Sushama Telwatte, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
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ORCID ORCID Icon0000-0003-4086-5212 Additional info
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    Collapse Education and Training
    Monash University , Melbourne, AustraliaBSc (Hons)11/2008Biomedical Science
    Monash University, Melbourne, AustraliaPh.D09/2015Virology
    San Francisco VA Medical Center, San FranciscoPostdoctoral Studies03/2020Infectious Diseases (HIV)
    University of California, San Francisco, San FranciscoInfectious Diseases (HIV)

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    Collapse Overview
    Dr. Telwatte received her undergraduate degree (Biomedical Science with First Class Honours) and Ph.D in Virology from Monash University in Melbourne, Australia. She undertook her postdoctoral training in the laboratory of Dr. Steven Yukl M.D. Dr. Telwatte is presently an Adjunct Instructor in the Division of Infectious Diseases at the VA and her research focuses on understanding the mechanisms that govern HIV latency and gaining insight into the transcription and replication strategy employed by SARS-CoV-2.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel assays to investigate the mechanisms of latent infection with HIV-2. PLoS One. 2022; 17(4):e0267402. Lu MD, Telwatte S, Kumar N, Ferreira F, Martin HA, Kadiyala GN, Wedrychowski A, Moron-Lopez S, Chen TH, Goecker EA, Coombs RW, Lu CM, Wong JK, Tsibris A, Yukl SA. PMID: 35476802; PMCID: PMC9045618.
      View in: PubMed   Mentions:
    2. Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts. Methods. 2021 Apr 18. Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA. PMID: 33882362; PMCID: PMC8105137.
      View in: PubMed   Mentions:    Fields:    
    3. Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA. J Virol Methods. 2021 06; 292:114115. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. PMID: 33667568; PMCID: PMC7923865.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2. bioRxiv. 2021 Jan 12. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. PMID: 33469579; PMCID: PMC7814816.
      View in: PubMed   Mentions:
    5. Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells. J Virol. 2020 12 22; 95(2). Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. PMID: 33115867; PMCID: PMC7944458.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals. PLoS Pathog. 2020 11; 16(11):e1009060. Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA. PMID: 33253324; PMCID: PMC7728277.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents. AIDS. 2020 11 15; 34(14):2013-2024. Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA. PMID: 32910065; PMCID: PMC7990078.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir. Elife. 2020 09 29; 9. Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR. PMID: 32990219; PMCID: PMC7524554.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    9. Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. PLoS Pathog. 2020 04; 16(4):e1008450. Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. PMID: 32353080; PMCID: PMC7192375.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay. J Acquir Immune Defic Syndr. 2020 04 15; 83(5):530-537. Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM. PMID: 32168200; PMCID: PMC7286563.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. Retrovirology. 2019 11 11; 16(1):32. Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA. PMID: 31711503; PMCID: PMC6849327.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS Pathog. 2018 11; 14(11):e1007357. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. PMID: 30440043; PMCID: PMC6237391.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    13. Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import. Cell Microbiol. 2019 01; 21(1):e12953. Wagstaff KM, Headey S, Telwatte S, Tyssen D, Hearps AC, Thomas DR, Tachedjian G, Jans DA. PMID: 30216959; PMCID: PMC6585680.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing. Sci Transl Med. 2018 02 28; 10(430). Yukl SA, Kaiser P, Kim P, Telwatte S, Joshi SK, Vu M, Lampiris H, Wong JK. PMID: 29491188; PMCID: PMC5959841.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    15. Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S40-S58. Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S. PMID: 28882067; PMCID: PMC5685216.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. PMID: 28882052; PMCID: PMC5684666.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    17. Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase. AIDS. 2016 11 28; 30(18):2787-2793. Telwatte S, Brumme CJ, Hearps AC, Latham CF, Hayward JA, Sonza S, Sluis-Cremer N, Harrigan PR, Tachedjian G. PMID: 27677159.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations. Nucleic Acids Res. 2015 Mar 31; 43(6):3256-71. Telwatte S, Hearps AC, Johnson A, Latham CF, Moore K, Agius P, Tachedjian M, Sonza S, Sluis-Cremer N, Harrigan PR, Tachedjian G. PMID: 25765644; PMCID: PMC4381058.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1. Antiviral Res. 2011 Jun; 90(3):195-9. Telwatte S, Moore K, Johnson A, Tyssen D, Sterjovski J, Aldunate M, Gorry PR, Ramsland PA, Lewis GR, Paull JR, Sonza S, Tachedjian G. PMID: 21459115; PMCID: PMC3115201.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
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