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Stephen Gluck, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address533 Parnassus Ave, UC Hall
San Francisco CA 94143
Phone415-476-2172
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    Collapse Biography 
    Collapse Education and Training
    University of California Los AngelesM.D.1977School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Renal H+ATPase by Glycolysis
    NIH/NIDDK R01DK064095Mar 1, 2003 - Dec 31, 2008
    Role: Principal Investigator
    EXPRESSION OF THE RENAL H+ ATPASE IN METANEPHROGENESIS
    NIH/NIDDK R01DK054362Aug 1, 1998 - Jul 31, 2003
    Role: Principal Investigator
    RENAL GENES, GROWTH FACTORS, DEVELOPMENT AND DISEASE
    NIH P50DK045181May 1, 1992 - Apr 30, 2003
    Role: Co-Investigator
    H+ ATPASE IN URINARY ACIDIFICATION
    NIH/NIDDK R01DK038848Dec 1, 1986 - Nov 30, 2002
    Role: Principal Investigator
    Pre &Post-Doctoral Training in Nephrology &Hypertension
    NIH/NIDDK T32DK007518Jul 1, 1985 - Jun 30, 2013
    Role: Co-Principal Investigator
    CHARACTERIZATION OF H+ATPASE IN URINARY ACIDIFICATION
    NIH/NIADDK R01AM034788Dec 1, 1984 - Nov 30, 1987
    Role: Principal Investigator
    CHARACTERIZATION OF H+ATPASE IN URINARY ACIDIFICATION
    NIH/NIDDK R01DK034788Dec 1, 1984 - Oct 15, 1986
    Role: Principal Investigator
    BIOLOGY OF CELL/CELL COMMUNICATION IN BONE
    NIH P01AR032087Apr 1, 1983 - Jun 30, 2003
    Role: Co-Investigator
    Academic Training Program in Nephrology
    NIH/NIDDK T32DK007219Jul 1, 1976 - Jun 30, 2018
    Role: Co-Principal Investigator
    PATHOPHYSIOLOGY OF RENAL DISEASE
    NIH P01DK009976Sep 1, 1974 - Dec 31, 2005
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Khalkhali-Ellis Z, Abbott DE, Bailey CM, Goossens W, Margaryan NV, Gluck S, Reuveni M, Hendrix MJ. IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells. J Cell Biochem. 2008 Sep 1; 105(1):208-18. PMID: 18494001; PMCID: PMC2575810.
    2. Lu M, Ammar D, Ives H, Albrecht F, Gluck S. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. J Biol Chem. 2007 Aug 24; 282(34):24495-503. PMID: 17576770.
      View in: PubMed
    3. Curtis LM, Gluck S. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase. Nephron Physiol. 2005; 100(3):p31-42. PMID: 15838183.
      View in: PubMed
    4. Sautin YY, Lu M, Gaugler A, Zhang L, Gluck S. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Mol Cell Biol. 2005 Jan; 25(2):575-89. PMID: 15632060; PMCID: PMC543406.
    5. Gluck S. Acid sensing in renal epithelial cells. J Clin Invest. 2004 Dec; 114(12):1696-9. PMID: 15599393; PMCID: PMC535075.
    6. Lu M, Sautin YY, Holliday LS, Gluck S. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase. J Biol Chem. 2004 Mar 5; 279(10):8732-9. PMID: 14672945.
      View in: PubMed
    7. Chen SH, Bubb MR, Yarmola EG, Zuo J, Jiang J, Lee BS, Lu M, Gluck S, Hurst IR, Holliday LS. Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. J Biol Chem. 2004 Feb 27; 279(9):7988-98. PMID: 14662773.
      View in: PubMed
    8. Holliday LS, Welgus HG, Hanna J, Lee BS, Lu M, Jeffrey JJ, Gluck S. Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts. Calcif Tissue Int. 2003 Mar; 72(3):206-14. PMID: 12522662.
      View in: PubMed
    9. Lu M, Vergara S, Zhang L, Holliday LS, Aris J, Gluck S. The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. J Biol Chem. 2002 Oct 11; 277(41):38409-15. PMID: 12163484.
      View in: PubMed
    10. Lu M, Holliday LS, Zhang L, Dunn WA, Gluck S. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. J Biol Chem. 2001 Aug 10; 276(32):30407-13. PMID: 11399750.
      View in: PubMed
    11. Holliday LS, Lu M, Lee BS, Nelson RD, Solivan S, Zhang L, Gluck S. The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. J Biol Chem. 2000 Oct 13; 275(41):32331-7. PMID: 10915794.
      View in: PubMed
    12. Holliday LS, Gluck S, Slatopolsky E, Brown AJ. 1,25-Dihydroxy-19-nor-vitamin D(2), a vitamin D analog with reduced bone resorbing activity in vitro. J Am Soc Nephrol. 2000 Oct; 11(10):1857-64. PMID: 11004216.
      View in: PubMed
    13. Lee BS, Holliday LS, Krits I, Gluck S. Vacuolar H+-ATPase activity and expression in mouse bone marrow cultures. J Bone Miner Res. 1999 Dec; 14(12):2127-36. PMID: 10620072.
      View in: PubMed
    14. Lee BS, Gluck S, Holliday LS. Interaction between vacuolar H(+)-ATPase and microfilaments during osteoclast activation. J Biol Chem. 1999 Oct 8; 274(41):29164-71. PMID: 10506172.
      View in: PubMed
    15. Gluck S, Lee BS, Wang SP, Underhill D, Nemoto J, Holliday LS. Plasma membrane V-ATPases in proton-transporting cells of the mammalian kidney and osteoclast. Acta Physiol Scand Suppl. 1998 Aug; 643:203-12. PMID: 9789562.
      View in: PubMed
    16. Niessen H, Meisenholder GW, Li HL, Gluck S, Lee BS, Bowman B, Engler RL, Babior BM, Gottlieb RA. Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils. Blood. 1997 Dec 1; 90(11):4598-601. PMID: 9373271.
      View in: PubMed
    17. Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck S. Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem. 1997 Aug 29; 272(35):22053-8. PMID: 9268345.
      View in: PubMed
    18. Bastani B, Underhill D, Chu N, Nelson RD, Haragsim L, Gluck S. Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis. J Am Soc Nephrol. 1997 Jul; 8(7):1109-17. PMID: 9219160.
      View in: PubMed
    19. Wax MB, Saito I, Tenkova T, Krupin T, Becker B, Nelson N, Brown D, Gluck S. Vacuolar H+-ATPase in ocular ciliary epithelium. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6752-7. PMID: 9192637; PMCID: PMC21230.
    20. Bastani B, Gluck S. Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney. J Am Soc Nephrol. 1997 Jun; 8(6):868-79. PMID: 9189852.
      View in: PubMed
    21. Holliday LS, Dean AD, Lin RH, Greenwald JE, Gluck S. Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanism. Am J Physiol. 1997 Mar; 272(3 Pt 2):F283-91. PMID: 9087669.
      View in: PubMed
    22. Lee BS, Krits I, Crane-Zelkovic MK, Gluck S. A novel transcription factor regulates expression of the vacuolar H+-ATPase B2 subunit through AP-2 sites during monocytic differentiation. J Biol Chem. 1997 Jan 3; 272(1):174-81. PMID: 8995244.
      View in: PubMed
    23. Sabolic I, Brown D, Gluck S, Alper SL. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int. 1997 Jan; 51(1):125-37. PMID: 8995726.
      View in: PubMed
    24. Gluck S, Iyori M, Holliday LS, Kostrominova T, Lee BS. Distal urinary acidification from Homer Smith to the present. Kidney Int. 1996 Jun; 49(6):1660-4. PMID: 8743472.
      View in: PubMed
    25. Bastani B, Ross FP, Kopito RR, Gluck S. Immunocytochemical localization of vacuolar H+-ATPase and Cl--HCO3- anion exchanger (erythrocyte band-3 protein) in avian osteoclasts: effect of calcium-deficient diet on polar expression of the H+-ATPase pump. Calcif Tissue Int. 1996 May; 58(5):332-6. PMID: 8661962.
      View in: PubMed
    26. Lee BS, Holliday LS, Ojikutu B, Krits I, Gluck S. Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes. Am J Physiol. 1996 Jan; 270(1 Pt 1):C382-8. PMID: 8772466.
      View in: PubMed
    27. Gluck S, Underhill DM, Iyori M, Holliday LS, Kostrominova TY, Lee BS. Physiology and biochemistry of the kidney vacuolar H+-ATPase. Annu Rev Physiol. 1996; 58:427-45. PMID: 8815802.
      View in: PubMed
    28. Sires UI, Schmid TM, Fliszar CJ, Wang ZQ, Gluck S, Welgus HG. Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B. J Clin Invest. 1995 May; 95(5):2089-95. PMID: 7738176; PMCID: PMC295804.
    29. Lee BS, Underhill DM, Crane MK, Gluck S. Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells. J Biol Chem. 1995 Mar 31; 270(13):7320-9. PMID: 7706273.
      View in: PubMed
    30. Gluck S, Nelson RD, Lee BS. Properties and regulation of the renal vacuolar H(+)-ATPase and H(+)-K(+)-ATPase. Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):715-24. PMID: 7922214.
      View in: PubMed
    31. Gluck S. The vacuolar H(+)-ATPases: versatile proton pumps participating in constitutive and specialized functions of eukaryotic cells. Int Rev Cytol. 1993; 137C:105-37. PMID: 8486470.
      View in: PubMed
    32. Gluck S, Nelson RD, Lee BS, Wang ZQ, Guo XL, Fu JY, Zhang K. Biochemistry of the renal V-ATPase. J Exp Biol. 1992 Nov; 172:219-29. PMID: 1337093.
      View in: PubMed
    33. Gluck S, Nelson RD, Lee BS. Introduction to the principles and methods of recombinant DNA technology. Semin Nephrol. 1992 Nov; 12(6):467-94. PMID: 1282273.
      View in: PubMed
    34. Gluck S, Nelson R. The role of the V-ATPase in renal epithelial H+ transport. J Exp Biol. 1992 Nov; 172:205-18. PMID: 1337092.
      View in: PubMed
    35. Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck S. Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis. J Am Soc Nephrol. 1992 Aug; 3(2):264-71. PMID: 1391725.
      View in: PubMed
    36. Wang ZQ, Hemken P, Menton D, Gluck S. Expression of vacuolar H(+)-ATPase in mouse osteoclasts during in vitro differentiation. Am J Physiol. 1992 Aug; 263(2 Pt 2):F277-83. PMID: 1387291.
      View in: PubMed
    37. Gluck S. The structure and biochemistry of the vacuolar H+ ATPase in proximal and distal urinary acidification. J Bioenerg Biomembr. 1992 Aug; 24(4):351-9. PMID: 1400280.
      View in: PubMed
    38. Marushack MM, Lee BS, Masood K, Gluck S. cDNA sequence and tissue expression of bovine vacuolar H(+)-ATPase M(r) 70,000 subunit. Am J Physiol. 1992 Jul; 263(1 Pt 2):F171-4. PMID: 1386191.
      View in: PubMed
    39. Zhang K, Wang ZQ, Gluck S. Identification and partial purification of a cytosolic activator of vacuolar H(+)-ATPases from mammalian kidney. J Biol Chem. 1992 May 15; 267(14):9701-5. PMID: 1533637.
      View in: PubMed
    40. Hemken P, Guo XL, Wang ZQ, Zhang K, Gluck S. Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney. J Biol Chem. 1992 May 15; 267(14):9948-57. PMID: 1533641.
      View in: PubMed
    41. Nelson RD, Guo XL, Masood K, Brown D, Kalkbrenner M, Gluck S. Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3541-5. PMID: 1373501; PMCID: PMC48904.
    42. Bastani B, Purcell H, Hemken P, Trigg D, Gluck S. Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat. J Clin Invest. 1991 Jul; 88(1):126-36. PMID: 1829094; PMCID: PMC296012.
    43. Schuster VL, Fejes-Tóth G, Naray-Fejes-Tóth A, Gluck S. Colocalization of H(+)-ATPase and band 3 anion exchanger in rabbit collecting duct intercalated cells. Am J Physiol. 1991 Apr; 260(4 Pt 2):F506-17. PMID: 1849362.
      View in: PubMed
    44. Rodman JS, Stahl PD, Gluck S. Distribution and structure of the vacuolar H+ ATPase in endosomes and lysosomes from LLC-PK1 cells. Exp Cell Res. 1991 Feb; 192(2):445-52. PMID: 1824836.
      View in: PubMed
    45. Wang ZQ, Gluck S. Isolation and properties of bovine kidney brush border vacuolar H(+)-ATPase. A proton pump with enzymatic and structural differences from kidney microsomal H(+)-ATPase. J Biol Chem. 1990 Dec 15; 265(35):21957-65. PMID: 2147691.
      View in: PubMed
    46. Blair HC, Teitelbaum SL, Ghiselli R, Gluck S. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science. 1989 Aug 25; 245(4920):855-7. PMID: 2528207.
      View in: PubMed
    47. Alper SL, Natale J, Gluck S, Lodish HF, Brown D. Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5429-33. PMID: 2526338; PMCID: PMC297636.
    48. Brown D, Hirsch S, Gluck S. Localization of a proton-pumping ATPase in rat kidney. J Clin Invest. 1988 Dec; 82(6):2114-26. PMID: 2904451; PMCID: PMC442795.
    49. Aithal HN, Walsh-Reitz MM, Kartha S, Gluck S, Franklin WA, Knigge KM, Toback FG. Kinetics of a novel cytosolic protein during the onset of renal epithelial cell growth. Am J Physiol. 1988 Nov; 255(5 Pt 2):F868-73. PMID: 3189562.
      View in: PubMed
    50. Hirsch S, Strauss A, Masood K, Lee S, Sukhatme V, Gluck S. Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1988 May; 85(9):3004-8. PMID: 2896353; PMCID: PMC280131.
    51. Gluck S, Caldwell J. Immunoaffinity purification and characterization of vacuolar H+ATPase from bovine kidney. J Biol Chem. 1987 Nov 15; 262(32):15780-9. PMID: 2890634.
      View in: PubMed
    52. Yurko MA, Gluck S. Production and characterization of a monoclonal antibody to vacuolar H+ATPase of renal epithelia. J Biol Chem. 1987 Nov 15; 262(32):15770-9. PMID: 2890633.
      View in: PubMed
    53. Brown D, Gluck S, Hartwig J. Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. J Cell Biol. 1987 Oct; 105(4):1637-48. PMID: 2889740; PMCID: PMC2114636.
    54. Gluck S, Al-Awqati Q. An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla. J Clin Invest. 1984 Jun; 73(6):1704-10. PMID: 6327769; PMCID: PMC437082.
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