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Siavash Fazel Darbandi, PhD

Title(s)Associate Specialist, Psychiatry
SchoolSchool of Medicine
Address1550 Fourth St
San Francisco CA 94158
Phone415-476-7872
EmailSiavash.FazelDarbandi@ucsf.edu
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and non-verbal communication, and by restricted and repetitive behavior. The diagnostic criteria require that symptoms become apparent before a child is three years old. Autism affects information processing in the brain by altering how nerve cells and their synapses connect and organize; how this occurs is not well understood. Autism has a strong genetic basis, although the genetics of autism are complex and it is unclear whether Autism Spectrum Disorder (ASD) is explained more by rare mutations, or by rare combinations of common genetic variants. It has long been presumed that there is a common cause at the genetic, cognitive, and neural levels for autism's characteristic triad of symptoms. However, there is increasing suspicion that autism is instead a complex disorder whose core aspects have distinct causes that often co-occur. Therefore, as a part of my postdoctoral project in Dr. State and Dr. Rubenstein's Labs, I am interested in understanding and investigating the transcriptional network downstream of Tbr1, a gene that has been shown to be associated with ASD, in order to understand the potential mechanisms underlying ASD.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation. Elife. 2020 May 26; 9. Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz JT, Vogt D, Paredes MF, Rubenstein JL. PMID: 32452758.
      View in: PubMed   Mentions:    Fields:    
    2. Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants. Cell Rep. 2020 Apr 14; 31(2):107495. Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR. PMID: 32294447.
      View in: PubMed   Mentions:    Fields:    
    3. Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. Cell Rep. 2019 01 29; 26(5):1157-1173.e5. Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR. PMID: 30699346.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Predicting Splicing from Primary Sequence with Deep Learning. Cell. 2019 01 24; 176(3):535-548.e24. Jaganathan K, Kyriazopoulou Panagiotopoulou S, McRae JF, Darbandi SF, Knowles D, Li YI, Kosmicki JA, Arbelaez J, Cui W, Schwartz GB, Chow ED, Kanterakis E, Gao H, Kia A, Batzoglou S, Sanders SJ, Farh KK. PMID: 30661751.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    5. Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity. Neuron. 2018 11 21; 100(4):831-845.e7. Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, Nord AS, Willsey AJ, Chen B, State MW, Sohal VS, Rubenstein JLR. PMID: 30318412.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Functional consequences of I56ii Dlx enhancer deletion in the developing mouse forebrain. Dev Biol. 2016 Oct 27. Fazel Darbandi S, Poitras L, Monis S, Lindtner S, Yu M, Hatch G, Rubenstein JL, Ekker M. PMID: 27983964.
      View in: PubMed   Mentions: 2     Fields:    
    7. TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016 08; 26(8):1013-22. Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G. PMID: 27325115.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    8. A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009 Dec; 154(4):443-8. Darbandi S, Franck JP. PMID: 19755169.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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