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Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1. ACS Chem Biol. 2021 Jul 16; 16(7):1159-1163.
Kholodar SA, Lang G, Cortopassi WA, Iizuka Y, Brah HS, Jacobson MP, England PM. PMID: 34165961.
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Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry. 2021 Apr 08.
Kholodar SA, Finer-Moore JS, Swiderek K, Arafet K, Moliner V, Stroud RM, Kohen A. PMID: 33829766.
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Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chem Biol. 2019 05 16; 26(5):674-685.e6.
Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM. PMID: 30853418.
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7 Fields:
Translation:
HumansAnimalsCells
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Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10311-10314.
Kholodar SA, Ghosh AK, Swiderek K, Moliner V, Kohen A. PMID: 30249644.
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Cells
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Measurement of Enzyme Isotope Effects. Methods Enzymol. 2017; 596:43-83.
Kholodar SA, Ghosh AK, Kohen A. PMID: 28911779.
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7 Fields:
Translation:
Cells
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Noncovalent Intermediate of Thymidylate Synthase: Fact or Fiction? J Am Chem Soc. 2016 07 06; 138(26):8056-9.
Kholodar SA, Kohen A. PMID: 27327197.
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4 Fields:
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HumansCells
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The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces. J Am Chem Soc. 2015 Feb 25; 137(7):2748-56.
Kholodar SA, Allen CL, Gulick AM, Murkin AS. PMID: 25642788.
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12 Fields:
Translation:
Cells
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Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorg Chem. 2014 Dec; 57:171-185.
Murkin AS, Manning KA, Kholodar SA. PMID: 24998420.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin. Biochemistry. 2014 Jun 03; 53(21):3423-31.
Kholodar SA, Tombline G, Liu J, Tan Z, Allen CL, Gulick AM, Murkin AS. PMID: 24825256.
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3 Fields:
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Cells
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Multipyrene tandem probes for point mutations detection in DNA. J Nucleic Acids. 2013; 2013:860457.
Kholodar SA, Novopashina DS, Meschaninova MI, Venyaminova AG. PMID: 24455205.
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DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group. Biochemistry. 2013 Apr 02; 52(13):2302-8.
Kholodar SA, Murkin AS. PMID: 23473304.
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14 Fields:
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Cells
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Multipyrene tandem probes for detection of C677T polymorphism in MTHFR gene. Nucleic Acids Symp Ser (Oxf). 2009; (53):143-4.
Kholodar SA, Novopashina DS, Meschaninova MI, Lomzov AA, Venyaminova AG. PMID: 19749301.
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2 Fields:
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Oligo(2'-O-methylribonucleotides) and their derivatives: III. 5'-Mono- and 5'-bispyrenyl derivatives of oligo(2'-O-methylribonucleotides) and their 3'-modified analogues: Synthesis and properties. Russian Journal of Bioorganic Chemistry. 2008 Sep 1; 34(5):602.
D. S. Novopashina, O. S. Totskaya, S. A. Kholodar’, M. I. Meshchaninova, A. G. Ven’yaminova. .
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New eximer-based tandem systems for SNP detection. Nucleic Acids Symp Ser (Oxf). 2008; (52):229-30.
Novopashina DS, Meschaninova MI, Kholodar SA, Lomzov AA, Venyaminova AG. PMID: 18776337.
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PubMed Mentions:
2 Fields:
Translation:
Cells