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NuMA mechanically reinforces the spindle independently of its partner dynein. Curr Biol. 2025 Sep 08; 35(17):4084-4095.e5.
Cho NH, Aslan M, Taheri A, Yildiz A, Dumont S. PMID: 40769151; PMCID: PMC12348805.
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Translation:
HumansAnimalsCells
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Mechanical force locally damages, remodels and stabilizes the lattice of spindle microtubules. bioRxiv. 2025 Jun 06.
Rux CJ, Chong MK, Myers S, Cho NH, Dumont S. PMID: 40501666; PMCID: PMC12157524.
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SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force. Curr Biol. 2025 Apr 21; 35(8):1805-1815.e4.
Rosas-Salvans M, Rux CJ, Das M, Dumont S. PMID: 40154475.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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BPS2025 - NuMA mechanically reinforces spindle poles independently of dynein through self-interactions. Biophysical Journal. 2025 Feb 1; 124(3):376a.
Cho CN, Dumont DS. .
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BPS2025 - NuMA mechanically reinforces spindle poles independently of dynein through self-interactions. Biophysical Journal. 2025 Feb 1; 124(3):476a-477a.
Cho CN, Dumont DS. .
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BPS2025 - Force-dependent spindle microtubule damage, remodeling, and stabilization. Biophysical Journal. 2025 Feb 1; 124(3):138a.
Rux RC, Chong CM, Myers MS, Cho CN, Dumont DS. .
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Structural and functional insights into activation and regulation of the dynein-dynactin-NuMA complex. bioRxiv. 2024 Dec 03.
Aslan M, d'Amico EA, Cho NH, Taheri A, Zhao Y, Zhong X, Blaauw M, Carter AP, Dumont S, Yildiz A. PMID: 39651296; PMCID: PMC11623564.
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PubMed Mentions:
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NuMA mechanically reinforces the spindle independently of its partner dynein. bioRxiv. 2024 Dec 01.
Cho NH, Aslan M, Yildiz A, Dumont S. PMID: 40741481; PMCID: PMC12309564.
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PubMed Mentions:
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SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force. bioRxiv. 2024 Aug 08.
Rosas-Salvans M, Rux C, Das M, Dumont S. PMID: 39149232; PMCID: PMC11326240.
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PubMed Mentions:
1
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Torques within and outside the human spindle balance twist at anaphase. J Cell Biol. 2024 Sep 02; 223(9).
Neahring L, Cho NH, He Y, Liu G, Fernandes J, Rux CJ, Nakos K, Subramanian R, Upadhyayula S, Yildiz A, Dumont S. PMID: 38869473; PMCID: PMC11176257.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction. J Cell Biol. 2024 Aug 05; 223(8).
Chong MK, Rosas-Salvans M, Tran V, Dumont S. PMID: 38727808; PMCID: PMC11090132.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force. PLoS One. 2024; 19(3):e0296779.
Sutanto R, Neahring L, Serra Marques A, Jacobo Jacobo M, Kilinc S, Goga A, Dumont S. PMID: 38478555; PMCID: PMC10936824.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Probing how the Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface. Biophysical Journal. 2024 Feb 1; 123(3):1a-2a.
Salvans SM, Dumont DS. .
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Publisher Site Mentions:
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NuMA mechanically reinforces mammalian spindle poles independent of its partner dynein. Biophysical Journal. 2024 Feb 1; 123(3):539a.
Cho CN, Dumont DS. .
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Publisher Site Mentions:
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Torques within and outside the human spindle balance twist at anaphase. bioRxiv. 2023 Dec 10.
Neahring L, He Y, Cho NH, Liu G, Fernandes J, Rux CJ, Nakos K, Subramanian R, Upadhyayula S, Yildiz A, Dumont S. PMID: 38405786; PMCID: PMC10888964.
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PubMed Mentions:
3
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Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction. bioRxiv. 2023 Oct 18.
Chong MK, Rosas-Salvans M, Tran V, Dumont S. PMID: 37905080; PMCID: PMC10614862.
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Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes. Cell. 2023 10 12; 186(21):4694-4709.e16.
Bakshi A, Iturra FE, Alamban A, Rosas-Salvans M, Dumont S, Aydogan MG. PMID: 37832525; PMCID: PMC10659773.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle. Elife. 2023 07 03; 12.
Richter M, Neahring L, Tao J, Sutanto R, Cho NH, Dumont S. PMID: 37395732; PMCID: PMC10348741.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force. bioRxiv. 2023 May 31.
Sutanto R, Neahring L, Marques AS, Kilinc S, Goga A, Dumont S. PMID: 37398487; PMCID: PMC10312523.
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PubMed Mentions:
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Mechanisms underlying spindle assembly and robustness. Nat Rev Mol Cell Biol. 2023 08; 24(8):523-542.
Valdez VA, Neahring L, Petry S, Dumont S. PMID: 36977834; PMCID: PMC10642710.
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PubMed Mentions:
30 Fields:
Translation:
Cells
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Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle. Elife. 2022 11 08; 11.
Suresh P, Galstyan V, Phillips R, Dumont S. PMID: 36346735; PMCID: PMC9642996.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells. EMBO J. 2022 09 01; 41(17):e109205.
Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM. PMID: 35880301; PMCID: PMC9434103.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface. Curr Biol. 2022 06 20; 32(12):2621-2631.e3.
Rosas-Salvans M, Sutanto R, Suresh P, Dumont S. PMID: 35580605; PMCID: PMC9295892.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Connections distributed within 3 µm of chromosomes are necessary and sufficient for the kinetochore-fiber’s robust anchorage in the mammalian spindle. Biophysical Journal. 2022 Feb 1; 121(3):448a-449a.
Suresh SP, Galstyan GV, Phillips PR, Dumont DS. .
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The Astrin-SKAP complex lubricates the kinetochore-microtubule interface. Biophysical Journal. 2022 Feb 1; 121(3):522a.
Salvans SM, Sutanto SR, Dumont DS. .
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Opposing motors provide mechanical and functional robustness in the human spindle. Dev Cell. 2021 11 08; 56(21):3006-3018.e5.
Neahring L, Cho NH, Dumont S. PMID: 34614397; PMCID: PMC8578449.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Understanding the Mechanisms that Give Rise to the Mammalian Spindle's Response to Force using Theory and Microneedle Manipulation. Biophysical Journal. 2021 Feb 1; 120(3):347a.
Galstyan GV, Suresh SP, Dumont DS, Phillips PR. .
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Opposing Motors Provide Mechanical and Functional Robustness in the Mammalian Spindle. Biophysical Journal. 2021 Feb 1; 120(3):347a.
Neahring NL, Dumont DS. .
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The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. J Cell Biol. 2020 12 07; 219(12).
Serra-Marques A, Houtekamer R, Hintzen D, Canty JT, Yildiz A, Dumont S. PMID: 33044554; PMCID: PMC7555356.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure. J Cell Biol. 2020 08 03; 219(8).
Long AF, Suresh P, Dumont S. PMID: 32435797; PMCID: PMC7401803.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes. Elife. 2020 03 19; 9.
Suresh P, Long AF, Dumont S. PMID: 32191206; PMCID: PMC7117910.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Cell Rep. 2020 03 10; 30(10):3368-3382.e7.
Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A. PMID: 32160543; PMCID: PMC7085414.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. J Cell Biol. 2019 11 04; 218(11):3583-3596.
Kuhn J, Dumont S. PMID: 31492713; PMCID: PMC6829666.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Abstract 1028: Extracellular matrix dimensionality reduces cellular cortical tension to stimulate pro-survival signaling in mammary epithelial cells. Cancer Research. 2019 Jul 1; 79(13_Supplement):1028-1028.
Kai KF, Ou OG, Long LA, Guo GW, Tourdot TR, Radhakrishnan RR, Chen CC, Dumont DS, Weaver WV. .
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Abstract 2902: Non-genetic TPX2/AURKA signaling facilitates tumor evolution in EGFR-TKI resistance in NSCLC. Tumor Biology. 2019 Jul 1; 2902-2902.
Shah SK, Bhatt BR, Rotow RJ, Rohrberg RJ, Olivas OV, Wang WV, Kuhn KJ, Dumont DS, Mccormick MF, Goga GA, Blakely BC, Bivona BT, Bandyopadhyay BS. .
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The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules. Curr Opin Cell Biol. 2019 10; 60:60-67.
Long AF, Kuhn J, Dumont S. PMID: 31132675; PMCID: PMC6756937.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Microtubule End-Clustering Maintains a Steady-State Spindle Shape. Curr Biol. 2019 02 18; 29(4):700-708.e5.
Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S. PMID: 30744975; PMCID: PMC6383811.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Chromosome Segregation Fidelity Integrates Information across Scales. Dev Cell. 2018 12 03; 47(5):525-526.
Neahring L, Dumont S. PMID: 30513291.
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PubMed Mentions: Fields:
Translation:
Humans
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Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118.
Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. PMID: 30478424; PMCID: PMC6324945.
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PubMed Mentions:
156 Fields:
Translation:
HumansAnimalsCells
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The Spindle: Integrating Architecture and Mechanics across Scales. Trends Cell Biol. 2018 11; 28(11):896-910.
Elting MW, Suresh P, Dumont S. PMID: 30093097; PMCID: PMC6197898.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Shining light on spindle positioning. Elife. 2018 07 09; 7.
Serra-Marques A, Dumont S. PMID: 29983140; PMCID: PMC6037469.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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NuMA recruits dynein activity to microtubule minus-ends at mitosis. Elife. 2017 11 29; 6.
Hueschen CL, Kenny SJ, Xu K, Dumont S. PMID: 29185983; PMCID: PMC5706958.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy. Curr Biol. 2017 Jul 24; 27(14):2112-2122.e5.
Elting MW, Prakash M, Udy DB, Dumont S. PMID: 28690110; PMCID: PMC5579025.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules. Curr Biol. 2017 Jun 05; 27(11):1692-1699.e3.
Long AF, Udy DB, Dumont S. PMID: 28552353; PMCID: PMC5502739.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension. J Cell Biol. 2017 06 05; 216(6):1533-1542.
Kuhn J, Dumont S. PMID: 28536121; PMCID: PMC5461026.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. J Cell Biol. 2017 06 05; 216(6):1597-1608.
Karg T, Elting MW, Vicars H, Dumont S, Sullivan W. PMID: 28500183; PMCID: PMC5461011.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell. 2017 Jul 07; 28(14):1975-1983.
Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. PMID: 28468979; PMCID: PMC5541847.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF. Stem Cells. 2016 06; 34(6):1501-12.
Guild J, Haque A, Gheibi P, Gao Y, Son KJ, Foster E, Dumont S, Revzin A. PMID: 26865369.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Kinesin-5: A Team Is Just the Sum of Its Parts. Dev Cell. 2015 Sep 28; 34(6):609-10.
Hueschen CL, Long AF, Dumont S. PMID: 26418291.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Draft De Novo Transcriptome of the Rat Kangaroo Potorous tridactylus as a Tool for Cell Biology. PLoS One. 2015; 10(8):e0134738.
Udy DB, Voorhies M, Chan PP, Lowe TM, Dumont S. PMID: 26252667; PMCID: PMC4529305.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Emergent mechanics of biological structures. Mol Biol Cell. 2014 Nov 05; 25(22):3461-5.
Dumont S, Prakash M. PMID: 25368421; PMCID: PMC4230603.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Force on spindle microtubule minus ends moves chromosomes. J Cell Biol. 2014 Jul 21; 206(2):245-56.
Elting MW, Hueschen CL, Udy DB, Dumont S. PMID: 25023517; PMCID: PMC4107791.
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PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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Spindle size: small droplets and a big step forward. Curr Biol. 2014 Feb 03; 24(3):R116-8.
Dumont S. PMID: 24502785.
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Translation:
AnimalsCells
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Imaging and physically probing kinetochores in live dividing cells. Methods Cell Biol. 2014; 123:467-87.
Kuhn J, Dumont S. PMID: 24974043; PMCID: PMC4441532.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Deformations within moving kinetochores reveal different sites of active and passive force generation. Science. 2012 Jul 20; 337(6092):355-8.
Dumont S, Salmon ED, Mitchison TJ. PMID: 22722252; PMCID: PMC3672420.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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Comprehensive Biophysics. Mechanical Forces in Mitosis. 2012; 298-320.
Dumont S, Mitchison TJ.
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4.16 Mechanical Forces in Mitosis. Comprehensive Biophysics. 2012 Jan 1; 298-320.
Dumont DS, Mitchison MT. .
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Chromosome segregation: spindle mechanics come to life. Curr Biol. 2011 Sep 27; 21(18):R688-90.
Dumont S. PMID: 21959154.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Force and length in the mitotic spindle. Curr Biol. 2009 Sep 15; 19(17):R749-61.
Dumont S, Mitchison TJ. PMID: 19906577; PMCID: PMC2791830.
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PubMed Mentions:
140 Fields:
Translation:
Cells
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Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol. 2009 Jul 14; 19(13):1086-95.
Dumont S, Mitchison TJ. PMID: 19540117; PMCID: PMC2722833.
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PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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How does a millimeter-sized cell find its center? Cell Cycle. 2009 Apr 15; 8(8):1115-21.
Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. PMID: 19282671; PMCID: PMC2880816.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Evidence for an upper limit to mitotic spindle length. Curr Biol. 2008 Aug 26; 18(16):1256-61.
Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. PMID: 18718761; PMCID: PMC2561182.
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PubMed Mentions:
120 Fields:
Translation:
AnimalsCells
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NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13954-9.
Cheng W, Dumont S, Tinoco I, Bustamante C. PMID: 17709749; PMCID: PMC1955789.
View in:
PubMed Mentions:
55 Fields:
Translation:
Cells
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RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature. 2006 Jan 05; 439(7072):105-8.
Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I, Pyle AM, Bustamante C. PMID: 16397502; PMCID: PMC1560093.
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PubMed Mentions:
165 Fields:
Translation:
Cells
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Identifying kinetic barriers to mechanical unfolding of the T. thermophila ribozyme. Science. 2003 Mar 21; 299(5614):1892-5.
Onoa B, Dumont S, Liphardt J, Smith SB, Tinoco I, Bustamante C. PMID: 12649482; PMCID: PMC1503549.
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PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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Equilibrium information from nonequilibrium measurements in an experimental test of Jarzynski's equality. Science. 2002 Jun 07; 296(5574):1832-5.
Liphardt J, Dumont S, Smith SB, Tinoco I, Bustamante C. PMID: 12052949.
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PubMed Mentions:
157 Fields:
Translation:
AnimalsCells