Stephanie Valderramos, MD, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentOb/Gyn, Reproductive Sciences
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Education and Training
    UC Berkeley, Berkeley, CABA1998Molecular and Cell Biology, Immunology
    Albert Einstein College of Medicine, Bronx, NYMD, PhD2009Medicine, Microbiology and Immunology
    UCSF, San Francisco, CAResidency2013Obstetrics and Gynecology
    UCLA, Los Angeles, CAFellowship2016Maternal-Fetal Medicine

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    Collapse Overview
    Dr. Valderramos graduated from Albert Einstein College of Medicine in 2009 from the Medical Scientist Training Program. She completed her PhD studies in the laboratory of Dr. David Fidock (Columbia University), where she investigated molecular mechanisms of antimalarial drug resistance in Plasmodium falciparum. While a UCSF OB/GYN resident, she began her work in placental malaria with Dr. Susan Fisher, investigating the role of placental macrophages in the pathogenesis of fetal growth restriction. She then went on to a Maternal-Fetal Medicine fellowship at UCLA, where she joined the innate immunology lab of Dr. Genhong Cheng to further her training in advanced methodologies in molecular immunology and bioinformatics. She joined UCSF faculty in 2016. Her research program is focused on translational approaches to understanding the pathophysiology of placental infections, especially malaria and Zika.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rao R, Gaw SL, Han CS, Platt LD, Silverman NS. Zika Risk and Pregnancy in Clinical Practice: Ongoing Experience as the Outbreak Evolves. Obstet Gynecol. 2017 May 05. PMID: 28486369.
      View in: PubMed
    2. Maykin MM, Mularz AJ, Lee LK, Valderramos S. Validation of a Prediction Model for Vaginal Birth after Cesarean Delivery Reveals Unexpected Success in a Diverse American Population. AJP Rep. 2017 Jan; 7(1):e31-e38. PMID: 28255520.
      View in: PubMed
    3. Rao RR, Valderramos S, Silverman NS, Han CS, Platt LD. The value of the first trimester ultrasound in the era of cell free DNA screening. Prenat Diagn. 2016 Dec; 36(13):1192-1198. PMID: 27813114.
      View in: PubMed
    4. Valderramos S, Rao RR, Scibetta EW, Silverman NS, Han CS, Platt LD. Cell-free DNA screening in clinical practice: abnormal autosomal aneuploidy and microdeletion results. Am J Obstet Gynecol. 2016 Nov; 215(5):626.e1-626.e10. PMID: 27371353.
      View in: PubMed
    5. Wang L, Valderramos S, Wu A, Ouyang S, Li C, Brasil P, Bonaldo M, Coates T, Nielsen-Saines K, Jiang T, Aliyari R, Cheng G. From Mosquitos to Humans: Genetic Evolution of Zika Virus. Cell Host Microbe. 2016 May 11; 19(5):561-5. PMID: 27091703.
      View in: PubMed
    6. Brasil P, Pereira JP, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, Rabello RS, Valderramos S, Halai UA, Salles TS, Zin AA, Horovitz D, Daltro P, Boechat M, Raja Gabaglia C, Carvalho de Sequeira P, Pilotto JH, Medialdea-Carrera R, Cotrim da Cunha D, Abreu de Carvalho LM, Pone M, Machado Siqueira A, Calvet GA, Rodrigues Baião AE, Neves ES, Nassar de Carvalho PR, Hasue RH, Marschik PB, Einspieler C, Janzen C, Cherry JD, Bispo de Filippis AM, Nielsen-Saines K. Zika Virus Infection in Pregnant Women in Rio de Janeiro. N Engl J Med. 2016 12 15; 375(24):2321-2334. PMID: 26943629.
      View in: PubMed
    7. Nguyen TA, Mularz AJ, Valderramos S. Power analysis for the MEXPRE study. Am J Obstet Gynecol. 2014 Aug; 211(2):182. PMID: 24613221.
      View in: PubMed
    8. Yee LM, Valderramos S, Pena S, Cheng YW, Bianco K. Perinatal outcomes in euploid pregnancies with 'double-positive' first trimester prenatal screening for trisomy 18 and 21. J Perinatol. 2013 Nov; 33(11):836-40. PMID: 23887195.
      View in: PubMed
    9. Lehane AM, van Schalkwyk DA, Valderramos S, Fidock DA, Kirk K. Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT. Antimicrob Agents Chemother. 2011 May; 55(5):2310-8. PMID: 21343459; PMCID: PMC3088201.
    10. Valderramos S, Scanfeld D, Uhlemann AC, Fidock DA, Krishna S. Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob Agents Chemother. 2010 Sep; 54(9):3842-52. PMID: 20566762; PMCID: PMC2935017.
    11. Valderramos SG, Valderramos S, Musset L, Purcell LA, Mercereau-Puijalon O, Legrand E, Fidock DA. Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum. PLoS Pathog. 2010 May 13; 6(5):e1000887. PMID: 20485514; PMCID: PMC2869323.
    12. Hunt P, Afonso A, Creasey A, Culleton R, Sidhu AB, Logan J, Valderramos S, McNae I, Cheesman S, do Rosario V, Carter R, Fidock DA, Cravo P. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Mol Microbiol. 2007 Jul; 65(1):27-40. PMID: 17581118; PMCID: PMC1974797.
    13. Freundlich JS, Wang F, Tsai HC, Kuo M, Shieh HM, Anderson JW, Nkrumah LJ, Valderramos JC, Yu M, Kumar TR, Valderramos S, Jacobs WR, Schiehser GA, Jacobus DP, Fidock DA, Sacchettini JC. X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. J Biol Chem. 2007 Aug 31; 282(35):25436-44. PMID: 17567585.
      View in: PubMed
    14. Valderramos S, Fidock DA. Transporters involved in resistance to antimalarial drugs. Trends Pharmacol Sci. 2006 Nov; 27(11):594-601. PMID: 16996622; PMCID: PMC2944664.
    15. Sidhu AB, Uhlemann AC, Valderramos SG, Valderramos S, Krishna S, Fidock DA. Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J Infect Dis. 2006 Aug 15; 194(4):528-35. PMID: 16845638; PMCID: PMC2978021.
    16. Randrianarivelojosia M, Fidock DA, Belmonte O, Valderramos S, Mercereau-Puijalon O, Ariey F. First evidence of pfcrt mutant Plasmodium falciparum in Madagascar. Trans R Soc Trop Med Hyg. 2006 Sep; 100(9):826-30. PMID: 16442577; PMCID: PMC2944659.
    17. Sidhu AB, Valderramos S, Fidock DA. pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol Microbiol. 2005 Aug; 57(4):913-26. PMID: 16091034.
      View in: PubMed
    18. Serwold T, Gaw S, Shastri N. ER aminopeptidases generate a unique pool of peptides for MHC class I molecules. Nat Immunol. 2001 Jul; 2(7):644-51. PMID: 11429550.
      View in: PubMed
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