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Steven Rosen, PhD

Title(s)Professor Emeritus, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-476-2526
ORCID ORCID Icon0000-0002-6245-701X Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    Mucosal Immune Barrier in Infection and Immunity
    NIH P01AI053194Sep 1, 2009 - Sep 24, 2008
    Role: Co-Investigator
    Role of Heparan Sulfate-Degrading Sulfatases in Pancreatic Adenocarcinomas
    NIH R21CA122025Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Conference: Molecular Mechanism of Leukocyte Trafficking
    NIH R13AI051316May 15, 2002 - Apr 30, 2003
    Role: Principal Investigator
    Sulfotransferases in the Synthesis of L-Selectin Ligands
    NIH R01GM057411Jan 1, 1999 - Dec 31, 2006
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF LEUKOCYTE TRAFFICKING
    NIH R13AI042586Mar 15, 1998 - Mar 14, 1999
    Role: Principal Investigator
    Interactions of Lymphocytes, Cytokines and Airway Cells
    NIH P50HL056385Sep 1, 1997 - Aug 31, 2006
    Role: Co-Investigator
    L-SELECTIN IN LEUKOCYTE MYELIN INTERACTIONS
    NIH R01NS032254May 1, 1994 - Apr 30, 1998
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Cell Surface Lectins and Intercellular Adhesion
    NIH R01GM023547Feb 1, 1977 - Jul 31, 2012
    Role: Principal Investigator
    CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    NIH R37GM023547Feb 1, 1977 - Jul 31, 2006
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SULF2 monoclonal antibody 5D5 suppresses human cholangiocarcinoma xenograft growth via regulation of a SULF2-PDGFRβ-YAP signaling axis. Hepatology. 2021 Mar 18. Luo X, Campbell NA, He L, O'Brien DR, Singer MS, Lemjabbar-Alaoui H, Ahn KS, Smoot R, Torbenson MS, Rosen SD, Roberts LR. PMID: 33735525.
      View in: PubMed   Mentions:    Fields:    
    2. Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck. Oncotarget. 2016 Jul 12; 7(28):43177-43187. Flowers SA, Zhou X, Wu J, Wang Y, Makambi K, Kallakury BV, Singer MS, Rosen SD, Davidson B, Goldman R. PMID: 27223083.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015 Feb 02; 440:72-8. Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD. PMID: 25444749.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    4. High endothelial venules through a transcriptomics lens. Nat Immunol. 2014 Oct; 15(10):906-8. Rosen SD, Daneman R. PMID: 25232814.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. PMID: 24889202.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    6. The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013; 8(8):e69642. Maltseva I, Chan M, Kalus I, Dierks T, Rosen SD. PMID: 23950901.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    7. Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem. 2013 Sep 13; 288(37):26533-45. Patnode ML, Cheng CW, Chou CC, Singer MS, Elin MS, Uchimura K, Crocker PR, Khoo KH, Rosen SD. PMID: 23880769.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    8. KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar; 23(3):381-94. Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjö L, Sakuma K, Uchimura K, Khoo KH, Kannagi R, Rosen SD. PMID: 23254996.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6). Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. PMID: 23180455.
      View in: PubMed   Mentions: 9     Fields:    
    10. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15; 189(8):3914-24. Zhang Y, Chen YC, Krummel MF, Rosen SD. PMID: 22962684.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    11. Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012 Mar; 122(3):911-22. Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. PMID: 22293178.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    12. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma. 2011 Sep; 28(9):1893-907. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. PMID: 21657851.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    13. Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs. Am J Pathol. 2011 Jan; 178(1):423-33. Arata-Kawai H, Singer MS, Bistrup A, Zante Av, Wang YQ, Ito Y, Bao X, Hemmerich S, Fukuda M, Rosen SD. PMID: 21224079.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    14. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49. Rosen SD, Lemjabbar-Alaoui H. PMID: 20629619.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    15. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. PMID: 20816204.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88. Glycobiology. 2010 Feb; 20(2):175-86. Hossain MM, Hosono-Fukao T, Tang R, Sugaya N, van Kuppevelt TH, Jenniskens GJ, Kimata K, Rosen SD, Uchimura K. PMID: 19822709.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    17. "Home sweet home" for lymphocytes. Blood. 2009 Jul 16; 114(3):499-500. Rosen SD, Arata-Kawai H. PMID: 19608758.
      View in: PubMed   Mentions:    Fields:    
    18. Functional consequences of the subdomain organization of the sulfs. J Biol Chem. 2009 Aug 07; 284(32):21505-14. Tang R, Rosen SD. PMID: 19520866.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    19. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. J Immunol. 2008 Jul 15; 181(2):1480-90. Kerr SC, Fieger CB, Snapp KR, Rosen SD. PMID: 18606703.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol. 2008 Apr; 9(4):415-23. Kanda H, Newton R, Klein R, Morita Y, Gunn MD, Rosen SD. PMID: 18327261.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    21. Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One. 2007 Apr 25; 2(4):e392. Nawroth R, van Zante A, Cervantes S, McManus M, Hebrok M, Rosen SD. PMID: 17460759.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    22. Rolling on N-linked glycans: a new way to present L-selectin binding sites. Nat Immunol. 2007 Apr; 8(4):339-41. Alon R, Rosen S. PMID: 17375095.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol. 2007 May; 8(5):532-9. Veerman KM, Williams MJ, Uchimura K, Singer MS, Merzaban JS, Naus S, Carlow DA, Owen P, Rivera-Nieves J, Rosen SD, Ziltener HJ. PMID: 17401367.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    24. Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol. 2007 Jan; 27(2):678-88. Lum DH, Tan J, Rosen SD, Werb Z. PMID: 17116694.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    25. Sulfated L-selectin ligands as a therapeutic target in chronic inflammation. Trends Immunol. 2006 Dec; 27(12):559-65. Uchimura K, Rosen SD. PMID: 17049924.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    26. Homing in on L-selectin. J Immunol. 2006 Jul 01; 177(1):3-4. Rosen SD. PMID: 16785488.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    27. Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. BMC Immunol. 2006 Jun 13; 7:12. Yang J, Rosen SD, Bendele P, Hemmerich S. PMID: 16772045.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochem. 2006 Jan 17; 7:2. Uchimura K, Morimoto-Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, Werb Z, Rosen SD. PMID: 16417632.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    29. Measuring the activities of the Sulfs: two novel heparin/heparan sulfate endosulfatases. Methods Enzymol. 2006; 416:243-53. Uchimura K, Morimoto-Tomita M, Rosen SD. PMID: 17113870.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia. 2005 Nov; 7(11):1001-10. Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD. PMID: 16331886.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    31. A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules. Nat Immunol. 2005 Nov; 6(11):1105-13. Uchimura K, Gauguet JM, Singer MS, Tsay D, Kannagi R, Muramatsu T, von Andrian UH, Rosen SD. PMID: 16227986.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    32. Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase. Glycobiology. 2005 Aug; 15(8):818-26. Saad OM, Ebel H, Uchimura K, Rosen SD, Bertozzi CR, Leary JA. PMID: 15843596.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    33. A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells. BMC Immunol. 2005 Mar 07; 6:6. Pablos JL, Santiago B, Tsay D, Singer MS, Palao G, Galindo M, Rosen SD. PMID: 15752429.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    34. Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma. Am J Pathol. 2005 Mar; 166(3):935-44. Rosen SD, Tsay D, Singer MS, Hemmerich S, Abraham WM. PMID: 15743804.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    35. Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes. Blood. 2004 Dec 15; 104(13):4104-12. Gauguet JM, Rosen SD, Marth JD, von Andrian UH. PMID: 15319280.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    36. N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing. J Biol Chem. 2004 Aug 13; 279(33):35001-8. Uchimura K, Kadomatsu K, El-Fasakhany FM, Singer MS, Izawa M, Kannagi R, Takeda N, Rosen SD, Muramatsu T. PMID: 15175329.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    37. Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope. Am J Pathol. 2004 May; 164(5):1635-44. Bistrup A, Tsay D, Shenoy P, Singer MS, Bangia N, Luther SA, Cyster JG, Ruddle NH, Rosen SD. PMID: 15111310.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking. J Leukoc Biol. 2004 May; 75(5):910-27. Palmeri D, Zuo FR, Rosen SD, Hemmerich S. PMID: 14761935.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    39. Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol. 2004; 22:129-56. Rosen SD. PMID: 15032576.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimalsCells
    40. Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse. J Exp Med. 2003 Nov 03; 198(9):1289-300. van Zante A, Gauguet JM, Bistrup A, Tsay D, von Andrian UH, Rosen SD. PMID: 14597732.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    41. Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan. J Biol Chem. 2004 Jan 16; 279(3):2291-8. Sarangapani KK, Yago T, Klopocki AG, Lawrence MB, Fieger CB, Rosen SD, McEver RP, Zhu C. PMID: 14573602.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    42. The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neurosci Methods. 2003 Oct 15; 129(1):49-59. Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen SD, Noble-Haeusslein LJ. PMID: 12951232.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J Biol Chem. 2003 Jul 25; 278(30):27390-8. Fieger CB, Sassetti CM, Rosen SD. PMID: 12889478.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    44. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003 Jan 17; 299(5605):405-8. Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, Yang ZQ, Kiessling LL, Rosen SD, Fisher SJ. PMID: 12532021.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    45. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. Glycobiology. 2003 Apr; 13(4):245-54. Lee JK, Bistrup A, van Zante A, Rosen SD. PMID: 12626414.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    46. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem. 2002 Dec 20; 277(51):49175-85. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD. PMID: 12368295.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
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