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Steven Yukl, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 3930
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    Novel single genome approaches to determine the mechanisms of HIV latent infection in blood, gut, and lymph nodes
    NIH/NIDDK R01DK120387Jun 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Understanding HIV latency reversal and clearance of infected cells in vivo
    NIH/NIAID R01AI132128Jul 21, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Investigating Mechanisms of HIV Persistence in the Gut
    NIH/NIDDK R01DK108349Sep 21, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Quantification of HIV Reservoirs in the Gut-Associated Lymphatic System
    VA IK2CX000520Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator
    Quantification of HIV-1 Reservoirs in the Gut
    NIH/NIAID K23AI089397Sep 3, 2010 - Jul 31, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo. Proc Natl Acad Sci U S A. 2020 Jun 22. Timmons A, Fray E, Kumar M, Wu F, Dai W, Bullen CK, Kim P, Hetzel C, Yang C, Beg S, Lai J, Pomerantz JL, Yukl SA, Siliciano JD, Siliciano RF. PMID: 32571938.
      View in: PubMed   Mentions:    Fields:    
    2. Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. PLoS Pathog. 2020 04; 16(4):e1008450. Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. PMID: 32353080.
      View in: PubMed   Mentions:    Fields:    
    3. Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay. J Acquir Immune Defic Syndr. 2020 Apr 15; 83(5):530-537. Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM. PMID: 32168200.
      View in: PubMed   Mentions: 1     Fields:    
    4. Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. Retrovirology. 2019 11 11; 16(1):32. Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA. PMID: 31711503.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate. JCI Insight. 2019 04 04; 4(7). Jiang G, Maverakis E, Cheng MY, Elsheikh MM, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O'Connor DJ, Thompson GR, Estes JD, Wong JK, Dandekar S. PMID: 30944245.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    6. Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals. AIDS. 2019 03 01; 33(3):425-431. Moron-Lopez S, Kim P, Søgaard OS, Tolstrup M, Wong JK, Yukl SA. PMID: 30531314.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsCTClinical Trials
    7. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS Pathog. 2018 11; 14(11):e1007357. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. PMID: 30440043.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    8. HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing. Sci Transl Med. 2018 02 28; 10(430). Yukl SA, Kaiser P, Kim P, Telwatte S, Joshi SK, Vu M, Lampiris H, Wong JK. PMID: 29491188.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    9. HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest. 2018 03 01; 128(3):1190-1198. Jiang G, Nguyen D, Archin NM, Yukl SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR, Hartigan-O'Connor DJ, Margolis DM, Wong JK, Dandekar S. PMID: 29457784.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Anatomic Compartments as a Barrier to HIV Cure. Encyclopedia of AIDS. 2018 Jan 1; 32-55. Steven A. Yukl, Joseph K. Wong. .
      View in: Publisher Site   Mentions:
    11. HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study. PLoS Med. 2017 Nov; 14(11):e1002417. Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG. PMID: 29112956.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCellsPHPublic Health
    12. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. PMID: 28882052.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S40-S58. Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S. PMID: 28882067.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals. Pathog Immun. 2017; 2(3):310-334. Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, Hatano H. PMID: 28936485.
      View in: PubMed   Mentions:
    15. Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals. J Acquir Immune Defic Syndr. 2017 07 01; 75(3):328-337. Koelsch KK, Rasmussen TA, Hey-Nguyen WJ, Pearson C, Xu Y, Bailey M, Marks KH, Sasson SC, Taylor MS, Tantau R, Obeid S, Milner B, Morrissey O, Pinto AN, Suzuki K, Busch MP, Keating SM, Kaiser P, Yukl S, Wong JK, Hiener BM, Palmer S, Zaunders J, Post JJ, Chan DJ, Avery S, Milliken ST, Kelleher AD, Lewin SR, Cooper DA. PMID: 28350553.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Exploring HIV latency using transcription profiling. Microbiology Australia. 2017 Jan 1. Sushama Telwatte, Steven A Yukl. .
      View in: Publisher Site   Mentions:
    17. Assays for precise quantification of total (including short) and elongated HIV-1 transcripts. J Virol Methods. 2017 04; 242:1-8. Kaiser P, Joshi SK, Kim P, Li P, Liu H, Rice AP, Wong JK, Yukl SA. PMID: 28034670.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    18. Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy. PLoS One. 2016; 11(8):e0160192. Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman DD, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD. PMID: 27483366.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. Tissue reservoirs of HIV. Curr Opin HIV AIDS. 2016 07; 11(4):362-70. Wong JK, Yukl SA. PMID: 27259045.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    20. Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation. Nat Med. 2016 07; 22(7):807-11. Li P, Kaiser P, Lampiris HW, Kim P, Yukl SA, Havlir DV, Greene WC, Wong JK. PMID: 27294875.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    21. Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults. PLoS One. 2015; 10(3):e0121290. Yukl SA, Shergill AK, Girling V, Li Q, Killian M, Epling L, Li P, Kaiser P, Haase A, Havlir DV, McQuaid K, Sinclair E, Wong JK. PMID: 25811360.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. Anatomic Compartments as a Barrier to HIV Cure. Encyclopedia of AIDS. 2015 Jan 1; 1-29. Steven A. Yukl, Joseph K. Wong. .
      View in: Publisher Site   Mentions:
    23. CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS One. 2014; 9(10):e110731. Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SG. PMID: 25340755.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    24. Exogenous and endogenous hyaluronic acid reduces HIV infection of CD4(+) T cells. Immunol Cell Biol. 2014 Oct; 92(9):770-80. Li P, Fujimoto K, Bourguingnon L, Yukl S, Deeks S, Wong JK. PMID: 24957217.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Decreased HIV type 1 transcription in CCR5-?32 heterozygotes during suppressive antiretroviral therapy. J Infect Dis. 2014 Dec 01; 210(11):1838-43. Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher CD, Hecht FM, Sinclair E, Liegler T, Richman DD, Deeks SG, Pillai SK. PMID: 24935955.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Advantages of using the QIAshredder instead of restriction digestion to prepare DNA for droplet digital PCR. Biotechniques. 2014; 56(4):194-6. Yukl SA, Kaiser P, Kim P, Li P, Wong JK. PMID: 24724845.
      View in: PubMed   Mentions: 11     Fields:    
    27. Discordance between peripheral and colonic markers of inflammation during suppressive ART. J Acquir Immune Defic Syndr. 2014 Feb 01; 65(2):133-41. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. PMID: 24121758.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    28. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells. AIDS. 2014 Jan 28; 28(3):439-42. Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H. PMID: 24322272.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    29. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. PMID: 24130489.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCellsCTClinical Trials
    30. Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. AIDS. 2013 Sep 10; 27(14):2255-60. Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA. PMID: 24157906.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    31. The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistence. J Infect Dis. 2013 Oct 15; 208(8):1212-20. Yukl SA, Shergill AK, Ho T, Killian M, Girling V, Epling L, Li P, Wong LK, Crouch P, Deeks SG, Havlir DV, McQuaid K, Sinclair E, Wong JK. PMID: 23852128.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    32. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 2013; 9(5):e1003347. Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG. PMID: 23671416.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCellsCTClinical Trials
    33. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog. 2013 Feb; 9(2):e1003174. Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD. PMID: 23459007.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansCells
    34. Role of retroviral restriction factors in the interferon-a-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK. PMID: 22315404.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    35. Modification of the Abbott RealTime assay for detection of HIV-1 plasma RNA viral loads less than one copy per milliliter. J Virol Methods. 2011 Aug; 175(2):261-5. Yukl SA, Li P, Fujimoto K, Lampiris H, Lu CM, Hare CB, Deeks SG, Liegler T, Pandori M, Havlir DV, Wong JK. PMID: 21536073.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. CD4+ T cell reconstitution, T cell activation, and memory T cell subset composition in blood and gut of HIV-negative and ART-suppressed HIV-positive patients: implications for HIV persistence in the gut. Journal of the International AIDS Society. 2010 Dec 1; 13(Suppl 3):o1. S Yukl, E Sinclair, L Epling, Q Li, A Shergill, K McQuaid, L Duan, B Hare, H Lampiris, A Haase, D Havlir, J Wong. .
      View in: Publisher Site   Mentions:
    37. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS. 2010 Oct 23; 24(16):2451-60. Yukl SA, Shergill AK, McQuaid K, Gianella S, Lampiris H, Hare CB, Pandori M, Sinclair E, Günthard HF, Fischer M, Wong JK, Havlir DV. PMID: 20827162.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    38. Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. J Infect Dis. 2010 Nov 15; 202(10):1553-61. Yukl SA, Gianella S, Sinclair E, Epling L, Li Q, Duan L, Choi AL, Girling V, Ho T, Li P, Fujimoto K, Lampiris H, Hare CB, Pandori M, Haase AT, Günthard HF, Fischer M, Shergill AK, McQuaid K, Havlir DV, Wong JK. PMID: 20939732.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCellsCTClinical Trials
    39. Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes. J Virol Methods. 2010 Dec; 170(1-2):115-20. Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK. PMID: 20863855.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity. Virology. 2009 Apr 25; 387(1):98-108. Yukl S, Pillai S, Li P, Chang K, Pasutti W, Ahlgren C, Havlir D, Strain M, Günthard H, Richman D, Rice AP, Daar E, Little S, Wong JK. PMID: 19268337.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    41. Blood and guts and HIV: preferential HIV persistence in GI mucosa. J Infect Dis. 2008 Mar 01; 197(5):640-2. Yukl S, Wong JK. PMID: 18260765.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    42. The W(sh), W(57), and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit. Blood. 1999 Oct 15; 94(8):2658-66. Berrozpe G, Timokhina I, Yukl S, Tajima Y, Ono M, Zelenetz AD, Besmer P. PMID: 10515869.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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