Sook Wah Yee, PhD

Title(s)Associate Professor, Bioengineering
SchoolSchool of Pharmacy
Address1550 Fourth St, #584A
San Francisco CA 94158
Phone415-514-4363
ORCID ORCID Icon0000-0001-8121-8746 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Cardiff University, U.K.MPharm2001Welsh School of Pharmacy
    Bristol-Myers Squibb/Whiston Hospital (U.K.)Pre-Registration Pharmacist2002Pharmacy
    Cardiff University, U.K.PhD2005Welsh School of Pharmacy
    The Scripps Research Institute, U.S.A.Postdoc2006Department of Immunology
    University of California San Francisco, U.S.A.Postdoc2012Department of Bioengineering and Therapeutic Sciences
    Collapse Awards and Honors
    15th North American Regional ISSX Meeting, San Diego2008Presentation Award Postdoctoral Research
    American Society for Clinical Pharmacology and Therapeutics Meeting2011Presidential Trainee Award
    American Society for Clinical Pharmacology and Therapeutics Meeting2014Presidential Trainee Award

    Collapse Overview 
    Collapse Overview
    My research project in laboratory of Dr. Kathy Giacomini focuses on genetic determinants of metformin response through genomewide association studies. In addition, my research also focuses on determining endogenous roles of membrane transporters through data from genomewide association studies and functional studies in cells. I am actively involved in Pharmacogenomics Research Network (PGRN)-Hub (www.pgrn.org) to enhance scientific exchange and to expand the boundaries of understanding drug response within the context of precision medicine, both within the PGRN and between the PGRN and the scientific community at large. I work together with the team to create a robust PGRN website with multiple features and facilitating opportunities to access large resources that will enable collaborative research.

    Collapse Research 
    Collapse Research Activities and Funding
    Pharmacogenomics of Membrane Transporters
    NIH U19GM061390Apr 1, 2000 - Jun 30, 2015
    Role: Co-Investigator

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    Collapse Academic Senate

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes. Diabetes Care. 2024 Feb 01; 47(2):208-215. Wu B, Yee SW, Xiao S, Xu F, Sridhar SB, Yang M, Hochstadt S, Cabral W, Lanfear DE, Hedderson MM, Giacomini KM, Williams LK. PMID: 37639712; PMCID: PMC10834390.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Membrane transporters in drug development and as determinants of precision medicine. Nat Rev Drug Discov. 2024 Jan 24. Galetin A, Brouwer KLR, Tweedie D, Yoshida K, Sjöstedt N, Aleksunes L, Chu X, Evers R, Hafey MJ, Lai Y, Matsson P, Riselli A, Shen H, Sparreboom A, Varma MVS, Yang J, Yang X, Yee SW, Zamek-Gliszczynski MJ, Zhang L, Giacomini KM. PMID: 38267543.
      View in: PubMed   Mentions: 2     Fields:    
    3. SLCO1B1 functional variants and statin-induced myopathy in people with recent genealogical ancestors from Africa: a population-based real-world study. medRxiv. 2023 Dec 03. Yee SW, Haldar T, Kvale M, Yang J, Douglas MP, Oni-Orisan A. PMID: 38076949; PMCID: PMC10705643.
      View in: PubMed   Mentions:
    4. Structural and molecular basis of choline uptake into the brain by FLVCR2. bioRxiv. 2023 Oct 05. Cater RJ, Mukherjee D, Iturbe EG, Erramilli SK, Chen T, Koo K, Grez NS, Reckers A, Kloss B, Gawda T, Choy BC, Zheng Z, Clarke OB, Yee SW, Kossiakoff AA, Quick M, Arnold T, Mancia F. PMID: 37873173; PMCID: PMC10592973.
      View in: PubMed   Mentions:
    5. Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates. Res Sq. 2023 Sep 14. Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. PMID: 37790518; PMCID: PMC10543398.
      View in: PubMed   Mentions:
    6. TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters. Clin Pharmacol Ther. 2023 Dec; 114(6):1293-1303. Michel ME, Wen CC, Yee SW, Giacomini KM, Hamdoun A, Nicklisch SCT. PMID: 37657924.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates. bioRxiv. 2023 Aug 12. Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. PMID: 37609337; PMCID: PMC10441401.
      View in: PubMed   Mentions:
    8. Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP). Diabetes. 2023 08 01; 72(8):1161-1172. Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC, Diabetes Prevention Program Research Group:. PMID: 36525397; PMCID: PMC10382652.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse. Metabolites. 2023 Jul 26; 13(8). Wen A, Zhu Y, Yee SW, Park BI, Giacomini KM, Greenberg AS, Newman JW. PMID: 37623829; PMCID: PMC10456376.
      View in: PubMed   Mentions:
    10. Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools. Nat Chem Biol. 2024 Jan; 20(1):62-73. Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R. PMID: 37474759; PMCID: PMC10746541.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. OR18-06-23 The Impacts of slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse. Current Developments in Nutrition. 2023 Jul 1; 7:101796. Wen WA, Greenberg GA, Giacomini GK, Newman NJ, Park PB, Yee YS, Zhu ZY. .
      View in: Publisher Site   Mentions:
    12. The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics. bioRxiv. 2023 Jun 07. Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. PMID: 37333090; PMCID: PMC10274788.
      View in: PubMed   Mentions:
    13. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther. 2023 08; 114(2):381-392. Vora B, Wen A, Yee SW, Trinh K, Azimi M, Green EAE, Sirota M, Greenberg AS, Newman JW, Giacomini KM. PMID: 37151050.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes. Pediatr Diabetes. 2023; 2023. Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson ER, Yee SW, Giacomini KM, Pollin T, Florez JC. PMID: 38590442; PMCID: PMC11000826.
      View in: PubMed   Mentions:
    15. Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat. J Vet Pharmacol Ther. 2023 Nov; 46(6):401-412. Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM. PMID: 37198956.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium. Clin Pharmacol Ther. 2022 09; 112(3):540-561. Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X. PMID: 35488474; PMCID: PMC9398938.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682. Diabetes Care. 2022 04 01; 45(4):e82-e83. Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium. PMID: 35349657; PMCID: PMC9016729.
      View in: PubMed   Mentions:    Fields:    
    18. The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms. Clin Pharmacol Ther. 2022 05; 111(5):1007-1021. Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A, Giacomini KM, Caudle KE, Voora D. PMID: 35152405; PMCID: PMC9035072.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    19. High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3. Pharm Res. 2022 Jul; 39(7):1599-1613. Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM. PMID: 35089508; PMCID: PMC9246766.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Chapter 13 Mechanisms and genetics of drug transport. . 2022 Jan 1; 213-239. Zhang ZL, Enogieru EO, Yee YS, Huang HS, Giacomini GK. .
      View in: Publisher Site   Mentions:
    21. Emerging Roles of the Human Solute Carrier 22 Family. Drug Metab Dispos. 2021 Dec 17. Yee SW, Giacomini KM. PMID: 34921098; PMCID: PMC9488978.
      View in: PubMed   Mentions: 14     Fields:    
    22. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care. 2021 12; 44(12):2673-2682. Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium, MetGen Plus investigators:. PMID: 34607834; PMCID: PMC8669535.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    23. Genomewide Association Studies in Pharmacogenomics. Clin Pharmacol Ther. 2021 09; 110(3):637-648. McInnes G, Yee SW, Pershad Y, Altman RB. PMID: 34185318; PMCID: PMC8376796.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    24. Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data. Clin Pharmacol Ther. 2021 07; 110(1):108-122. Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM. PMID: 33759449; PMCID: PMC8217266.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    25. The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2. AAPS J. 2021 03 01; 23(2):35. Enogieru OJ, Koleske ML, Vora B, Ngo H, Yee SW, Chatad D, Sirota M, Giacomini KM. PMID: 33649974; PMCID: PMC7921063.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. FASEB J. 2020 12; 34(12):15734-15752. Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML, Giacomini KM. PMID: 33124720; PMCID: PMC7839234.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    27. Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols. Pharmaceuticals (Basel). 2020 Aug 08; 13(8). Lebouvier N, Pagniez F, Na YM, Shi D, Pinson P, Marchivie M, Guillon J, Hakki T, Bernhardt R, Yee SW, Simons C, Lézé MP, Hartmann RW, Mularoni A, Le Baut G, Krimm I, Abagyan R, Le Pape P, Le Borgne M. PMID: 32784450; PMCID: PMC7464559.
      View in: PubMed   Mentions: 3  
    28. GenEpi: gene-based epistasis discovery using machine learning. BMC Bioinformatics. 2020 Feb 24; 21(1):68. Chang YC, Wu JT, Hong MY, Tung YA, Hsieh PH, Yee SW, Giacomini KM, Oyang YJ, Chen CY, Alzheimer’s Disease Neuroimaging Initiative. PMID: 32093643; PMCID: PMC7041299.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    29. SC1.3 - Influence of transporter polymorphisms on drug disposition and response: A Perspective from the international transporter consortium. Drug Metabolism and Pharmacokinetics. 2020 Jan 1; 35(1):s1. Yee YS. .
      View in: Publisher Site   Mentions:
    30. Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics. Clin Pharmacol Ther. 2020 01; 107(1):96-101. Yee SW, Do TP, Huang SM, Krauss RM, Kusuhara H, Sugiyama Y, Unadkat JD, Giacomini KM. PMID: 31774556.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PLoS Genet. 2019 09; 15(9):e1008208. Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM. PMID: 31553721; PMCID: PMC6760779.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol. Clin Pharmacol Ther. 2019 09; 106(3):623-631. Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM. PMID: 30924126; PMCID: PMC6941886.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    33. Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits. Hum Mutat. 2019 07; 40(7):983-995. Enogieru OJ, Ung PMU, Yee SW, Schlessinger A, Giacomini KM. PMID: 30950137; PMCID: PMC7137536.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    34. Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers. Clin Transl Sci. 2019 07; 12(4):388-399. Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM. PMID: 30982223; PMCID: PMC6662551.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    35. Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. PLoS Biol. 2019 01; 17(1):e2006571. Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L. PMID: 30653498; PMCID: PMC6336244.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    36. Unveiling the Genetic Architecture of Human Disease for Precision Medicine. Clin Transl Sci. 2019 01; 12(1):3-5. Ramamoorthy A, Yee SW, Karnes J. PMID: 30474919; PMCID: PMC6342243.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. GenEpi: Gene-based Epistasis Discovery Using Machine Learning. bioRxiv. 2018 Sep 20; 421719. Chang CY, Wu WJ, Hong HM, Tung TY, Hsieh HP, Yee YS, Giacomini GK, Oyang OY, Chen CC, Initiative If. .
      View in: Publisher Site   Mentions:
    38. Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance. Clin Pharmacol Ther. 2018 11; 104(5):890-899. Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y, International Transporter Consortium. PMID: 30091177; PMCID: PMC8211378.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    39. Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium. Clin Pharmacol Ther. 2018 11; 104(5):803-817. Yee SW, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM. PMID: 29679469; PMCID: PMC6348109.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    40. Pharmacogenetics of Antidiabetic Drugs. Adv Pharmacol. 2018; 83:361-389. Srinivasan S, Yee SW, Giacomini KM. PMID: 29801583.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity. Mol Pharmacol. 2018 07; 94(1):689-699. Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM. PMID: 29720497; PMCID: PMC5987998.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    42. Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. PLoS Biol. 2018 04; 16(4):e2002907. Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM. PMID: 29659562; PMCID: PMC5919692.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    43. Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1428-1440. Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA, MetGen Investigators, ACCORD/ACCORDion Investigators. PMID: 29650774; PMCID: PMC6014560.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    44. New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine. Clin Pharmacol Ther. 2017 Dec; 102(6):897-902. Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM. PMID: 28795399; PMCID: PMC5706548.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    45. Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1. J Chem Inf Model. 2017 06 26; 57(6):1402-1413. Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM. PMID: 28562037.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    46. Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). J Med Chem. 2017 04 13; 60(7):2685-2696. Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM. PMID: 28230985.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    47. Genomic Characterization of Metformin Hepatic Response. PLoS Genet. 2016 Nov; 12(11):e1006449. Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, Ahituv N. PMID: 27902686; PMCID: PMC5130177.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    48. Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine. Nat Rev Drug Discov. 2017 Jan; 16(1):1. Giacomini KM, Yee SW, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M. PMID: 27885282; PMCID: PMC5443656.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    49. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clin Pharmacol Ther. 2016 Nov; 100(5):537-547. Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. PMID: 27415606; PMCID: PMC5534241.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    50. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clin Pharmacol Ther. 2016 Nov; 100(5):524-536. Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM. PMID: 27447836; PMCID: PMC6365106.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCellsCTClinical Trials
    51. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet. 2016 09; 48(9):1055-1059. Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkác I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, MetGen Investigators, DPP Investigators, ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER. PMID: 27500523; PMCID: PMC5007158.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    52. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Clin Pharmacol Ther. 2016 Nov; 100(5):423-426. Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M. PMID: 27256705; PMCID: PMC5056156.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    53. Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans. Front Pharmacol. 2016; 7:135. Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R. PMID: 27378919; PMCID: PMC4906013.
      View in: PubMed   Mentions: 12  
    54. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016 06; 55(6):711-21. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. PMID: 26597253; PMCID: PMC4876051.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    55. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J. 2017 03; 17(2):137-145. Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE. PMID: 26856248; PMCID: PMC4980276.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    56. Pharmacogenetics of Metformin. The Genetics of Type 2 Diabetes and Related Traits. 2016 Jan 1; 463-481. Yee YS, Zhou ZK, Giacomini GK. .
      View in: Publisher Site   Mentions:
    57. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. Drug Metab Dispos. 2016 Mar; 44(3):356-64. Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM. PMID: 26700958; PMCID: PMC6047207.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    58. Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 07; 12(12):4301-10. Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM. PMID: 26528626; PMCID: PMC4800991.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    59. Prediction and validation of enzyme and transporter off-targets for metformin. J Pharmacokinet Pharmacodyn. 2015 Oct; 42(5):463-75. Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. PMID: 26335661; PMCID: PMC4656030.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    60. SLC transporters as therapeutic targets: emerging opportunities. Nat Rev Drug Discov. 2015 Aug; 14(8):543-60. Lin L, Yee SW, Kim RB, Giacomini KM. PMID: 26111766; PMCID: PMC4698371.
      View in: PubMed   Mentions: 312     Fields:    Translation:HumansAnimals
    61. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Mol Pharmacol. 2015 Jul; 88(1):75-83. Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM. PMID: 25920679; PMCID: PMC4468641.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    62. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther. 2015 May; 97(5):518-25. Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. PMID: 25676789; PMCID: PMC4479153.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    63. OCT1 in hepatic steatosis and thiamine disposition. Cell Cycle. 2015; 14(3):283-4. Chen L, Yee SW, Giacomini KM. PMID: 25590948; PMCID: PMC4353231.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    64. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9983-8. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. PMID: 24961373; PMCID: PMC4103324.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    65. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2014 Sep; 96(3):370-9. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. PMID: 24853734; PMCID: PMC4171106.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    66. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype. Clin Pharmacol Ther. 2014 Jun; 95(6):592-7. Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM, Clinical Pharmacogenetics Implementation Consortium. PMID: 24598717; PMCID: PMC4026598.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    67. Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther. 2013 Dec; 94(6):636-9. Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM. PMID: 24013810; PMCID: PMC3906042.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    68. A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol. 2014 Feb; 133(2):370-8. Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG. PMID: 23992748; PMCID: PMC3938989.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    69. International Transporter Consortium commentary on clinically important transporter polymorphisms. Clin Pharmacol Ther. 2013 Jul; 94(1):23-6. Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M, International Transporter Consortium. PMID: 23778707.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    70. SLC classification: an update. Clin Pharmacol Ther. 2013 Jul; 94(1):19-23. Schlessinger A, Yee SW, Sali A, Giacomini KM. PMID: 23778706; PMCID: PMC4068830.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    71. Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. J Hum Genet. 2013 Jun; 58(6):353-61. Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C. PMID: 23677058; PMCID: PMC4068832.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    72. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep; 102(9):3451-7. Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. PMID: 23649425; PMCID: PMC4151246.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    73. The Pharmacogenomics of Membrane Transporters Project. Pharmacogenomics of Human Drug Transporters. 2013 Mar 15; 73-108. Yee YS, Kroetz KD, Giacomini GK. .
      View in: Publisher Site   Mentions:
    74. Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update. Clin Pharmacol Ther. 2013 Apr; 93(4):324-5. Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Hicks JK, Schwab M, Klein TE, Clinical Pharmacogenetics Implementation Consortium. PMID: 23422873; PMCID: PMC3604643.
      View in: PubMed   Mentions: 136     Fields:    Translation:Humans
    75. Germline Genetic Polymorphisms Are Associated with Disease-Free Survival in Adults with Acute Myeloid Leukemia (AML): A Genomewide Association Study From the Pgrn-Riken Global Alliance. Blood. 2012 Nov 16; 120(21):2548-2548. Yee YS, Mefford MJ, Witte WJ, Kubo KM, Matsuda MK, Giacomini GK, Andreadis AC. .
      View in: Publisher Site   Mentions:
    76. Pharmacogenomics and patient care: one size does not fit all. Sci Transl Med. 2012 Sep 26; 4(153):153ps18. Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y. PMID: 23019654; PMCID: PMC3963516.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    77. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. Int J Mol Imaging. 2012; 2012:250834. Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK. PMID: 23050139; PMCID: PMC3463166.
      View in: PubMed   Mentions: 32  
    78. Pharmacogene regulatory elements: from discovery to applications. Genome Med. 2012 May 25; 4(5):45. Smith RP, Lam ET, Markova S, Yee SW, Ahituv N. PMID: 22630332; PMCID: PMC3506911.
      View in: PubMed   Mentions: 13     Fields:    
    79. The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet. 2012 Mar 28; 44(4):359-60. Yee SW, Chen L, Giacomini KM. PMID: 22456732; PMCID: PMC3359140.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    80. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther. 2011 Nov; 90(5):674-84. Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM. PMID: 21956618; PMCID: PMC3329222.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    81. Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters. Xenobiotica. 2011 Sep; 41(9):752-7. Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P. PMID: 21524191.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    82. Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. Pharmacogenomics J. 2012 Jun; 12(3):214-26. Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM. PMID: 21383772; PMCID: PMC3325368.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    83. Functional characterization of liver enhancers that regulate drug-associated transporters. Clin Pharmacol Ther. 2011 Apr; 89(4):571-8. Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N. PMID: 21368754; PMCID: PMC3227682.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    84. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar; 89(3):387-91. Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Klein TE, Clinical Pharmacogenetics Implementation Consortium. PMID: 21270794; PMCID: PMC3098761.
      View in: PubMed   Mentions: 229     Fields:    Translation:Humans
    85. SLC19A1 pharmacogenomics summary. Pharmacogenet Genomics. 2010 Nov; 20(11):708-15. Yee SW, Gong L, Badagnani I, Giacomini KM, Klein TE, Altman RB. PMID: 20811316; PMCID: PMC2956130.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    86. Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides. Bioorg Med Chem. 2010 Jul 15; 18(14):4939-46. Aboraia AS, Yee SW, Gomaa MS, Shah N, Robotham AC, Makowski B, Prosser D, Brancale A, Jones G, Simons C. PMID: 20594862.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    87. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther. 2010 Apr; 9(4):1058-69. More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM. PMID: 20371711; PMCID: PMC3258025.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    88. Pharmacogenomics of membrane transporters: past, present and future. Pharmacogenomics. 2010 Apr; 11(4):475-9. Yee SW, Chen L, Giacomini KM. PMID: 20350125; PMCID: PMC3234298.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    89. Comparison of human solute carriers. Protein Sci. 2010 Mar; 19(3):412-28. Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A. PMID: 20052679; PMCID: PMC2866268.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    90. Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar; 9(3):215-36. International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L. PMID: 20190787; PMCID: PMC3326076.
      View in: PubMed   Mentions: 992     Fields:    Translation:HumansAnimals
    91. The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology. Clin Pharmacol Ther. 2010 Jan; 87(1):109-16. Kroetz DL, Yee SW, Giacomini KM. PMID: 19940846; PMCID: PMC2923224.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    92. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics. Clin Pharmacol Ther. 2010 Jan; 87(1):100-8. Picard N, Yee SW, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM, Marquet P. PMID: 19890249; PMCID: PMC2884029.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCellsCTClinical Trials
    93. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009 Oct; 19(10):770-80. Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM. PMID: 19745787; PMCID: PMC2976711.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    94. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One. 2009 Sep 09; 4(9):e6942. Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM. PMID: 19742321; PMCID: PMC2735003.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    95. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics. 2009 Jul; 19(7):497-504. Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. PMID: 19483665; PMCID: PMC3104496.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCellsCTClinical Trials
    96. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Pharmacogenomics J. 2009 Apr; 9(2):127-36. Chen Y, Teranishi K, Li S, Yee SW, Hesselson S, Stryke D, Johns SJ, Ferrin TE, Kwok P, Giacomini KM. PMID: 19172157; PMCID: PMC2949062.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    97. Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5). J Pharmacol Exp Ther. 2009 Apr; 329(1):262-71. Tahara H, Yee SW, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM. PMID: 19141711; PMCID: PMC2670604.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    98. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). J Pharmacol Exp Ther. 2009 Mar; 328(3):699-707. Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. PMID: 19098160; PMCID: PMC2682268.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    99. Genetic variation in drug transporters in ethnic populations. Clin Pharmacol Ther. 2008 Sep; 84(3):412-6. Cropp CD, Yee SW, Giacomini KM. PMID: 18528433; PMCID: PMC2976712.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    100. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol. 2008 Apr; 73(4):1151-8. Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM. PMID: 18216183; PMCID: PMC2698938.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    101. Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding. J Enzyme Inhib Med Chem. 2006 Aug; 21(4):361-9. Gomaa MS, Yee SW, Milbourne CE, Barbera MC, Simons C, Brancale A. PMID: 17059167.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    102. Inhibition of Vitamin D3 metabolism enhances VDR signalling in androgen-independent prostate cancer cells. J Steroid Biochem Mol Biol. 2006 Mar; 98(4-5):228-35. Yee SW, Campbell MJ, Simons C. PMID: 16483768.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    103. Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation. J Med Chem. 2006 Feb 09; 49(3):1016-22. Saberi MR, Vinh TK, Yee SW, Griffiths BJ, Evans PJ, Simons C. PMID: 16451067.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    104. Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles. Bioorg Med Chem. 2006 Jun 01; 14(11):3643-53. Pautus S, Yee SW, Jayne M, Coogan MP, Simons C. PMID: 16458519.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    105. Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays. J Med Chem. 2005 Nov 17; 48(23):7123-31. Yee SW, Jarno L, Gomaa MS, Elford C, Ooi LL, Coogan MP, McClelland R, Nicholson RI, Evans BA, Brancale A, Simons C. PMID: 16279770.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    106. Synthesis and CYP24 Inhibitory Activity of 2-Substituted-3,4-dihydro-2H-naphthalen-1-one (Tetralone) Derivatives. ChemInform. 2005 Apr 5; 36(14). Yee YS, Simons SC. .
      View in: Publisher Site   Mentions:
    107. Synthesis and antimycobacterial activity of 7-O-substituted-4-methyl-2H-2-chromenone derivatives vs Mycobacterium tuberculosis. J Enzyme Inhib Med Chem. 2005 Apr; 20(2):109-13. Yee SW, Shah B, Simons C. PMID: 15968814.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    108. Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives. Bioorg Med Chem Lett. 2004 Nov 15; 14(22):5651-4. Yee SW, Simons C. PMID: 15482941.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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