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Svetlana Kholodar, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentPharmaceutical Chemistry
Address600 16th St
San Francisco CA 94158
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    1. Kholodar SA, Ghosh AK, Swiderek K, Moliner V, Kohen A. Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools. Proc Natl Acad Sci U S A. 2018 Sep 24. PMID: 30249644.
      View in: PubMed
    2. Kholodar SA, Ghosh AK, Kohen A. Measurement of Enzyme Isotope Effects. Methods Enzymol. 2017; 596:43-83. PMID: 28911779.
      View in: PubMed
    3. Kholodar SA, Kohen A. Noncovalent Intermediate of Thymidylate Synthase: Fact or Fiction? J Am Chem Soc. 2016 Jul 06; 138(26):8056-9. PMID: 27327197; PMCID: PMC4957585 [Available on 07/06/17].
    4. Kholodar SA, Allen CL, Gulick AM, Murkin AS. The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces. J Am Chem Soc. 2015 Feb 25; 137(7):2748-56. PMID: 25642788; PMCID: PMC4507815.
    5. Murkin AS, Manning KA, Kholodar SA. Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorg Chem. 2014 Dec; 57:171-85. PMID: 24998420.
      View in: PubMed
    6. Kholodar SA, Tombline G, Liu J, Tan Z, Allen CL, Gulick AM, Murkin AS. Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin. Biochemistry. 2014 Jun 03; 53(21):3423-31. PMID: 24825256; PMCID: PMC4045324.
    7. Kholodar SA, Novopashina DS, Meschaninova MI, Venyaminova AG. Multipyrene tandem probes for point mutations detection in DNA. J Nucleic Acids. 2013; 2013:860457. PMID: 24455205; PMCID: PMC3886547.
    8. Kholodar SA, Murkin AS. DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group. Biochemistry. 2013 Apr 02; 52(13):2302-8. PMID: 23473304.
      View in: PubMed
    9. Kholodar SA, Novopashina DS, Meschaninova MI, Lomzov AA, Venyaminova AG. Multipyrene tandem probes for detection of C677T polymorphism in MTHFR gene. Nucleic Acids Symp Ser (Oxf). 2009; (53):143-4. PMID: 19749301.
      View in: PubMed
    10. Novopashina DS, Meschaninova MI, Kholodar SA, Lomzov AA, Venyaminova AG. New eximer-based tandem systems for SNP detection. Nucleic Acids Symp Ser (Oxf). 2008; (52):229-30. PMID: 18776337.
      View in: PubMed
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