Simone Mayer, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentRegeneration Medicine
Address35 Medical Center Way
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    Max Planck Institute of Experimental MedicinePhD2014Molecular Neurobiology
    Georg August University GoettingenMaster of Science2011Molecular Biology
    University of CambridgeBA (hons)2009Physiology, Development, Neuroscience
    Collapse Awards and Honors
    EMBO (European Molecular Biology Organization)2015  - 2017Long-term fellowship
    German Research Foundation2017  - 2019Research fellowship

    Collapse Overview 
    Collapse Overview
    I received my BA in Natural Sciences from the University of Cambridge, UK. I went on to study Molecular Biology at the International Max Planck Research School and received my MSc and PhD degrees from the University of Goettingen in Germany. During my graduate studies I performed a research project at Yale University in the lab of Dr. Nenad Sestan, where I showed that ANKRD32 is differentially expressed in human and mouse cortical development. My PhD work focused on the intracellular mechanisms that allow clustering of inhibitory neurotransmitter receptors at synapses. I found that the small GTPase TC10 triggers the recruitment of the scaffold protein gephyrin to synapses by activating the guanine nucleotide exchange factor collybistin. This work was guided by Dr. Theofilos Papadopoulos in the lab of Dr. Nils Brose at the Max Planck Institute of Experimental Medicine. I joined the lab of Dr. Arnold Kriegstein at UCSF as a postdoctoral researcher in 2015. My current research interest is in brain development and evolution. I am exploring the role of activated gene networks and cellular signaling in the germinal zones of the developing neocortex. Relating brain development to the evolutionary expansion of the neocortex has the potential to provide insights into the molecular mechanisms underlying the diverse brain disorders, for example brain tumors, that may have emerged as the cost of the expansion of the neocortex.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15; 555(7696):377-381. PMID: 29513649.
      View in: PubMed
    2. Mayer, S., Kriegstein, A.R. .Kaas, J (ed.), Evolution of Nervous Systems. The Expansion of the Cortical Sheet in Primates. 2017; 3:59–71.
    3. Mayer S, Kumar R, Jaiswal M, Soykan T, Ahmadian MR, Brose N, Betz H, Rhee JS, Papadopoulos T. Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20795-800. PMID: 24297911; PMCID: PMC3870750.
    4. Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, Sousa AM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE, Sestan N. Spatio-temporal transcriptome of the human brain. Nature. 2011 Oct 26; 478(7370):483-9. PMID: 22031440; PMCID: PMC3566780.