Stephen Gluck, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address500 Parnassus Avenue, #E406
San Francisco CA 94117
Phone415-476-2172
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    Collapse Biography 
    Collapse Education and Training
    University of California Los AngelesM.D.1977School of Medicine

    Collapse Overview 
    Collapse Overview
    Professor, Division of Nephrology
    Areas of expertise: acute and chronic kidney disease, electrolyte disorders, kidney stones, outpatient and home dialysis

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Renal H+ATPase by Glycolysis
    NIH R01DK064095Mar 1, 2003 - Dec 31, 2008
    Role: Principal Investigator
    EXPRESSION OF THE RENAL H+ ATPASE IN METANEPHROGENESIS
    NIH R01DK054362Aug 1, 1998 - Jul 31, 2003
    Role: Principal Investigator
    RENAL GENES, GROWTH FACTORS, DEVELOPMENT AND DISEASE
    NIH P50DK045181May 1, 1992 - Apr 30, 2003
    Role: Co-Investigator
    H+ ATPASE IN URINARY ACIDIFICATION
    NIH R01DK038848Dec 1, 1986 - Nov 30, 2002
    Role: Principal Investigator
    Pre &Post-Doctoral Training in Nephrology &Hypertension
    NIH T32DK007518Jul 1, 1985 - Jun 30, 2013
    Role: Co-Principal Investigator
    CHARACTERIZATION OF H+ATPASE IN URINARY ACIDIFICATION
    NIH R01AM034788Dec 1, 1984 - Nov 30, 1987
    Role: Principal Investigator
    CHARACTERIZATION OF H+ATPASE IN URINARY ACIDIFICATION
    NIH R01DK034788Dec 1, 1984 - Oct 15, 1986
    Role: Principal Investigator
    BIOLOGY OF CELL/CELL COMMUNICATION IN BONE
    NIH P01AR032087Apr 1, 1983 - Jun 30, 2003
    Role: Co-Investigator
    Academic Training Program in Nephrology
    NIH T32DK007219Jul 1, 1976 - Jun 30, 2023
    Role: Co-Principal Investigator
    PATHOPHYSIOLOGY OF RENAL DISEASE
    NIH P01DK009976Sep 1, 1974 - Dec 31, 2005
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Case Report of Kidney-Only Transplantation in Primary Hyperoxaluria Type 1: A Novel Approach with the Use of Nedosiran. Case Rep Nephrol Dial. 2023 Jan-Dec; 13(1):63-69. Breeggemann MC, Gluck SL, Stoller ML, Lee MM. PMID: 37497389; PMCID: PMC10368091.
      View in: PubMed   Mentions:
    2. Transient Hyperkalemia Following Treatment of Chronic Hypokalemia: A Case Report and Review of Distal Tubule Physiology. Case Rep Nephrol Dial. 2022 Jan-Apr; 12(1):1-4. Breeggemann MC, Gluck SL. PMID: 35224021; PMCID: PMC8832181.
      View in: PubMed   Mentions:
    3. IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells. J Cell Biochem. 2008 Sep 01; 105(1):208-18. Khalkhali-Ellis Z, Abbott DE, Bailey CM, Goossens W, Margaryan NV, Gluck SL, Reuveni M, Hendrix MJ. PMID: 18494001; PMCID: PMC2575810.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    4. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. J Biol Chem. 2007 Aug 24; 282(34):24495-503. Lu M, Ammar D, Ives H, Albrecht F, Gluck SL. PMID: 17576770.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    5. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase. Nephron Physiol. 2005; 100(3):p31-42. Curtis LM, Gluck S. PMID: 15838183.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Mol Cell Biol. 2005 Jan; 25(2):575-89. Sautin YY, Lu M, Gaugler A, Zhang L, Gluck SL. PMID: 15632060; PMCID: PMC543406.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    7. Acid sensing in renal epithelial cells. J Clin Invest. 2004 Dec; 114(12):1696-9. Gluck SL. PMID: 15599393; PMCID: PMC535075.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase. J Biol Chem. 2004 Mar 05; 279(10):8732-9. Lu M, Sautin YY, Holliday LS, Gluck SL. PMID: 14672945.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    9. Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. J Biol Chem. 2004 Feb 27; 279(9):7988-98. Chen SH, Bubb MR, Yarmola EG, Zuo J, Jiang J, Lee BS, Lu M, Gluck SL, Hurst IR, Holliday LS. PMID: 14662773.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    10. Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts. Calcif Tissue Int. 2003 Mar; 72(3):206-14. Holliday LS, Welgus HG, Hanna J, Lee BS, Lu M, Jeffrey JJ, Gluck SL. PMID: 12522662.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    11. The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. J Biol Chem. 2002 Oct 11; 277(41):38409-15. Lu M, Vergara S, Zhang L, Holliday LS, Aris J, Gluck SL. PMID: 12163484.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    12. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. J Biol Chem. 2001 Aug 10; 276(32):30407-13. Lu M, Holliday LS, Zhang L, Dunn WA, Gluck SL. PMID: 11399750.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    13. The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. J Biol Chem. 2000 Oct 13; 275(41):32331-7. Holliday LS, Lu M, Lee BS, Nelson RD, Solivan S, Zhang L, Gluck SL. PMID: 10915794.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    14. 1,25-Dihydroxy-19-nor-vitamin D(2), a vitamin D analog with reduced bone resorbing activity in vitro. J Am Soc Nephrol. 2000 Oct; 11(10):1857-1864. Holliday LS, Gluck SL, Slatopolsky E, Brown AJ. PMID: 11004216.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. Vacuolar H+-ATPase activity and expression in mouse bone marrow cultures. J Bone Miner Res. 1999 Dec; 14(12):2127-36. Lee BS, Holliday LS, Krits I, Gluck SL. PMID: 10620072.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    16. Interaction between vacuolar H(+)-ATPase and microfilaments during osteoclast activation. J Biol Chem. 1999 Oct 08; 274(41):29164-71. Lee BS, Gluck SL, Holliday LS. PMID: 10506172.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    17. Plasma membrane V-ATPases in proton-transporting cells of the mammalian kidney and osteoclast. Acta Physiol Scand Suppl. 1998 Aug; 643:203-12. Gluck SL, Lee BS, Wang SP, Underhill D, Nemoto J, Holliday LS. PMID: 9789562.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils. Blood. 1997 Dec 01; 90(11):4598-601. Niessen H, Meisenholder GW, Li HL, Gluck SL, Lee BS, Bowman B, Engler RL, Babior BM, Gottlieb RA. PMID: 9373271.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem. 1997 Aug 29; 272(35):22053-8. Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL. PMID: 9268345.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    20. Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis. J Am Soc Nephrol. 1997 Jul; 8(7):1109-17. Bastani B, Underhill D, Chu N, Nelson RD, Haragsim L, Gluck S. PMID: 9219160.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    21. Vacuolar H+-ATPase in ocular ciliary epithelium. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6752-7. Wax MB, Saito I, Tenkova T, Krupin T, Becker B, Nelson N, Brown D, Gluck SL. PMID: 9192637; PMCID: PMC21230.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    22. Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney. J Am Soc Nephrol. 1997 Jun; 8(6):868-79. Bastani B, Gluck S. PMID: 9189852.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanism. Am J Physiol. 1997 Mar; 272(3 Pt 2):F283-91. Holliday LS, Dean AD, Lin RH, Greenwald JE, Gluck SL. PMID: 9087669.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. A novel transcription factor regulates expression of the vacuolar H+-ATPase B2 subunit through AP-2 sites during monocytic differentiation. J Biol Chem. 1997 Jan 03; 272(1):174-81. Lee BS, Krits I, Crane-Zelkovic MK, Gluck SL. PMID: 8995244.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int. 1997 Jan; 51(1):125-37. Sabolic I, Brown D, Gluck SL, Alper SL. PMID: 8995726.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    26. Distal urinary acidification from Homer Smith to the present. Kidney Int. 1996 Jun; 49(6):1660-4. Gluck SL, Iyori M, Holliday LS, Kostrominova T, Lee BS. PMID: 8743472.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    27. Immunocytochemical localization of vacuolar H+-ATPase and Cl--HCO3- anion exchanger (erythrocyte band-3 protein) in avian osteoclasts: effect of calcium-deficient diet on polar expression of the H+-ATPase pump. Calcif Tissue Int. 1996 May; 58(5):332-6. Bastani B, Ross FP, Kopito RR, Gluck SL. PMID: 8661962.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    28. Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes. Am J Physiol. 1996 Jan; 270(1 Pt 1):C382-8. Lee BS, Holliday LS, Ojikutu B, Krits I, Gluck SL. PMID: 8772466.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. Physiology and biochemistry of the kidney vacuolar H+-ATPase. Annu Rev Physiol. 1996; 58:427-45. Gluck SL, Underhill DM, Iyori M, Holliday LS, Kostrominova TY, Lee BS. PMID: 8815802.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    30. Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B. J Clin Invest. 1995 May; 95(5):2089-95. Sires UI, Schmid TM, Fliszar CJ, Wang ZQ, Gluck SL, Welgus HG. PMID: 7738176; PMCID: PMC295804.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells. J Biol Chem. 1995 Mar 31; 270(13):7320-9. Lee BS, Underhill DM, Crane MK, Gluck SL. PMID: 7706273.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. Properties and regulation of the renal vacuolar H(+)-ATPase and H(+)-K(+)-ATPase. Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):715-24. Gluck SL, Nelson RD, Lee BS. PMID: 7922214.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    33. The vacuolar H(+)-ATPases: versatile proton pumps participating in constitutive and specialized functions of eukaryotic cells. Int Rev Cytol. 1993; 137C:105-37. Gluck SL. PMID: 8486470.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    34. Biochemistry of the renal V-ATPase. J Exp Biol. 1992 Nov; 172:219-29. Gluck SL, Nelson RD, Lee BS, Wang ZQ, Guo XL, Fu JY, Zhang K. PMID: 1337093.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. The role of the V-ATPase in renal epithelial H+ transport. J Exp Biol. 1992 Nov; 172:205-18. Gluck S, Nelson R. PMID: 1337092.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    36. Introduction to the principles and methods of recombinant DNA technology. Semin Nephrol. 1992 Nov; 12(6):467-94. Gluck SL, Nelson RD, Lee BS. PMID: 1282273.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    37. The structure and biochemistry of the vacuolar H+ ATPase in proximal and distal urinary acidification. J Bioenerg Biomembr. 1992 Aug; 24(4):351-9. Gluck SL. PMID: 1400280.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    38. Expression of vacuolar H(+)-ATPase in mouse osteoclasts during in vitro differentiation. Am J Physiol. 1992 Aug; 263(2 Pt 2):F277-83. Wang ZQ, Hemken P, Menton D, Gluck S. PMID: 1387291.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis. J Am Soc Nephrol. 1992 Aug; 3(2):264-71. Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck SL. PMID: 1391725.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    40. cDNA sequence and tissue expression of bovine vacuolar H(+)-ATPase M(r) 70,000 subunit. Am J Physiol. 1992 Jul; 263(1 Pt 2):F171-4. Marushack MM, Lee BS, Masood K, Gluck S. PMID: 1386191.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    41. Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney. J Biol Chem. 1992 May 15; 267(14):9948-57. Hemken P, Guo XL, Wang ZQ, Zhang K, Gluck S. PMID: 1533641.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    42. Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3541-5. Nelson RD, Guo XL, Masood K, Brown D, Kalkbrenner M, Gluck S. PMID: 1373501; PMCID: PMC48904.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    43. Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat. J Clin Invest. 1991 Jul; 88(1):126-36. Bastani B, Purcell H, Hemken P, Trigg D, Gluck S. PMID: 1829094; PMCID: PMC296012.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    44. Colocalization of H(+)-ATPase and band 3 anion exchanger in rabbit collecting duct intercalated cells. Am J Physiol. 1991 Apr; 260(4 Pt 2):F506-17. Schuster VL, Fejes-Tóth G, Naray-Fejes-Tóth A, Gluck S. PMID: 1849362.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    45. Distribution and structure of the vacuolar H+ ATPase in endosomes and lysosomes from LLC-PK1 cells. Exp Cell Res. 1991 Feb; 192(2):445-52. Rodman JS, Stahl PD, Gluck S. PMID: 1824836.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    46. Isolation and properties of bovine kidney brush border vacuolar H(+)-ATPase. A proton pump with enzymatic and structural differences from kidney microsomal H(+)-ATPase. J Biol Chem. 1990 Dec 15; 265(35):21957-65. Wang ZQ, Gluck S. PMID: 2147691.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science. 1989 Aug 25; 245(4920):855-7. Blair HC, Teitelbaum SL, Ghiselli R, Gluck S. PMID: 2528207.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    48. Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5429-33. Alper SL, Natale J, Gluck S, Lodish HF, Brown D. PMID: 2526338; PMCID: PMC297636.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    49. Localization of a proton-pumping ATPase in rat kidney. J Clin Invest. 1988 Dec; 82(6):2114-26. Brown D, Hirsch S, Gluck S. PMID: 2904451; PMCID: PMC442795.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    50. Kinetics of a novel cytosolic protein during the onset of renal epithelial cell growth. Am J Physiol. 1988 Nov; 255(5 Pt 2):F868-73. Aithal HN, Walsh-Reitz MM, Kartha S, Gluck SL, Franklin WA, Knigge KM, Toback FG. PMID: 3189562.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    51. Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1988 May; 85(9):3004-8. Hirsch S, Strauss A, Masood K, Lee S, Sukhatme V, Gluck S. PMID: 2896353; PMCID: PMC280131.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    52. Production and characterization of a monoclonal antibody to vacuolar H+ATPase of renal epithelia. J Biol Chem. 1987 Nov 15; 262(32):15770-9. Yurko MA, Gluck S. PMID: 2890633.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    53. Immunoaffinity purification and characterization of vacuolar H+ATPase from bovine kidney. J Biol Chem. 1987 Nov 15; 262(32):15780-9. Gluck S, Caldwell J. PMID: 2890634.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    54. Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. J Cell Biol. 1987 Oct; 105(4):1637-48. Brown D, Gluck S, Hartwig J. PMID: 2889740; PMCID: PMC2114636.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    55. An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla. J Clin Invest. 1984 Jun; 73(6):1704-10. Gluck S, Al-Awqati Q. PMID: 6327769; PMCID: PMC437082.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
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