we have been studying the transcriptional regulation of brown fat development. As an example, we have defined key transcriptional regulators, such as PRDM16 (PR-domain containing 16), C/EBPß, and EHMT1 that determine the cellular fate of brown and beige adipocytes. By employing a wide range of molecular biology, developmental biology, and biochemical/pharmacological approaches, we aim to engineer adipose cell fate and generate energy-burning brown/beige adipocytes in vivo. We hope these studies lead to the development of novel therapeutic interventions for obesity and obesity-related metabolic diseases, such as type 2 diabetes.

    Collapse Research 
    Collapse Research Activities and Funding
    Mitochondrial metabolite compartmentalization in health and disease
    NIH/NIDDK DP1DK126160Aug 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Molecular control of beige fat heterogeneity
    NIH/NIDDK R01DK125281Jul 20, 2020 - Jun 30, 2024
    Role: Principal Investigator
    Molecular Control of Brown Adipose Cell Fate and Energy Metabolism
    NIH/NIDDK R01DK097441Jul 1, 2020 - Jun 30, 2023
    Role: Principal Investigator
    Biological roles and developmental pathway of burn-induced beige fat in humans
    NIH/NIDDK R01DK112268Sep 20, 2016 - Jun 30, 2018
    Role: Principal Investigator
    BAT-mediated inter-organ communication in energy homeostasis
    NIH/NIDDK R01DK108822Apr 1, 2016 - Feb 29, 2020
    Role: Principal Investigator
    Engineering Functional Brown Fat with Anti-Obesity Potential
    NIH/NIDDK R00DK087853May 1, 2011 - Apr 30, 2014
    Role: Principal Investigator
    Engineering Functional Brown Fat with Anti-Obesity Potential
    NIH/NIDDK K99DK087853Apr 1, 2010 - Mar 31, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A new way to ignite thermogenesis in human adipose tissue. Nat Rev Endocrinol. 2020 Sep; 16(9):475-476. Verkerke ARP, Kajimura S. PMID: 32641836.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication. EMBO Rep. 2020 Sep 03; 21(9):e49828. Sponton CH, Hosono T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradhan RN, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokoyama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S. PMID: 32672883.
      View in: PubMed   Mentions:
    3. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020 Aug 06; 182(3):563-577.e20. Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. PMID: 32615086.
      View in: PubMed   Mentions: 2     Fields:    
    4. Beta-3 Adrenergic Receptor Agonist Treats Rotator Cuff Fatty Infiltration by Activating Brown/beige Fat in Mice. J Shoulder Elbow Surg. 2020 Jun 26. Wang Z, Liu X, Liu M, Jiang K, Kajimura S, Kim H, Feeley BT. PMID: 32599287.
      View in: PubMed   Mentions:    Fields:    
    5. Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation. Dev Cell. 2020 Jul 06; 54(1):106-116.e5. Jun H, Ma Y, Chen Y, Gong J, Liu S, Wang J, Knights AJ, Qiao X, Emont MP, Xu XZS, Kajimura S, Wu J. PMID: 32533922.
      View in: PubMed   Mentions:    Fields:    
    6. Intramuscular Brown Fat Activation Decreases Muscle Atrophy and Fatty Infiltration and Improves Gait After Delayed Rotator Cuff Repair in Mice. Am J Sports Med. 2020 06; 48(7):1590-1600. Wang Z, Liu X, Jiang K, Kim H, Kajimura S, Feeley BT. PMID: 32282238.
      View in: PubMed   Mentions:    Fields:    
    7. Confounding issues in the "humanized" BAT of mice. Nat Metab. 2020; 2(4):303-304. Kajimura S, Spiegelman BM. PMID: 32405619.
      View in: PubMed   Mentions:
    8. Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. Nat Commun. 2020 04 07; 11(1):1730. Tajima K, Ikeda K, Tanabe Y, Thomson EA, Yoneshiro T, Oguri Y, Ferro MD, Poon ASY, Kajimura S. PMID: 32265443.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Cellular heterogeneity in brown adipose tissue. J Clin Invest. 2020 01 02; 130(1):65-67. Oguri Y, Kajimura S. PMID: 31763995.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Naa10P puts a brake on PGC1a and fat browning. Nat Struct Mol Biol. 2019 10; 26(10):849-851. Wang Q, Kajimura S. PMID: 31527714.
      View in: PubMed   Mentions:    Fields:    
    11. Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nat Metab. 2019 Sep; 1(9):886-898. Tajima K, Ikeda K, Chang HY, Chang CH, Yoneshiro T, Oguri Y, Jun H, Wu J, Ishihama Y, Kajimura S. PMID: 32313871.
      View in: PubMed   Mentions:
    12. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019 08; 572(7771):614-619. Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. PMID: 31435015.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    13. An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Cell Metab. 2019 07 02; 30(1):190-200.e6. Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM. PMID: 31105043.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Metabolic adaptation and maladaptation in adipose tissue. Nat Metab. 2019 Feb; 1(2):189-200. Chouchani ET, Kajimura S. PMID: 31903450.
      View in: PubMed   Mentions:
    15. Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature. 2019 01; 565(7738):180-185. Chen Y, Ikeda K, Yoneshiro T, Scaramozza A, Tajima K, Wang Q, Kim K, Shinoda K, Sponton CH, Brown Z, Brack A, Kajimura S. PMID: 30568302.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    16. AAV-mediated gene therapy as a strategy to fight obesity and metabolic diseases. EMBO Mol Med. 2018 08; 10(8). Sponton CH, Kajimura S. PMID: 30021799.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018 08; 560(7716):102-106. Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. PMID: 30022159.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    18. Multifaceted Roles of Beige Fat in Energy Homeostasis Beyond UCP1. Endocrinology. 2018 07 01; 159(7):2545-2553. Sponton CH, Kajimura S. PMID: 29757365.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    19. Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism. Sci Signal. 2018 04 24; 11(527). Lu X, Altshuler-Keylin S, Wang Q, Chen Y, Henrique Sponton C, Ikeda K, Maretich P, Yoneshiro T, Kajimura S. PMID: 29692364.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    20. Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch. Nat Commun. 2018 04 19; 9(1):1566. Abe Y, Fujiwara Y, Takahashi H, Matsumura Y, Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura H, Osborne TF, Aburatani H, Kodama T, Inagaki T, Sakai J. PMID: 29674659.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues. Cell Metab. 2018 03 06; 27(3):602-615.e4. Tharp KM, Kang MS, Timblin GA, Dempersmier J, Dempsey GE, Zushin PH, Benavides J, Choi C, Li CX, Jha AK, Kajimura S, Healy KE, Sul HS, Saijo K, Kumar S, Stahl A. PMID: 29514068.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. The Common and Distinct Features of Brown and Beige Adipocytes. Trends Endocrinol Metab. 2018 03; 29(3):191-200. Ikeda K, Maretich P, Kajimura S. PMID: 29366777.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    23. Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis. Cell Metab. 2018 01 09; 27(1):180-194.e6. Hasegawa Y, Ikeda K, Chen Y, Alba DL, Stifler D, Shinoda K, Hosono T, Maretich P, Yang Y, Ishigaki Y, Chi J, Cohen P, Koliwad SK, Kajimura S. PMID: 29320702.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    24. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med. 2017 Dec; 23(12):1454-1465. Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M, Shinoda K, Chen Y, Lu X, Maretich P, Tajima K, Ajuwon KM, Soga T, Kajimura S. PMID: 29131158.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    25. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-ß expression. PLoS Genet. 2017 Aug; 13(8):e1006950. Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y. PMID: 28854265.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. Burning Fat and Building Bone by FSH Blockade. Cell Metab. 2017 08 01; 26(2):285-287. Sponton CH, Kajimura S. PMID: 28768167.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. Mol Cell Biol. 2017 08 01; 37(15). Choi SE, Kwon S, Seok S, Xiao Z, Lee KW, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. PMID: 28533219.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    28. Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol. 2017 08; 18(8):527. Inagaki T, Sakai J, Kajimura S. PMID: 28698600.
      View in: PubMed   Mentions: 4     Fields:    
    29. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017 Apr 04; 25(4):811-822.e4. Bertholet AM, Kazak L, Chouchani ET, Bogaczynska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. PMID: 28380374.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    30. Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression. Adipocyte. 2017 04 03; 6(2):124-133. Sonne SB, Yadav R, Yin G, Dalgaard MD, Myrmel LS, Gupta R, Wang J, Madsen L, Kajimura S, Kristiansen K. PMID: 28481699.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    31. Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice. J Cell Physiol. 2017 Nov; 232(11):2923-2928. Giordano A, Perugini J, Kristensen DM, Sartini L, Frontini A, Kajimura S, Kristiansen K, Cinti S. PMID: 28191637.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. Mitochondrial homeostasis in adipose tissue remodeling. Sci Signal. 2017 02 28; 10(468). Altshuler-Keylin S, Kajimura S. PMID: 28246203.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    33. Adipose tissue in 2016: Advances in the understanding of adipose tissue biology. Nat Rev Endocrinol. 2017 02; 13(2):69-70. Kajimura S. PMID: 28051117.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    34. PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance. Cell Stem Cell. 2016 12 01; 19(6):675-676. Kajimura S. PMID: 27912085.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    35. Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis. J Biol Chem. 2016 Nov 18; 291(47):24747-24755. Koh EH, Chen Y, Bader DA, Hamilton MP, He B, York B, Kajimura S, McGuire SE, Hartig SM. PMID: 27758866.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    36. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 09 13; 24(3):402-419. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. PMID: 27568548.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    37. Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol. 2016 08; 17(8):480-95. Inagaki T, Sakai J, Kajimura S. PMID: 27251423.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    38. Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. Cell Metab. 2016 06 14; 23(6):1200-1206. Chondronikola M, Volpi E, Børsheim E, Porter C, Saraf MK, Annamalai P, Yfanti C, Chao T, Wong D, Shinoda K, Labbe SM, Hurren NM, Cesani F, Kajimura S, Sidossis LS. PMID: 27238638.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCellsCTClinical Trials
    39. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016 04; 22(4):427-32. Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. PMID: 26950360.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    40. A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. Diabetes. 2016 05; 65(5):1410-23. Ohyama K, Nogusa Y, Shinoda K, Suzuki K, Bannai M, Kajimura S. PMID: 26936964.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    41. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 Mar 08; 23(3):454-66. Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. PMID: 26876562.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    42. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. PMID: 26799652.
      View in: PubMed   Mentions: 1474     Fields:    Translation:HumansAnimals
    43. Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. Cell Metab. 2015 Dec 01; 22(6):997-1008. Shinoda K, Ohyama K, Hasegawa Y, Chang HY, Ogura M, Sato A, Hong H, Hosono T, Sharp LZ, Scheel DW, Graham M, Ishihama Y, Kajimura S. PMID: 26525534.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    44. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell. 2015 Oct 22; 163(3):643-55. Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. PMID: 26496606.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    45. Comparative analysis of microRNA expression in mouse and human brown adipose tissue. BMC Genomics. 2015 Oct 19; 16:820. Güller I, McNaughton S, Crowley T, Gilsanz V, Kajimura S, Watt M, Russell AP. PMID: 26482036.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    46. Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metab. 2015 Oct 06; 22(4):546-59. Kajimura S, Spiegelman BM, Seale P. PMID: 26445512.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimals
    47. Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway. Int J Obes Suppl. 2015 Aug; 5(Suppl 1):S11-4. Kajimura S. PMID: 27152168.
      View in: PubMed   Mentions:
    48. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Nat Commun. 2015 May 07; 6:7052. Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J. PMID: 25948511.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    49. Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nat Commun. 2015 Apr 13; 6:6794. Oh CM, Namkung J, Go Y, Shong KE, Kim K, Kim H, Park BY, Lee HW, Jeon YH, Song J, Shong M, Yadav VK, Karsenty G, Kajimura S, Lee IK, Park S, Kim H. PMID: 25864946.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    50. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015 Apr; 21(4):389-94. Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. PMID: 25774848.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    51. Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J Clin Invest. 2015 Feb; 125(2):478-86. Sidossis L, Kajimura S. PMID: 25642708.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimals
    52. Engineering Fat Cell Fate to Fight Obesity and Metabolic Diseases. Keio J Med. 2015; 64(4):65. Kajimura S. PMID: 26727580.
      View in: PubMed   Mentions: 4     Fields:    
    53. A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E315-23. Ohyama K, Nogusa Y, Suzuki K, Shinoda K, Kajimura S, Bannai M. PMID: 25516550.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    54. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Rep. 2014 Dec 11; 9(5):1584-1593. Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IHN, Chang JW, Sharp LZ, Cravatt BF, Saez E, Kajimura S. PMID: 25466254.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    55. Lightening up a notch: Notch regulation of energy metabolism. Nat Med. 2014 Aug; 20(8):811-2. Gridley T, Kajimura S. PMID: 25100522.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    56. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16; 156(1-2):304-16. Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. PMID: 24439384.
      View in: PubMed   Mentions: 248     Fields:    Translation:AnimalsCells
    57. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013 Dec 05; 504(7478):163-7. Ohno H, Shinoda K, Ohyama K, Sharp LZ, Kajimura S. PMID: 24196706.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    58. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol. 2014; 76:225-49. Kajimura S, Saito M. PMID: 24188710.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    59. Isolation and differentiation of stromal vascular cells to beige/brite cells. J Vis Exp. 2013 Mar 28; (73). Aune UL, Ruiz L, Kajimura S. PMID: 23568137.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    60. Regulation of early adipose commitment by Zfp521. PLoS Biol. 2012; 10(11):e1001433. Kang S, Akerblad P, Kiviranta R, Gupta RK, Kajimura S, Griffin MJ, Min J, Baron R, Rosen ED. PMID: 23209378.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    61. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One. 2012; 7(11):e49452. Sharp LZ, Shinoda K, Ohno H, Scheel DW, Tomoda E, Ruiz L, Hu H, Wang L, Pavlova Z, Gilsanz V, Kajimura S. PMID: 23166672.
      View in: PubMed   Mentions: 208     Fields:    Translation:HumansAnimals
    62. Relevance of brown adipose tissue in infancy and adolescence. Pediatr Res. 2013 Jan; 73(1):3-9. Gilsanz V, Hu HH, Kajimura S. PMID: 23090604.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    63. A novel therapeutic approach to treating obesity through modulation of TGFß signaling. Endocrinology. 2012 Jul; 153(7):3133-46. Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J. PMID: 22549226.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    64. PPAR? agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012 Mar 07; 15(3):395-404. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PMID: 22405074.
      View in: PubMed   Mentions: 223     Fields:    Translation:Animals
    65. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 11; 481(7382):463-8. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. PMID: 22237023.
      View in: PubMed   Mentions: 962     Fields:    Translation:HumansAnimalsCells
    66. Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability. Development. 2011 Feb; 138(4):777-86. Kamei H, Ding Y, Kajimura S, Wells M, Chiang P, Duan C. PMID: 21266413.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    67. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011 Jan; 121(1):96-105. Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. PMID: 21123942.
      View in: PubMed   Mentions: 406     Fields:    Translation:Animals
    68. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature. 2010 Jul 22; 466(7305):451-6. Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM. PMID: 20651683.
      View in: PubMed   Mentions: 314     Fields:    Translation:HumansAnimalsCells
    69. Transcriptional control of brown fat development. Cell Metab. 2010 Apr 07; 11(4):257-62. Kajimura S, Seale P, Spiegelman BM. PMID: 20374957.
      View in: PubMed   Mentions: 143     Fields:    Translation:Humans
    70. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27; 460(7259):1154-8. Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. PMID: 19641492.
      View in: PubMed   Mentions: 263     Fields:    Translation:HumansAnimalsCells
    71. Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev. 2009 Apr 01; 23(7):788-97. Seale P, Kajimura S, Spiegelman BM. PMID: 19339685.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    72. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem. 2008 Nov 14; 283(46):31960-7. Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. PMID: 18728005.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    73. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21; 454(7207):961-7. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PMID: 18719582.
      View in: PubMed   Mentions: 750     Fields:    Translation:AnimalsCells
    74. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15; 22(10):1397-409. Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. PMID: 18483224.
      View in: PubMed   Mentions: 180     Fields:    Translation:AnimalsCells
    75. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007 Jul; 6(1):38-54. Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. PMID: 17618855.
      View in: PubMed   Mentions: 363     Fields:    Translation:AnimalsCells
    76. Prolactin receptor and proliferating/apoptotic cells in esophagus of the Mozambique tilapia (Oreochromis mossambicus) in fresh water and in seawater. Gen Comp Endocrinol. 2007 Jun-Jul; 152(2-3):326-31. Takahashi H, Prunet P, Kitahashi T, Kajimura S, Hirano T, Grau EG, Sakamoto T. PMID: 17418192.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    77. Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebra fish insulin-like growth factor binding protein 1 gene expression. Mol Cell Biol. 2006 Feb; 26(3):1142-55. Kajimura S, Aida K, Duan C. PMID: 16428465.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    78. Physiological concentrations of ouabain rapidly inhibit prolactin release from the tilapia pituitary. Gen Comp Endocrinol. 2005 Sep 15; 143(3):240-50. Kajimura S, Seale AP, Hirano T, Cooke IM, Grau EG. PMID: 15922343.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    79. Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1240-5. Kajimura S, Aida K, Duan C. PMID: 15644436.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    80. Identification of the growth hormone receptor in an advanced teleost, the tilapia (Oreochromis mossambicus) with special reference to its distinct expression pattern in the ovary. J Endocrinol. 2004 Apr; 181(1):65-76. Kajimura S, Kawaguchi N, Kaneko T, Kawazoe I, Hirano T, Visitacion N, Grau EG, Aida K. PMID: 15072567.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    81. In vitro effects of cortisol on the release and gene expression of prolactin and growth hormone in the tilapia, Oreochromis mossambicus. Gen Comp Endocrinol. 2004 Jan 01; 135(1):116-25. Uchida K, Yoshikawa-Ebesu JS, Kajimura S, Yada T, Hirano T, Gordon Grau E. PMID: 14644651.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    82. Changes in plasma concentrations of immunoreactive ouabain in the tilapia in response to changing salinity: is ouabain a hormone in fish? Gen Comp Endocrinol. 2004 Jan 01; 135(1):90-9. Kajimura S, Hirano T, Moriyama S, Vakkuri O, Leppäluoto J, Grau EG. PMID: 14644648.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    83. Dual mode of cortisol action on GH/IGF-I/IGF binding proteins in the tilapia, Oreochromis mossambicus. J Endocrinol. 2003 Jul; 178(1):91-9. Kajimura S, Hirano T, Visitacion N, Moriyama S, Aida K, Grau EG. PMID: 12844340.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    84. Effects of fasting on growth hormone/insulin-like growth factor I axis in the tilapia, Oreochromis mossambicus. Comp Biochem Physiol A Mol Integr Physiol. 2003 Feb; 134(2):429-39. Uchida K, Kajimura S, Riley LG, Hirano T, Aida K, Grau EG. PMID: 12547273.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    85. Effects of environmental osmolality on release of prolactin, growth hormone and ACTH from the tilapia pituitary. Gen Comp Endocrinol. 2002 Sep; 128(2):91-101. Seale AP, Riley LG, Leedom TA, Kajimura S, Dores RM, Hirano T, Grau EG. PMID: 12392682.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    86. Effects of insulin-like growth factors (IGF-I and -II) on growth hormone and prolactin release and gene expression in euryhaline tilapia, Oreochromis mossambicus. Gen Comp Endocrinol. 2002 Jul; 127(3):223-31. Kajimura S, Uchida K, Yada T, Hirano T, Aida K, Gordon Grau E. PMID: 12225763.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    87. Immunomodulatory effects of prolactin and growth hormone in the tilapia, Oreochromis mossambicus. J Endocrinol. 2002 Jun; 173(3):483-92. Yada T, Uchida K, Kajimura S, Azuma T, Hirano T, Grau EG. PMID: 12065238.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    88. cDNA cloning of two gonadotropin beta subunits (GTH-Ibeta and -IIbeta) and their expression profiles during gametogenesis in the Japanese flounder (Paralichthys olivaceus). Gen Comp Endocrinol. 2001 May; 122(2):117-29. Kajimura S, Yoshiura Y, Suzuki M, Aida K. PMID: 11316417.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    Shingo's Networks
    Concepts (369)
    Derived automatically from this person's publications.
    _
    Co-Authors (41)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _