Stephen Gluck, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address500 Parnassus Avenue, #E406
San Francisco CA 94143
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    University of California Los AngelesM.D.1977School of Medicine

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    Professor, Division of Nephrology
    Areas of expertise: acute and chronic kidney disease, electrolyte disorders, kidney stones, outpatient and home dialysis

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    Collapse Research Activities and Funding
    Regulation of Renal H+ATPase by Glycolysis
    NIH R01DK064095Mar 1, 2003 - Dec 31, 2008
    Role: Principal Investigator
    NIH R01DK054362Aug 1, 1998 - Jul 31, 2003
    Role: Principal Investigator
    NIH P50DK045181May 1, 1992 - Apr 30, 2003
    Role: Co-Investigator
    NIH R01DK038848Dec 1, 1986 - Nov 30, 2002
    Role: Principal Investigator
    Pre &Post-Doctoral Training in Nephrology &Hypertension
    NIH T32DK007518Jul 1, 1985 - Jun 30, 2013
    Role: Co-Principal Investigator
    NIH R01AM034788Dec 1, 1984 - Nov 30, 1987
    Role: Principal Investigator
    NIH R01DK034788Dec 1, 1984 - Oct 15, 1986
    Role: Principal Investigator
    NIH P01AR032087Apr 1, 1983 - Jun 30, 2003
    Role: Co-Investigator
    Academic Training Program in Nephrology
    NIH T32DK007219Jul 1, 1976 - Jun 30, 2023
    Role: Co-Principal Investigator
    NIH P01DK009976Sep 1, 1974 - Dec 31, 2005
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. A Case Report of Kidney-Only Transplantation in Primary Hyperoxaluria Type 1: A Novel Approach with the Use of Nedosiran. Case Rep Nephrol Dial. 2023 Jan-Dec; 13(1):63-69. Breeggemann MC, Gluck SL, Stoller ML, Lee MM. PMID: 37497389; PMCID: PMC10368091.
      View in: PubMed   Mentions:
    2. Transient Hyperkalemia Following Treatment of Chronic Hypokalemia: A Case Report and Review of Distal Tubule Physiology. Case Rep Nephrol Dial. 2022 Jan-Apr; 12(1):1-4. Breeggemann MC, Gluck SL. PMID: 35224021; PMCID: PMC8832181.
      View in: PubMed   Mentions:
    3. IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells. J Cell Biochem. 2008 Sep 01; 105(1):208-18. Khalkhali-Ellis Z, Abbott DE, Bailey CM, Goossens W, Margaryan NV, Gluck SL, Reuveni M, Hendrix MJ. PMID: 18494001; PMCID: PMC2575810.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    4. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. J Biol Chem. 2007 Aug 24; 282(34):24495-503. Lu M, Ammar D, Ives H, Albrecht F, Gluck SL. PMID: 17576770.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    5. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase. Nephron Physiol. 2005; 100(3):p31-42. Curtis LM, Gluck S. PMID: 15838183.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Mol Cell Biol. 2005 Jan; 25(2):575-89. Sautin YY, Lu M, Gaugler A, Zhang L, Gluck SL. PMID: 15632060; PMCID: PMC543406.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    7. Acid sensing in renal epithelial cells. J Clin Invest. 2004 Dec; 114(12):1696-9. Gluck SL. PMID: 15599393; PMCID: PMC535075.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase. J Biol Chem. 2004 Mar 05; 279(10):8732-9. Lu M, Sautin YY, Holliday LS, Gluck SL. PMID: 14672945.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    9. Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. J Biol Chem. 2004 Feb 27; 279(9):7988-98. Chen SH, Bubb MR, Yarmola EG, Zuo J, Jiang J, Lee BS, Lu M, Gluck SL, Hurst IR, Holliday LS. PMID: 14662773.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    10. Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts. Calcif Tissue Int. 2003 Mar; 72(3):206-14. Holliday LS, Welgus HG, Hanna J, Lee BS, Lu M, Jeffrey JJ, Gluck SL. PMID: 12522662.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    11. The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. J Biol Chem. 2002 Oct 11; 277(41):38409-15. Lu M, Vergara S, Zhang L, Holliday LS, Aris J, Gluck SL. PMID: 12163484.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    12. The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. J Biol Chem. 2000 Oct 13; 275(41):32331-7. Holliday LS, Lu M, Lee BS, Nelson RD, Solivan S, Zhang L, Gluck SL. PMID: 10915794.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    13. 1,25-Dihydroxy-19-nor-vitamin D(2), a vitamin D analog with reduced bone resorbing activity in vitro. J Am Soc Nephrol. 2000 Oct; 11(10):1857-1864. Holliday LS, Gluck SL, Slatopolsky E, Brown AJ. PMID: 11004216.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Vacuolar H+-ATPase activity and expression in mouse bone marrow cultures. J Bone Miner Res. 1999 Dec; 14(12):2127-36. Lee BS, Holliday LS, Krits I, Gluck SL. PMID: 10620072.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    15. Interaction between vacuolar H(+)-ATPase and microfilaments during osteoclast activation. J Biol Chem. 1999 Oct 08; 274(41):29164-71. Lee BS, Gluck SL, Holliday LS. PMID: 10506172.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    16. Plasma membrane V-ATPases in proton-transporting cells of the mammalian kidney and osteoclast. Acta Physiol Scand Suppl. 1998 Aug; 643:203-12. Gluck SL, Lee BS, Wang SP, Underhill D, Nemoto J, Holliday LS. PMID: 9789562.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils. Blood. 1997 Dec 01; 90(11):4598-601. Niessen H, Meisenholder GW, Li HL, Gluck SL, Lee BS, Bowman B, Engler RL, Babior BM, Gottlieb RA. PMID: 9373271.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem. 1997 Aug 29; 272(35):22053-8. Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL. PMID: 9268345.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    19. Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis. J Am Soc Nephrol. 1997 Jul; 8(7):1109-17. Bastani B, Underhill D, Chu N, Nelson RD, Haragsim L, Gluck S. PMID: 9219160.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    20. Vacuolar H+-ATPase in ocular ciliary epithelium. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6752-7. Wax MB, Saito I, Tenkova T, Krupin T, Becker B, Nelson N, Brown D, Gluck SL. PMID: 9192637; PMCID: PMC21230.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    21. Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney. J Am Soc Nephrol. 1997 Jun; 8(6):868-79. Bastani B, Gluck S. PMID: 9189852.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanism. Am J Physiol. 1997 Mar; 272(3 Pt 2):F283-91. Holliday LS, Dean AD, Lin RH, Greenwald JE, Gluck SL. PMID: 9087669.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    23. A novel transcription factor regulates expression of the vacuolar H+-ATPase B2 subunit through AP-2 sites during monocytic differentiation. J Biol Chem. 1997 Jan 03; 272(1):174-81. Lee BS, Krits I, Crane-Zelkovic MK, Gluck SL. PMID: 8995244.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int. 1997 Jan; 51(1):125-37. Sabolic I, Brown D, Gluck SL, Alper SL. PMID: 8995726.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    25. Distal urinary acidification from Homer Smith to the present. Kidney Int. 1996 Jun; 49(6):1660-4. Gluck SL, Iyori M, Holliday LS, Kostrominova T, Lee BS. PMID: 8743472.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Immunocytochemical localization of vacuolar H+-ATPase and Cl--HCO3- anion exchanger (erythrocyte band-3 protein) in avian osteoclasts: effect of calcium-deficient diet on polar expression of the H+-ATPase pump. Calcif Tissue Int. 1996 May; 58(5):332-6. Bastani B, Ross FP, Kopito RR, Gluck SL. PMID: 8661962.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes. Am J Physiol. 1996 Jan; 270(1 Pt 1):C382-8. Lee BS, Holliday LS, Ojikutu B, Krits I, Gluck SL. PMID: 8772466.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    28. Physiology and biochemistry of the kidney vacuolar H+-ATPase. Annu Rev Physiol. 1996; 58:427-45. Gluck SL, Underhill DM, Iyori M, Holliday LS, Kostrominova TY, Lee BS. PMID: 8815802.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    29. Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B. J Clin Invest. 1995 May; 95(5):2089-95. Sires UI, Schmid TM, Fliszar CJ, Wang ZQ, Gluck SL, Welgus HG. PMID: 7738176; PMCID: PMC295804.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells. J Biol Chem. 1995 Mar 31; 270(13):7320-9. Lee BS, Underhill DM, Crane MK, Gluck SL. PMID: 7706273.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    31. Properties and regulation of the renal vacuolar H(+)-ATPase and H(+)-K(+)-ATPase. Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):715-24. Gluck SL, Nelson RD, Lee BS. PMID: 7922214.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    32. The vacuolar H(+)-ATPases: versatile proton pumps participating in constitutive and specialized functions of eukaryotic cells. Int Rev Cytol. 1993; 137C:105-37. Gluck SL. PMID: 8486470.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. Biochemistry of the renal V-ATPase. J Exp Biol. 1992 Nov; 172:219-29. Gluck SL, Nelson RD, Lee BS, Wang ZQ, Guo XL, Fu JY, Zhang K. PMID: 1337093.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. Introduction to the principles and methods of recombinant DNA technology. Semin Nephrol. 1992 Nov; 12(6):467-94. Gluck SL, Nelson RD, Lee BS. PMID: 1282273.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    35. The role of the V-ATPase in renal epithelial H+ transport. J Exp Biol. 1992 Nov; 172:205-18. Gluck S, Nelson R. PMID: 1337092.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    36. The structure and biochemistry of the vacuolar H+ ATPase in proximal and distal urinary acidification. J Bioenerg Biomembr. 1992 Aug; 24(4):351-9. Gluck SL. PMID: 1400280.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. Expression of vacuolar H(+)-ATPase in mouse osteoclasts during in vitro differentiation. Am J Physiol. 1992 Aug; 263(2 Pt 2):F277-83. Wang ZQ, Hemken P, Menton D, Gluck S. PMID: 1387291.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    38. Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis. J Am Soc Nephrol. 1992 Aug; 3(2):264-71. Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck SL. PMID: 1391725.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    39. cDNA sequence and tissue expression of bovine vacuolar H(+)-ATPase M(r) 70,000 subunit. Am J Physiol. 1992 Jul; 263(1 Pt 2):F171-4. Marushack MM, Lee BS, Masood K, Gluck S. PMID: 1386191.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    40. Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney. J Biol Chem. 1992 May 15; 267(14):9948-57. Hemken P, Guo XL, Wang ZQ, Zhang K, Gluck S. PMID: 1533641.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    41. Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3541-5. Nelson RD, Guo XL, Masood K, Brown D, Kalkbrenner M, Gluck S. PMID: 1373501; PMCID: PMC48904.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    42. Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat. J Clin Invest. 1991 Jul; 88(1):126-36. Bastani B, Purcell H, Hemken P, Trigg D, Gluck S. PMID: 1829094; PMCID: PMC296012.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    43. Colocalization of H(+)-ATPase and band 3 anion exchanger in rabbit collecting duct intercalated cells. Am J Physiol. 1991 Apr; 260(4 Pt 2):F506-17. Schuster VL, Fejes-Tóth G, Naray-Fejes-Tóth A, Gluck S. PMID: 1849362.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    44. Distribution and structure of the vacuolar H+ ATPase in endosomes and lysosomes from LLC-PK1 cells. Exp Cell Res. 1991 Feb; 192(2):445-52. Rodman JS, Stahl PD, Gluck S. PMID: 1824836.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Isolation and properties of bovine kidney brush border vacuolar H(+)-ATPase. A proton pump with enzymatic and structural differences from kidney microsomal H(+)-ATPase. J Biol Chem. 1990 Dec 15; 265(35):21957-65. Wang ZQ, Gluck S. PMID: 2147691.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    46. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science. 1989 Aug 25; 245(4920):855-7. Blair HC, Teitelbaum SL, Ghiselli R, Gluck S. PMID: 2528207.
      View in: PubMed   Mentions: 216     Fields:    Translation:AnimalsCells
    47. Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5429-33. Alper SL, Natale J, Gluck S, Lodish HF, Brown D. PMID: 2526338; PMCID: PMC297636.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    48. Localization of a proton-pumping ATPase in rat kidney. J Clin Invest. 1988 Dec; 82(6):2114-26. Brown D, Hirsch S, Gluck S. PMID: 2904451; PMCID: PMC442795.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    49. Kinetics of a novel cytosolic protein during the onset of renal epithelial cell growth. Am J Physiol. 1988 Nov; 255(5 Pt 2):F868-73. Aithal HN, Walsh-Reitz MM, Kartha S, Gluck SL, Franklin WA, Knigge KM, Toback FG. PMID: 3189562.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    50. Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1988 May; 85(9):3004-8. Hirsch S, Strauss A, Masood K, Lee S, Sukhatme V, Gluck S. PMID: 2896353; PMCID: PMC280131.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    51. Production and characterization of a monoclonal antibody to vacuolar H+ATPase of renal epithelia. J Biol Chem. 1987 Nov 15; 262(32):15770-9. Yurko MA, Gluck S. PMID: 2890633.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    52. Immunoaffinity purification and characterization of vacuolar H+ATPase from bovine kidney. J Biol Chem. 1987 Nov 15; 262(32):15780-9. Gluck S, Caldwell J. PMID: 2890634.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    53. Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. J Cell Biol. 1987 Oct; 105(4):1637-48. Brown D, Gluck S, Hartwig J. PMID: 2889740; PMCID: PMC2114636.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    54. An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla. J Clin Invest. 1984 Jun; 73(6):1704-10. Gluck S, Al-Awqati Q. PMID: 6327769; PMCID: PMC437082.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
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