Sophie Dumont, PhD

Title(s)Associate Professor, Bioengineering
SchoolSchool of Pharmacy
Address600 16th St
San Francisco CA 94158
Phone415-502-1229
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    Collapse Biography 
    Collapse Awards and Honors
    2021UCSF Byers Award in Basic Science
    2020Chan Zuckerberg Biohub Investigator
    2018Women in Cell Biology Junior Award for Excellence in Research (ASCB)
    2018UCSF Outstanding Faculty Mentorship Award
    2016NSF CAREER Award
    2016Margaret Oakley Dayhoff Award of the Biophysical Society
    2015NIH New Innovator Award
    2013Rita Allen Foundation and Milton E. Cassel Scholar
    2013Searle Scholar
    2013Sloan Research Fellow
    2013Kimmel Cancer Foundation Scholar
    2010NIH K99/R00 Award
    2006Junior Fellow, Harvard Society of Fellows
    2006Weintraub Graduate Student Award
    2006Alan Bearden Outstanding Graduate Research Award, UC Berkeley
    1999Rhodes Scholarship
    1999Allen G. Shenstone Prize in Physics, Princeton University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    UCSF Program in Breakthrough Biomedical Research PBBRJan 15, 2021 - Jan 14, 2023
    Role: Principal Investigator
    Emergent mechanics of mammalian chromosome segregation
    NIH R35GM136420Jun 1, 2020 - May 31, 2025
    Role: Principal Investigator
    CZ Biohub Investigator CZ BiohubMay 15, 2020 - May 14, 2025
    Role: Principal Investigator
    Mechanics of the dynamic mammalian kinetochore-microtubule interface
    NIH R01GM134132Sep 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Center for Cellular Construction
    NSF 1548297Sep 1, 2016 - Sep 30, 2022
    Role: Sophie Dumont, Investigator
    CAREER: Slip-Clutch of Biological Machines: The Kinetochore-Microtubule Interface
    NSF 1554139Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Rewiring cellular architecture to probe mechanical signal processing at kinetochores
    NIH DP2GM119177Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator
    Rita Allen Foundation Scholars Program Rita AllenDec 1, 2013 - Nov 30, 2020
    Role: Principal Investigator
    Sloan Research Fellowships BR2013-125Sep 15, 2013 - Sep 14, 2017
    Role: Principal Investigator
    Searle Scholars Program 13-SSP-213Jul 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Sidney Kimmel Foundation for Cancer Research SKF-13-053Jul 1, 2013 - Jun 30, 2016
    Role: Principal Investigator
    UCSF Program for Breakthrough Biomedical Research PBBRSep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Dynamics in the tissue state: from normal to tumor and back
    NIH/NCI U54CA143836Jul 1, 2012 - Jul 31, 2014
    Role: Sophie Dumont, Investigator
    Spindle forces for chromosome movement
    NIH R00GM094335Sep 1, 2010 - Jul 31, 2016
    Role: Principal Investigator
    Force generation and detection in the spindle: the case of the kinetochore
    NIH K99GM094335Sep 1, 2010 - May 31, 2012
    Role: Principal Investigator

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface. Curr Biol. 2022 May 11. Rosas-Salvans M, Sutanto R, Suresh P, Dumont S. PMID: 35580605.
      View in: PubMed   Mentions:
    2. Opposing motors provide mechanical and functional robustness in the human spindle. Dev Cell. 2021 11 08; 56(21):3006-3018.e5. Neahring L, Cho NH, Dumont S. PMID: 34614397; PMCID: PMC8578449.
      View in: PubMed   Mentions:    Fields:    
    3. Opposing Motors Provide Mechanical and Functional Robustness in the Mammalian Spindle. Biophysical Journal. 2021 Feb 1; 120(3):347a. Neahring NL, Dumont DS. .
      View in: Publisher Site   Mentions:
    4. Understanding the Mechanisms that Give Rise to the Mammalian Spindle's Response to Force using Theory and Microneedle Manipulation. Biophysical Journal. 2021 Feb 1; 120(3):347a. Galstyan GV, Suresh SP, Dumont DS, Phillips PR. .
      View in: Publisher Site   Mentions:
    5. The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. J Cell Biol. 2020 12 07; 219(12). Serra-Marques A, Houtekamer R, Hintzen D, Canty JT, Yildiz A, Dumont S. PMID: 33044554; PMCID: PMC7555356.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure. J Cell Biol. 2020 08 03; 219(8). Long AF, Suresh P, Dumont S. PMID: 32435797; PMCID: PMC7401803.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes. Elife. 2020 03 19; 9. Suresh P, Long AF, Dumont S. PMID: 32191206; PMCID: PMC7117910.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Cell Rep. 2020 03 10; 30(10):3368-3382.e7. Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A. PMID: 32160543; PMCID: PMC7085414.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. J Cell Biol. 2019 11 04; 218(11):3583-3596. Kuhn J, Dumont S. PMID: 31492713; PMCID: PMC6829666.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules. Curr Opin Cell Biol. 2019 10; 60:60-67. Long AF, Kuhn J, Dumont S. PMID: 31132675; PMCID: PMC6756937.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Microtubule End-Clustering Maintains a Steady-State Spindle Shape. Curr Biol. 2019 02 18; 29(4):700-708.e5. Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S. PMID: 30744975; PMCID: PMC6383811.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Chromosome Segregation Fidelity Integrates Information across Scales. Dev Cell. 2018 12 03; 47(5):525-526. Neahring L, Dumont S. PMID: 30513291.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118. Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. PMID: 30478424; PMCID: PMC6324945.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    14. The Spindle: Integrating Architecture and Mechanics across Scales. Trends Cell Biol. 2018 11; 28(11):896-910. Elting MW, Suresh P, Dumont S. PMID: 30093097; PMCID: PMC6197898.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. Shining light on spindle positioning. Elife. 2018 07 09; 7. Serra-Marques A, Dumont S. PMID: 29983140; PMCID: PMC6037469.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. NuMA recruits dynein activity to microtubule minus-ends at mitosis. Elife. 2017 11 29; 6. Hueschen CL, Kenny SJ, Xu K, Dumont S. PMID: 29185983; PMCID: PMC5706958.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    17. Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy. Curr Biol. 2017 Jul 24; 27(14):2112-2122.e5. Elting MW, Prakash M, Udy DB, Dumont S. PMID: 28690110; PMCID: PMC5579025.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules. Curr Biol. 2017 Jun 05; 27(11):1692-1699.e3. Long AF, Udy DB, Dumont S. PMID: 28552353; PMCID: PMC5502739.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    19. Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension. J Cell Biol. 2017 06 05; 216(6):1533-1542. Kuhn J, Dumont S. PMID: 28536121; PMCID: PMC5461026.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    20. The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. J Cell Biol. 2017 06 05; 216(6):1597-1608. Karg T, Elting MW, Vicars H, Dumont S, Sullivan W. PMID: 28500183; PMCID: PMC5461011.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell. 2017 Jul 07; 28(14):1975-1983. Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. PMID: 28468979; PMCID: PMC5541847.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF. Stem Cells. 2016 06; 34(6):1501-12. Guild J, Haque A, Gheibi P, Gao Y, Son KJ, Foster E, Dumont S, Revzin A. PMID: 26865369.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Kinesin-5: A Team Is Just the Sum of Its Parts. Dev Cell. 2015 Sep 28; 34(6):609-10. Hueschen CL, Long AF, Dumont S. PMID: 26418291.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    24. Draft De Novo Transcriptome of the Rat Kangaroo Potorous tridactylus as a Tool for Cell Biology. PLoS One. 2015; 10(8):e0134738. Udy DB, Voorhies M, Chan PP, Lowe TM, Dumont S. PMID: 26252667; PMCID: PMC4529305.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Emergent mechanics of biological structures. Mol Biol Cell. 2014 Nov 05; 25(22):3461-5. Dumont S, Prakash M. PMID: 25368421; PMCID: PMC4230603.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Force on spindle microtubule minus ends moves chromosomes. J Cell Biol. 2014 Jul 21; 206(2):245-56. Elting MW, Hueschen CL, Udy DB, Dumont S. PMID: 25023517; PMCID: PMC4107791.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    27. Spindle size: small droplets and a big step forward. Curr Biol. 2014 Feb 03; 24(3):R116-8. Dumont S. PMID: 24502785.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    28. Imaging and physically probing kinetochores in live dividing cells. Methods Cell Biol. 2014; 123:467-87. Kuhn J, Dumont S. PMID: 24974043; PMCID: PMC4441532.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    29. Deformations within moving kinetochores reveal different sites of active and passive force generation. Science. 2012 Jul 20; 337(6092):355-8. Dumont S, Salmon ED, Mitchison TJ. PMID: 22722252; PMCID: PMC3672420.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    30. 4.16 Mechanical Forces in Mitosis. Comprehensive Biophysics. 2012 Jan 1; 298-320. Dumont DS, Mitchison MT. .
      View in: Publisher Site   Mentions:
    31. Comprehensive Biophysics. Mechanical Forces in Mitosis. 2012; 298-320. Dumont S, Mitchison TJ.
    32. Chromosome segregation: spindle mechanics come to life. Curr Biol. 2011 Sep 27; 21(18):R688-90. Dumont S. PMID: 21959154.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    33. Force and length in the mitotic spindle. Curr Biol. 2009 Sep 15; 19(17):R749-61. Dumont S, Mitchison TJ. PMID: 19906577; PMCID: PMC2791830.
      View in: PubMed   Mentions: 110     Fields:    Translation:Cells
    34. Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol. 2009 Jul 14; 19(13):1086-95. Dumont S, Mitchison TJ. PMID: 19540117; PMCID: PMC2722833.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    35. How does a millimeter-sized cell find its center? Cell Cycle. 2009 Apr 15; 8(8):1115-21. Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. PMID: 19282671; PMCID: PMC2880816.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    36. Evidence for an upper limit to mitotic spindle length. Curr Biol. 2008 Aug 26; 18(16):1256-61. Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. PMID: 18718761; PMCID: PMC2561182.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    37. NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13954-9. Cheng W, Dumont S, Tinoco I, Bustamante C. PMID: 17709749; PMCID: PMC1955789.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    38. RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature. 2006 Jan 05; 439(7072):105-8. Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I, Pyle AM, Bustamante C. PMID: 16397502; PMCID: PMC1560093.
      View in: PubMed   Mentions: 149     Fields:    Translation:Cells
    39. Identifying kinetic barriers to mechanical unfolding of the T. thermophila ribozyme. Science. 2003 Mar 21; 299(5614):1892-5. Onoa B, Dumont S, Liphardt J, Smith SB, Tinoco I, Bustamante C. PMID: 12649482; PMCID: PMC1503549.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    40. Equilibrium information from nonequilibrium measurements in an experimental test of Jarzynski's equality. Science. 2002 Jun 07; 296(5574):1832-5. Liphardt J, Dumont S, Smith SB, Tinoco I, Bustamante C. PMID: 12052949.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
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