Sook Wah Yee, PhD

TitleProfessional Research
InstitutionUniversity of California San Francisco
Address1550 Fourth St
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Cardiff University, U.K.MPharm2001Welsh School of Pharmacy
    Bristol-Myers Squibb/Whiston Hospital (U.K.)Pre-Registration Pharmacist2002Pharmacy
    Cardiff University, U.K.PhD2005Welsh School of Pharmacy
    The Scripps Research Institute, U.S.A.Postdoc2006Department of Immunology
    University of California San Francisco, U.S.A.Postdoc2012Department of Bioengineering and Therapeutic Sciences
    Collapse Awards and Honors
    15th North American Regional ISSX Meeting, San Diego2008Presentation Award Postdoctoral Research
    American Society for Clinical Pharmacology and Therapeutics Meeting2011Presidential Trainee Award
    American Society for Clinical Pharmacology and Therapeutics Meeting2014Presidential Trainee Award

    Collapse Overview 
    Collapse Overview
    My research project in laboratory of Dr. Kathy Giacomini focuses on genetic determinants of metformin response through genomewide association studies. In addition, my research also focuses on determining endogenous roles of membrane transporters through data from genomewide association studies and functional studies in cells. I am actively involved in Pharmacogenomics Research Network (PGRN)-Hub (www.pgrn.org) to enhance scientific exchange and to expand the boundaries of understanding drug response within the context of precision medicine, both within the PGRN and between the PGRN and the scientific community at large. I work together with the team to create a robust PGRN website with multiple features and facilitating opportunities to access large resources that will enable collaborative research.

    Collapse Research 
    Collapse Research Activities and Funding
    Pharmacogenomics of Membrane Transporters
    NIH U19GM061390Apr 1, 2000 - Jun 30, 2015
    Role: Co-Investigator

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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Srinivasan S, Yee S, Giacomini KM. Pharmacogenetics of Antidiabetic Drugs. Adv Pharmacol. 2018; 83:361-389. PMID: 29801583.
      View in: PubMed
    2. Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee S, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM. Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity. Mol Pharmacol. 2018 May 02. PMID: 29720497.
      View in: PubMed
    3. Yee S, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM. Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective from the International Transporter Consortium. Clin Pharmacol Ther. 2018 Apr 21. PMID: 29679469.
      View in: PubMed
    4. Liang X, Yee S, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM. Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. PLoS Biol. 2018 Apr 16; 16(4):e2002907. PMID: 29659562.
      View in: PubMed
    5. Rotroff DM, Yee S, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA. Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes. Diabetes. 2018 Apr 12. PMID: 29650774.
      View in: PubMed
    6. Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee S, Johnson GT, Giacomini KM. New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine. Clin Pharmacol Ther. 2017 Dec; 102(6):897-902. PMID: 28795399.
      View in: PubMed
    7. Khuri N, Zur AA, Wittwer MB, Lin L, Yee S, Sali A, Giacomini KM. Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1. J Chem Inf Model. 2017 06 26; 57(6):1402-1413. PMID: 28562037.
      View in: PubMed
    8. Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee S, Huang Y, Sali A, Giacomini KM. Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). J Med Chem. 2017 Apr 13; 60(7):2685-2696. PMID: 28230985.
      View in: PubMed
    9. Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee S, Giacomini KM, Ahituv N. Genomic Characterization of Metformin Hepatic Response. PLoS Genet. 2016 Nov; 12(11):e1006449. PMID: 27902686.
      View in: PubMed
    10. Giacomini KM, Yee S, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M. Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine. Nat Rev Drug Discov. 2017 Jan; 16(1):1. PMID: 27885282.
      View in: PubMed
    11. Goswami S, Yee S, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clin Pharmacol Ther. 2016 Nov; 100(5):537-547. PMID: 27415606.
      View in: PubMed
    12. Yee S, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clin Pharmacol Ther. 2016 Nov; 100(5):524-536. PMID: 27447836.
      View in: PubMed
    13. Zhou K, Yee S, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkác I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet. 2016 09; 48(9):1055-1059. PMID: 27500523.
      View in: PubMed
    14. Yee S, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Clin Pharmacol Ther. 2016 Nov; 100(5):423-426. PMID: 27256705.
      View in: PubMed
    15. Rotroff DM, Oki NO, Liang X, Yee S, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R. Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans. Front Pharmacol. 2016; 7:135. PMID: 27378919; PMCID: PMC4906013.
    16. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee S, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016 Jun; 55(6):711-21. PMID: 26597253; PMCID: PMC4876051 [Available on 06/01/17].
    17. Chhibber A, French CE, Yee S, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J. 2017 Mar; 17(2):137-145. PMID: 26856248.
      View in: PubMed
    18. Chien HC, Zur AA, Maurer TS, Yee S, Tolsma J, Jasper P, Scott DO, Giacomini KM. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. Drug Metab Dispos. 2016 Mar; 44(3):356-64. PMID: 26700958.
      View in: PubMed
    19. Liang X, Chien HC, Yee S, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM. Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 07; 12(12):4301-10. PMID: 26528626; PMCID: PMC4800991 [Available on 12/07/16].
    20. Yee S, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. Prediction and validation of enzyme and transporter off-targets for metformin. J Pharmacokinet Pharmacodyn. 2015 Oct; 42(5):463-75. PMID: 26335661; PMCID: PMC4656030.
    21. Lin L, Yee S, Kim RB, Giacomini KM. SLC transporters as therapeutic targets: emerging opportunities. Nat Rev Drug Discov. 2015 Aug; 14(8):543-60. PMID: 26111766; PMCID: PMC4698371.
    22. Chen EC, Liang X, Yee S, Geier EG, Stocker SL, Chen L, Giacomini KM. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Mol Pharmacol. 2015 Jul; 88(1):75-83. PMID: 25920679; PMCID: PMC4468641.
    23. Wen CC, Yee S, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther. 2015 May; 97(5):518-25. PMID: 25676789; PMCID: PMC4479153.
    24. Chen L, Yee S, Giacomini KM. OCT1 in hepatic steatosis and thiamine disposition. Cell Cycle. 2015; 14(3):283-4. PMID: 25590948; PMCID: PMC4353231.
    25. Chen L, Shu Y, Liang X, Chen EC, Yee S, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9983-8. PMID: 24961373; PMCID: PMC4103324.
    26. Goswami S, Yee S, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2014 Sep; 96(3):370-9. PMID: 24853734; PMCID: PMC4171106.
    27. Clancy JP, Johnson SG, Yee S, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype. Clin Pharmacol Ther. 2014 Jun; 95(6):592-7. PMID: 24598717; PMCID: PMC4026598.
    28. Geier EG, Chen EC, Webb A, Papp AC, Yee S, Sadee W, Giacomini KM. Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther. 2013 Dec; 94(6):636-9. PMID: 24013810; PMCID: PMC3906042.
    29. Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee S, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG. A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol. 2014 Feb; 133(2):370-8. PMID: 23992748.
      View in: PubMed
    30. Schlessinger A, Yee S, Sali A, Giacomini KM. SLC classification: an update. Clin Pharmacol Ther. 2013 Jul; 94(1):19-23. PMID: 23778706; PMCID: PMC4068830.
    31. Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee S, Zimdahl H, Niemi M. International Transporter Consortium commentary on clinically important transporter polymorphisms. Clin Pharmacol Ther. 2013 Jul; 94(1):23-6. PMID: 23778707.
      View in: PubMed
    32. Yee S, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C. Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. J Hum Genet. 2013 Jun; 58(6):353-61. PMID: 23677058; PMCID: PMC4068832.
    33. Yee S, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep; 102(9):3451-7. PMID: 23649425; PMCID: PMC4151246.
    34. Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee S, Stein CM, Carrillo M, Evans WE, Hicks JK, Schwab M, Klein TE. Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update. Clin Pharmacol Ther. 2013 Apr; 93(4):324-5. PMID: 23422873; PMCID: PMC3604643.
    35. Giacomini KM, Yee S, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y. Pharmacogenomics and patient care: one size does not fit all. Sci Transl Med. 2012 Sep 26; 4(153):153ps18. PMID: 23019654; PMCID: PMC3963516.
    36. Dubois SG, Geier E, Batra V, Yee S, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. Int J Mol Imaging. 2012; 2012:250834. PMID: 23050139; PMCID: PMC3463166.
    37. Smith RP, Lam ET, Markova S, Yee S, Ahituv N. Pharmacogene regulatory elements: from discovery to applications. Genome Med. 2012 May 25; 4(5):45. PMID: 22630332; PMCID: PMC3506911.
    38. Yee S, Chen L, Giacomini KM. The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet. 2012 Mar 28; 44(4):359-60. PMID: 22456732; PMCID: PMC3359140.
    39. Choi JH, Yee S, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther. 2011 Nov; 90(5):674-84. PMID: 21956618; PMCID: PMC3329222.
    40. Picard N, Levoir L, Lamoureux F, Yee S, Giacomini KM, Marquet P. Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters. Xenobiotica. 2011 Sep; 41(9):752-7. PMID: 21524191.
      View in: PubMed
    41. Matsson P, Yee S, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM. Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. Pharmacogenomics J. 2012 Jun; 12(3):214-26. PMID: 21383772; PMCID: PMC3325368.
    42. Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee S, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N. Functional characterization of liver enhancers that regulate drug-associated transporters. Clin Pharmacol Ther. 2011 Apr; 89(4):571-8. PMID: 21368754; PMCID: PMC3227682.
    43. Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee S, Stein CM, Carrillo M, Evans WE, Klein TE. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar; 89(3):387-91. PMID: 21270794; PMCID: PMC3098761.
    44. Yee S, Gong L, Badagnani I, Giacomini KM, Klein TE, Altman RB. SLC19A1 pharmacogenomics summary. Pharmacogenet Genomics. 2010 Nov; 20(11):708-15. PMID: 20811316; PMCID: PMC2956130.
    45. Aboraia AS, Yee S, Gomaa MS, Shah N, Robotham AC, Makowski B, Prosser D, Brancale A, Jones G, Simons C. Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides. Bioorg Med Chem. 2010 Jul 15; 18(14):4939-46. PMID: 20594862.
      View in: PubMed
    46. More SS, Li S, Yee S, Chen L, Xu Z, Jablons DM, Giacomini KM. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther. 2010 Apr; 9(4):1058-69. PMID: 20371711; PMCID: PMC3258025.
    47. Yee S, Chen L, Giacomini KM. Pharmacogenomics of membrane transporters: past, present and future. Pharmacogenomics. 2010 Apr; 11(4):475-9. PMID: 20350125; PMCID: PMC3234298.
    48. Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar; 9(3):215-36. PMID: 20190787; PMCID: PMC3326076.
    49. Schlessinger A, Matsson P, Shima JE, Pieper U, Yee S, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A. Comparison of human solute carriers. Protein Sci. 2010 Mar; 19(3):412-28. PMID: 20052679; PMCID: PMC2866268.
    50. Kroetz DL, Yee S, Giacomini KM. The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology. Clin Pharmacol Ther. 2010 Jan; 87(1):109-16. PMID: 19940846; PMCID: PMC2923224.
    51. Picard N, Yee S, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM, Marquet P. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics. Clin Pharmacol Ther. 2010 Jan; 87(1):100-8. PMID: 19890249; PMCID: PMC2884029.
    52. Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009 Oct; 19(10):770-80. PMID: 19745787; PMCID: PMC2976711.
    53. Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee S, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One. 2009 Sep 09; 4(9):e6942. PMID: 19742321; PMCID: PMC2735003.
    54. Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee S, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics. 2009 Jul; 19(7):497-504. PMID: 19483665; PMCID: PMC3104496.
    55. Chen Y, Teranishi K, Li S, Yee S, Hesselson S, Stryke D, Johns SJ, Ferrin TE, Kwok P, Giacomini KM. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Pharmacogenomics J. 2009 Apr; 9(2):127-36. PMID: 19172157; PMCID: PMC2949062.
    56. Tahara H, Yee S, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM. Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5). J Pharmacol Exp Ther. 2009 Apr; 329(1):262-71. PMID: 19141711; PMCID: PMC2670604.
    57. Yee S, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). J Pharmacol Exp Ther. 2009 Mar; 328(3):699-707. PMID: 19098160; PMCID: PMC2682268.
    58. Cropp CD, Yee S, Giacomini KM. Genetic variation in drug transporters in ethnic populations. Clin Pharmacol Ther. 2008 Sep; 84(3):412-6. PMID: 18528433; PMCID: PMC2976712.
    59. Cropp CD, Komori T, Shima JE, Urban TJ, Yee S, More SS, Giacomini KM. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol. 2008 Apr; 73(4):1151-8. PMID: 18216183; PMCID: PMC2698938.
    60. Gomaa MS, Yee S, Milbourne CE, Barbera MC, Simons C, Brancale A. Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding. J Enzyme Inhib Med Chem. 2006 Aug; 21(4):361-9. PMID: 17059167.
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    61. Yee S, Campbell MJ, Simons C. Inhibition of Vitamin D3 metabolism enhances VDR signalling in androgen-independent prostate cancer cells. J Steroid Biochem Mol Biol. 2006 Mar; 98(4-5):228-35. PMID: 16483768.
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    62. Saberi MR, Vinh TK, Yee S, Griffiths BJ, Evans PJ, Simons C. Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation. J Med Chem. 2006 Feb 09; 49(3):1016-22. PMID: 16451067.
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    63. Pautus S, Yee S, Jayne M, Coogan MP, Simons C. Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles. Bioorg Med Chem. 2006 Jun 01; 14(11):3643-53. PMID: 16458519.
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    64. Yee S, Jarno L, Gomaa MS, Elford C, Ooi LL, Coogan MP, McClelland R, Nicholson RI, Evans BA, Brancale A, Simons C. Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays. J Med Chem. 2005 Nov 17; 48(23):7123-31. PMID: 16279770.
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    65. Yee S, Shah B, Simons C. Synthesis and antimycobacterial activity of 7-O-substituted-4-methyl-2H-2-chromenone derivatives vs Mycobacterium tuberculosis. J Enzyme Inhib Med Chem. 2005 Apr; 20(2):109-13. PMID: 15968814.
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    66. Yee S, Simons C. Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives. Bioorg Med Chem Lett. 2004 Nov 15; 14(22):5651-4. PMID: 15482941.
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