The Floor Lab studies the control of gene expression at the level of RNA. DEAD-box RNA chaperones are a major focus of the lab, which remodel RNA structures and RNA-protein interactions. Some questions we’re interested in are: how do DEAD-box proteins influence RNA structure and bound proteins in cells? How do these changes affect cell state? Do DEAD-box proteins act as molecular dispersants for RNA? How can we measure translation and protein binding on single RNA molecules in cells? We use diverse deep sequencing approaches, biochemistry, imaging, computational analysis, and develop new methods to answer these questions.