Som Chatterjee, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
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    Dr. Chatterjee received his master’s degree from the Department of Biophysics and Molecular Biology, University of Kolkata (Calcutta), India. He performed his doctoral studies in the laboratory of Dr. Trinad Chakraborty, Justus-Liebig University, Germany where he studied the infection process of an intracellular bacterial pathogen, Listeria monocytogenes, which is responsible for causing food borne illnesses. Upon completion of his doctoral study, he joined Dr. Michael Otto’s group at the National Institutes of Health (NIH) to study the secretion process of a group of cytolytic peptides toxins called Phenol Soluble Modulins (PSMs) in Staphylococcus aureus, an important human bacterial pathogen that is responsible for causing high morbidity and mortality worldwide. In 2014, Dr. Chatterjee joined Dr. Henry Chambers’ group at University of California, San Francisco to study the major public health problem of antimicrobial resistance in S. aureus. In 2015, he became an assistant professor and currently his research interests are to determine the mechanistic basis of several interesting and novel pathways that mediate antibiotic resistance in S. aureus.

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    Novel Mechanisms of Beta-lactam Resistance in Staph aureus
    NIH/NIAID 2R56AI100291-05Aug 1, 2017 - Jul 31, 2018
    Role: Co-PI

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chatterjee S, Chen L, Gilbert A, da Costa TM, Nair V, Datta SK, Kreiswirth BN, Chambers HF. PBP4 mediates ß-lactam resistance by altered function. Antimicrob Agents Chemother. 2017 Aug 14. PMID: 28807923.
      View in: PubMed
    2. Hamilton SM, Alexander JAN, Choo EJ, Basuino L, da Costa TM, Severin A, Chung M, Aedo S, Strynadka NCJ, Tomasz A, Chatterjee S, Chambers HF. High-Level Resistance of Staphylococcus aureus to ß-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4). Antimicrob Agents Chemother. 2017 Jun; 61(6). PMID: 28373193.
      View in: PubMed
    3. Joo HS, Chatterjee S, Villaruz AE, Dickey SW, Tan VY, Chen Y, Sturdevant DE, Ricklefs SM, Otto M. Mechanism of Gene Regulation by a Staphylococcus aureus Toxin. MBio. 2016 Oct 25; 7(5). PMID: 27795396.
      View in: PubMed
    4. Chan LC, Gilbert A, Basuino L, da Costa TM, Hamilton SM, Dos Santos KR, Chambers HF, Chatterjee S. PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus. Antimicrob Agents Chemother. 2016 Jul; 60(7):3934-41. PMID: 27067335; PMCID: PMC4914628 [Available on 01/01/17].
    5. Greninger AL, Chatterjee S, Chan LC, Hamilton SM, Chambers HF, Chiu CY. Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance. PLoS One. 2016; 11(2):e0149541. PMID: 26890675; PMCID: PMC4758708.
    6. Dastgheyb SS, Villaruz AE, Le KY, Tan VY, Duong AC, Chatterjee S, Cheung GY, Joo HS, Hickok NJ, Otto M. Role of Phenol-Soluble Modulins in Formation of Staphylococcus aureus Biofilms in Synovial Fluid. Infect Immun. 2015 Jul; 83(7):2966-75. PMID: 25964472; PMCID: PMC4468530.
    7. Chan LC, Basuino L, Diep B, Hamilton S, Chatterjee S, Chambers HF. Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2015 May; 59(5):2960-3. PMID: 25753637; PMCID: PMC4394828.
    8. Chen Y, Yeh AJ, Cheung GY, Villaruz AE, Tan VY, Joo HS, Chatterjee S, Yu Y, Otto M. Basis of virulence in a Panton-Valentine leukocidin-negative community-associated methicillin-resistant Staphylococcus aureus strain. J Infect Dis. 2015 Feb 01; 211(3):472-80. PMID: 25139021; PMCID: PMC4296174.
    9. Cheung GY, Joo HS, Chatterjee S, Otto M. Phenol-soluble modulins--critical determinants of staphylococcal virulence. FEMS Microbiol Rev. 2014 Jul; 38(4):698-719. PMID: 24372362; PMCID: PMC4072763.
    10. Grosz M, Kolter J, Paprotka K, Winkler AC, Schäfer D, Chatterjee S, Geiger T, Wolz C, Ohlsen K, Otto M, Rudel T, Sinha B, Fraunholz M. Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin α. Cell Microbiol. 2014 Apr; 16(4):451-65. PMID: 24164701; PMCID: PMC3969633.
    11. Chen Y, Chatterjee S, Porcella SF, Yu YS, Otto M. Complete genome sequence of a Pantón-Valentine leukocidin-negative community-associated methicillin-resistant Staphylococcus aureus strain of sequence type 72 from Korea. PLoS One. 2013; 8(8):e72803. PMID: 23977354; PMCID: PMC3748019.
    12. Chatterjee S, Otto M. Improved understanding of factors driving methicillin-resistant Staphylococcus aureus epidemic waves. Clin Epidemiol. 2013; 5:205-17. PMID: 23861600; PMCID: PMC3707418.
    13. Chatterjee S, Otto M. How can Staphylococcus aureus phenol-soluble modulins be targeted to inhibit infection? Future Microbiol. 2013 Jun; 8(6):693-6. PMID: 23701324.
      View in: PubMed
    14. Chatterjee S, Joo HS, Duong AC, Dieringer TD, Tan VY, Song Y, Fischer ER, Cheung GY, Li M, Otto M. Essential Staphylococcus aureus toxin export system. Nat Med. 2013 Mar; 19(3):364-7. PMID: 23396209; PMCID: PMC3594369.
    15. Periasamy S, Chatterjee S, Cheung GY, Otto M. Phenol-soluble modulins in staphylococci: What are they originally for? Commun Integr Biol. 2012 May 01; 5(3):275-7. PMID: 22896791; PMCID: PMC3419113.
    16. Periasamy S, Joo HS, Duong AC, Bach TH, Tan VY, Chatterjee S, Cheung GY, Otto M. How Staphylococcus aureus biofilms develop their characteristic structure. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1281-6. PMID: 22232686; PMCID: PMC3268330.
    17. Chatterjee S, Chen L, Joo HS, Cheung GY, Kreiswirth BN, Otto M. Distribution and regulation of the mobile genetic element-encoded phenol-soluble modulin PSM-mec in methicillin-resistant Staphylococcus aureus. PLoS One. 2011; 6(12):e28781. PMID: 22174895; PMCID: PMC3236207.
    18. Hain T, Hossain H, Chatterjee S, Machata S, Volk U, Wagner S, Brors B, Haas S, Kuenne CT, Billion A, Otten S, Pane-Farre J, Engelmann S, Chakraborty T. Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon. BMC Microbiol. 2008 Jan 28; 8:20. PMID: 18226246; PMCID: PMC2248587.
    19. Hain T, Otten S, von Both U, Chatterjee S, Technow U, Billion A, Ghai R, Mohamed W, Domann E, Chakraborty T. Novel bacterial artificial chromosome vector pUvBBAC for use in studies of the functional genomics of Listeria spp. Appl Environ Microbiol. 2008 Mar; 74(6):1892-901. PMID: 18223114; PMCID: PMC2268298.
    20. Hain T, Chatterjee S, Ghai R, Kuenne CT, Billion A, Steinweg C, Domann E, Kärst U, Jänsch L, Wehland J, Eisenreich W, Bacher A, Joseph B, Schär J, Kreft J, Klumpp J, Loessner MJ, Dorscht J, Neuhaus K, Fuchs TM, Scherer S, Doumith M, Jacquet C, Martin P, Cossart P, Rusniock C, Glaser P, Buchrieser C, Goebel W, Chakraborty T. Pathogenomics of Listeria spp. Int J Med Microbiol. 2007 Nov; 297(7-8):541-57. PMID: 17482873.
      View in: PubMed
    21. Hain T, Steinweg C, Kuenne CT, Billion A, Ghai R, Chatterjee S, Domann E, Kärst U, Goesmann A, Bekel T, Bartels D, Kaiser O, Meyer F, Pühler A, Weisshaar B, Wehland J, Liang C, Dandekar T, Lampidis R, Kreft J, Goebel W, Chakraborty T. Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes. J Bacteriol. 2006 Nov; 188(21):7405-15. PMID: 16936040; PMCID: PMC1636279.
    22. Chatterjee S, Otten S, Hain T, Lingnau A, Carl UD, Wehland J, Domann E, Chakraborty T. Invasiveness is a variable and heterogeneous phenotype in Listeria monocytogenes serotype strains. Int J Med Microbiol. 2006 Aug; 296(4-5):277-86. PMID: 16527541.
      View in: PubMed
    23. Chatterjee S, Hossain H, Otten S, Kuenne C, Kuchmina K, Machata S, Domann E, Chakraborty T, Hain T. Intracellular gene expression profile of Listeria monocytogenes. Infect Immun. 2006 Feb; 74(2):1323-38. PMID: 16428782; PMCID: PMC1360297.
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