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Stavros Lomvardas, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentAnatomy
Address401 Parnassus Ave, LangPorter
San Francisco CA 94143
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    Collapse Research 
    Collapse Research Activities and Funding
    Deciphering the molecular principles of olfactory receptor gene choice
    NIH/NIDCD R01DC015451Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Deciphering nuclear bodies and compartments that govern singular olfactory receptor expression.
    NIH/NIDA U01DA040582Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Understanding the Role of Nuclear Architecture in Olfactory Receptor Choice
    NIH/NIDCD R01DC013560Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    The Unfolded Protein Response as an Organizer of Chemosensory Response
    NIH/NIDCD R01DC014144Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Controlling epigenetic states and nuclear architecture in the brain
    NIH/NIDA R01DA036894Sep 15, 2013 - May 31, 2018
    Role: Co-Principal Investigator
    Influence of drug abuse on neuronal nuclear and chromatin architecture
    NIH/NIDA R01DA036985Jul 1, 2013 - Mar 31, 2017
    Role: Co-Principal Investigator
    Epigenetic and genetic contributors to chronic neuropathic pain
    NIH/NIDCR R01DE022001Aug 1, 2011 - Jul 31, 2016
    Role: Co-Principal Investigator
    Devising New Technologies for Live Imaging of Epigenetic Processes
    NIH/NIDA R01DA030320Sep 15, 2010 - May 31, 2015
    Role: Principal Investigator
    Insight into MeCP2 function raises therapeutic possibilities for Rett Syndrome
    NIH/NIMH R01MH091661Aug 17, 2010 - Jul 31, 2014
    Role: Principal Investigator
    Characterization of the role of CpA methylation in neuronal plasticity
    NIH DP2OD006667Sep 30, 2009 - Jun 13, 2014
    Role: Principal Investigator
    Mechanisms of epigenetic silencing of olfactory receptor genes
    NIH/NIDCD R03DC010273Jul 1, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Resource for X-ray Tomography of Whole Cells
    NIH/NCRR P41RR019664May 6, 2004 - Apr 30, 2013
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Le Gros MA, Clowney EJ, Magklara A, Yen A, Markenscoff-Papadimitriou E, Colquitt B, Myllys M, Kellis M, Lomvardas S, Larabell CA. Soft X-Ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis In Vivo. Cell Rep. 2016 Nov 15; 17(8):2125-2136. PMID: 27851973.
      View in: PubMed
    2. Lomvardas S, Maniatis T. Histone and DNA Modifications as Regulators of Neuronal Development and Function. Cold Spring Harb Perspect Biol. 2016; 8(7). PMID: 27371659.
      View in: PubMed
    3. Dekker J, Guttman M, Lomvardas S. A Guide to Packing Your DNA. Cell. 2016 Apr 7; 165(2):259-61. PMID: 27058655.
      View in: PubMed
    4. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI. Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016 Jan; 19(1):94-101. PMID: 26642091.
      View in: PubMed
    5. Gray JM, Kim TK, West AE, Nord AS, Markenscoff-Papadimitriou E, Lomvardas S. Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS. J Neurosci. 2015 Oct 14; 35(41):13819-26. PMID: 26468181; PMCID: PMC4604220 [Available on 04/14/16].
    6. Monahan K, Lomvardas S. Monoallelic Expression of Olfactory Receptors. Annu Rev Cell Dev Biol. 2015 Nov 13; 31:721-40. PMID: 26359778.
      View in: PubMed
    7. Dalton RP, Lomvardas S. Chemosensory receptor specificity and regulation. Annu Rev Neurosci. 2015 Jul 8; 38:331-49. PMID: 25938729.
      View in: PubMed
    8. Lyons DB, Magklara A, Goh T, Sampath SC, Schaefer A, Schotta G, Lomvardas S. Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons. Cell Rep. 2014 Nov 6; 9(3):884-92. PMID: 25437545; PMCID: PMC4251488.
    9. Markenscoff-Papadimitriou E, Allen WE, Colquitt BM, Goh T, Murphy KK, Monahan K, Mosley CP, Ahituv N, Lomvardas S. Enhancer interaction networks as a means for singular olfactory receptor expression. Cell. 2014 Oct 23; 159(3):543-57. PMID: 25417106; PMCID: PMC4243057.
    10. Colquitt BM, Markenscoff-Papadimitriou E, Duffié R, Lomvardas S. Dnmt3a regulates global gene expression in olfactory sensory neurons and enables odorant-induced transcription. Neuron. 2014 Aug 20; 83(4):823-38. PMID: 25123312; PMCID: PMC4153871.
    11. Lyons DB, Lomvardas S. Repressive histone methylation: a case study in deterministic versus stochastic gene regulation. Biochim Biophys Acta. 2014 Dec; 1839(12):1373-84. PMID: 24859457.
      View in: PubMed
    12. Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ, Lomvardas S, Rowitch DH. Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. Nat Neurosci. 2014 Apr; 17(4):506-12. PMID: 24609463; PMCID: PMC3975168.
    13. Alexander JM, Lomvardas S. Nuclear architecture as an epigenetic regulator of neural development and function. Neuroscience. 2014 Apr 4; 264:39-50. PMID: 24486963; PMCID: PMC4006947.
    14. Dalton RP, Lyons DB, Lomvardas S. Co-opting the unfolded protein response to elicit olfactory receptor feedback. Cell. 2013 Oct 10; 155(2):321-32. PMID: 24120133; PMCID: PMC3843319.
    15. Colquitt BM, Allen WE, Barnea G, Lomvardas S. Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity. Proc Natl Acad Sci U S A. 2013 Sep 3; 110(36):14682-7. PMID: 23969834; PMCID: PMC3767503.
    16. Lyons DB, Allen WE, Goh T, Tsai L, Barnea G, Lomvardas S. An epigenetic trap stabilizes singular olfactory receptor expression. Cell. 2013 Jul 18; 154(2):325-36. PMID: 23870122; PMCID: PMC3929589.
    17. Magklara A, Lomvardas S. Stochastic gene expression in mammals: lessons from olfaction. Trends Cell Biol. 2013 Sep; 23(9):449-56. PMID: 23689023; PMCID: PMC3755038.
    18. Monahan K, Lomvardas S. How keeping active pays off in the olfactory system. Elife. 2012; 1:e00326. PMID: 23240088; PMCID: PMC3510477.
    19. Clowney EJ, LeGros MA, Mosley CP, Clowney FG, Markenskoff-Papadimitriou EC, Myllys M, Barnea G, Larabell CA, Lomvardas S. Nuclear aggregation of olfactory receptor genes governs their monogenic expression. Cell. 2012 Nov 9; 151(4):724-37. PMID: 23141535; PMCID: PMC3659163.
    20. Johnson MA, Tsai L, Roy DS, Valenzuela DH, Mosley C, Magklara A, Lomvardas S, Liberles SD, Barnea G. Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13410-5. PMID: 22837392; PMCID: PMC3421222.
    21. Birnbaum RY, Clowney EJ, Agamy O, Kim MJ, Zhao J, Yamanaka T, Pappalardo Z, Clarke SL, Wenger AM, Nguyen L, Gurrieri F, Everman DB, Schwartz CE, Birk OS, Bejerano G, Lomvardas S, Ahituv N. Coding exons function as tissue-specific enhancers of nearby genes. Genome Res. 2012 Jun; 22(6):1059-68. PMID: 22442009; PMCID: PMC3371700.
    22. Clowney EJ, Magklara A, Colquitt BM, Pathak N, Lane RP, Lomvardas S. High-throughput mapping of the promoters of the mouse olfactory receptor genes reveals a new type of mammalian promoter and provides insight into olfactory receptor gene regulation. Genome Res. 2011 Aug; 21(8):1249-59. PMID: 21705439; PMCID: PMC3149492.
    23. Magklara A, Yen A, Colquitt BM, Clowney EJ, Allen W, Markenscoff-Papadimitriou E, Evans ZA, Kheradpour P, Mountoufaris G, Carey C, Barnea G, Kellis M, Lomvardas S. An epigenetic signature for monoallelic olfactory receptor expression. Cell. 2011 May 13; 145(4):555-70. PMID: 21529909; PMCID: PMC3094500.
    24. Nolis IK, McKay DJ, Mantouvalou E, Lomvardas S, Merika M, Thanos D. Transcription factors mediate long-range enhancer-promoter interactions. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20222-7. PMID: 19923429; PMCID: PMC2779200.
    25. Lomvardas S, Barnea G, Pisapia DJ, Mendelsohn M, Kirkland J, Axel R. Interchromosomal interactions and olfactory receptor choice. Cell. 2006 Jul 28; 126(2):403-13. PMID: 16873069.
      View in: PubMed
    26. Guan Z, Kim JH, Lomvardas S, Holick K, Xu S, Kandel ER, Schwartz JH. p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia. J Neurosci. 2003 Aug 13; 23(19):7317-25. PMID: 12917365.
      View in: PubMed
    27. Guan Z, Giustetto M, Lomvardas S, Kim JH, Miniaci MC, Schwartz JH, Thanos D, Kandel ER. Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Cell. 2002 Nov 15; 111(4):483-93. PMID: 12437922.
      View in: PubMed
    28. Lomvardas S, Thanos D. Modifying gene expression programs by altering core promoter chromatin architecture. Cell. 2002 Jul 26; 110(2):261-71. PMID: 12150933.
      View in: PubMed
    29. Lomvardas S, Thanos D. Opening chromatin. Mol Cell. 2002 Feb; 9(2):209-11. PMID: 11864594.
      View in: PubMed
    30. Lomvardas S, Thanos D. Nucleosome sliding via TBP DNA binding in vivo. Cell. 2001 Sep 21; 106(6):685-96. PMID: 11572775.
      View in: PubMed
    31. Munshi N, Agalioti T, Lomvardas S, Merika M, Chen G, Thanos D. Coordination of a transcriptional switch by HMGI(Y) acetylation. Science. 2001 Aug 10; 293(5532):1133-6. PMID: 11498590.
      View in: PubMed
    32. Agalioti T, Lomvardas S, Parekh B, Yie J, Maniatis T, Thanos D. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell. 2000 Nov 10; 103(4):667-78. PMID: 11106736.
      View in: PubMed
    33. Jho Eh, Lomvardas S, Costantini F. A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. Biochem Biophys Res Commun. 1999 Dec 9; 266(1):28-35. PMID: 10581160.
      View in: PubMed
    34. Munshi N, Yie Y, Merika M, Senger K, Lomvardas S, Agalioti T, Thanos D. The IFN-beta enhancer: a paradigm for understanding activation and repression of inducible gene expression. Cold Spring Harb Symp Quant Biol. 1999; 64:149-59. PMID: 11232280.
      View in: PubMed
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