 Siavash Fazel Darbandi, PhD
| Title(s) | UCSF Weill Institute for Neurosciences |
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 Overview Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and non-verbal communication, and by restricted and repetitive behavior. The diagnostic criteria require that symptoms become apparent before a child is three years old. Autism affects information processing in the brain by altering how nerve cells and their synapses connect and organize; how this occurs is not well understood. Autism has a strong genetic basis, although the genetics of autism are complex and it is unclear whether Autism Spectrum Disorder (ASD) is explained more by rare mutations, or by rare combinations of common genetic variants. It has long been presumed that there is a common cause at the genetic, cognitive, and neural levels for autism's characteristic triad of symptoms. However, there is increasing suspicion that autism is instead a complex disorder whose core aspects have distinct causes that often co-occur. Therefore, as a part of my postdoctoral project in Dr. State and Dr. Rubenstein's Labs, I am interested in understanding and investigating the transcriptional network downstream of Tbr1, a gene that has been shown to be associated with ASD, in order to understand the potential mechanisms underlying ASD.
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Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation. Elife. 2020 May 26; 9.
Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz JT, Vogt D, Paredes MF, Rubenstein JL. PMID: 32452758.
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Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants. Cell Rep. 2020 04 14; 31(2):107495.
Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR. PMID: 32294447.
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Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. Cell Rep. 2019 01 29; 26(5):1157-1173.e5.
Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR. PMID: 30699346.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Predicting Splicing from Primary Sequence with Deep Learning. Cell. 2019 01 24; 176(3):535-548.e24.
Jaganathan K, Kyriazopoulou Panagiotopoulou S, McRae JF, Darbandi SF, Knowles D, Li YI, Kosmicki JA, Arbelaez J, Cui W, Schwartz GB, Chow ED, Kanterakis E, Gao H, Kia A, Batzoglou S, Sanders SJ, Farh KK. PMID: 30661751.
View in: PubMed Mentions: 49 Fields: Translation: HumansCells
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Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity. Neuron. 2018 11 21; 100(4):831-845.e7.
Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, Nord AS, Willsey AJ, Chen B, State MW, Sohal VS, Rubenstein JLR. PMID: 30318412.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Functional consequences of I56ii Dlx enhancer deletion in the developing mouse forebrain. Dev Biol. 2016 Oct 27.
Fazel Darbandi S, Poitras L, Monis S, Lindtner S, Yu M, Hatch G, Rubenstein JL, Ekker M. PMID: 27983964.
View in: PubMed Mentions: 2 Fields:
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TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016 08; 26(8):1013-22.
Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G. PMID: 27325115.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
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A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009 Dec; 154(4):443-8.
Darbandi S, Franck JP. PMID: 19755169.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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| Year | Publications |
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| 2009 | 1 | | 2016 | 2 | | 2018 | 1 | | 2019 | 2 | | 2020 | 2 |
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