Stephen Floor, PhD

Title(s)Associate Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address35 Medical Center Way, #614
San Francisco CA 94143
Phone415-476-3275
ORCID ORCID Icon0000-0002-9965-9694 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyPostdoc2017Molecular and cell biology, systems biology
    University of California, San FranciscoPhD20177Biophysics
    University of KansasBS2005Physics
    University of KansasBS2005Computer Science
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    2018NIH New Innovator Award
    2012HHMI Fellow of the Helen Hay Whitney Foundation
    2011Frank M. Goyan Award for Outstanding Physical Chemistry Thesis
    2009Mel Jones Award for Scientific Achievement in Biophysics
    2004Barry M. Goldwater Scholar

    Collapse Overview 
    Collapse Overview
    The Floor Lab studies the control of gene expression at the level of RNA. DEAD-box RNA chaperones are a major focus of the lab, which remodel RNA structures and RNA-protein interactions. Some questions we’re interested in are: how do DEAD-box proteins influence RNA structure and bound proteins in cells? How do these changes affect cell state? Do DEAD-box proteins act as molecular dispersants for RNA? How can we measure translation and protein binding on single RNA molecules in cells? We use diverse deep sequencing approaches, biochemistry, imaging, computational analysis, and develop new methods to answer these questions.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Cellular and molecular mechanisms underlying DDX3X syndrome
    NIH R01NS120667Jan 1, 2021 - Nov 30, 2025
    Role: Co-Principal Investigator
    The impact of human RNA diversity on protein production and cell fate
    NIH DP2GM132932Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    Oncogenic reprogramming of protein translation by DDX3 inactivation
    California Tobacco Related Disease Research Program 27KT-0003Apr 1, 2018 - Mar 31, 2021
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A novel reporter for helicase activity in translation uncovers DDX3X interactions. RNA. 2024 Jul 16; 30(8):1041-1057. Wilkins KC, Schroeder T, Gu S, Revalde JL, Floor SN. PMID: 38697667; PMCID: PMC11251518.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle. Mol Cell. 2024 Jul 25; 84(14):2765-2784.e16. Ietswaart R, Smalec BM, Xu A, Choquet K, McShane E, Jowhar ZM, Guegler CK, Baxter-Koenigs AR, West ER, Fu BXH, Gilbert L, Floor SN, Churchman LS. PMID: 38964322; PMCID: PMC11315470.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    3. IGHMBP2 deletion suppresses translation and activates the integrated stress response. Life Sci Alliance. 2024 Aug; 7(8). Park J, Desai H, Liboy-Lugo JM, Gu S, Jowhar Z, Xu A, Floor SN. PMID: 38803225; PMCID: PMC11109757.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress. bioRxiv. 2024 Feb 07. Liboy-Lugo JM, Espinoza CA, Sheu-Gruttadauria J, Park JE, Xu A, Jowhar Z, Gao AL, Carmona-Negrón JA, Wittmann T, Jura N, Floor SN. PMID: 38370785; PMCID: PMC10871250.
      View in: PubMed   Mentions:
    5. A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X. Mol Syst Biol. 2024 Mar; 20(3):276-290. Jowhar Z, Xu A, Venkataramanan S, Dossena F, Hoye ML, Silver DL, Floor SN, Calviello L. PMID: 38273160; PMCID: PMC10912769.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. IGHMBP2 deletion suppresses translation and activates the integrated stress response. bioRxiv. 2023 Dec 12. Park JE, Desai H, Liboy-Lugo J, Gu S, Jowhar Z, Xu A, Floor SN. PMID: 38168189; PMCID: PMC10760061.
      View in: PubMed   Mentions:
    7. A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X. bioRxiv. 2023 Nov 23. Jowhar Z, Xu A, Venkataramanan S, Dossena F, Hoye ML, Silver DL, Floor SN, Calviello L. PMID: 37214951; PMCID: PMC10197686.
      View in: PubMed   Mentions:
    8. RNA molecular recording with an engineered RNA deaminase. Nat Methods. 2023 Dec; 20(12):1887-1899. Lin Y, Kwok S, Hein AE, Thai BQ, Alabi Y, Ostrowski MS, Wu K, Floor SN. PMID: 37857907.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response. Nat Cell Biol. 2023 Nov; 25(11):1600-1615. Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S. PMID: 37857833; PMCID: PMC11005034.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Nucleolar dynamics are determined by the ordered assembly of the ribosome. bioRxiv. 2023 Sep 27. Sheu-Gruttadauria J, Yan X, Stuurman N, Floor SN, Vale RD. PMID: 37808656; PMCID: PMC10557630.
      View in: PubMed   Mentions:
    11. Determinants of DDX3X sensitivity uncovered using a helicase activity in translation reporter. bioRxiv. 2023 Sep 14. Wilkins KC, Schroeder T, Gu S, Revalde JL, Floor SN. PMID: 37745530; PMCID: PMC10515938.
      View in: PubMed   Mentions:
    12. Dynamic regulation of messenger RNA structure controls translation. Nature. 2023 Sep; 621(7978):259-260. Lin Y, Floor SN. PMID: 37674086.
      View in: PubMed   Mentions:    Fields:    
    13. The variant landscape and function of DDX3X in cancer and neurodevelopmental disorders. Trends Mol Med. 2023 09; 29(9):726-739. Gadek M, Sherr EH, Floor SN. PMID: 37422363.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression. Cell Rep. 2023 06 27; 42(6):112642. Campbell AE, Dyle MC, Albanese R, Matheny T, Sudheendran K, Cortázar MA, Forman T, Fu R, Gillen AE, Caruthers MH, Floor SN, Calviello L, Jagannathan S. PMID: 37314931; PMCID: PMC10592454.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. Elife. 2022 06 28; 11. Hoye ML, Calviello L, Poff AJ, Ejimogu NE, Newman CR, Montgomery MD, Ou J, Floor SN, Silver DL. PMID: 35762573; PMCID: PMC9239684.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    16. Lysate and cell-based assays to probe the translational role of RNA helicases. Methods Enzymol. 2022; 673:141-168. Wilkins KC, Venkataramanan S, Floor SN. PMID: 35965005.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    17. SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal. Dev Cell. 2022 03 14; 57(5):624-637.e4. Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD. PMID: 35202586; PMCID: PMC8974236.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. The role of G3BP stress granules assembly in cell fitness during the integrated stress response. Biophysical Journal. 2022 Feb 1; 121(3):497a. Liboy-Lugo LJ, Sheu-Gruttadauria SJ, Floor FS. .
      View in: Publisher Site   Mentions:
    19. Mapping the regulatory landscape of membraneless organelle assembly and dynamics. Biophysical Journal. 2022 Feb 1; 121(3):293a-294a. Sheu-Gruttadauria SJ, Yan YX, Stuurman SN, Floor FS, Vale VR. .
      View in: Publisher Site   Mentions:
    20. Determining the impact of stress granule composition on cell survival. Biophysical Journal. 2022 Feb 1; 121(3):210a. Park PJ, Venkataramanan VS, Liboy-Lugo LJ, Blackwell BV, Floor FS. .
      View in: Publisher Site   Mentions:
    21. The impact of periodic stress on stress granules in human cells. Biophysical Journal. 2022 Feb 1; 121(3):211a. Gao GA, Liboy-Lugo LJ, Park PJ, Floor FS. .
      View in: Publisher Site   Mentions:
    22. Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance. Elife. 2022 01 11; 11. Tsai K, Stojkovic V, Noda-Garcia L, Young ID, Myasnikov AG, Kleinman J, Palla A, Floor SN, Frost A, Fraser JS, Tawfik DS, Fujimori DG. PMID: 35015630; PMCID: PMC8752094.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    23. DDX3X and DDX3Y are redundant in protein synthesis. RNA. 2021 12; 27(12):1577-1588. Venkataramanan S, Gadek M, Calviello L, Wilkins K, Floor SN. PMID: 34535544; PMCID: PMC8594478.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    24. DDX3 depletion represses translation of mRNAs with complex 5' UTRs. Nucleic Acids Res. 2021 05 21; 49(9):5336-5350. Calviello L, Venkataramanan S, Rogowski KJ, Wyler E, Wilkins K, Tejura M, Thai B, Krol J, Filipowicz W, Landthaler M, Floor SN. PMID: 33905506; PMCID: PMC8136831.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    25. Control of ribosomal protein synthesis by the Microprocessor complex. Sci Signal. 2021 02 23; 14(671). Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. PMID: 33622983; PMCID: PMC8012103.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A. Cell Chem Biol. 2021 04 15; 28(4):475-486.e8. Chen M, Asanuma M, Takahashi M, Shichino Y, Mito M, Fujiwara K, Saito H, Floor SN, Ingolia NT, Sodeoka M, Dodo K, Ito T, Iwasaki S. PMID: 33296667; PMCID: PMC8052261.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
      View in: PubMed   Mentions: 2385     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329; PMCID: PMC7239059.
      View in: PubMed   Mentions: 30  
    29. Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development. Neuron. 2020 05 06; 106(3):404-420.e8. Lennox AL, Hoye ML, Jiang R, Johnson-Kerner BL, Suit LA, Venkataramanan S, Sheehan CJ, Alsina FC, Fregeau B, Aldinger KA, Moey C, Lobach I, Afenjar A, Babovic-Vuksanovic D, Bézieau S, Blackburn PR, Bunt J, Burglen L, Campeau PM, Charles P, Chung BHY, Cogné B, Curry C, D'Agostino MD, Di Donato N, Faivre L, Héron D, Innes AM, Isidor B, Keren B, Kimball A, Klee EW, Kuentz P, Küry S, Martin-Coignard D, Mirzaa G, Mignot C, Miyake N, Matsumoto N, Fujita A, Nava C, Nizon M, Rodriguez D, Blok LS, Thauvin-Robinet C, Thevenon J, Vincent M, Ziegler A, Dobyns W, Richards LJ, Barkovich AJ, Floor SN, Silver DL, Sherr EH. PMID: 32135084; PMCID: PMC7331285.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    30. PTBP1 mRNA isoforms and regulation of their translation. RNA. 2019 10; 25(10):1324-1336. Arake de Tacca LM, Pulos-Holmes MC, Floor SN, Cate JHD. PMID: 31263002; PMCID: PMC6800477.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    31. The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA. Mol Cell. 2019 02 21; 73(4):738-748.e9. Iwasaki S, Iwasaki W, Takahashi M, Sakamoto A, Watanabe C, Shichino Y, Floor SN, Fujiwara K, Mito M, Dodo K, Sodeoka M, Imataka H, Honma T, Fukuzawa K, Ito T, Ingolia NT. PMID: 30595437; PMCID: PMC6386617.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    32. CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway. Nat Genet. 2018 08; 50(8):1132-1139. Richardson CD, Kazane KR, Feng SJ, Zelin E, Bray NL, Schäfer AJ, Floor SN, Corn JE. PMID: 30054595.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    33. The Traffic Jam: Polyamine Prevalence Pauses Protein Production. Mol Cell. 2018 04 19; 70(2):191-192. Venkataramanan S, Floor SN. PMID: 29677487.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    34. Move Over, Genomes: Here Comes Transcriptome Engineering. CRISPR J. 2018 04; 1:126-127. Thai B, Floor SN. PMID: 31021197.
      View in: PubMed   Mentions: 1     Fields:    
    35. Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Rep. 2017 Nov 14; 21(7):2005-2016. Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN. PMID: 29141229; PMCID: PMC5759054.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    36. Widespread translational remodeling during human neuronal differentiation. bioRxiv preprint. 2017. John D Blair, Dirk Hockemeyer, Jennifer A Doudna, Helen S Bateup, Stephen N Floor. . View Publication.
    37. CRISPR-Cas9 Genome Editing In Human Cells Works Via The Fanconi Anemia Pathway. bioRxiv preprint. 2017. Chris D. Richardson, Katelynn R. Kazane, Sharon J. Feng, Nicholas L. Bray, Axel J. Schaefer, Stephen Floor, Jacob Corn. View Publication.
    38. Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes. Nat Biotechnol. 2017 05; 35(5):431-434. Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor SN, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna JA. PMID: 28191903; PMCID: PMC6649674.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    39. Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor. Nature. 2016 06 23; 534(7608):558-61. Iwasaki S, Floor SN, Ingolia NT. PMID: 27309803; PMCID: PMC4946961.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCells
    40. Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget. 2016 May 10; 7(19):28169-82. Oh S, Flynn RA, Floor SN, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, Warnatz HJ, Yaspo ML, Adams CM, Leib RD, Breese M, Marra MA, Malkin D, Lichter P, Doudna JA, Pfister SM, Taylor MD, Chang HY, Cho YJ. PMID: 27058758; PMCID: PMC5053718.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    41. Tunable protein synthesis by transcript isoforms in human cells. Elife. 2016 Jan 06; 5. Floor SN, Doudna JA. PMID: 26735365; PMCID: PMC4764583.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansCells
    42. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Sci. 2016 Mar; 25(3):638-49. Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA. PMID: 26650549; PMCID: PMC4815421.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    43. Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome. Mol Cell. 2015 Dec 03; 60(5):712-714. Floor SN, Doudna JA. PMID: 26638173.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    44. Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. J Biol Chem. 2016 Jan 29; 291(5):2412-21. Floor SN, Condon KJ, Sharma D, Jankowsky E, Doudna JA. PMID: 26598523; PMCID: PMC4732223.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    45. Engineering Inhibitor Specificity in the Dead-Box Protein Family. Biophysical Journal. 2014 Jan 1; 106(2):495a-496a. Condon CK, Floor FS, Doudna DJ. .
      View in: Publisher Site   Mentions:
    46. Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2. Structure. 2013 Sep 03; 21(9):1571-80. Aglietti RA, Floor SN, McClendon CL, Jacobson MP, Gross JD. PMID: 23911090; PMCID: PMC3769517.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    47. Preliminary in vitro functional analysis of the DEAD-box protein DDX3. The FASEB Journal. 2012 Apr 1; 26:947.2-947.2. Floor FS, Smith SA, Zhou ZK, Doudna DJ. .
      View in: Publisher Site   Mentions:
    48. Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2872-7. Floor SN, Borja MS, Gross JD. PMID: 22323607; PMCID: PMC3286934.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    49. A split active site couples cap recognition by Dcp2 to activation. Nat Struct Mol Biol. 2010 Sep; 17(9):1096-101. Floor SN, Jones BN, Hernandez GA, Gross JD. PMID: 20711189; PMCID: PMC2933276.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    50. Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc. 2008 Dec 03; 130(48):16168-9. Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR. PMID: 18998650; PMCID: PMC2645923.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    51. Control of mRNA decapping by Dcp2: An open and shut case? RNA Biol. 2008 Oct-Dec; 5(4):189-92. Floor SN, Jones BN, Gross JD. PMID: 18971632; PMCID: PMC2699264.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    52. SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol. 2008 Sep; 15(9):916-23. Neher SB, Bradshaw N, Floor SN, Gross JD, Walter P. PMID: 19172744; PMCID: PMC2767265.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    53. mRNA decapping is promoted by an RNA-binding channel in Dcp2. Mol Cell. 2008 Feb 15; 29(3):324-36. Deshmukh MV, Jones BN, Quang-Dang DU, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD. PMID: 18280238.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    54. Simulated Versus Observed Cluster Eccentricity Evolution. The Astrophysical Journal. 2004 Aug 10; 611(1):153-157. Floor FS, Melott MA, Motl MP. .
      View in: Publisher Site   Mentions:
    55. Simulated versus observed cluster eccentricity evolution. The Astrophysical Journal. 2004; 611:153. Floor, S. N., Melott, A. L., & Motl, P. M.
    56. Eccentricity Evolution in Simulated Galaxy Clusters. The Astrophysical Journal. 2003 Jul 10; 591(2):741-748. Floor FS, Melott MA, Miller MC, Bryan BG. .
      View in: Publisher Site   Mentions:
    57. Eccentricity evolution in simulated galaxy clusters. The Astrophysical Journal. 2003; 591:741. Floor, S. N., Melott, A. L., Miller, C. J., & Bryan, G. L.
    58. Empirical investigation of extreme single-particle behavior of nuclear quadrupole moments in highly collective A~150 superdeformed bands. AIP Conference Proceedings. 2002 Apr 2; 610(1):825-829. Clark CS, Hackman HG, Janssens JR, Clark CR, Fallon FP, Floor FS, Lane LG, Macchiavelli MA, Norris NJ, Sanders SS, Svensson SC. .
      View in: Publisher Site   Mentions:
    59. Empirical investigation of extreme single-particle behavior of nuclear quadrupole moments in highly collective A approximately 150 superdeformed bands. Phys Rev Lett. 2001 Oct 22; 87(17):172503. Clark ST, Hackman G, Janssens RV, Clark RM, Fallon P, Floor SN, Lane GJ, Macchiavelli AO, Norris J, Sanders SJ, Svensson CE. PMID: 11690269.
      View in: PubMed   Mentions:    Fields:    
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