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Steven Rosen, PhD

Title(s)Professor Emeritus, Anatomy
SchoolSchool of Medicine
Phone415-476-1579
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of Heparan Sulfate-Degrading Sulfatases in Pancreatic Adenocarcinomas
    NIH/NCI R21CA122025Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Conference: Molecular Mechanism of Leukocyte Trafficking
    NIH/NIAID R13AI051316May 15, 2002 - Apr 30, 2003
    Role: Principal Investigator
    Sulfotransferases in the Synthesis of L-Selectin Ligands
    NIH/NIGMS R01GM057411Jan 1, 1999 - Aug 31, 2012
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF LEUKOCYTE TRAFFICKING
    NIH/NIAID R13AI042586Mar 15, 1998 - Mar 14, 1999
    Role: Principal Investigator
    Interactions of Lymphocytes, Cytokines and Airway Cells
    NIH/NHLBI P50HL056385Sep 30, 1996 - Aug 31, 2006
    Role: Co-Investigator
    L-SELECTIN IN LEUKOCYTE MYELIN INTERACTIONS
    NIH/NINDS R01NS032254May 1, 1994 - Apr 30, 1998
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Cell Surface Lectins and Intercellular Adhesion
    NIH/NIGMS R01GM023547Feb 1, 1977 - Jul 31, 2012
    Role: Principal Investigator
    CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    NIH/NIGMS R37GM023547Feb 1, 1977 - Jul 31, 2006
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Flowers SA, Zhou X, Wu J, Wang Y, Makambi K, Kallakury BV, Singer MS, Rosen SD, Davidson B, Goldman R. Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck. Oncotarget. 2016 Jul 12; 7(28):43177-43187. PMID: 27223083.
      View in: PubMed
    2. Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015 Feb 02; 440:72-8. PMID: 25444749.
      View in: PubMed
    3. Rosen SD, Daneman R. High endothelial venules through a transcriptomics lens. Nat Immunol. 2014 Oct; 15(10):906-8. PMID: 25232814.
      View in: PubMed
    4. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8. PMID: 24889202; PMCID: PMC4076593.
      View in: PubMed, PubMed Central
    5. Maltseva I, Chan M, Kalus I, Dierks T, Rosen SD. The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013; 8(8):e69642. PMID: 23950901; PMCID: PMC3738537.
      View in: PubMed, PubMed Central
    6. Patnode ML, Cheng CW, Chou CC, Singer MS, Elin MS, Uchimura K, Crocker PR, Khoo KH, Rosen SD. Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem. 2013 Sep 13; 288(37):26533-45. PMID: 23880769.
      View in: PubMed
    7. Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjö L, Sakuma K, Uchimura K, Khoo KH, Kannagi R, Rosen SD. KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar; 23(3):381-94. PMID: 23254996; PMCID: PMC3555504.
      View in: PubMed, PubMed Central
    8. Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6). PMID: 23180455; PMCID: PMC3532995.
      View in: PubMed, PubMed Central
    9. Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15; 189(8):3914-24. PMID: 22962684; PMCID: PMC3509168.
      View in: PubMed, PubMed Central
    10. Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar; 122(3):911-22. PMID: 22293178; PMCID: PMC3287216.
      View in: PubMed, PubMed Central
    11. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma. 2011 Sep; 28(9):1893-907. PMID: 21657851; PMCID: PMC3172879.
      View in: PubMed, PubMed Central
    12. Arata-Kawai H, Singer MS, Bistrup A, Zante Av, Wang YQ, Ito Y, Bao X, Hemmerich S, Fukuda M, Rosen SD. Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs. Am J Pathol. 2011 Jan; 178(1):423-33. PMID: 21224079; PMCID: PMC3070580.
      View in: PubMed, PubMed Central
    13. Rosen SD, Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49. PMID: 20629619; PMCID: PMC3126665.
      View in: PubMed, PubMed Central
    14. Feng G, Du P, Krett NL, Tessel M, Rosen S, Kibbe WA, Lin SM. A collection of bioconductor methods to visualize gene-list annotations. BMC Res Notes. 2010 Jan 19; 3:10. PMID: 20180973; PMCID: PMC2829581.
      View in: PubMed, PubMed Central
    15. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64. PMID: 20816204.
      View in: PubMed
    16. Hossain MM, Hosono-Fukao T, Tang R, Sugaya N, van Kuppevelt TH, Jenniskens GJ, Kimata K, Rosen SD, Uchimura K. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88. Glycobiology. 2010 Feb; 20(2):175-86. PMID: 19822709; PMCID: PMC2800247.
      View in: PubMed, PubMed Central
    17. Rosen SD, Arata-Kawai H. "Home sweet home" for lymphocytes. Blood. 2009 Jul 16; 114(3):499-500. PMID: 19608758.
      View in: PubMed
    18. Tang R, Rosen SD. Functional consequences of the subdomain organization of the sulfs. J Biol Chem. 2009 Aug 07; 284(32):21505-14. PMID: 19520866; PMCID: PMC2755875.
      View in: PubMed, PubMed Central
    19. Kerr SC, Fieger CB, Snapp KR, Rosen SD. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. J Immunol. 2008 Jul 15; 181(2):1480-90. PMID: 18606703; PMCID: PMC2700822.
      View in: PubMed, PubMed Central
    20. Kanda H, Newton R, Klein R, Morita Y, Gunn MD, Rosen SD. Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol. 2008 Apr; 9(4):415-23. PMID: 18327261; PMCID: PMC2783613.
      View in: PubMed, PubMed Central
    21. Nawroth R, van Zante A, Cervantes S, McManus M, Hebrok M, Rosen SD. Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One. 2007 Apr 25; 2(4):e392. PMID: 17460759; PMCID: PMC1849966.
      View in: PubMed, PubMed Central
    22. Alon R, Rosen S. Rolling on N-linked glycans: a new way to present L-selectin binding sites. Nat Immunol. 2007 Apr; 8(4):339-41. PMID: 17375095.
      View in: PubMed
    23. Veerman KM, Williams MJ, Uchimura K, Singer MS, Merzaban JS, Naus S, Carlow DA, Owen P, Rivera-Nieves J, Rosen SD, Ziltener HJ. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol. 2007 May; 8(5):532-9. PMID: 17401367.
      View in: PubMed
    24. Lum DH, Tan J, Rosen SD, Werb Z. Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol. 2007 Jan; 27(2):678-88. PMID: 17116694; PMCID: PMC1800820.
      View in: PubMed, PubMed Central
    25. Uchimura K, Rosen SD. Sulfated L-selectin ligands as a therapeutic target in chronic inflammation. Trends Immunol. 2006 Dec; 27(12):559-65. PMID: 17049924.
      View in: PubMed
    26. Rosen SD. Homing in on L-selectin. J Immunol. 2006 Jul 01; 177(1):3-4. PMID: 16785488.
      View in: PubMed
    27. Yang J, Rosen SD, Bendele P, Hemmerich S. Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. BMC Immunol. 2006 Jun 13; 7:12. PMID: 16772045; PMCID: PMC1533857.
      View in: PubMed, PubMed Central
    28. Uchimura K, Morimoto-Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, Werb Z, Rosen SD. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochem. 2006 Jan 17; 7:2. PMID: 16417632; PMCID: PMC1386684.
      View in: PubMed, PubMed Central
    29. Uchimura K, Morimoto-Tomita M, Rosen SD. Measuring the activities of the Sulfs: two novel heparin/heparan sulfate endosulfatases. Methods Enzymol. 2006; 416:243-53. PMID: 17113870.
      View in: PubMed
    30. Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia. 2005 Nov; 7(11):1001-10. PMID: 16331886; PMCID: PMC1502017.
      View in: PubMed, PubMed Central
    31. Uchimura K, Gauguet JM, Singer MS, Tsay D, Kannagi R, Muramatsu T, von Andrian UH, Rosen SD. A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules. Nat Immunol. 2005 Nov; 6(11):1105-13. PMID: 16227986.
      View in: PubMed
    32. Saad OM, Ebel H, Uchimura K, Rosen SD, Bertozzi CR, Leary JA. Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase. Glycobiology. 2005 Aug; 15(8):818-26. PMID: 15843596.
      View in: PubMed
    33. Pablos JL, Santiago B, Tsay D, Singer MS, Palao G, Galindo M, Rosen SD. A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells. BMC Immunol. 2005 Mar 07; 6:6. PMID: 15752429; PMCID: PMC1079838.
      View in: PubMed, PubMed Central
    34. Rosen SD, Tsay D, Singer MS, Hemmerich S, Abraham WM. Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma. Am J Pathol. 2005 Mar; 166(3):935-44. PMID: 15743804; PMCID: PMC1602362.
      View in: PubMed, PubMed Central
    35. Gauguet JM, Rosen SD, Marth JD, von Andrian UH. Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes. Blood. 2004 Dec 15; 104(13):4104-12. PMID: 15319280.
      View in: PubMed
    36. Uchimura K, Kadomatsu K, El-Fasakhany FM, Singer MS, Izawa M, Kannagi R, Takeda N, Rosen SD, Muramatsu T. N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing. J Biol Chem. 2004 Aug 13; 279(33):35001-8. PMID: 15175329.
      View in: PubMed
    37. Bistrup A, Tsay D, Shenoy P, Singer MS, Bangia N, Luther SA, Cyster JG, Ruddle NH, Rosen SD. Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope. Am J Pathol. 2004 May; 164(5):1635-44. PMID: 15111310; PMCID: PMC1615668.
      View in: PubMed, PubMed Central
    38. Palmeri D, Zuo FR, Rosen SD, Hemmerich S. Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking. J Leukoc Biol. 2004 May; 75(5):910-27. PMID: 14761935.
      View in: PubMed
    39. Rosen SD. Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol. 2004; 22:129-56. PMID: 15032576.
      View in: PubMed
    40. van Zante A, Gauguet JM, Bistrup A, Tsay D, von Andrian UH, Rosen SD. Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse. J Exp Med. 2003 Nov 03; 198(9):1289-300. PMID: 14597732; PMCID: PMC2194250.
      View in: PubMed, PubMed Central
    41. Sarangapani KK, Yago T, Klopocki AG, Lawrence MB, Fieger CB, Rosen SD, McEver RP, Zhu C. Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan. J Biol Chem. 2004 Jan 16; 279(3):2291-8. PMID: 14573602.
      View in: PubMed
    42. Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen SD, Noble-Haeusslein LJ. The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neurosci Methods. 2003 Oct 15; 129(1):49-59. PMID: 12951232.
      View in: PubMed
    43. Fieger CB, Sassetti CM, Rosen SD. Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J Biol Chem. 2003 Jul 25; 278(30):27390-8. PMID: 12889478.
      View in: PubMed
    44. Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, Yang ZQ, Kiessling LL, Rosen SD, Fisher SJ. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003 Jan 17; 299(5605):405-8. PMID: 12532021.
      View in: PubMed
    45. Lee JK, Bistrup A, van Zante A, Rosen SD. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. Glycobiology. 2003 Apr; 13(4):245-54. PMID: 12626414.
      View in: PubMed
    46. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem. 2002 Dec 20; 277(51):49175-85. PMID: 12368295; PMCID: PMC2779716.
      View in: PubMed, PubMed Central
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