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Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 04; 37(2):151-175.
Allard J, Bucher S, Massart J, Ferron PJ, Le Guillou D, Loyant R, Daniel Y, Launay Y, Buron N, Begriche K, Borgne-Sanchez A, Fromenty B. PMID: 32535746.
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1 Fields:
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Non-oxidative ethanol metabolism in human hepatic cells in vitro: Involvement of uridine diphospho-glucuronosyltransferase 1A9 in ethylglucuronide production. Toxicol In Vitro. 2020 Aug; 66:104842.
Hugbart C, Verres Y, Le Daré B, Bucher S, Vène E, Bodin A, Lagente V, Fromenty B, Bouvet R, Morel I, Loyer P, Gicquel T. PMID: 32283135.
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2 Fields:
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HumansCells
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Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor. Toxicol Sci. 2019 Jul 31.
van Meteren N, Lagadic-Gossmann D, Chevanne M, Gallais I, Gobart D, Burel A, Bucher S, Grova N, Fromenty B, Appenzeller BMR, Chevance S, Gauffre F, Le Ferrec E, Sergent O. PMID: 31368503.
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1 Fields:
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Moderate chronic ethanol consumption exerts beneficial effects on nonalcoholic fatty liver in mice fed a high-fat diet: possible role of higher formation of triglycerides enriched in monounsaturated fatty acids. Eur J Nutr. 2020 Jun; 59(4):1619-1632.
Bucher S, Begriche K, Catheline D, Trak-Smayra V, Tiaho F, Coulouarn C, Pinon G, Lagadic-Gossmann D, Rioux V, Fromenty B. PMID: 31161349.
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2 Fields:
Translation:
Animals
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Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide. Free Radic Biol Med. 2018 12; 129:323-337.
Tête A, Gallais I, Imran M, Chevanne M, Liamin M, Sparfel L, Bucher S, Burel A, Podechard N, Appenzeller BMR, Fromenty B, Grova N, Sergent O, Lagadic-Gossmann D. PMID: 30268890.
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2 Fields:
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AnimalsCells
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Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes. Arch Toxicol. 2018 10; 92(10):3077-3091.
Quesnot N, Bucher S, Gade C, Vlach M, Vene E, Valença S, Gicquel T, Holst H, Robin MA, Loyer P. PMID: 30151596.
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PubMed Mentions:
4 Fields:
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HumansAnimalsCells
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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure. Oxid Med Cell Longev. 2018; 2018:4396403.
Bucher S, Le Guillou D, Allard J, Pinon G, Begriche K, Tête A, Sergent O, Lagadic-Gossmann D, Fromenty B. PMID: 30147834.
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PubMed Mentions:
8 Fields:
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HumansCells
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Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells. J Pharmacol Exp Ther. 2018 06; 365(3):711-726.
Le Guillou D, Bucher S, Begriche K, Hoët D, Lombès A, Labbe G, Fromenty B. PMID: 29669730.
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7 Fields:
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HumansCells
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Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo. Sci Rep. 2018 04 13; 8(1):5963.
Bucher S, Tête A, Podechard N, Liamin M, Le Guillou D, Chevanne M, Coulouarn C, Imran M, Gallais I, Fernier M, Hamdaoui Q, Robin MA, Sergent O, Fromenty B, Lagadic-Gossmann D. PMID: 29654281.
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5 Fields:
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HumansAnimalsCells
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Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure. Environ Toxicol. 2017 Mar; 32(3):1024-1036.
Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin MA, Fromenty B. PMID: 27322340.
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3 Fields:
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HumansCellsPHPublic Health
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A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. Toxicol Appl Pharmacol. 2016 Feb 01; 292:40-55.
Michaut A, Le Guillou D, Moreau C, Bucher S, McGill MR, Martinais S, Gicquel T, Morel I, Robin MA, Jaeschke H, Fromenty B. PMID: 26739624.
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PubMed Mentions:
11 Fields:
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HumansCells
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Protein kinase C-dependent regulation of human hepatic drug transporter expression. Biochem Pharmacol. 2015 Dec 15; 98(4):703-17.
Mayati A, Le Vee M, Moreau A, Jouan E, Bucher S, Stieger B, Denizot C, Parmentier Y, Fardel O. PMID: 26462574.
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PubMed Mentions:
7 Fields:
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HumansCells
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Modulation of metabolizing enzymes by bisphenol a in human and animal models. Chem Res Toxicol. 2014 Sep 15; 27(9):1463-73.
Quesnot N, Bucher S, Fromenty B, Robin MA. PMID: 25142872.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Regulation of hepatic drug transporter activity and expression by organochlorine pesticides. J Biochem Mol Toxicol. 2014 Mar; 28(3):119-28.
Bucher S, Le Vee M, Jouan E, Fardel O. PMID: 24464585.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells