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Sophie Dumont, PhD

Title(s)Associate Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Phone415-502-1229
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    Collapse Biography 
    Collapse Awards and Honors
    2018Women in Cell Biology Junior Award for Excellence in Research (ASCB)
    2018UCSF Outstanding Faculty Mentorship Award
    2016  - 2021NSF CAREER Award
    2016Margaret Oakley Dayhoff Award of the Biophysical Society
    2015  - 2020NIH New Innovator Award
    2013  - 2018Rita Allen Foundation and Milton E. Cassel Scholar
    2013  - 2016Searle Scholar
    2013  - 2015Sloan Research Fellow
    2013  - 2015Kimmel Cancer Foundation Scholar
    2006  - 2009Junior Fellow, Harvard Society of Fellows
    2006Weintraub Graduate Student Award
    2006Alan Bearden Outstanding Graduate Research Award, UC Berkeley
    1999Rhodes Scholarship
    1999Allen G. Shenstone Prize in Physics, Princeton University

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanics of the dynamic mammalian kinetochore-microtubule interface
    NIH/NIGMS R01GM134132Sep 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Center for Cellular Construction
    NSF 1548297Sep 1, 2016 - Sep 30, 2022
    Role: Sophie Dumont, Investigator
    CAREER: Slip-Clutch of Biological Machines: The Kinetochore-Microtubule Interface
    NSF 1554139Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Rewiring cellular architecture to probe mechanical signal processing at kinetochores
    NIH/NIGMS DP2GM119177Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator
    Rita Allen Foundation Scholars Program ###Dec 1, 2013 - Nov 30, 2020
    Role: Principal Investigator
    Sloan Research Fellowships BR2013-125Sep 15, 2013 - Sep 14, 2017
    Role: Principal Investigator
    Searle Scholars Program 13-SSP-213Jul 1, 2013 - Jun 30, 2017
    Role: Principal Investigator
    Sidney Kimmel Foundation for Cancer Research SKF-13-053Jul 1, 2013 - Jun 30, 2016
    Role: Principal Investigator
    UCSF Program for Breakthrough Biomedical Research ###Sep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Dynamics in the tissue state: from normal to tumor and back
    NIH/NCI U54CA143836Jul 1, 2012 - Jul 31, 2014
    Role: Sophie Dumont, Investigator
    Spindle forces for chromosome movement
    NIH/NIGMS R00GM094335Sep 1, 2010 - Jul 31, 2015
    Role: Principal Investigator
    Force generation and detection in the spindle: the case of the kinetochore
    NIH/NIGMS K99GM094335Sep 1, 2010 - May 31, 2012
    Role: Principal Investigator

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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kuhn J, Dumont S. Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. J Cell Biol. 2019 Nov 04; 218(11):3583-3596. PMID: 31492713.
      View in: PubMed
    2. Long AF, Kuhn J, Dumont S. The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules. Curr Opin Cell Biol. 2019 Oct; 60:60-67. PMID: 31132675.
      View in: PubMed
    3. Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S. Microtubule End-Clustering Maintains a Steady-State Spindle Shape. Curr Biol. 2019 Feb 18; 29(4):700-708.e5. PMID: 30744975.
      View in: PubMed
    4. Neahring L, Dumont S. Chromosome Segregation Fidelity Integrates Information across Scales. Dev Cell. 2018 12 03; 47(5):525-526. PMID: 30513291.
      View in: PubMed
    5. Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118. PMID: 30478424.
      View in: PubMed
    6. Elting MW, Suresh P, Dumont S. The Spindle: Integrating Architecture and Mechanics across Scales. Trends Cell Biol. 2018 11; 28(11):896-910. PMID: 30093097.
      View in: PubMed
    7. Serra-Marques A, Dumont S. Shining light on spindle positioning. Elife. 2018 07 09; 7. PMID: 29983140.
      View in: PubMed
    8. Alexandra F. Long, Dylan B. Udy, Pooja Suresh, Sophie Dumont. Probing How the Mammalian Kinetochore Holds on to Growing versus Shrinking Microtubules. Biophysical Journal. 2018 Feb 1; 114(3):518a.
      View in: Publisher Site
    9. Pooja Suresh, Alexandra F. Long, Sophie Dumont. Probing the Physical and Molecular Basis of the Mammalian Mitotic Spindle's Response to Force. Biophysical Journal. 2018 Feb 1; 114(3):655a.
      View in: Publisher Site
    10. Christina L. Hueschen, Samuel J. Kenny, Ke Xu, Sophie Dumont. NuMA Recruits Dynein Activity to Microtubule Minus-Ends at Mitosis. Biophysical Journal. 2018 Feb 1; 114(3):506a.
      View in: Publisher Site
    11. Hueschen CL, Kenny SJ, Xu K, Dumont S. NuMA recruits dynein activity to microtubule minus-ends at mitosis. Elife. 2017 11 29; 6. PMID: 29185983.
      View in: PubMed
    12. Elting MW, Prakash M, Udy DB, Dumont S. Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy. Curr Biol. 2017 Jul 24; 27(14):2112-2122.e5. PMID: 28690110.
      View in: PubMed
    13. Hueschen CL, Kenny SJ, Xu K, Dumont S.. NuMA Targets Dynein to Microtubule Minus-Ends at Mitosis. BioRxiv doi.org/10.1101/148692. 2017.
    14. Long AF, Udy DB, Dumont S. Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules. Curr Biol. 2017 Jun 05; 27(11):1692-1699.e3. PMID: 28552353.
      View in: PubMed
    15. Kuhn J, Dumont S. Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension. J Cell Biol. 2017 06 05; 216(6):1533-1542. PMID: 28536121.
      View in: PubMed
    16. Karg T, Elting MW, Vicars H, Dumont S, Sullivan W. The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. J Cell Biol. 2017 06 05; 216(6):1597-1608. PMID: 28500183.
      View in: PubMed
    17. Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell. 2017 Jul 07; 28(14):1975-1983. PMID: 28468979.
      View in: PubMed
    18. Mary Williard Elting, Dylan B. Udy, Manu Prakash, Sophie Dumont. Local Load-Bearing by Kinetochore-Fibers in the Mammalian Spindle Provides Mechanical Isolation and Redundancy. Biophysical Journal. 2017 Feb 1; 112(3):432a.
      View in: Publisher Site
    19. Guild J, Haque A, Gheibi P, Gao Y, Son KJ, Foster E, Dumont S, Revzin A. Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF. Stem Cells. 2016 06; 34(6):1501-12. PMID: 26865369.
      View in: PubMed
    20. Mary W. Elting, Dylan B. Udy, Sophie Dumont. Local Anchorage of Kinetochore-Fibers to the Mammalian Spindle Provides Mechanical Isolation and Load-Bearing Redundancy. Biophysical Journal. 2016 Feb 1; 110(3):355a.
      View in: Publisher Site
    21. Hueschen CL, Long AF, Dumont S. Kinesin-5: A Team Is Just the Sum of Its Parts. Dev Cell. 2015 Sep 28; 34(6):609-10. PMID: 26418291.
      View in: PubMed
    22. Udy DB, Voorhies M, Chan PP, Lowe TM, Dumont S. Draft De Novo Transcriptome of the Rat Kangaroo Potorous tridactylus as a Tool for Cell Biology. PLoS One. 2015; 10(8):e0134738. PMID: 26252667.
      View in: PubMed
    23. Dumont S, Prakash M. Emergent mechanics of biological structures. Mol Biol Cell. 2014 Nov 05; 25(22):3461-5. PMID: 25368421.
      View in: PubMed
    24. Elting MW, Hueschen CL, Udy DB, Dumont S. Force on spindle microtubule minus ends moves chromosomes. J Cell Biol. 2014 Jul 21; 206(2):245-56. PMID: 25023517.
      View in: PubMed
    25. Dumont S. Spindle size: small droplets and a big step forward. Curr Biol. 2014 Feb 03; 24(3):R116-8. PMID: 24502785.
      View in: PubMed
    26. Kuhn J, Dumont S. Imaging and physically probing kinetochores in live dividing cells. Methods Cell Biol. 2014; 123:467-87. PMID: 24974043.
      View in: PubMed
    27. Mary W. Elting, Christina L. Hueschen, Dylan B. Udy, Sophie Dumont. Probing Forces on Newly Generated Spindle Microtubule Minus-Ends. Biophysical Journal. 2014 Jan 1; 106(2):9a-10a.
      View in: Publisher Site
    28. Christina L. Hueschen, Mary W. Elting, Dylan B. Udy, Sophie Dumont. Probing Forces on Newly Generated Spindle Microtubule Minus-Ends. Biophysical Journal. 2014 Jan 1; 106(2):787a.
      View in: Publisher Site
    29. Dumont S, Salmon ED, Mitchison TJ. Deformations within moving kinetochores reveal different sites of active and passive force generation. Science. 2012 Jul 20; 337(6092):355-8. PMID: 22722252.
      View in: PubMed
    30. S. Dumont, T.J. Mitchison. 4.16 Mechanical Forces in Mitosis. Comprehensive Biophysics. 2012 Jan 1; 298-320.
      View in: Publisher Site
    31. Dumont S, Mitchison TJ.Comprehensive Biophysics. Mechanical Forces in Mitosis. 2012; 298-320.
    32. Dumont S. Chromosome segregation: spindle mechanics come to life. Curr Biol. 2011 Sep 27; 21(18):R688-90. PMID: 21959154.
      View in: PubMed
    33. Sophie Dumont, Edward D. Salmon, Timothy J. Mitchison. Separate Locations of the Active and Passive Microtubule Interfaces in Kinetochores Inferred from Direction-Dependent Structural Changes. Biophysical Journal. 2011 Feb 1; 100(3):514a.
      View in: Publisher Site
    34. Dumont S, Mitchison TJ. Force and length in the mitotic spindle. Curr Biol. 2009 Sep 15; 19(17):R749-61. PMID: 19906577.
      View in: PubMed
    35. Dumont S, Mitchison TJ. Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol. 2009 Jul 14; 19(13):1086-95. PMID: 19540117.
      View in: PubMed
    36. Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. How does a millimeter-sized cell find its center? Cell Cycle. 2009 Apr 15; 8(8):1115-21. PMID: 19282671.
      View in: PubMed
    37. Sophie Dumont, Timothy J. Mitchison. Response of the Mitotic Spindle to Mechanical Force. Biophysical Journal. 2009 Feb 1; 96(3):505a.
      View in: Publisher Site
    38. Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. Evidence for an upper limit to mitotic spindle length. Curr Biol. 2008 Aug 26; 18(16):1256-61. PMID: 18718761.
      View in: PubMed
    39. Cheng W, Dumont S, Tinoco I, Bustamante C. NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13954-9. PMID: 17709749.
      View in: PubMed
    40. Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I, Pyle AM, Bustamante C. RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature. 2006 Jan 05; 439(7072):105-8. PMID: 16397502.
      View in: PubMed
    41. Onoa B, Dumont S, Liphardt J, Smith SB, Tinoco I, Bustamante C. Identifying kinetic barriers to mechanical unfolding of the T. thermophila ribozyme. Science. 2003 Mar 21; 299(5614):1892-5. PMID: 12649482.
      View in: PubMed
    42. Liphardt J, Dumont S, Smith SB, Tinoco I, Bustamante C. Equilibrium information from nonequilibrium measurements in an experimental test of Jarzynski's equality. Science. 2002 Jun 07; 296(5574):1832-5. PMID: 12052949.
      View in: PubMed