Sindhu Chandran, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Phone415-353-8374
ORCID ORCID Icon0000-0003-4547-3381 Additional info
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    Collapse Education and Training
    All India Institute of Medical Sciences, New Delhi, IndiaM.B., B.S.2002Medical School
    University of Arizona, Tucson, AZInternship & Residency2007Internal Medicine
    Stanford University, Palo Alto, CAClinical & Research Fellowship2010Nephrology
    University of California, San Francisco, San Francisco, CAClinical Fellowship 2011Transplant Nephrology

    Collapse Overview 
    Collapse Overview
    A transplant nephrologist with expertise in kidney and pancreas transplantation, Dr. Chandran earned her medical degree at All India Institute of Medical Sciences, and completed her residency at the University of Arizona. After completing her nephrology fellowship at Stanford University, she joined UCSF in 2010 for additional training in kidney transplantation and stayed on as a member of the transplant nephrology faculty. She is currently the Director of the Inpatient Kidney Transplant Unit.

    Dr. Chandran is a member of the American Society of Nephrology and the American Society of Transplantation. She is board certified in internal medicine and nephrology. She has a strong background in renal physiology dating back to her research fellowship at Stanford during which she worked on the mechanisms of sodium transport in the distal nephron. At UCSF, she has focused her research interests on the treatment of renal graft inflammation with novel immunosuppressive regimens including cellular therapy with the overall goal of improving long term graft survival. Dr. Chandran is also involved in studying therapies that can promote tolerance in her role as an Associate Director with the clinical trials group at the Immune Tolerance Network.

    Collapse Research 
    Collapse Research Activities and Funding
    Applying precision MEdicine to optimize desensitization with noveL bIOlogics or cellular theRApies in highly sensiTized kidney transplant patiEnts (AMELIORATE)
    NIH U01AI113362Jul 1, 2014 - May 31, 2024
    Role: Co-Investigator
    Role Description: Protocol chair

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Approaches to Establishing Tolerance in Immune Mediated Diseases. Front Immunol. 2021; 12:744804. Huffaker MF, Sanda S, Chandran S, Chung SA, St Clair EW, Nepom GT, Smilek DE. PMID: 34616405; PMCID: PMC8488342.
      View in: PubMed   Mentions:    Fields:    
    2. Interleukin-6 blockade with tocilizumab increases Tregs and reduces T effector cytokines in renal graft inflammation: A randomized controlled trial. Am J Transplant. 2021 07; 21(7):2543-2554. Chandran S, Leung J, Hu C, Laszik ZG, Tang Q, Vincenti FG. PMID: 33331082.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Single-Cell RNA Sequencing of Tocilizumab-Treated Peripheral Blood Mononuclear Cells as an in vitro Model of Inflammation. Front Genet. 2020; 11:610682. Zarinsefat A, Hartoularos G, Rychkov D, Rashmi P, Chandran S, Vincenti F, Yee CJ, Sarwal MM. PMID: 33469465.
      View in: PubMed   Mentions:
    4. Treatment of immunocompromised COVID-19 patients with convalescent plasma. Transpl Infect Dis. 2021 Apr; 23(2):e13477. Fung M, Nambiar A, Pandey S, Aldrich JM, Teraoka J, Freise C, Roberts J, Chandran S, Hays SR, Bainbridge E, DeVoe C, Roque Gardner A, Yokoe D, Henrich TJ, Babik JM, Chin-Hong P. PMID: 32989856.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    5. Converting Maintenance Kidney-Transplant Patients From Belatacept to Another Immunosuppressive Regimen: A Cautionary Tale. Kidney Int Rep. 2020 Dec; 5(12):2123-2124. Chandran S, Wojciechowski D. PMID: 33306045.
      View in: PubMed   Mentions:
    6. The impact of belatacept on the phenotypic heterogeneity of renal T cell-mediated alloimmune response: The critical role of maintenance treatment and inflammatory load. Clin Transplant. 2020 11; 34(11):e14084. Dobi D, Vincenti F, Chandran S, Greenland JR, Bowman C, Chen A, Junger H, Laszik ZG. PMID: 32939817.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Single-cell RNA sequencing of Tocilizumab-treated peripheral blood mononuclear cells as an in vitro model of inflammation. bioRxiv. 2020 Oct 06. Zarinsefat A, Hartoularos G, Chandran S, Yee CJ, Vincenti F, Sarwal MM. PMID: 32935096.
      View in: PubMed   Mentions:
    8. SINGLE-CELL RNA SEQUENCING TO ASSESS THE EFFECT OF IL-6 RECEPTOR BLOCKADE IN KIDNEY TRANSPLANTATION. Transplantation. 2020 Sep 1; 104(S3):s31-s32. Zarinsefat ZA, Rashmi RP, Silva SA, Sigdel ST, Chandran CS, Tang TQ, Ye YC, Vincenti VF, Sarwal SM. .
      View in: Publisher Site   Mentions:
    9. The Fourth International Workshop on Clinical Transplant Tolerance. Am J Transplant. 2021 01; 21(1):21-31. Issa F, Strober S, Leventhal JR, Kawai T, Kaufman DB, Levitsky J, Sykes M, Mas V, Wood KJ, Bridges N, Welniak LA, Chandran S, Madsen JC, Nickerson P, Demetris AJ, Lakkis FG, Thomson AW. PMID: 32529725.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Clinical outcomes and serologic response in solid organ transplant recipients with COVID-19: A case series from the United States. Am J Transplant. 2020 11; 20(11):3225-3233. Fung M, Chiu CY, DeVoe C, Doernberg SB, Schwartz BS, Langelier C, Henrich TJ, Yokoe D, Davis J, Hays SR, Chandran S, Kukreja J, Ng D, Prostko J, Taylor R, Reyes K, Bainbridge E, Bond A, Chin-Hong P, Babik JM. PMID: 32476258.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansPHPublic Health
    11. SP729CLINICAL AND IMMUNOLOGIC PREDICTORS OF OUTCOME WITH A NOVEL BELATACEPT REGIMEN. Nephrology,Dialysis and Transplantation. 2018 May 1; 33(suppl_1):i592-i592. Vincenti VF, Chandran CS, Wojciechowski WD, Leung LC, Tavares TE, Tang TQ, Shoji SJ. .
      View in: Publisher Site   Mentions:
    12. Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. Transplant Proc. 2017 Oct; 49(8):1773-1778. Wojciechowski D, Chandran S, Webber A, Hirose R, Vincenti F. PMID: 28923623.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Nov; 17(11):2945-2954. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. PMID: 28675676.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCellsCTClinical Trials
    14. Retrospective evaluation of the efficacy and safety of belatacept with thymoglobulin induction and maintenance everolimus: A single-center clinical experience. Clin Transplant. 2017 Sep; 31(9). Wojciechowski D, Chandran S, Yang JYC, Sarwal MM, Vincenti F. PMID: 28662293.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Refining the Policy for Timing of Kidney Transplant Waitlist Qualification. Transplant Direct. 2017 Aug; 3(8):e195. Lee BJ, McCulloch CE, Grimes BA, Chandran S, Allen IE, Delgado C, Hsu CY. PMID: 28795146.
      View in: PubMed   Mentions:
    16. Correlation of BK Virus Neutralizing Serostatus With the Incidence of BK Viremia in Kidney Transplant Recipients. Transplantation. 2017 06; 101(6):1495-1505. Abend JR, Changala M, Sathe A, Casey F, Kistler A, Chandran S, Howard A, Wojciechowski D. PMID: 27854236.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    17. Early post-transplant conversion from tacrolimus to belatacept for prolonged delayed graft function improves renal function in kidney transplant recipients. Clin Transplant. 2017 05; 31(5). Wojciechowski D, Chandran S, Vincenti F. PMID: 28190259.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    18. Opportunities and Challenges for Kidney Donation from and to HIV-Positive Individuals. Clin J Am Soc Nephrol. 2017 03 07; 12(3):385-387. Chandran S, Stock PG. PMID: 28232405.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Chapter 21 Novel Drugs in Kidney Transplantation. Kidney Transplantation, Bioengineering and Regeneration. 2017 Jan 1; 277-290. Chandran CS, Vincenti VF. .
      View in: Publisher Site   Mentions:
    20. Current status of tolerance in kidney transplantation. Curr Opin Nephrol Hypertens. 2016 11; 25(6):591-601. Chandran S, Feng S. PMID: 27636772.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. BK Virus Infection After Kidney Transplantation: The Data Are Mounting for a Personalized Approach. Transplantation. 2016 Apr; 100(4):703-4. Wojciechowski D, Chandran S. PMID: 26760573.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Complications of Ultrasound-Guided Renal Transplant Biopsies. Am J Transplant. 2016 Apr; 16(4):1298-305. Morgan TA, Chandran S, Burger IM, Zhang CA, Goldstein RB. PMID: 26601796.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    23. Erratum to: Pharmacologic Targeting of Regulatory T Cells for Solid Organ Transplantation: Current and Future Prospects. Drugs. 2015 Dec; 75(18):2171. Safa K, Chandran S, Wojciechowski D. PMID: 26553341.
      View in: PubMed   Mentions:    Fields:    
    24. Pharmacologic targeting of regulatory T cells for solid organ transplantation: current and future prospects. Drugs. 2015 Nov; 75(16):1843-52. Safa K, Chandran S, Wojciechowski D. PMID: 26493288.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Multiple high MFI Class I DSA can cause acute AMR of kidney allograft in simultaneous liver and kidney transplant recipients: outcome analysis from a single-center. Human Immunology. 2015 Oct 1; 76:137. Rajalingam RR, Chandran CS, Cunniffe CK, Feng FS. .
      View in: Publisher Site   Mentions:
    26. Prevalence of abdominal aortic calcifications in older living renal donors and its effect on graft function and histology. Transpl Int. 2015 Oct; 28(10):1172-8. Wu EH, Wojciechowski D, Chandran S, Yeh BM, Park M, Westphalen A, Wang ZJ. PMID: 26011061.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. FP886T REGULATORY CELL THERAPY TO CONTROL INFLAMMATION IN RENAL ALLOGRAFTS. Nephrology,Dialysis and Transplantation. 2015 May 1; 30(suppl_3):iii372-iii373. Vincenti VF, Tang TQ, Laszik LZ, Sarwal SM, Bluestone BJ, Chandran CS. .
      View in: Publisher Site   Mentions:
    28. Adjuvant Ciprofloxacin Therapy for Refractory BK Polyomavirus Infection in Kidney Transplant Recipients. Transplantation Journal. 2014 Jul 1; 98:560. Chandran CS, Arroyo AD, Vagefi VP, Wojciechowski WD. .
      View in: Publisher Site   Mentions:
    29. Novel Strategy to Improve the Efficacy of Belatacept. Transplantation Journal. 2014 Jul 1; 98:455. Wojciechowski WD, Chandran CS, Vincenti VF. .
      View in: Publisher Site   Mentions:
    30. Belatacept Conversion in Kidney Transplant Recipients for Prolonged DGF. Transplantation Journal. 2014 Jul 1; 98:456. Wojciechowski WD, Chandran CS, Vincenti VF. .
      View in: Publisher Site   Mentions:
    31. Pharmacodynamic Monitoring of NFAT- Regulated Gene Expression and P70S6 Kinase Activity in Kidney Transplant Patients With BKV Infection. Transplantation Journal. 2014 Jul 1; 98:880. Webber WA, Wojciechowski WD, Leung LC, Chandran CS, Hirose HR, Vincenti VF. .
      View in: Publisher Site   Mentions:
    32. Everolimus Conversion to Treat BK Virus Infection in Renal Transplant Recipients: Interim Analysis of a Pilot Study. Transplantation Journal. 2014 Jul 1; 98:558-559. Wojciechowski WD, Webber WA, Chandran CS, Hirose HR, Vincenti VF. .
      View in: Publisher Site   Mentions:
    33. Adjuvant Ciprofloxacin for Persistent BK Polyomavirus Infection in Kidney Transplant Recipients. J Transplant. 2014; 2014:107459. Arroyo D, Chandran S, Vagefi PA, Wojciechowski D. PMID: 25349720.
      View in: PubMed   Mentions:
    34. Prediabetic living kidney donors have preserved kidney function at 10 years after donation. Transplantation. 2014 Apr 15; 97(7):748-54. Chandran S, Masharani U, Webber AB, Wojciechowski DM. PMID: 24342975.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. Clinical aspects: focusing on key unique organ-specific issues of renal transplantation. Cold Spring Harb Perspect Med. 2014 Feb 01; 4(2). Chandran S, Vincenti F. PMID: 24370927.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. 63 Immunosuppression in Transplantation. National Kidney Foundation Primer on Kidney Diseases. 2014 Jan 1; (Science2701995):564-574. Chandran CS, Vincenti VF. .
      View in: Publisher Site   Mentions:
    37. Effect of ciprofloxacin combined with sulfamethoxazole-trimethoprim prophylaxis on the incidence of urinary tract infections after kidney transplantation. Transplantation. 2013 Aug 27; 96(4):400-5. Wojciechowski D, Chandran S. PMID: 23698597.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    38. Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation. Am J Kidney Dis. 2013 Aug; 62(2):335-8. Chandran S, Jen KY, Laszik ZG. PMID: 23481367.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Ciprofloxacin prophylaxis in kidney transplant recipients reduces BK virus infection at 3 months but not at 1 year. Transplantation. 2012 Dec 15; 94(11):1117-23. Wojciechowski D, Chanda R, Chandran S, Lee B, Webber A, Macaraig M, Tomlanovich S, Vincenti F. PMID: 23060281.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    40. Fever, hepatosplenomegaly and a skin nodule in a kidney-pancreas transplant recipient. Am J Transplant. 2012 Sep; 12(9):2556-8; quiz 2558. Freed MM, Ramirez-Valle F, Chandran S. PMID: 22925186.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. The Scribner shunt: 50 years later. Kidney Int. 2012 Jan; 81(1):120. Lockridge JB, Chandran S. PMID: 22170532.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V. PMID: 21900244.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    43. Eculizumab for the treatment of de novo thrombotic microangiopathy post simultaneous pancreas-kidney transplantation--a case report. Transplant Proc. 2011 Jun; 43(5):2097-101. Chandran S, Baxter-Lowe L, Olson JL, Tomlanovich SJ, Webber A. PMID: 21693335.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    44. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. PMID: 20466724.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    45. Imatinib in the treatment of nephrogenic systemic fibrosis. Am J Kidney Dis. 2009 Jan; 53(1):129-32. Chandran S, Petersen J, Jacobs C, Fiorentino D, Doeden K, Lafayette RA. PMID: 19012999.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    46. The Akt pathway in human breast cancer: a tissue-array-based analysis. Mod Pathol. 2006 Feb; 19(2):238-45. Bose S, Chandran S, Mirocha JM, Bose N. PMID: 16341149.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
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