Tack Kuntz, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address600 16th Street, #N472D
San Francisco CA 94158
vCardDownload vCard

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Structure Biology and Targeted Drug Design for AIDS
    NIH P01GM056531Sep 1, 1997 - Aug 31, 2007
    Role: Co-Investigator
    Molecular Biophysics Training Grant
    NIH T32GM008284Sep 30, 1988 - Jun 30, 2023
    Role: Principal Investigator
    NIH P01GM039552Sep 1, 1987 - Aug 31, 1997
    Role: Co-Investigator
    NIH U09RG014287Jul 1, 1984 - Jun 30, 1991
    Role: Principal Investigator
    NIH R24RR001695Jun 1, 1984 - Nov 30, 1994
    Role: Principal Investigator
    NIH R01GM031497Mar 1, 1983 - Jun 30, 2003
    Role: Principal Investigator
    NIH R01GM029072Feb 1, 1982 - Jan 31, 2005
    Role: Principal Investigator
    NIH R01GM019267Dec 1, 1977 - Jan 31, 1992
    Role: Principal Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. DOCK 6: Impact of new features and current docking performance. J Comput Chem. 2015 Jun 05; 36(15):1132-56. Allen WJ, Balius TE, Mukherjee S, Brozell SR, Moustakas DT, Lang PT, Case DA, Kuntz ID, Rizzo RC. PMID: 25914306; PMCID: PMC4469538.
      View in: PubMed   Mentions: 242     Fields:    Translation:Cells
    2. Darwinian docking. J Comput Aided Mol Des. 2012 Jan; 26(1):73-5. Kuntz ID. PMID: 22143893.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. DOCK 6: combining techniques to model RNA-small molecule complexes. RNA. 2009 Jun; 15(6):1219-30. Lang PT, Brozell SR, Mukherjee S, Pettersen EF, Meng EC, Thomas V, Rizzo RC, Case DA, James TL, Kuntz ID. PMID: 19369428; PMCID: PMC2685511.
      View in: PubMed   Mentions: 260     Fields:    Translation:Cells
    4. Computational investigation of kinetics of cross-linking reactions in proteins: importance in structure prediction. Biopolymers. 2009 Jan; 91(1):68-77. Bandyopadhyay P, Kuntz ID. PMID: 18781627.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. The collaboratory for MS3D: a new cyberinfrastructure for the structural elucidation of biological macromolecules and their assemblies using mass spectrometry-based approaches. J Proteome Res. 2008 Nov; 7(11):4848-57. Yu ET, Hawkins A, Kuntz ID, Rahn LA, Rothfuss A, Sale K, Young MM, Yang CL, Pancerella CM, Fabris D. PMID: 18817429; PMCID: PMC2677910.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    6. Partial acetylation of lysine residues improves intraprotein cross-linking. Anal Chem. 2008 Feb 15; 80(4):951-60. Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK, Kuntz ID, Gibson BW. PMID: 18201069.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    7. Development and validation of a modular, extensible docking program: DOCK 5. J Comput Aided Mol Des. 2006 Oct-Nov; 20(10-11):601-19. Moustakas DT, Lang PT, Pegg S, Pettersen E, Kuntz ID, Brooijmans N, Rizzo RC. PMID: 17149653.
      View in: PubMed   Mentions: 126     Fields:    Translation:Cells
    8. Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions. Bioorg Med Chem Lett. 2007 Jan 15; 17(2):549-52. Fujii N, Haresco JJ, Novak KA, Gage RM, Pedemonte N, Stokoe D, Kuntz ID, Guy RK. PMID: 17055267.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    9. Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors. J Comb Chem. 2006 May-Jun; 8(3):315-25. Lu F, Chi SW, Kim DH, Han KH, Kuntz ID, Guy RK. PMID: 16677000.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    10. Estimation of Absolute Free Energies of Hydration Using Continuum Methods:  Accuracy of Partial Charge Models and Optimization of Nonpolar Contributions. J Chem Theory Comput. 2006 Jan; 2(1):128-39. Rizzo RC, Aynechi T, Case DA, Kuntz ID. PMID: 26626387.
      View in: PubMed   Mentions: 54     Fields:    
    11. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18700-5. Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. PMID: 16344478; PMCID: PMC1311738.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    12. An information theoretic approach to macromolecular modeling: I. Sequence alignments. Biophys J. 2005 Nov; 89(5):2998-3007. Aynechi T, Kuntz ID. PMID: 16254389; PMCID: PMC1366797.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    13. An information theoretic approach to macromolecular modeling: II. Force fields. Biophys J. 2005 Nov; 89(5):3008-16. Aynechi T, Kuntz ID. PMID: 16254390; PMCID: PMC1366798.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    14. Evaluating the high-throughput screening computations. J Biomol Screen. 2005 Oct; 10(7):649-52. Lang PT, Kuntz ID, Maggiora GM, Bajorath J. PMID: 16170047.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    15. Hierarchical database screenings for HIV-1 reverse transcriptase using a pharmacophore model, rigid docking, solvation docking, and MM-PB/SA. J Med Chem. 2005 Apr 07; 48(7):2432-44. Wang J, Kang X, Kuntz ID, Kollman PA. PMID: 15801834.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    16. Photochemically knocking out glutamate receptors in vivo. J Am Chem Soc. 2004 Nov 03; 126(43):13886-7. Chambers JJ, Gouda H, Young DM, Kuntz ID, England PM. PMID: 15506725.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. SitePrint: three-dimensional pharmacophore descriptors derived from protein binding sites for family based active site analysis, classification, and drug design. J Chem Inf Comput Sci. 2004 Nov-Dec; 44(6):2190-8. Arnold JR, Burdick KW, Pegg SC, Toba S, Lamb ML, Kuntz ID. PMID: 15554689.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. Distributions in protein conformation space: implications for structure prediction and entropy. Biophys J. 2004 Jul; 87(1):113-20. Sullivan DC, Kuntz ID. PMID: 15240450; PMCID: PMC1304334.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    19. Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress. Antimicrob Agents Chemother. 2004 Jul; 48(7):2424-30. Koshkin A, Zhou XT, Kraus CN, Brenner JM, Bandyopadhyay P, Kuntz ID, Barry CE, Ortiz de Montellano PR. PMID: 15215090; PMCID: PMC434156.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    20. Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes. J Med Chem. 2004 Jul 01; 47(14):3572-9. Verras A, Kuntz ID, Ortiz de Montellano PR. PMID: 15214784.
      View in: PubMed   Mentions: 12     Fields:    
    21. A molecular basis for the selectivity of thiadiazole urea inhibitors with stromelysin-1 and gelatinase-A from generalized born molecular dynamics simulations. J Med Chem. 2004 Jun 03; 47(12):3065-74. Rizzo RC, Toba S, Kuntz ID. PMID: 15163188.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    22. Calculation of ligand-nucleic acid binding free energies with the generalized-born model in DOCK. Biopolymers. 2004 Feb 05; 73(2):192-204. Kang X, Shafer RH, Kuntz ID. PMID: 14755577.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    23. Investigation of neuraminidase-substrate recognition using molecular dynamics and free energy calculations. J Med Chem. 2003 Dec 18; 46(26):5628-37. Masukawa KM, Kollman PA, Kuntz ID. PMID: 14667217.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    24. A selective irreversible inhibitor targeting a PDZ protein interaction domain. J Am Chem Soc. 2003 Oct 08; 125(40):12074-5. Fujii N, Haresco JJ, Novak KA, Stokoe D, Kuntz ID, Guy RK. PMID: 14518976.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    25. Direct hydroxide attack is a plausible mechanism for amidase antibody 43C9. J Comput Chem. 2003 Sep; 24(12):1371-7. Chong LT, Bandyopadhyay P, Scanlan TS, Kuntz ID, Kollman PA. PMID: 12868101.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    26. Information content of molecular structures. Biophys J. 2003 Jul; 85(1):174-90. Sullivan DC, Aynechi T, Voelz VA, Kuntz ID. PMID: 12829474; PMCID: PMC1303075.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    27. Molecular recognition and docking algorithms. Annu Rev Biophys Biomol Struct. 2003; 32:335-73. Brooijmans N, Kuntz ID. PMID: 12574069.
      View in: PubMed   Mentions: 164     Fields:    Translation:Cells
    28. Free energy calculations for theophylline binding to an RNA aptamer: Comparison of MM-PBSA and thermodynamic integration methods. Biopolymers. 2003 Jan; 68(1):16-34. Gouda H, Kuntz ID, Case DA, Kollman PA. PMID: 12579577.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    29. Assessment of the role of computations in structural biology. Adv Protein Chem. 2003; 66:1-25. Kuntz ID, Agard DA. PMID: 14631815.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Principles and methods of docking and ligand design. Methods Biochem Anal. 2003; 44:443-76. Krumrine J, Raubacher F, Brooijmans N, Kuntz I. PMID: 12647399.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    31. A novel mechanism for inhibition of HIV-1 reverse transcriptase. Bioorg Chem. 2002 Dec; 30(6):443-58. Skillman AG, Maurer KW, Roe DC, Stauber MJ, Eargle D, Ewing TJ, Muscate A, Davioud-Charvet E, Medaglia MV, Fisher RJ, Arnold E, Gao HQ, Buckheit R, Boyer PL, Hughes SH, Kuntz ID, Kenyon GL. PMID: 12642128.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    32. Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design. Chem Biol. 2002 Oct; 9(10):1085-94. Greenbaum DC, Arnold WD, Lu F, Hayrapetian L, Baruch A, Krumrine J, Toba S, Chehade K, Brömme D, Kuntz ID, Bogyo M. PMID: 12401493.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    33. Stability of macromolecular complexes. Proteins. 2002 Sep 01; 48(4):645-53. Brooijmans N, Sharp KA, Kuntz ID. PMID: 12211032.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    34. Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. J Biol Chem. 2002 Jul 19; 277(29):26623-31. Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS. PMID: 11959867.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    35. Molecular dynamics and free energy analyses of cathepsin D-inhibitor interactions: insight into structure-based ligand design. J Med Chem. 2002 Mar 28; 45(7):1412-9. Huo S, Wang J, Cieplak P, Kollman PA, Kuntz ID. PMID: 11906282.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    36. A genetic algorithm for structure-based de novo design. J Comput Aided Mol Des. 2001 Oct; 15(10):911-33. Pegg SC, Haresco JJ, Kuntz ID. PMID: 11918076.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    37. Virtual screening of combinatorial libraries across a gene family: in search of inhibitors of Giardia lamblia guanine phosphoribosyltransferase. Antimicrob Agents Chemother. 2001 Sep; 45(9):2571-6. Aronov AM, Munagala NR, Kuntz ID, Wang CC. PMID: 11502531; PMCID: PMC90694.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    38. Definition of the extended substrate specificity determinants for beta-tryptases I and II. J Biol Chem. 2001 Sep 14; 276(37):34941-7. Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS. PMID: 11438529.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    39. DOCK 4.0: search strategies for automated molecular docking of flexible molecule databases. J Comput Aided Mol Des. 2001 May; 15(5):411-28. Ewing TJ, Makino S, Skillman AG, Kuntz ID. PMID: 11394736.
      View in: PubMed   Mentions: 320     Fields:    Translation:Cells
    40. Conformation spaces of proteins. Proteins. 2001 Mar 01; 42(4):495-511. Sullivan DC, Kuntz ID. PMID: 11170204.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    41. Design, docking, and evaluation of multiple libraries against multiple targets. Proteins. 2001 Feb 15; 42(3):296-318. Lamb ML, Burdick KW, Toba S, Young MM, Skillman AG, Zou X, Arnold JR, Kuntz ID. PMID: 11151003.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    42. High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5802-6. Young MM, Tang N, Hempel JC, Oshiro CM, Taylor EW, Kuntz ID, Gibson BW, Dollinger G. PMID: 10811876; PMCID: PMC18514.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    43. Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase. Biochemistry. 2000 Apr 25; 39(16):4684-91. Aronov AM, Munagala NR, Ortiz De Montellano PR, Kuntz ID, Wang CC. PMID: 10769124.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    44. Inhibitors of kinesin activity from structure-based computer screening. Biochemistry. 2000 Mar 14; 39(10):2805-14. Hopkins SC, Vale RD, Kuntz ID. PMID: 10704233.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    45. DREAM++: flexible docking program for virtual combinatorial libraries. J Comput Aided Mol Des. 1999 Sep; 13(5):513-32. Makino S, Ewing TJ, Kuntz ID. PMID: 10483532.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    46. The maximal affinity of ligands. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):9997-10002. Kuntz ID, Chen K, Sharp KA, Kollman PA. PMID: 10468550; PMCID: PMC17830.
      View in: PubMed   Mentions: 199     Fields:    Translation:Cells
    47. Flexible ligand docking: a multistep strategy approach. Proteins. 1999 Jul 01; 36(1):1-19. Wang J, Kollman PA, Kuntz ID. PMID: 10373002.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    48. Macromolecular docking of a three-body system: the recognition of human growth hormone by its receptor. Protein Sci. 1999 May; 8(5):1010-22. Hendrix DK, Klein TE, Kuntz ID, Klien TE. PMID: 10338012; PMCID: PMC2144328.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    49. A rapid method for exploring the protein structure universe. Proteins. 1999 Feb 15; 34(3):317-32. Young MM, Skillman AG, Kuntz ID. PMID: 10024019.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    50. Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 1999 Feb 02; 38(5):1607-17. Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. PMID: 9931028.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    51. CombiDOCK: structure-based combinatorial docking and library design. J Comput Aided Mol Des. 1998 Nov; 12(6):597-604. Sun Y, Ewing TJ, Skillman AG, Kuntz ID. PMID: 9879507.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    52. Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan. Biochemistry. 1998 Apr 21; 37(16):5344-8. Somoza JR, Skillman AG, Munagala NR, Oshiro CM, Knegtel RM, Mpoke S, Fletterick RJ, Kuntz ID, Wang CC. PMID: 9548915.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    53. Characterization of receptors with a new negative image: use in molecular docking and lead optimization. Proteins. 1998 Feb 15; 30(3):321-36. Oshiro CM, Kuntz ID. PMID: 9517547.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    54. Surface solid angle-based site points for molecular docking. Pac Symp Biocomput. 1998; 317-26. Hendrix DK, Kuntz ID. PMID: 9697192.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    55. Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Exp Parasitol. 1997 Nov; 87(3):212-21. Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari JA, Cohen FE, McKerrow JH. PMID: 9371086.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    56. Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor. Bioorg Med Chem. 1997 Nov; 5(11):2019-27. Caldera PS, Yu Z, Knegtel RM, McPhee F, Burlingame AL, Craik CS, Kuntz ID, Ortiz de Montellano PR. PMID: 9416419.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    57. Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity. J Virol. 1997 Nov; 71(11):8808-20. Hoffman LR, Kuntz ID, White JM. PMID: 9343241; PMCID: PMC192347.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    58. Structure-based discovery of ligands targeted to the RNA double helix. Biochemistry. 1997 Sep 23; 36(38):11402-7. Chen Q, Shafer RH, Kuntz ID. PMID: 9298959.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    59. Specificity in structure-based drug design: identification of a novel, selective inhibitor of Pneumocystis carinii dihydrofolate reductase. Proteins. 1997 Sep; 29(1):59-67. Gschwend DA, Sirawaraporn W, Santi DV, Kuntz ID. PMID: 9294866.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    60. Molecular docking to ensembles of protein structures. J Mol Biol. 1997 Feb 21; 266(2):424-40. Knegtel RM, Kuntz ID, Oshiro CM. PMID: 9047373.
      View in: PubMed   Mentions: 89     Fields:    Translation:Cells
    61. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro. Biochem J. 1996 Dec 01; 320 ( Pt 2):681-6. McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. PMID: 8973584; PMCID: PMC1217983.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    62. Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11477-81. McPhee F, Good AC, Kuntz ID, Craik CS. PMID: 8876160; PMCID: PMC56635.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    63. Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):2635-9. Chen Q, Kuntz ID, Shafer RH. PMID: 8610093; PMCID: PMC39682.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    64. Orientational sampling and rigid-body minimization in molecular docking revisited: on-the-fly optimization and degeneracy removal. J Comput Aided Mol Des. 1996 Apr; 10(2):123-32. Gschwend DA, Kuntz ID. PMID: 8741016.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    65. Molecular docking towards drug discovery. J Mol Recognit. 1996 Mar-Apr; 9(2):175-86. Gschwend DA, Good AC, Kuntz ID. PMID: 8877811.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    66. Conformational switching in designed peptides: the helix/sheet transition. Fold Des. 1996; 1(2):91-101. Cerpa R, Cohen FE, Kuntz ID. PMID: 9079369.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    67. Solution structure of the GTPase activating domain of alpha s. J Mol Biol. 1995 Dec 08; 254(4):681-91. Benjamin DR, Markby DW, Bourne HR, Kuntz ID. PMID: 7500342.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    68. Modeled structure of the 75-kDa neurotrophin receptor. Protein Sci. 1995 Sep; 4(9):1696-707. Chapman BS, Kuntz ID. PMID: 8528068; PMCID: PMC2143228.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    69. Investigating the extension of pairwise distance pharmacophore measures to triplet-based descriptors. J Comput Aided Mol Des. 1995 Aug; 9(4):373-9. Good AC, Kuntz ID. PMID: 8523046.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    70. BUILDER v.2: improving the chemistry of a de novo design strategy. J Comput Aided Mol Des. 1995 Jun; 9(3):269-82. Roe DC, Kuntz ID. PMID: 7561978.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    71. Flexible ligand docking using a genetic algorithm. J Comput Aided Mol Des. 1995 Apr; 9(2):113-30. Oshiro CM, Kuntz ID, Dixon JS. PMID: 7608743.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    72. New molecular shape descriptors: application in database screening. J Comput Aided Mol Des. 1995 Feb; 9(1):1-12. Good AC, Ewing TJ, Gschwend DA, Kuntz ID. PMID: 7751866.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    73. Complete 1H, 13C, and 15N assignments and secondary structure of the GTPase activating domain of Gs. Biochemistry. 1995 Jan 10; 34(1):155-62. Benjamin DR, Markby DW, Bourne HR, Kuntz ID. PMID: 7819191.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    74. Finding potential DNA-binding compounds by using molecular shape. J Comput Aided Mol Des. 1994 Dec; 8(6):731-50. Grootenhuis PD, Roe DC, Kollman PA, Kuntz ID. PMID: 7738607.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    75. Evaluating docked complexes with the HINT exponential function and empirical atomic hydrophobicities. J Comput Aided Mol Des. 1994 Jun; 8(3):299-306. Meng EC, Kuntz ID, Abraham DJ, Kellogg GE. PMID: 7964929.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    76. Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor. J Cell Biol. 1993 Dec; 123(5):1149-60. Aroeti B, Kosen PA, Kuntz ID, Cohen FE, Mostov KE. PMID: 8245123; PMCID: PMC2119873.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    77. Orientational sampling and rigid-body minimization in molecular docking. Proteins. 1993 Nov; 17(3):266-78. Meng EC, Gschwend DA, Blaney JM, Kuntz ID. PMID: 8272425.
      View in: PubMed   Mentions: 24     Fields:    
    78. Matching chemistry and shape in molecular docking. Protein Eng. 1993 Sep; 6(7):723-32. Shoichet BK, Kuntz ID. PMID: 7504257.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    79. Novel heteronuclear methods of assignment transfer from a diamagnetic to a paramagnetic protein: application to rat cytochrome b5. Biochemistry. 1993 Aug 17; 32(32):8329-40. Guiles RD, Basus VJ, Sarma S, Malpure S, Fox KM, Kuntz ID, Waskell L. PMID: 8347629.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    80. Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design. J Biol Chem. 1993 Jul 25; 268(21):15343-6. Rutenber E, Fauman EB, Keenan RJ, Fong S, Furth PS, Ortiz de Montellano PR, Meng E, Kuntz ID, DeCamp DL, Salto R, et al. PMID: 8340363.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    81. Structure-based inhibitor design by using protein models for the development of antiparasitic agents. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3583-7. Ring CS, Sun E, McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, Cohen FE. PMID: 8475107; PMCID: PMC46345.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    82. Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones. Biochemistry. 1993 Mar 30; 32(12):2967-78. Bodian DL, Yamasaki RB, Buswell RL, Stearns JF, White JM, Kuntz ID. PMID: 8457561.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    83. Structure-based discovery of inhibitors of thymidylate synthase. Science. 1993 Mar 05; 259(5100):1445-50. Shoichet BK, Stroud RM, Santi DV, Kuntz ID, Perry KM. PMID: 8451640.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    84. A fast and efficient method for 2D and 3D molecular shape description. J Comput Aided Mol Des. 1992 Dec; 6(6):607-28. Bemis GW, Kuntz ID. PMID: 1291629.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    85. Sequence-specific 1H and 15N resonance assignments for both equilibrium forms of the soluble heme binding domain of rat ferrocytochrome b5. Biochemistry. 1992 Nov 24; 31(46):11365-75. Guiles RD, Basus VJ, Kuntz ID, Waskell L. PMID: 1332756.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    86. Structure-based strategies for drug design and discovery. Science. 1992 Aug 21; 257(5073):1078-82. Kuntz ID. PMID: 1509259.
      View in: PubMed   Mentions: 179     Fields:    Translation:Cells
    87. Disulfide bond-coupled folding of bovine pancreatic trypsin inhibitor derivatives missing one or two disulfide bonds. Biochemistry. 1992 Jun 30; 31(25):5705-17. Kosen PA, Marks CB, Falick AM, Anderson S, Kuntz ID. PMID: 1377024.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    88. Automated site-directed drug design using molecular lattices. J Mol Graph. 1992 Jun; 10(2):66-78, 106. Lewis RA, Roe DC, Huang C, Ferrin TE, Langridge R, Kuntz ID. PMID: 1637751.
      View in: PubMed   Mentions: 23     Fields:    
    89. Comparison of solution structures of mutant bovine pancreatic trypsin inhibitor proteins using two-dimensional nuclear magnetic resonance. Protein Sci. 1992 Jan; 1(1):91-106. Hurle MR, Eads CD, Pearlman DA, Seibel GL, Thomason J, Kosen PA, Kollman P, Anderson S, Kuntz ID. PMID: 1284804; PMCID: PMC2142081.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    90. Protein docking and complementarity. J Mol Biol. 1991 Sep 05; 221(1):327-46. Shoichet BK, Kuntz ID. PMID: 1920412.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    91. A molecular dynamics simulation of polyalanine: an analysis of equilibrium motions and helix-coil transitions. Biopolymers. 1991 Aug; 31(9):1115-34. Daggett V, Kollman PA, Kuntz ID. PMID: 1786342.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    92. Intracellular expression of BPTI fusion proteins and single column cleavage/affinity purification by chymotrypsin. Protein Eng. 1991 Jun; 4(5):593-600. Altman JD, Henner D, Nilsson B, Anderson S, Kuntz ID. PMID: 1716367.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    93. Confirmation of the predicted source of a slow folding reaction: proline 8 of bovine pancreatic trypsin inhibitor. Protein Eng. 1991 Apr; 4(4):451-5. Hurle MR, Anderson S, Kuntz ID. PMID: 1881870.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    94. Molecular dynamics simulations of small peptides: dependence on dielectric model and pH. Biopolymers. 1991 Feb 15; 31(3):285-304. Daggett V, Kollman PA, Kuntz ID. PMID: 1868159.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    95. Structure-based inhibition of HIV-1 protease activity and viral infectivity. Adv Exp Med Biol. 1991; 306:489-92. DeCamp DL, Babé LM, Furth P, Ortiz de Montellano P, Kuntz ID, Craik CS. PMID: 1812747.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    96. Studies of synthetic helical peptides using circular dichroism and nuclear magnetic resonance. J Mol Biol. 1990 Oct 20; 215(4):607-22. Bradley EK, Thomason JF, Cohen FE, Kosen PA, Kuntz ID. PMID: 2231722.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    97. Removal of a proteolytic activity associated with aggregates formed from expression of creatine kinase in Escherichia coli leads to improved recovery of active enzyme. Biotechnology (N Y). 1990 Oct; 8(10):945-9. Babbitt PC, West BL, Buechter DD, Kuntz ID, Kenyon GL. PMID: 1370005.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    98. Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6644-8. DesJarlais RL, Seibel GL, Kuntz ID, Furth PS, Alvarez JC, Ortiz de Montellano PR, DeCamp DL, Babé LM, Craik CS. PMID: 2204060; PMCID: PMC54593.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    99. Computerized selection of potential DNA binding compounds. Anticancer Drug Des. 1990 Aug; 5(3):237-42. Grootenhuis PD, Kollman PA, Seibel GL, DesJarlais RL, Kuntz ID. PMID: 2169249.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    100. Denaturant-dependent folding of bovine pancreatic trypsin inhibitor mutants with two intact disulfide bonds. Biochemistry. 1990 May 08; 29(18):4410-9. Hurle MR, Marks CB, Kosen PA, Anderson S, Kuntz ID. PMID: 1693524.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    101. Structural studies of cytochrome b5: complete sequence-specific resonance assignments for the trypsin-solubilized microsomal ferrocytochrome b5 obtained from pig and calf. Biochemistry. 1990 Feb 06; 29(5):1276-89. Guiles RD, Altman J, Kuntz ID, Waskell L, Lipka JJ. PMID: 2322562.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    102. Identification by proton nuclear magnetic resonance of the histidines in cytochrome b5 modified by diethyl pyrocarbonate. Biochemistry. 1989 Sep 19; 28(19):7516-23. Altman J, Lipka JJ, Kuntz I, Waskell L. PMID: 2558710.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    103. Protein structure predictions: new theoretical approaches. Prog Clin Biol Res. 1989; 289:75-85. Cohen FE, Gregoret L, Presnell SR, Kuntz ID. PMID: 2657754.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    104. Structural studies of alpha-bungarotoxin. 1. Sequence-specific 1H NMR resonance assignments. Biochemistry. 1988 Apr 19; 27(8):2763-71. Basus VJ, Billeter M, Love RA, Stroud RM, Kuntz ID. PMID: 3401447.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    105. Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure. J Med Chem. 1988 Apr; 31(4):722-9. DesJarlais RL, Sheridan RP, Seibel GL, Dixon JS, Kuntz ID, Venkataraghavan R. PMID: 3127588.
      View in: PubMed   Mentions: 88     Fields:    Translation:Cells
    106. Protein-ligand dynamics. A 96 picosecond simulation of a myoglobin-xenon complex. J Mol Biol. 1988 Jan 05; 199(1):195-211. Tilton RF, Singh UC, Kuntz ID, Kollman PA. PMID: 3351919.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    107. Macromolecular structure in solution. Protein Eng. 1987 Jun; 1(3):147-8. Kuntz ID. PMID: 3507700.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    108. Thermal expansion of a protein. Biochemistry. 1987 Jan 13; 26(1):254-61. Frauenfelder H, Hartmann H, Karplus M, Kuntz ID, Kuriyan J, Parak F, Petsko GA, Ringe D, Tilton RF, Connolly ML, et al. PMID: 3828301.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    109. Prediction of the three-dimensional structure of human growth hormone. Proteins. 1987; 2(2):162-6. Cohen FE, Kuntz ID. PMID: 3447173.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    110. Computational studies of the interaction of myoglobin and xenon. J Mol Biol. 1986 Nov 20; 192(2):443-56. Tilton RF, Singh UC, Weiner SJ, Connolly ML, Kuntz ID, Kollman PA, Max N, Case DA. PMID: 3560222.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    111. Cavities in proteins: structure of a metmyoglobin-xenon complex solved to 1.9 A. Biochemistry. 1984 Jun 19; 23(13):2849-57. Tilton RF, Kuntz ID, Petsko GA. PMID: 6466620.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    112. Nuclear magnetic resonance studies of xenon-129 with myoglobin and hemoglobin. Biochemistry. 1982 Dec 21; 21(26):6850-7. Tilton RF, Kuntz ID. PMID: 7159568.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    113. Hydration of proteins and polypeptides. Adv Protein Chem. 1974; 28:239-345. Kuntz ID, Kauzmann W. PMID: 4598824.
      View in: PubMed   Mentions: 145     Fields:    Translation:Cells
    114. Hydration of macromolecules. II. Effects of urea on protein hydration. Arch Biochem Biophys. 1971 Feb; 142(2):660-4. Kuntz ID, Brassfield TS. PMID: 5550166.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    115. Hydration of macromolecules. Science. 1969 Mar 21; 163(3873):1329-31. Kuntz ID, Brassfield TS, Law GD, Purcell GV. PMID: 5765111.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    Tack's Networks
    Concepts (442)
    Derived automatically from this person's publications.
    Co-Authors (17)
    People in Profiles who have published with this person.
    Similar People (60)
    People who share similar concepts with this person.
    Same Department
    Search Department