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Sulggi Lee, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-735-5127
ORCID ORCID Icon0000-0003-1560-2250 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford University, Stanford, CAB.A.06/1998Human Biology
    University of Southern California, Los Angeles, CAM.D., Ph.D.06/2007Medicine, Genetic Epidemiology
    Stanford Hospital & Clinics, Stanford, CAResidency06/2010Internal Medicine
    University of California San Francisco, San Francisco, CAFellowship07/2013Infectious Diseases
    Collapse Awards and Honors
    UCSF Center for AIDS Research Program (CFAR)2018  - 2018Excellence in Translational Science Award

    Collapse Overview 
    Collapse Overview
    Sulggi Lee, MD PhD, is an Associate Professor of Medicine in Residence at the University of California, San Francisco (UCSF) and a faculty member in the Division of HIV, Infectious Diseases, and Global Medicine at the Zuckerberg San Francisco General Hospital. She is Co-PI of the UCSF SCOPE HIV cohort which includes over 2,500+ HIV+ participants, the PI of the UCSF Acute HIV study (individuals diagnosed within 100 days of infection), the PI of the acute COVID-19 Host Immune Response Pathogenesis (CHIRP) study (over 300 longitudinal specimens from recently COVID-19 convalescent individuals in the outpatient setting), and the Clinical Core Director of the UCSF amfAR HIV Cure Institute. Her lab investigates the role of host genetics and immunology in infectious diseases pathogenesis and persistence using a variety of high-throughput sequencing methods (whole exome DNA sequencing, single-cell RNA and antibody sequencing) and discovery-based ‘multi-omic’ analytic approaches. Her work leverages patients samples from observational and clinical trials to identify novel targets for the treatment of infectious diseases. This work includes research focused on host-specific drug responses to interventions (e.g., HIV cure interventional trials) using pharmacokinetic/ pharmacodynamic modeling and research to identify genetic and immunologic signatures that predict extreme clinical phenotypes (e.g., HIV “elite” controllers who are able to suppress virus in the absence of therapy or asymptomatic COVID+ individuals with robust immune responses to SARS-CoV-2).

    Collapse Research 
    Collapse Research Activities and Funding
    Host genetic predictors of plasma IL-1b levels and pharmacogenomics of in vivo IL-1b blockade during treated HIV disease
    NIH/NIAID R01AI143464Jun 1, 2019 - May 31, 2024
    Role: Principal Investigator
    Short-term and long-term effects of methamphetamine exposure on residual viral transcription during treated HIV disease
    NIH/NIDA R61DA047024Aug 1, 2018 - May 31, 2021
    Role: Principal Investigator
    Immediate Initiation of Antiretroviral Therapy During Acute HIV Infection - Tissue-Based Studies
    Gilead Sciences IN-US-236-1354Jul 1, 2018 - Jul 1, 2021
    Role: Principal Investigator
    Immediate Initiation of Antiretroviral Therapy During Acute HIV Infection
    VIiv Healthcare CA-0101618Apr 1, 2017 - Apr 30, 2020
    Role: Principal Investigator
    amfAR Institute for HIV Cure Research
    The Foundation for AIDS Research (amfAR) 109380-59-RGRLJan 1, 2016 - Dec 31, 2020
    Role: Co-Investigator; UCSF amfAR HIV Cure Institute Clinical Core Director
    A pharmacogenomics study of HIV latency: the role of PD-1 signaling
    NIH/NIGMS K23GM112526Aug 5, 2014 - Jul 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2-specific T cells exhibit unique features characterized by robust helper function, lack of terminal differentiation, and high proliferative potential. bioRxiv. 2020 Jun 08. Neidleman J, Luo X, Frouard J, Xie G, Gill G, Stein ES, McGregor M, Ma T, George A, Kosters A, Greene WC, Vasquez J, Ghosn E, Lee S, Roan NR. PMID: 32577663.
      View in: PubMed   Mentions:
    2. Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. PLoS Pathog. 2020 04; 16(4):e1008450. Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. PMID: 32353080.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay. J Acquir Immune Defic Syndr. 2020 Apr 15; 83(5):530-537. Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM. PMID: 32168200.
      View in: PubMed   Mentions: 1     Fields:    
    4. RAPID antiretroviral therapy: high virologic suppression rates with immediate antiretroviral therapy initiation in a vulnerable urban clinic population. AIDS. 2019 04 01; 33(5):825-832. Coffey S, Bacchetti P, Sachdev D, Bacon O, Jones D, Ospina-Norvell C, Torres S, Lynch E, Camp C, Mercer-Slomoff R, Lee S, Christopoulos K, Pilcher C, Hsu L, Jin C, Scheer S, Havlir D, Gandhi M. PMID: 30882490.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    5. Acquisition of tenofovir-susceptible, emtricitabine-resistant HIV despite high adherence to daily pre-exposure prophylaxis: a case report. Lancet HIV. 2018 Nov 29. Cohen SE, Sachdev D, Lee SA, Scheer S, Bacon O, Chen MJ, Okochi H, Anderson PL, Kearney MF, Coffey S, Scott H, Grant RM, Havlir D, Gandhi M. PMID: 30503324.
      View in: PubMed   Mentions: 9     Fields:    
    6. 1298. Acquisition of TDF-Susceptible HIV Despite High Level Adherence to Daily TDF/FTC PrEP as Measured by Dried Blood Spot (DBS) and Segmental Hair Analysis: A Case Report. Open Forum Infectious Diseases. 2018 Nov 26; 5(suppl_1):s396-s397. Stephanie E Cohen, Darpun Sachdev, Sulggi Lee, Susan Scheer, Oliver Bacon, Miao-Jung Chen, Clarissa Ospina Norvell, Hideaki Okochi, Peter Anderson, Susa Coffey, Hyman Scott, Diane Havlir, Monica Gandhi. .
      View in: Publisher Site   Mentions:
    7. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS Pathog. 2018 11; 14(11):e1007357. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. PMID: 30440043.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    8. Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial. Clin Pharmacol Ther. 2019 03; 105(3):692-702. Lee SA, Elliott JH, McMahon J, Hartogenesis W, Bumpus NN, Lifson JD, Gorelick RJ, Bacchetti P, Deeks SG, Lewin SR, Savic RM. PMID: 30137649.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsCTClinical Trials
    9. CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies. AIDS Res Hum Retroviruses. 2018 11; 34(11):982-992. Chang JL, Lee SA, Tsai AC, Musinguzi N, Muzoora C, Bwana B, Boum Y, Haberer JE, Hunt PW, Martin J, Bangsberg DR, Kroetz DL, Siedner MJ. PMID: 29973058.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection. Brain Behav Immun. 2018 07; 71:108-115. Carrico AW, Flentje A, Kober K, Lee S, Hunt P, Riley ED, Shoptaw S, Flowers E, Dilworth SE, Pahwa S, Aouizerat BE. PMID: 29679637.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy. J Infect Dis. 2017 04 15; 215(8):1270-1274. Lee S, Byakwaga H, Boum Y, Burdo TH, Williams KC, Lederman MM, Huang Y, Tracy RP, Cao H, Haberer JE, Kembabazi A, Bangsberg DR, Martin JN, Hunt PW. PMID: 28329310.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    12. Efavirenz-metabolizing polymorphisms, viral suppression, and depression in HIV-infected individuals initiating antiretroviral therapy in southwestern Uganda. Open Forum Infectious Diseases. 2017 Jan 1; 4(suppl_1):s430-s431. Jonathan Chang, Sulggi Lee, Peter Hunt, Deanna Kroetz, Mark Siedner. .
      View in: Publisher Site   Mentions:
    13. Immunologic Biomarkers, Morbidity, and Mortality in Treated HIV Infection. J Infect Dis. 2016 Oct 01; 214 Suppl 2:S44-50. Hunt PW, Lee SA, Siedner MJ. PMID: 27625430.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    14. The Benefits of Early Antiretroviral Therapy for HIV Infection: How Early is Early Enough? EBioMedicine. 2016 Sep; 11:7-8. Lee SA, Deeks SG. PMID: 27515690.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy. PLoS One. 2016; 11(8):e0160192. Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman DD, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD. PMID: 27483366.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    16. Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans. AIDS. 2016 07 17; 30(11):1807-15. Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, Mclaren PJ, Mushiroda T, Kubo M, Byakwaga H, Hunt PW, Kroetz DL. PMID: 27088321.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection. J Clin Invest. 2016 07 01; 126(7):2745-56. Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM. PMID: 27322062.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    18. Immunologic profiles distinguish aviremic HIV-infected adults. AIDS. 2016 06 19; 30(10):1553-62. Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW. PMID: 26854811.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Reply to Barrett, et al. Clin Infect Dis. 2016 06 01; 62(11):1468-9. Freeman ML, Mudd JC, Shive CL, Younes SA, Panigrahi S, Sieg SF, Lee SA, Hunt PW, Calabrese LH, Gianella S, Rodriguez B, Lederman MM. PMID: 27001803.
      View in: PubMed   Mentions: 1     Fields:    
    20. Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study. Lancet HIV. 2015 Dec; 2(12):e520-9. Elliott JH, McMahon JH, Chang CC, Lee SA, Hartogensis W, Bumpus N, Savic R, Roney J, Hoh R, Solomon A, Piatak M, Gorelick RJ, Lifson J, Bacchetti P, Deeks SG, Lewin SR. PMID: 26614966.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCellsCTClinical Trials
    21. CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection. Clin Infect Dis. 2016 Feb 01; 62(3):392-6. Freeman ML, Mudd JC, Shive CL, Younes SA, Panigrahi S, Sieg SF, Lee SA, Hunt PW, Calabrese LH, Gianella S, Rodriguez B, Lederman MM. PMID: 26400999.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    22. Highlights from the Keystone Symposium on HIV Persistence 2015: 26-30 April 2015, Boston, Massachusetts, USA. J Virus Erad. 2015 Jul 01; 1(3):225-6. Lee SA. PMID: 27482417.
      View in: PubMed   Mentions:
    23. Bartonella quintana Aortitis in a Man with AIDS, Diagnosed by Needle Biopsy and 16S rRNA Gene Amplification. J Clin Microbiol. 2015 Aug; 53(8):2773-6. Lee SA, Plett SK, Luetkemeyer AF, Borgo GM, Ohliger MA, Conrad MB, Cookson BT, Sengupta DJ, Koehler JE. PMID: 26063867.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    24. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014 May; 10(5):e1004078. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. PMID: 24831517.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansCells
    25. Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. J Infect Dis. 2014 Aug 01; 210(3):374-82. Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW. PMID: 24585893.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    26. Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging. PLoS One. 2014; 9(2):e89444. Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW. PMID: 24586783.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    27. A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort. BMC Med Genet. 2007 Dec 01; 8:72. Lee SA, Haiman CA, Burtt NP, Pooler LC, Cheng I, Kolonel LN, Pike MC, Altshuler D, Hirschhorn JN, Henderson BE, Stram DO. PMID: 18053149.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    28. Chapter 40 Body weight, menopausal hormone therapy, and risk of breast cancer. Treatment of the Postmenopausal Woman. 2007 Jan 1; (J Natl Cancer Inst481972):569-578. Anna H. Wu, C. Leigh Pearce, Darcy V. Spicer, Sulggi Lee, Malalcolm C. Pike. .
      View in: Publisher Site   Mentions:
    29. Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda. J Infect Dis. 2006 Apr 15; 193(8):1160-3. Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G. PMID: 16544257.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    30. Postmenopausal hormone therapy and breast cancer risk: the Multiethnic Cohort. Int J Cancer. 2006 Mar 01; 118(5):1285-91. Lee S, Kolonel L, Wilkens L, Wan P, Henderson B, Pike M. PMID: 16170777.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    31. An overview of menopausal oestrogen-progestin hormone therapy and breast cancer risk. Br J Cancer. 2005 Jun 06; 92(11):2049-58. Lee SA, Ross RK, Pike MC. PMID: 15900297.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
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