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Steven Rosen, PhD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentAnatomy
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-1579
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of Heparan Sulfate-Degrading Sulfatases in Pancreatic Adenocarcinomas
    NIH/NCI R21CA122025Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Conference: Molecular Mechanism of Leukocyte Trafficking
    NIH/NIAID R13AI051316May 15, 2002 - Apr 30, 2003
    Role: Principal Investigator
    Sulfotransferases in the Synthesis of L-Selectin Ligands
    NIH/NIGMS R01GM057411Jan 1, 1999 - Aug 31, 2012
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF LEUKOCYTE TRAFFICKING
    NIH/NIAID R13AI042586Mar 15, 1998 - Mar 14, 1999
    Role: Principal Investigator
    Interactions of Lymphocytes, Cytokines and Airway Cells
    NIH/NHLBI P50HL056385Sep 30, 1996 - Aug 31, 2006
    Role: Co-Investigator
    L-SELECTIN IN LEUKOCYTE MYELIN INTERACTIONS
    NIH/NINDS R01NS032254May 1, 1994 - Apr 30, 1998
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Cell Surface Lectins and Intercellular Adhesion
    NIH/NIGMS R01GM023547Feb 1, 1977 - Jul 31, 2012
    Role: Principal Investigator
    CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    NIH/NIGMS R37GM023547Feb 1, 1977 - Jul 31, 2006
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Flowers SA, Zhou X, Wu J, Wang Y, Makambi K, Kallakury BV, Singer MS, Rosen S, Davidson B, Goldman R. Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck. Oncotarget. 2016 Jul 12; 7(28):43177-43187. PMID: 27223083.
      View in: PubMed
    2. Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen S. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015 Feb 02; 440:72-8. PMID: 25444749; PMCID: PMC4305470.
      View in: PubMed, PubMed Central
    3. Rosen S, Daneman R. High endothelial venules through a transcriptomics lens. Nat Immunol. 2014 Oct; 15(10):906-8. PMID: 25232814.
      View in: PubMed
    4. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen S. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8. PMID: 24889202; PMCID: PMC4076593.
      View in: PubMed, PubMed Central
    5. Maltseva I, Chan M, Kalus I, Dierks T, Rosen S. The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013; 8(8):e69642. PMID: 23950901; PMCID: PMC3738537.
      View in: PubMed, PubMed Central
    6. Patnode ML, Cheng CW, Chou CC, Singer MS, Elin MS, Uchimura K, Crocker PR, Khoo KH, Rosen S. Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem. 2013 Sep 13; 288(37):26533-45. PMID: 23880769; PMCID: PMC3772201.
      View in: PubMed, PubMed Central
    7. Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen S, Engel JN. Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection. Cell Microbiol. 2013 Sep; 15(9):1560-71. PMID: 23480519; PMCID: PMC3722241.
      View in: PubMed, PubMed Central
    8. Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjö L, Sakuma K, Uchimura K, Khoo KH, Kannagi R, Rosen S. KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar; 23(3):381-94. PMID: 23254996; PMCID: PMC3555504.
      View in: PubMed, PubMed Central
    9. Lui NS, van Zante A, Rosen S, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6). PMID: 23180455; PMCID: PMC3532995.
      View in: PubMed, PubMed Central
    10. Zhang Y, Chen YC, Krummel MF, Rosen S. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15; 189(8):3914-24. PMID: 22962684; PMCID: PMC3509168.
      View in: PubMed, PubMed Central
    11. Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen S, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar; 122(3):911-22. PMID: 22293178; PMCID: PMC3287216.
      View in: PubMed, PubMed Central
    12. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma. 2011 Sep; 28(9):1893-907. PMID: 21657851; PMCID: PMC3172879.
      View in: PubMed, PubMed Central
    13. Arata-Kawai H, Singer MS, Bistrup A, Zante Av, Wang YQ, Ito Y, Bao X, Hemmerich S, Fukuda M, Rosen S. Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs. Am J Pathol. 2011 Jan; 178(1):423-33. PMID: 21224079; PMCID: PMC3070580.
      View in: PubMed, PubMed Central
    14. Rosen S, Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49. PMID: 20629619; PMCID: PMC3126665.
      View in: PubMed, PubMed Central
    15. Feng G, Du P, Krett NL, Tessel M, Rosen S, Kibbe WA, Lin SM. A collection of bioconductor methods to visualize gene-list annotations. BMC Res Notes. 2010 Jan 19; 3:10. PMID: 20180973; PMCID: PMC2829581.
      View in: PubMed, PubMed Central
    16. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen S. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64. PMID: 20816204.
      View in: PubMed
    17. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen S. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene. 2010 Feb 04; 29(5):635-46. PMID: 19855436; PMCID: PMC2818095.
      View in: PubMed, PubMed Central
    18. Hossain MM, Hosono-Fukao T, Tang R, Sugaya N, van Kuppevelt TH, Jenniskens GJ, Kimata K, Rosen S, Uchimura K. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88. Glycobiology. 2010 Feb; 20(2):175-86. PMID: 19822709; PMCID: PMC2800247.
      View in: PubMed, PubMed Central
    19. Rosen S, Arata-Kawai H. "Home sweet home" for lymphocytes. Blood. 2009 Jul 16; 114(3):499-500. PMID: 19608758.
      View in: PubMed
    20. Tang R, Rosen S. Functional consequences of the subdomain organization of the sulfs. J Biol Chem. 2009 Aug 07; 284(32):21505-14. PMID: 19520866; PMCID: PMC2755875.
      View in: PubMed, PubMed Central
    21. Kerr SC, Fieger CB, Snapp KR, Rosen S. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. J Immunol. 2008 Jul 15; 181(2):1480-90. PMID: 18606703; PMCID: PMC2700822.
      View in: PubMed, PubMed Central
    22. Kanda H, Newton R, Klein R, Morita Y, Gunn MD, Rosen S. Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol. 2008 Apr; 9(4):415-23. PMID: 18327261; PMCID: PMC2783613.
      View in: PubMed, PubMed Central
    23. Nawroth R, van Zante A, Cervantes S, McManus M, Hebrok M, Rosen S. Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One. 2007 Apr 25; 2(4):e392. PMID: 17460759; PMCID: PMC1849966.
      View in: PubMed, PubMed Central
    24. Veerman KM, Williams MJ, Uchimura K, Singer MS, Merzaban JS, Naus S, Carlow DA, Owen P, Rivera-Nieves J, Rosen S, Ziltener HJ. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol. 2007 May; 8(5):532-9. PMID: 17401367.
      View in: PubMed
    25. Alon R, Rosen S. Rolling on N-linked glycans: a new way to present L-selectin binding sites. Nat Immunol. 2007 Apr; 8(4):339-41. PMID: 17375095.
      View in: PubMed
    26. Lum DH, Tan J, Rosen S, Werb Z. Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol. 2007 Jan; 27(2):678-88. PMID: 17116694; PMCID: PMC1800820.
      View in: PubMed, PubMed Central
    27. Uchimura K, Rosen S. Sulfated L-selectin ligands as a therapeutic target in chronic inflammation. Trends Immunol. 2006 Dec; 27(12):559-65. PMID: 17049924.
      View in: PubMed
    28. Rosen S. Homing in on L-selectin. J Immunol. 2006 Jul 01; 177(1):3-4. PMID: 16785488.
      View in: PubMed
    29. Yang J, Rosen S, Bendele P, Hemmerich S. Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. BMC Immunol. 2006 Jun 13; 7:12. PMID: 16772045; PMCID: PMC1533857.
      View in: PubMed, PubMed Central
    30. Uchimura K, Morimoto-Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, Werb Z, Rosen S. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochem. 2006 Jan 17; 7:2. PMID: 16417632; PMCID: PMC1386684.
      View in: PubMed, PubMed Central
    31. Uchimura K, Morimoto-Tomita M, Rosen S. Measuring the activities of the Sulfs: two novel heparin/heparan sulfate endosulfatases. Methods Enzymol. 2006; 416:243-53. PMID: 17113870.
      View in: PubMed
    32. Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen S. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia. 2005 Nov; 7(11):1001-10. PMID: 16331886; PMCID: PMC1502017.
      View in: PubMed, PubMed Central
    33. Uchimura K, Gauguet JM, Singer MS, Tsay D, Kannagi R, Muramatsu T, von Andrian UH, Rosen S. A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules. Nat Immunol. 2005 Nov; 6(11):1105-13. PMID: 16227986.
      View in: PubMed
    34. Saad OM, Ebel H, Uchimura K, Rosen S, Bertozzi CR, Leary JA. Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase. Glycobiology. 2005 Aug; 15(8):818-26. PMID: 15843596.
      View in: PubMed
    35. Pablos JL, Santiago B, Tsay D, Singer MS, Palao G, Galindo M, Rosen S. A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells. BMC Immunol. 2005 Mar 07; 6:6. PMID: 15752429; PMCID: PMC1079838.
      View in: PubMed, PubMed Central
    36. Rosen S, Tsay D, Singer MS, Hemmerich S, Abraham WM. Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma. Am J Pathol. 2005 Mar; 166(3):935-44. PMID: 15743804; PMCID: PMC1602362.
      View in: PubMed, PubMed Central
    37. Gauguet JM, Rosen S, Marth JD, von Andrian UH. Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes. Blood. 2004 Dec 15; 104(13):4104-12. PMID: 15319280.
      View in: PubMed
    38. Uchimura K, Kadomatsu K, El-Fasakhany FM, Singer MS, Izawa M, Kannagi R, Takeda N, Rosen S, Muramatsu T. N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing. J Biol Chem. 2004 Aug 13; 279(33):35001-8. PMID: 15175329.
      View in: PubMed
    39. Bistrup A, Tsay D, Shenoy P, Singer MS, Bangia N, Luther SA, Cyster JG, Ruddle NH, Rosen S. Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope. Am J Pathol. 2004 May; 164(5):1635-44. PMID: 15111310; PMCID: PMC1615668.
      View in: PubMed, PubMed Central
    40. Palmeri D, Zuo FR, Rosen S, Hemmerich S. Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking. J Leukoc Biol. 2004 May; 75(5):910-27. PMID: 14761935.
      View in: PubMed
    41. Rosen S. Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol. 2004; 22:129-56. PMID: 15032576.
      View in: PubMed
    42. van Zante A, Gauguet JM, Bistrup A, Tsay D, von Andrian UH, Rosen S. Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse. J Exp Med. 2003 Nov 03; 198(9):1289-300. PMID: 14597732; PMCID: PMC2194250.
      View in: PubMed, PubMed Central
    43. Sarangapani KK, Yago T, Klopocki AG, Lawrence MB, Fieger CB, Rosen S, McEver RP, Zhu C. Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan. J Biol Chem. 2004 Jan 16; 279(3):2291-8. PMID: 14573602.
      View in: PubMed
    44. Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen S, Noble-Haeusslein LJ. The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neurosci Methods. 2003 Oct 15; 129(1):49-59. PMID: 12951232.
      View in: PubMed
    45. Fieger CB, Sassetti CM, Rosen S. Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J Biol Chem. 2003 Jul 25; 278(30):27390-8. PMID: 12889478.
      View in: PubMed
    46. van Zante A, Rosen S. Sulphated endothelial ligands for L-selectin in lymphocyte homing and inflammation. Biochem Soc Trans. 2003 Apr; 31(2):313-7. PMID: 12653627.
      View in: PubMed
    47. Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, Yang ZQ, Kiessling LL, Rosen S, Fisher SJ. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003 Jan 17; 299(5605):405-8. PMID: 12532021.
      View in: PubMed
    48. Lee JK, Bistrup A, van Zante A, Rosen S. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. Glycobiology. 2003 Apr; 13(4):245-54. PMID: 12626414.
      View in: PubMed
    49. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen S. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem. 2002 Dec 20; 277(51):49175-85. PMID: 12368295; PMCID: PMC2779716.
      View in: PubMed, PubMed Central
    50. Matsui NM, Borsig L, Rosen S, Yaghmai M, Varki A, Embury SH. P-selectin mediates the adhesion of sickle erythrocytes to the endothelium. Blood. 2001 Sep 15; 98(6):1955-62. PMID: 11535535.
      View in: PubMed
    51. Hemmerich S, Bistrup A, Singer MS, van Zante A, Lee JK, Tsay D, Peters M, Carminati JL, Brennan TJ, Carver-Moore K, Leviten M, Fuentes ME, Ruddle NH, Rosen S. Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Immunity. 2001 Aug; 15(2):237-47. PMID: 11520459.
      View in: PubMed
    52. Bruehl RE, Dasgupta F, Katsumoto TR, Tan JH, Bertozzi CR, Spevak W, Ahn DJ, Rosen S, Nagy JO. Polymerized liposome assemblies: bifunctional macromolecular selectin inhibitors mimicking physiological selectin ligands. Biochemistry. 2001 May 22; 40(20):5964-74. PMID: 11352731.
      View in: PubMed
    53. Strausbaugh HJ, Rosen S. A potential role for annexin 1 as a physiologic mediator of glucocorticoid-induced L-selectin shedding from myeloid cells. J Immunol. 2001 May 15; 166(10):6294-300. PMID: 11342653.
      View in: PubMed
    54. Hemmerich S, Lee JK, Bhakta S, Bistrup A, Ruddle NR, Rosen S. Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family. Glycobiology. 2001 Jan; 11(1):75-87. PMID: 11181564.
      View in: PubMed
    55. Gartrell NK, Koh AS, Becker C, LaVoy A, Rosen S, Thiemann S. Prevalence of hormone replacement therapy and antidepressant use in peri- and postmenopausal women. J Gend Specif Med. 2001; 4(1):60-3. PMID: 11324242.
      View in: PubMed
    56. Bhakta S, Bartes A, Bowman KG, Kao WM, Polsky I, Lee JK, Cook BN, Bruehl RE, Rosen S, Bertozzi CR, Hemmerich S. Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5). J Biol Chem. 2000 Dec 22; 275(51):40226-34. PMID: 10956661.
      View in: PubMed
    57. Bruehl RE, Bertozzi CR, Rosen S. Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody. J Biol Chem. 2000 Oct 20; 275(42):32642-8. PMID: 10938267.
      View in: PubMed
    58. Hemmerich S, Rosen S. Carbohydrate sulfotransferases in lymphocyte homing. Glycobiology. 2000 Sep; 10(9):849-56. PMID: 10988246.
      View in: PubMed
    59. Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen S. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. J Biol Chem. 2000 Jun 23; 275(25):19139-45. PMID: 10779521.
      View in: PubMed
    60. Sassetti C, Van Zante A, Rosen S. Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins. J Biol Chem. 2000 Mar 24; 275(12):9001-10. PMID: 10722749.
      View in: PubMed
    61. Tangemann K, Bistrup A, Hemmerich S, Rosen S. Sulfation of a high endothelial venule-expressed ligand for L-selectin. Effects on tethering and rolling of lymphocytes. J Exp Med. 1999 Oct 04; 190(7):935-42. PMID: 10510083; PMCID: PMC2195654.
      View in: PubMed, PubMed Central
    62. Rosen S. Endothelial ligands for L-selectin: from lymphocyte recirculation to allograft rejection. Am J Pathol. 1999 Oct; 155(4):1013-20. PMID: 10514381; PMCID: PMC1867022.
      View in: PubMed, PubMed Central
    63. Lee JK, Bhakta S, Rosen S, Hemmerich S. Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue. Biochem Biophys Res Commun. 1999 Sep 24; 263(2):543-9. PMID: 10491328.
      View in: PubMed
    64. Strausbaugh HJ, Green PG, Lo E, Tangemann K, Reichling DB, Rosen S, Levine JD. Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils. Nat Med. 1999 Sep; 5(9):1057-61. PMID: 10470085.
      View in: PubMed
    65. Papadopoulos EJ, Sassetti C, Saeki H, Yamada N, Kawamura T, Fitzhugh DJ, Saraf MA, Schall T, Blauvelt A, Rosen S, Hwang ST. Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol. 1999 Aug; 29(8):2551-9. PMID: 10458770.
      View in: PubMed
    66. Prakobphol A, Tangemann K, Rosen S, Hoover CI, Leffler H, Fisher SJ. Separate oligosaccharide determinants mediate interactions of the low-molecular-weight salivary mucin with neutrophils and bacteria. Biochemistry. 1999 May 25; 38(21):6817-25. PMID: 10346903.
      View in: PubMed
    67. Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen S, Hemmerich S. Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. J Cell Biol. 1999 May 17; 145(4):899-910. PMID: 10330415; PMCID: PMC2133194.
      View in: PubMed, PubMed Central
    68. Tangemann K, Gunn MD, Giblin P, Rosen S. A high endothelial cell-derived chemokine induces rapid, efficient, and subset-selective arrest of rolling T lymphocytes on a reconstituted endothelial substrate. J Immunol. 1998 Dec 01; 161(11):6330-7. PMID: 9834123.
      View in: PubMed
    69. Bowman KG, Hemmerich S, Bhakta S, Singer MS, Bistrup A, Rosen S, Bertozzi CR. Identification of an N-acetylglucosamine-6-0-sulfotransferase activity specific to lymphoid tissue: an enzyme with a possible role in lymphocyte homing. Chem Biol. 1998 Aug; 5(8):447-60. PMID: 9710564.
      View in: PubMed
    70. Sassetti C, Tangemann K, Singer MS, Kershaw DB, Rosen S. Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. J Exp Med. 1998 Jun 15; 187(12):1965-75. PMID: 9625756; PMCID: PMC2212365.
      View in: PubMed, PubMed Central
    71. Prakobphol A, Thomsson KA, Hansson GC, Rosen S, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ. Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity. Biochemistry. 1998 Apr 07; 37(14):4916-27. PMID: 9538010.
      View in: PubMed
    72. Nicholson MW, Barclay AN, Singer MS, Rosen S, van der Merwe PA. Affinity and kinetic analysis of L-selectin (CD62L) binding to glycosylation-dependent cell-adhesion molecule-1. J Biol Chem. 1998 Jan 09; 273(2):763-70. PMID: 9422729.
      View in: PubMed
    73. Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen S, Williams LT. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci U S A. 1998 Jan 06; 95(1):258-63. PMID: 9419363; PMCID: PMC18193.
      View in: PubMed, PubMed Central
    74. Dwir O, Shimron F, Chen C, Singer MS, Rosen S, Alon R. GlyCAM-1 supports leukocyte rolling in flow: evidence for a greater dynamic stability of L-selectin rolling of lymphocytes than of neutrophils. Cell Adhes Commun. 1998; 6(4):349-70. PMID: 9865468.
      View in: PubMed
    75. Giblin PA, Hwang ST, Katsumoto TR, Rosen S. Ligation of L-selectin on T lymphocytes activates beta1 integrins and promotes adhesion to fibronectin. J Immunol. 1997 Oct 01; 159(7):3498-507. PMID: 9317149.
      View in: PubMed
    76. Rosen S, Hwang ST, Giblin PA, Singer MS. High-endothelial-venule ligands for L-selectin: identification and functions. Biochem Soc Trans. 1997 May; 25(2):428-33. PMID: 9191130.
      View in: PubMed
    77. Bertozzi CR, Singer MS, Rosen S. An ELISA for selectins based on binding to a physiological ligand. J Immunol Methods. 1997 Apr 25; 203(2):157-65. PMID: 9149809.
      View in: PubMed
    78. Sanders WJ, Katsumoto TR, Bertozzi CR, Rosen S, Kiessling LL. L-selectin-carbohydrate interactions: relevant modifications of the Lewis x trisaccharide. Biochemistry. 1996 Nov 26; 35(47):14862-7. PMID: 8942649.
      View in: PubMed
    79. Hwang ST, Singer MS, Giblin PA, Yednock TA, Bacon KB, Simon SI, Rosen S. GlyCAM-1, a physiologic ligand for L-selectin, activates beta 2 integrins on naive peripheral lymphocytes. J Exp Med. 1996 Oct 01; 184(4):1343-8. PMID: 8879206; PMCID: PMC2192819.
      View in: PubMed, PubMed Central
    80. Singer MS, Rosen S. Purification and quantification of L-selectin-reactive GlyCAM-1 from mouse serum. J Immunol Methods. 1996 Sep 27; 196(2):153-61. PMID: 8841453.
      View in: PubMed
    81. Rosen S, Bertozzi CR. Two selectins converge on sulphate. Leukocyte adhesion. Curr Biol. 1996 Mar 01; 6(3):261-4. PMID: 8805242.
      View in: PubMed
    82. Mallett S, Rosen S, Hyun W. Calcium-dependent lectin activity with novel distribution on thymocyte subsets. Eur J Immunol. 1996 Jan; 26(1):77-83. PMID: 8566087.
      View in: PubMed
    83. Onrust SV, Hartl PM, Rosen S, Hanahan D. Modulation of L-selectin ligand expression during an immune response accompanying tumorigenesis in transgenic mice. J Clin Invest. 1996 Jan 01; 97(1):54-64. PMID: 8550850; PMCID: PMC507062.
      View in: PubMed, PubMed Central
    84. Bertozzi CR, Fukuda S, Rosen S. Sulfated disaccharide inhibitors of L-selectin: deriving structural leads from a physiological selectin ligand. Biochemistry. 1995 Nov 07; 34(44):14271-8. PMID: 7578028.
      View in: PubMed
    85. Crommie D, Rosen S. Biosynthesis of GlyCAM-1, a mucin-like ligand for L-selectin. J Biol Chem. 1995 Sep 22; 270(38):22614-24. PMID: 7545681.
      View in: PubMed
    86. Hemmerich S, Leffler H, Rosen S. Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin. J Biol Chem. 1995 May 19; 270(20):12035-47. PMID: 7538131.
      View in: PubMed
    87. Whyte A, Wooding P, Nayeem N, Watson SR, Rosen S, Binns RM. The L-selectin counter-receptor in porcine lymph nodes. Biochem Soc Trans. 1995 May; 23(2):159S. PMID: 7545594.
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    88. Daniels BF, Nakamura MC, Rosen S, Yokoyama WM, Seaman WE. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. Immunity. 1994 Dec; 1(9):785-92. PMID: 7895167.
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    89. Kikuta A, Rosen S. Localization of ligands for L-selectin in mouse peripheral lymph node high endothelial cells by colloidal gold conjugates. Blood. 1994 Dec 01; 84(11):3766-75. PMID: 7524748.
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    90. Hemmerich S, Butcher EC, Rosen S. Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody. J Exp Med. 1994 Dec 01; 180(6):2219-26. PMID: 7525849; PMCID: PMC2191797.
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    91. Rosen S, Bertozzi CR. The selectins and their ligands. Curr Opin Cell Biol. 1994 Oct; 6(5):663-73. PMID: 7530461.
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    92. Huang K, Kikuta A, Rosen S. Myelin localization of a central nervous system ligand for L-selectin. J Neuroimmunol. 1994 Sep; 53(2):133-41. PMID: 7520918.
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    93. Hemmerich S, Bertozzi CR, Leffler H, Rosen S. Identification of the sulfated monosaccharides of GlyCAM-1, an endothelial-derived ligand for L-selectin. Biochemistry. 1994 Apr 26; 33(16):4820-9. PMID: 7512827.
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    94. Hemmerich S, Rosen S. 6'-sulfated sialyl Lewis x is a major capping group of GlyCAM-1. Biochemistry. 1994 Apr 26; 33(16):4830-5. PMID: 8161542.
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    95. Rosen S. Ligands for L-selectin: where and how many? Res Immunol. 1993 Nov-Dec; 144(9):699-703; discussion 754-62. PMID: 7512742.
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    96. Baumheter S, Singer MS, Henzel W, Hemmerich S, Renz M, Rosen S, Lasky LA. Binding of L-selectin to the vascular sialomucin CD34. Science. 1993 Oct 15; 262(5132):436-8. PMID: 7692600.
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    97. Rosen S. Robert Feulgen Lecture 1993. L-selectin and its biological ligands. Histochemistry. 1993 Sep; 100(3):185-91. PMID: 7503971.
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    98. Rosen S. Cell surface lectins in the immune system. Semin Immunol. 1993 Aug; 5(4):237-47. PMID: 7693021.
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    99. Imai Y, Lasky LA, Rosen S. Sulphation requirement for GlyCAM-1, an endothelial ligand for L-selectin. Nature. 1993 Feb 11; 361(6412):555-7. PMID: 7679207.
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    100. Imai Y, Rosen S. Direct demonstration of heterogeneous, sulfated O-linked carbohydrate chains on an endothelial ligand for L-selectin. Glycoconj J. 1993 Feb; 10(1):34-9. PMID: 7689376.
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    101. Imai Y, Lasky LA, Rosen S. Further characterization of the interaction between L-selectin and its endothelial ligands. Glycobiology. 1992 Aug; 2(4):373-81. PMID: 1384820.
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    102. Lasky LA, Singer MS, Dowbenko D, Imai Y, Henzel WJ, Grimley C, Fennie C, Gillett N, Watson SR, Rosen S. An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell. 1992 Jun 12; 69(6):927-38. PMID: 1376638.
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    103. Lasky LA, Singer MS, Dowbenko D, Imai Y, Henzel W, Fennie C, Watson S, Rosen S. Glycosylation-dependent cell adhesion molecule 1: a novel mucin-like adhesion ligand for L-selectin. Cold Spring Harb Symp Quant Biol. 1992; 57:259-69. PMID: 1285051.
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    104. Huang K, Geoffroy JS, Singer MS, Rosen S. A lymphocyte homing receptor (L-selectin) mediates the in vitro attachment of lymphocytes to myelinated tracts of the central nervous system. J Clin Invest. 1991 Nov; 88(5):1778-83. PMID: 1719030; PMCID: PMC295727.
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    105. Watson SR, Imai Y, Fennie C, Geoffrey J, Singer M, Rosen S, Lasky LA. The complement binding-like domains of the murine homing receptor facilitate lectin activity. J Cell Biol. 1991 Oct; 115(1):235-43. PMID: 1717479; PMCID: PMC2289932.
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    106. Ley K, Gaehtgens P, Fennie C, Singer MS, Lasky LA, Rosen S. Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo. Blood. 1991 Jun 15; 77(12):2553-5. PMID: 2043760.
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    107. Imai Y, Singer MS, Fennie C, Lasky LA, Rosen S. Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor. J Cell Biol. 1991 Jun; 113(5):1213-21. PMID: 2040648; PMCID: PMC2289002.
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    108. True DD, Singer MS, Lasky LA, Rosen S. Requirement for sialic acid on the endothelial ligand of a lymphocyte homing receptor. J Cell Biol. 1990 Dec; 111(6 Pt 1):2757-64. PMID: 2277086; PMCID: PMC2116434.
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    109. Corral L, Singer MS, Macher BA, Rosen S. Requirement for sialic acid on neutrophils in a GMP-140 (PADGEM) mediated adhesive interaction with activated platelets. Biochem Biophys Res Commun. 1990 Nov 15; 172(3):1349-56. PMID: 1700907.
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    110. Rosen S. The LEC-CAMs: an emerging family of cell-cell adhesion receptors based upon carbohydrate recognition. Am J Respir Cell Mol Biol. 1990 Nov; 3(5):397-402. PMID: 2223096.
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    111. Imai Y, True DD, Singer MS, Rosen S. Direct demonstration of the lectin activity of gp90MEL, a lymphocyte homing receptor. J Cell Biol. 1990 Sep; 111(3):1225-32. PMID: 2202735; PMCID: PMC2116278.
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    112. Watson SR, Imai Y, Fennie C, Geoffroy JS, Rosen S, Lasky LA. A homing receptor-IgG chimera as a probe for adhesive ligands of lymph node high endothelial venules. J Cell Biol. 1990 Jun; 110(6):2221-9. PMID: 2190992; PMCID: PMC2116131.
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    113. Geoffroy JS, Rosen S. Demonstration that a lectin-like receptor (gp90MEL) directly mediates adhesion of lymphocytes to high endothelial venules of lymph nodes. J Cell Biol. 1989 Nov; 109(5):2463-9. PMID: 2681232; PMCID: PMC2115886.
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    114. Rosen S. Lymphocyte homing: progress and prospects. Curr Opin Cell Biol. 1989 Oct; 1(5):913-9. PMID: 2697294.
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    115. Lasky LA, Singer MS, Yednock TA, Dowbenko D, Fennie C, Rodriguez H, Nguyen T, Stachel S, Rosen S. Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell. 1989 Mar 24; 56(6):1045-55. PMID: 2647302.
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    116. Rosen S, Chi SI, True DD, Singer MS, Yednock TA. Intravenously injected sialidase inactivates attachment sites for lymphocytes on high endothelial venules. J Immunol. 1989 Mar 15; 142(6):1895-902. PMID: 2921520.
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    117. Yednock TA, Rosen S. Lymphocyte homing. Adv Immunol. 1989; 44:313-78. PMID: 2646861.
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    118. Kramer RH, Rosen S, McDonald KA. Basement-membrane components associated with the extracellular matrix of the lymph node. Cell Tissue Res. 1988 May; 252(2):367-75. PMID: 3383216.
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    119. Stoolman LM, Yednock TA, Rosen S. Homing receptors on human and rodent lymphocytes--evidence for a conserved carbohydrate-binding specificity. Blood. 1987 Dec; 70(6):1842-50. PMID: 2823939.
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    120. Yednock TA, Butcher EC, Stoolman LM, Rosen S. Receptors involved in lymphocyte homing: relationship between a carbohydrate-binding receptor and the MEL-14 antigen. J Cell Biol. 1987 Mar; 104(3):725-31. PMID: 2950122; PMCID: PMC2114538.
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    121. Yednock TA, Stoolman LM, Rosen S. Phosphomannosyl-derivatized beads detect a receptor involved in lymphocyte homing. J Cell Biol. 1987 Mar; 104(3):713-23. PMID: 2950121; PMCID: PMC2114559.
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    122. Rosen S, Yednock TA. Lymphocyte attachment to high endothelial venules during recirculation: a possible role for carbohydrates as recognition determinants. Mol Cell Biochem. 1986 Nov-Dec; 72(1-2):153-64. PMID: 3029559.
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    123. Rosen S, Singer MS, Yednock TA, Stoolman LM. Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation. Science. 1985 May 24; 228(4702):1005-7. PMID: 4001928.
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    124. Grabel LB, Singer MS, Martin GR, Rosen S. Isolation of a teratocarcinoma stem cell lectin implicated in intercellular adhesion. FEBS Lett. 1985 Apr 22; 183(2):228-31. PMID: 3987889.
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    125. Stoolman LM, Tenforde TS, Rosen S. Phosphomannosyl receptors may participate in the adhesive interaction between lymphocytes and high endothelial venules. J Cell Biol. 1984 Oct; 99(4 Pt 1):1535-40. PMID: 6090473; PMCID: PMC2113299.
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    126. Grabel LB, Singer MS, Martin GR, Rosen S. Teratocarcinoma stem cell adhesion: the role of divalent cations and a cell surface lectin. J Cell Biol. 1983 Jun; 96(6):1532-7. PMID: 6406515; PMCID: PMC2112446.
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    127. Glabe CG, Yednock T, Rosen S. Reversible disruption of cultured endothelial monolayers by sulphated fucans. J Cell Sci. 1983 May; 61:475-90. PMID: 6885946.
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    128. Stoolman LM, Rosen S. Possible role for cell-surface carbohydrate-binding molecules in lymphocyte recirculation. J Cell Biol. 1983 Mar; 96(3):722-9. PMID: 6833380; PMCID: PMC2112421.
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    129. Glabe CG, Grabel LB, Vacquier VD, Rosen S. Carbohydrate specificity of sea urchin sperm bindin: a cell surface lectin mediating sperm-egg adhesion. J Cell Biol. 1982 Jul; 94(1):123-8. PMID: 7119010; PMCID: PMC2112180.
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    130. Drake DK, Rosen S. Identification and purification of an endogenous receptor for the lectin pallidin from Polysphondylium pallidum. J Cell Biol. 1982 May; 93(2):383-9. PMID: 6896517; PMCID: PMC2112866.
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    131. Grabel LB, Glabe CG, Singer MS, Martin GR, Rosen S. A fucan specific lectin on teratocarcinoma stem cells. Biochem Biophys Res Commun. 1981 Oct 30; 102(4):1165-71. PMID: 7317046.
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    132. Rosen S, Singer MS, Glabe CG, Grabel LB. Specific rosette formation between fibroblasts and erythrocytes. J Cell Sci. 1981 Oct; 51:279-94. PMID: 7033257.
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    133. Rosen S, Kaur J, Clark DL, Pardos BT, Frazier WA. Purification and characterization of multiple species (isolectins) of a slime mold lectin implicated in intercellular adhesion. J Biol Chem. 1979 Oct 10; 254(19):9408-15. PMID: 90676.
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    134. Grabel LB, Rosen S, Martin GR. Teratocarcinoma stem cells have a cell surface carbohydrate-binding component implicated in cell-cell adhesion. Cell. 1979 Jul; 17(3):477-84. PMID: 476826.
      View in: PubMed
    135. Barondes SH, Simpson DL, Rosen S, Haywood PL. Polysphondylium pallidum agglutinin (pallidin). Methods Enzymol. 1978; 50:312-6. PMID: 566368.
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    136. Barondes SH, Rosen S, Frazier WA, Simpson DL, Haywood PL. Dictyostelium discoideum agglutinins (discoidins I and II). Methods Enzymol. 1978; 50:306-12. PMID: 566367.
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    137. Rosen S, Simpson DL, Rose JE, Barondes SH. Carbohydrate-binding protein from Polysphondylium pallidum implicated in intercellular adhesion. Nature. 1974 Nov 08; 252(5479):128, 149-50. PMID: 4472989.
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    138. Simpson DL, Rosen S, Barondes SH. Discoidin, a developmentally regulated carbohydrate-binding protein from Dictyostelium discoideum. Purification and characterization. Biochemistry. 1974 Aug 13; 13(17):3487-93. PMID: 4858710.
      View in: PubMed
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