Stephen Floor, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentCell and Tissue Biology
Address513 Parnassus Ave
San Francisco CA 94143
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Richardson CD, Kazane KR, Feng SJ, Zelin E, Bray NL, Schäfer AJ, Floor S, Corn JE. CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway. Nat Genet. 2018 Aug; 50(8):1132-1139. PMID: 30054595.
      View in: PubMed
    2. Venkataramanan S, Floor S. The Traffic Jam: Polyamine Prevalence Pauses Protein Production. Mol Cell. 2018 Apr 19; 70(2):191-192. PMID: 29677487.
      View in: PubMed
    3. Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor S. Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Rep. 2017 Nov 14; 21(7):2005-2016. PMID: 29141229.
      View in: PubMed
    4. John D Blair, Dirk Hockemeyer, Jennifer A Doudna, Helen S Bateup, Stephen N Floor.Widespread translational remodeling during human neuronal differentiation. bioRxiv preprint. 2017.
    5. Chris D. Richardson, Katelynn R. Kazane, Sharon J. Feng, Nicholas L. Bray, Axel J. Schaefer, Stephen Floor, Jacob Corn.CRISPR-Cas9 Genome Editing In Human Cells Works Via The Fanconi Anemia Pathway. bioRxiv preprint. 2017.
    6. Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor S, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna JA. Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes. Nat Biotechnol. 2017 05; 35(5):431-434. PMID: 28191903.
      View in: PubMed
    7. Iwasaki S, Floor S, Ingolia NT. Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor. Nature. 2016 06 23; 534(7608):558-61. PMID: 27309803; PMCID: PMC4946961 [Available on 12/15/16].
    8. Oh S, Flynn RA, Floor S, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, Warnatz HJ, Yaspo ML, Adams CM, Leib RD, Breese M, Marra MA, Malkin D, Lichter P, Doudna JA, Pfister SM, Taylor MD, Chang HY, Cho YJ. Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget. 2016 May 10; 7(19):28169-82. PMID: 27058758.
      View in: PubMed
    9. Floor S, Doudna JA. Tunable protein synthesis by transcript isoforms in human cells. Elife. 2016 Jan 06; 5. PMID: 26735365; PMCID: PMC4764583.
    10. Floor S, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Sci. 2016 Mar; 25(3):638-49. PMID: 26650549; PMCID: PMC4815421 [Available on 03/01/17].
    11. Floor S, Doudna JA. Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome. Mol Cell. 2015 Dec 03; 60(5):712-714. PMID: 26638173.
      View in: PubMed
    12. Floor S, Condon KJ, Sharma D, Jankowsky E, Doudna JA. Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. J Biol Chem. 2016 Jan 29; 291(5):2412-21. PMID: 26598523; PMCID: PMC4732223 [Available on 01/29/17].
    13. Aglietti RA, Floor S, McClendon CL, Jacobson MP, Gross JD. Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2. Structure. 2013 Sep 03; 21(9):1571-80. PMID: 23911090; PMCID: PMC3769517.
    14. Floor S, Borja MS, Gross JD. Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2872-7. PMID: 22323607; PMCID: PMC3286934.
    15. Floor S, Jones BN, Hernandez GA, Gross JD. A split active site couples cap recognition by Dcp2 to activation. Nat Struct Mol Biol. 2010 Sep; 17(9):1096-101. PMID: 20711189; PMCID: PMC2933276.
    16. Lampe JN, Floor S, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR. Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc. 2008 Dec 03; 130(48):16168-9. PMID: 18998650; PMCID: PMC2645923.
    17. Floor S, Jones BN, Gross JD. Control of mRNA decapping by Dcp2: An open and shut case? RNA Biol. 2008 Oct-Dec; 5(4):189-92. PMID: 18971632; PMCID: PMC2699264.
    18. Neher SB, Bradshaw N, Floor S, Gross JD, Walter P. SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol. 2008 Sep; 15(9):916-23. PMID: 19172744; PMCID: PMC2767265.
    19. Deshmukh MV, Jones BN, Quang-Dang DU, Flinders J, Floor S, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD. mRNA decapping is promoted by an RNA-binding channel in Dcp2. Mol Cell. 2008 Feb 15; 29(3):324-36. PMID: 18280238.
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    20. Floor, S. N., Melott, A. L., & Motl, P. M.Simulated versus observed cluster eccentricity evolution. The Astrophysical Journal. 2004; 611:153.
    21. Floor, S. N., Melott, A. L., Miller, C. J., & Bryan, G. L.Eccentricity evolution in simulated galaxy clusters. The Astrophysical Journal. 2003; 591:741.
    22. Clark ST, Hackman G, Janssens RV, Clark RM, Fallon P, Floor S, Lane GJ, Macchiavelli AO, Norris J, Sanders SJ, Svensson CE. Empirical investigation of extreme single-particle behavior of nuclear quadrupole moments in highly collective A approximately 150 superdeformed bands. Phys Rev Lett. 2001 Oct 22; 87(17):172503. PMID: 11690269.
      View in: PubMed