Sindhu Chandran, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0003-4547-3381 Additional info
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    All India Institute of Medical Sciences, New Delhi, IndiaM.B., B.S.2002Medical School
    University of Arizona, Tucson, AZInternship & Residency2007Internal Medicine
    Stanford University, Palo Alto, CAClinical & Research Fellowship2010Nephrology
    University of California, San Francisco, San Francisco, CAClinical Fellowship 2011Transplant Nephrology

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    A transplant nephrologist with expertise in kidney and pancreas transplantation, Dr. Chandran earned her medical degree at All India Institute of Medical Sciences, and completed her residency at the University of Arizona. After completing her nephrology fellowship at Stanford University, she joined UCSF in 2010 for additional training in kidney transplantation and stayed on as a member of the faculty. She has been the Director of the Inpatient Kidney Transplant Unit since 2014.

    Dr. Chandran is a member of the American Society of Nephrology and the American Society of Transplantation. She is board certified in internal medicine and nephrology. She has a strong background in renal physiology dating back to her research fellowship at Stanford on mechanisms of sodium transport in the distal nephron. At UCSF, she has focused her research interests on the treatment of renal graft inflammation with novel immunosuppressive regimens including cellular therapy with the overall goal of improving long-term graft survival. As the Lead Clinical Trial Physician for the Transplant Portfolio at the Immune Tolerance Network, Dr. Chandran is involved in developing protocols to promote transplant tolerance in liver and kidney transplant recipients.

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    Collapse Research Activities and Funding
    Applying precision MEdicine to optimize desensitization with noveL bIOlogics or cellular theRApies in highly sensiTized kidney transplant patiEnts (AMELIORATE)
    NIH U01AI113362Jul 1, 2014 - May 31, 2024
    Role: Co-Investigator
    Description: Protocol chair

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Meeting Report: The Fifth International Samuel Strober Workshop on Clinical Immune Tolerance. Transplantation. 2023 Mar 01; 107(3):564-569. Sykes M, Chandran S, Kawai T, Levitsky J, Mapara M, Mathew J, Thomson A, Yamada K. PMID: 36808845.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses. bioRxiv. 2023 Jan 20. Duan M, Nguyen DC, Joyner CJ, Saney CL, Tipton CM, Andrews J, Lonial S, Kim C, Hentenaar I, Kosters A, Ghosn E, Jackson A, Knechtle S, Maruthamuthu S, Chandran S, Martin T, Rajalingam R, Vincenti F, Breeden C, Sanz I, Gibson G, Eun-Hyung Lee F. PMID: 36711623; PMCID: PMC9882341.
      View in: PubMed   Mentions:
    3. Impact of interleukin-6 on T cells in kidney transplant recipients. Am J Transplant. 2022 Dec; 22 Suppl 4:18-27. Chandran S, Tang Q. PMID: 36453710.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial. J Am Soc Nephrol. 2023 01 01; 34(1):145-159. Hricik DE, Armstrong B, Alhamad T, Brennan DC, Bromberg JS, Bunnapradist S, Chandran S, Fairchild RL, Foley DP, Formica R, Gibson IW, Kesler K, Kim SJ, Mannon RB, Menon MC, Newell KA, Nickerson P, Odim J, Poggio ED, Sung R, Shapiro R, Tinckam K, Vincenti F, Heeger PS. PMID: 36195441.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsCTClinical Trials
    5. T cell-mediated rejection in kidney transplant recipients: The end(point) is also the beginning. Am J Transplant. 2022 03; 22(3):683-684. Chandran S, Mannon RB. PMID: 35073440.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. COVID-19 Vaccination in Kidney Transplant Recipients: An Ounce Pre-Transplant is Worth a Pound Post-Transplant. J Am Soc Nephrol. 2021 12 01; 32(12):2977-2978. Chandran S, Stock PG. PMID: 36734819; PMCID: PMC8638393.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    7. Approaches to Establishing Tolerance in Immune Mediated Diseases. Front Immunol. 2021; 12:744804. Huffaker MF, Sanda S, Chandran S, Chung SA, St Clair EW, Nepom GT, Smilek DE. PMID: 34616405; PMCID: PMC8488342.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Interleukin-6 blockade with tocilizumab increases Tregs and reduces T effector cytokines in renal graft inflammation: A randomized controlled trial. Am J Transplant. 2021 07; 21(7):2543-2554. Chandran S, Leung J, Hu C, Laszik ZG, Tang Q, Vincenti FG. PMID: 33331082.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    9. Single-Cell RNA Sequencing of Tocilizumab-Treated Peripheral Blood Mononuclear Cells as an in vitro Model of Inflammation. Front Genet. 2020; 11:610682. Zarinsefat A, Hartoularos G, Rychkov D, Rashmi P, Chandran S, Vincenti F, Yee CJ, Sarwal MM. PMID: 33469465; PMCID: PMC7813999.
      View in: PubMed   Mentions: 4  
    10. Treatment of immunocompromised COVID-19 patients with convalescent plasma. Transpl Infect Dis. 2021 Apr; 23(2):e13477. Fung M, Nambiar A, Pandey S, Aldrich JM, Teraoka J, Freise C, Roberts J, Chandran S, Hays SR, Bainbridge E, DeVoe C, Roque Gardner A, Yokoe D, Henrich TJ, Babik JM, Chin-Hong P. PMID: 32989856; PMCID: PMC7537112.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    11. Converting Maintenance Kidney-Transplant Patients From Belatacept to Another Immunosuppressive Regimen: A Cautionary Tale. Kidney Int Rep. 2020 Dec; 5(12):2123-2124. Chandran S, Wojciechowski D. PMID: 33306045; PMCID: PMC7710880.
      View in: PubMed   Mentions:
    12. The impact of belatacept on the phenotypic heterogeneity of renal T cell-mediated alloimmune response: The critical role of maintenance treatment and inflammatory load. Clin Transplant. 2020 11; 34(11):e14084. Dobi D, Vincenti F, Chandran S, Greenland JR, Bowman C, Chen A, Junger H, Laszik ZG. PMID: 32939817; PMCID: PMC8059253.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. The Fourth International Workshop on Clinical Transplant Tolerance. Am J Transplant. 2021 01; 21(1):21-31. Issa F, Strober S, Leventhal JR, Kawai T, Kaufman DB, Levitsky J, Sykes M, Mas V, Wood KJ, Bridges N, Welniak LA, Chandran S, Madsen JC, Nickerson P, Demetris AJ, Lakkis FG, Thomson AW. PMID: 32529725.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    14. Clinical outcomes and serologic response in solid organ transplant recipients with COVID-19: A case series from the United States. Am J Transplant. 2020 11; 20(11):3225-3233. Fung M, Chiu CY, DeVoe C, Doernberg SB, Schwartz BS, Langelier C, Henrich TJ, Yokoe D, Davis J, Hays SR, Chandran S, Kukreja J, Ng D, Prostko J, Taylor R, Reyes K, Bainbridge E, Bond A, Chin-Hong P, Babik JM. PMID: 32476258; PMCID: PMC7300859.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCellsPHPublic Health
    15. Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. Transplant Proc. 2017 Oct; 49(8):1773-1778. Wojciechowski D, Chandran S, Webber A, Hirose R, Vincenti F. PMID: 28923623.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Nov; 17(11):2945-2954. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. PMID: 28675676; PMCID: PMC5662482.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCellsCTClinical Trials
    17. Retrospective evaluation of the efficacy and safety of belatacept with thymoglobulin induction and maintenance everolimus: A single-center clinical experience. Clin Transplant. 2017 Sep; 31(9). Wojciechowski D, Chandran S, Yang JYC, Sarwal MM, Vincenti F. PMID: 28662293.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Refining the Policy for Timing of Kidney Transplant Waitlist Qualification. Transplant Direct. 2017 Aug; 3(8):e195. Lee BJ, McCulloch CE, Grimes BA, Chandran S, Allen IE, Delgado C, Hsu CY. PMID: 28795146; PMCID: PMC5540633.
      View in: PubMed   Mentions: 1  
    19. Correlation of BK Virus Neutralizing Serostatus With the Incidence of BK Viremia in Kidney Transplant Recipients. Transplantation. 2017 06; 101(6):1495-1505. Abend JR, Changala M, Sathe A, Casey F, Kistler A, Chandran S, Howard A, Wojciechowski D. PMID: 27854236.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. Early post-transplant conversion from tacrolimus to belatacept for prolonged delayed graft function improves renal function in kidney transplant recipients. Clin Transplant. 2017 05; 31(5). Wojciechowski D, Chandran S, Vincenti F. PMID: 28190259.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    21. Opportunities and Challenges for Kidney Donation from and to HIV-Positive Individuals. Clin J Am Soc Nephrol. 2017 03 07; 12(3):385-387. Chandran S, Stock PG. PMID: 28232405; PMCID: PMC5338696.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Chapter 21 Novel Drugs in Kidney Transplantation. Kidney Transplantation, Bioengineering and Regeneration. 2017 Jan 1; 277-290. Chandran CS, Vincenti VF. .
      View in: Publisher Site   Mentions:
    23. Current status of tolerance in kidney transplantation. Curr Opin Nephrol Hypertens. 2016 11; 25(6):591-601. Chandran S, Feng S. PMID: 27636772.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. BK Virus Infection After Kidney Transplantation: The Data Are Mounting for a Personalized Approach. Transplantation. 2016 Apr; 100(4):703-4. Wojciechowski D, Chandran S. PMID: 26760573.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Complications of Ultrasound-Guided Renal Transplant Biopsies. Am J Transplant. 2016 Apr; 16(4):1298-305. Morgan TA, Chandran S, Burger IM, Zhang CA, Goldstein RB. PMID: 26601796.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    26. Erratum to: Pharmacologic Targeting of Regulatory T Cells for Solid Organ Transplantation: Current and Future Prospects. Drugs. 2015 Dec; 75(18):2171. Safa K, Chandran S, Wojciechowski D. PMID: 26553341.
      View in: PubMed   Mentions:    Fields:    
    27. Pharmacologic targeting of regulatory T cells for solid organ transplantation: current and future prospects. Drugs. 2015 Nov; 75(16):1843-52. Safa K, Chandran S, Wojciechowski D. PMID: 26493288.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    28. Multiple high MFI Class I DSA can cause acute AMR of kidney allograft in simultaneous liver and kidney transplant recipients: outcome analysis from a single-center. Human Immunology. 2015 Oct 1; 76:137. Rajalingam RR, Chandran CS, Cunniffe CK, Feng FS. .
      View in: Publisher Site   Mentions:
    29. Prevalence of abdominal aortic calcifications in older living renal donors and its effect on graft function and histology. Transpl Int. 2015 Oct; 28(10):1172-8. Wu EH, Wojciechowski D, Chandran S, Yeh BM, Park M, Westphalen A, Wang ZJ. PMID: 26011061.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    30. Belatacept Conversion in Kidney Transplant Recipients for Prolonged DGF. Transplantation Journal. 2014 Jul 1; 98:456. Wojciechowski WD, Chandran CS, Vincenti VF. .
      View in: Publisher Site   Mentions:
    31. Adjuvant Ciprofloxacin Therapy for Refractory BK Polyomavirus Infection in Kidney Transplant Recipients. Transplantation Journal. 2014 Jul 1; 98:560. Chandran CS, Arroyo AD, Vagefi VP, Wojciechowski WD. .
      View in: Publisher Site   Mentions:
    32. Everolimus Conversion to Treat BK Virus Infection in Renal Transplant Recipients: Interim Analysis of a Pilot Study. Transplantation Journal. 2014 Jul 1; 98:558-559. Wojciechowski WD, Webber WA, Chandran CS, Hirose HR, Vincenti VF. .
      View in: Publisher Site   Mentions:
    33. Pharmacodynamic Monitoring of NFAT- Regulated Gene Expression and P70S6 Kinase Activity in Kidney Transplant Patients With BKV Infection. Transplantation Journal. 2014 Jul 1; 98:880. Webber WA, Wojciechowski WD, Leung LC, Chandran CS, Hirose HR, Vincenti VF. .
      View in: Publisher Site   Mentions:
    34. Novel Strategy to Improve the Efficacy of Belatacept. Transplantation Journal. 2014 Jul 1; 98:455. Wojciechowski WD, Chandran CS, Vincenti VF. .
      View in: Publisher Site   Mentions:
    35. Adjuvant Ciprofloxacin for Persistent BK Polyomavirus Infection in Kidney Transplant Recipients. J Transplant. 2014; 2014:107459. Arroyo D, Chandran S, Vagefi PA, Wojciechowski D. PMID: 25349720; PMCID: PMC4034659.
      View in: PubMed   Mentions: 6  
    36. Prediabetic living kidney donors have preserved kidney function at 10 years after donation. Transplantation. 2014 Apr 15; 97(7):748-54. Chandran S, Masharani U, Webber AB, Wojciechowski DM. PMID: 24342975.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    37. Clinical aspects: focusing on key unique organ-specific issues of renal transplantation. Cold Spring Harb Perspect Med. 2014 Feb 01; 4(2). Chandran S, Vincenti F. PMID: 24370927; PMCID: PMC3904099.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Effect of ciprofloxacin combined with sulfamethoxazole-trimethoprim prophylaxis on the incidence of urinary tract infections after kidney transplantation. Transplantation. 2013 Aug 27; 96(4):400-5. Wojciechowski D, Chandran S. PMID: 23698597.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    39. Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation. Am J Kidney Dis. 2013 Aug; 62(2):335-8. Chandran S, Jen KY, Laszik ZG. PMID: 23481367; PMCID: PMC4121438.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Ciprofloxacin prophylaxis in kidney transplant recipients reduces BK virus infection at 3 months but not at 1 year. Transplantation. 2012 Dec 15; 94(11):1117-23. Wojciechowski D, Chanda R, Chandran S, Lee B, Webber A, Macaraig M, Tomlanovich S, Vincenti F. PMID: 23060281.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    41. Fever, hepatosplenomegaly and a skin nodule in a kidney-pancreas transplant recipient. Am J Transplant. 2012 Sep; 12(9):2556-8; quiz 2558. Freed MM, Ramirez-Valle F, Chandran S. PMID: 22925186; PMCID: PMC4087158.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. The Scribner shunt: 50 years later. Kidney Int. 2012 Jan; 81(1):120. Lockridge JB, Chandran S. PMID: 22170532; PMCID: PMC4124935.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V. PMID: 21900244; PMCID: PMC3199524.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    44. Eculizumab for the treatment of de novo thrombotic microangiopathy post simultaneous pancreas-kidney transplantation--a case report. Transplant Proc. 2011 Jun; 43(5):2097-101. Chandran S, Baxter-Lowe L, Olson JL, Tomlanovich SJ, Webber A. PMID: 21693335.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    45. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. PMID: 20466724; PMCID: PMC2898378.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    46. Imatinib in the treatment of nephrogenic systemic fibrosis. Am J Kidney Dis. 2009 Jan; 53(1):129-32. Chandran S, Petersen J, Jacobs C, Fiorentino D, Doeden K, Lafayette RA. PMID: 19012999.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    47. The Akt pathway in human breast cancer: a tissue-array-based analysis. Mod Pathol. 2006 Feb; 19(2):238-45. Bose S, Chandran S, Mirocha JM, Bose N. PMID: 16341149.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
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