Takashi Mikawa, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Collapse Research 
    Collapse Research Activities and Funding
    Induction and Patterning of Cardiogenic Fields
    NIH R01HL153736Aug 28, 2020 - May 31, 2024
    Role: Principal Investigator
    Development of Vascular Smooth Muscle Stem Cell Niche
    NIH R01HL148125Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Atrioventricular Junction Development
    NIH R01HL132832Aug 1, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Heart Field Development
    NIH R01HL122375Apr 10, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Cardiac Pacemaker Development
    NIH R01HL112268Dec 2, 2011 - Nov 30, 2016
    Role: Principal Investigator
    Vascular Differentiation and Patterning
    NIH R01HL092429Dec 1, 2008 - Nov 30, 2012
    Role: Principal Investigator
    Cardiac Conduction System Development
    NIH R01HL093566Jul 1, 2008 - Jun 30, 2013
    Role: Principal Investigator
    Coronary Vascular Cell Development
    NIH R37HL078921Dec 15, 2004 - Nov 30, 2020
    Role: Principal Investigator
    NIH R01HL078921Dec 15, 2004 - Nov 30, 2009
    Role: Principal Investigator
    NIH R01HL076242Apr 1, 2004 - Feb 28, 2009
    Role: Principal Investigator
    Molecular Regulation of Coronary Vessel Development
    NIH P01HL067105May 1, 2001 - Apr 30, 2008
    Role: Co-Investigator
    NIH R01HL062175Apr 1, 1999 - Mar 31, 2009
    Role: Principal Investigator
    NIH R01HL054128Aug 1, 1996 - Jul 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Avians as a Model System of Vascular Development. Methods Mol Biol. 2021; 2206:103-127. Asai R, Bressan M, Mikawa T. PMID: 32754814.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Programmed cell death along the midline axis patterns ipsilaterality in gastrulation. Science. 2020 01 10; 367(6474):197-200. Maya-Ramos L, Mikawa T. PMID: 31919222.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12235-E12244. Hua LL, Mikawa T. PMID: 30530674.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. Body Cavity Development Is Guided by Morphogen Transfer between Germ Layers. Cell Rep. 2018 08 07; 24(6):1456-1463. Schlueter J, Mikawa T. PMID: 30089257.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    5. Dynamic Cellular Integration Drives Functional Assembly of the Heart's Pacemaker Complex. Cell Rep. 2018 05 22; 23(8):2283-2291. Bressan M, Henley T, Louie JD, Liu G, Christodoulou D, Bai X, Taylor J, Seidman CE, Seidman JG, Mikawa T. PMID: 29791840.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol. 2018 12 01; 444 Suppl 1:S252-S261. Genuth MA, Allen CDC, Mikawa T, Weiner OD. PMID: 29501457.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. Chromosome Painting of Mouse Chromosomes. Methods Mol Biol. 2018; 1752:133-143. Hua LL, Mikawa T. PMID: 29564769.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Avians as a model system of vascular development. Methods Mol Biol. 2015; 1214:225-42. Bressan M, Mikawa T. PMID: 25468608.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    9. Hemodynamic forces regulate developmental patterning of atrial conduction. PLoS One. 2014; 9(12):e115207. Bressan MC, Louie JD, Mikawa T. PMID: 25503944.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    10. Early divergence of central and peripheral neural retina precursors during vertebrate eye development. Dev Dyn. 2015 Mar; 244(3):266-76. Venters SJ, Mikawa T, Hyer J. PMID: 25329498.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction. Development. 2014 Nov; 141(21):4149-57. Bressan M, Yang PB, Louie JD, Navetta AM, Garriock RJ, Mikawa T. PMID: 25273084.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    12. Microtubules coordinate VEGFR2 signaling and sorting. PLoS One. 2013; 8(9):e75833. Czeisler C, Mikawa T. PMID: 24073279.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Induction of the Proepicardium. J Dev Biol. 2013 Sep 01; 1(2):82-91. Maya-Ramos L, Cleland J, Bressan M, Mikawa T. PMID: 23956959.
      View in: PubMed   Mentions:
    14. Isolation and culture of mouse proepicardium using serum-free conditions. Methods. 2014 Apr 01; 66(3):365-9. Garriock RJ, Mikawa T, Yamaguchi TP. PMID: 23816793.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Central and peripheral retina arise through distinct developmental paths. PLoS One. 2013; 8(4):e61422. Venters SJ, Mikawa T, Hyer J. PMID: 23613848.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field. Science. 2013 May 10; 340(6133):744-8. Bressan M, Liu G, Mikawa T. PMID: 23519212.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    17. Early arterial differentiation and patterning in the avian embryo model. Semin Cell Dev Biol. 2011 Dec; 22(9):985-92. Garriock RJ, Mikawa T. PMID: 22020129.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis. Development. 2010 Nov; 137(21):3697-706. Garriock RJ, Czeisler C, Ishii Y, Navetta AM, Mikawa T. PMID: 20940228.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    19. A dual role for ErbB2 signaling in cardiac trabeculation. Development. 2010 Nov; 137(22):3867-75. Liu J, Bressan M, Hassel D, Huisken J, Staudt D, Kikuchi K, Poss KD, Mikawa T, Stainier DY. PMID: 20978078.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    20. Eph regulates dorsoventral asymmetry of the notochord plate and convergent extension-mediated notochord formation. PLoS One. 2010 Oct 29; 5(10):e13689. Oda-Ishii I, Ishii Y, Mikawa T. PMID: 21060822.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    21. BMP signals promote proepicardial protrusion necessary for recruitment of coronary vessel and epicardial progenitors to the heart. Dev Cell. 2010 Aug 17; 19(2):307-16. Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T. PMID: 20708592.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    22. Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes. Development. 2009 Aug; 136(15):2579-89. Ishii Y, Weinberg K, Oda-Ishii I, Coughlin L, Mikawa T. PMID: 19570849.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    23. FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation. Dev Biol. 2009 Apr 01; 328(1):148-59. Pennisi DJ, Mikawa T. PMID: 19389363.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    24. Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation. Dev Biol. 2009 Feb 01; 326(1):101-11. Bressan M, Davis P, Timmer J, Herzlinger D, Mikawa T. PMID: 19041859.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    25. Endothelial cell lineages of the heart. Cell Tissue Res. 2009 Jan; 335(1):67-73. Ishii Y, Langberg J, Rosborough K, Mikawa T. PMID: 18682987.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    26. Induction of proepicardial marker gene expression by the liver bud. Development. 2007 Oct; 134(20):3627-37. Ishii Y, Langberg JD, Hurtado R, Lee S, Mikawa T. PMID: 17855432.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    27. Development of the cardiac conduction system. Semin Cell Dev Biol. 2007 Feb; 18(1):90-100. Mikawa T, Hurtado R. PMID: 17289407.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    28. FGF-mediated induction of ciliary body tissue in the chick eye. Dev Biol. 2007 Apr 01; 304(1):272-85. Dias da Silva MR, Tiffin N, Mima T, Mikawa T, Hyer J. PMID: 17275804.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    29. Bone marrow Oct3/4+ cells differentiate into cardiac myocytes via age-dependent paracrine mechanisms. Circ Res. 2007 Jan 05; 100(1):e1-11. Pallante BA, Duignan I, Okin D, Chin A, Bressan MC, Mikawa T, Edelberg JM. PMID: 17122441.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. Enhanced sensitivity and stability in two-color in situ hybridization by means of a novel chromagenic substrate combination. Dev Dyn. 2006 Oct; 235(10):2811-6. Hurtado R, Mikawa T. PMID: 16894600.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    31. TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions. Dev Biol. 2006 Nov 15; 299(2):455-65. Turner BA, Sparrow J, Cai B, Monroe J, Mikawa T, Hempstead BL. PMID: 17005175.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo. Circ Res. 2006 Apr 14; 98(7):947-53. Tomanek RJ, Ishii Y, Holifield JS, Sjogren CL, Hansen HK, Mikawa T. PMID: 16527987.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    33. Normal patterning of the coronary capillary plexus is dependent on the correct transmural gradient of FGF expression in the myocardium. Dev Biol. 2005 Mar 15; 279(2):378-90. Pennisi DJ, Mikawa T. PMID: 15733666.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    34. Somatic transgenesis in the avian model system. Birth Defects Res C Embryo Today. 2005 Mar; 75(1):19-27. Ishii Y, Mikawa T. PMID: 15838916.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    35. Developmental transitions in electrical activation patterns in chick embryonic heart. Anat Rec A Discov Mol Cell Evol Biol. 2004 Oct; 280(2):1001-9. Sedmera D, Reckova M, Bigelow MR, Dealmeida A, Stanley CP, Mikawa T, Gourdie RG, Thompson RP. PMID: 15368341.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    36. A role for Tbx5 in proepicardial cell migration during cardiogenesis. Physiol Genomics. 2004 Jul 08; 18(2):129-40. Hatcher CJ, Diman NY, Kim MS, Pennisi D, Song Y, Goldstein MM, Mikawa T, Basson CT. PMID: 15138308.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    37. Negative regulation of midline vascular development by the notochord. Dev Cell. 2004 May; 6(5):699-708. Reese DE, Hall CE, Mikawa T. PMID: 15130494.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    38. Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote. Dev Dyn. 2004 Mar; 229(3):422-32. Mikawa T, Poh AM, Kelly KA, Ishii Y, Reese DE. PMID: 14991697.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Folding of the tectal cortex by local remodeling of neural differentiation. Dev Dyn. 2004 Mar; 229(3):475-9. Mima T, Mikawa T. PMID: 14991703.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    40. Somatic transgenesis using retroviral vectors in the chicken embryo. Dev Dyn. 2004 Mar; 229(3):630-42. Ishii Y, Reese DE, Mikawa T. PMID: 14991718.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    41. Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes. Circ Res. 2004 Mar 19; 94(5):E39-45. Xaymardan M, Tang L, Zagreda L, Pallante B, Zheng J, Chazen JL, Chin A, Duignan I, Nahirney P, Rafii S, Mikawa T, Edelberg JM. PMID: 14963008.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    42. Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart. Development. 2004 Feb; 131(3):581-92. Hall CE, Hurtado R, Hewett KW, Shulimovich M, Poma CP, Reckova M, Justus C, Pennisi DJ, Tobita K, Sedmera D, Gourdie RG, Mikawa T. PMID: 14711873.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    43. Epicardium is required for the full rate of myocyte proliferation and levels of expression of myocyte mitogenic factors FGF2 and its receptor, FGFR-1, but not for transmural myocardial patterning in the embryonic chick heart. Dev Dyn. 2003 Oct; 228(2):161-72. Pennisi DJ, Ballard VL, Mikawa T. PMID: 14517988.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    44. Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos. Dev Dyn. 2003 Aug; 227(4):511-23. Nahirney PC, Mikawa T, Fischman DA. PMID: 12889060.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    45. Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation. Dev Biol. 2003 Jul 15; 259(2):351-63. Hyer J, Kuhlman J, Afif E, Mikawa T. PMID: 12871706.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    46. Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation. Dev Biol. 2003 Jun 15; 258(2):252-63. Sugi Y, Ito N, Szebenyi G, Myers K, Fallon JF, Mikawa T, Markwald RR. PMID: 12798286.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    47. His-Purkinje lineages and development. Novartis Found Symp. 2003; 250:110-22; discussion 122-4, 276-9. Gourdie RG, Harris BS, Bond J, Edmondson AM, Cheng G, Sedmera D, O'Brien TX, Mikawa T, Thompson RP. PMID: 12956326.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    48. Induction and patterning of the Purkinje fibre network. Novartis Found Symp. 2003; 250:142-53; discussion 153-6, 276-9. Mikawa T, Gourdie RG, Takebayashi-Suzuki K, Kanzawa N, Hyer J, Pennisi DJ, Poma CP, Shulimovich M, Diaz KG, Layliev J, Prasad A. PMID: 12956328.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    49. Development of the coronary vessel system. Circ Res. 2002 Nov 01; 91(9):761-8. Reese DE, Mikawa T, Bader DM. PMID: 12411389.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    50. Constitutive expression of preproendothelin in the cardiac neural crest selectively promotes expansion of the adventitia of the great vessels in vivo. Dev Biol. 2002 Nov 01; 251(1):167-77. Ballard VL, Mikawa T. PMID: 12413906.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    51. Induction and patterning of the cardiac conduction system. Int J Dev Biol. 2002 Sep; 46(6):765-75. Pennisi DJ, Rentschler S, Gourdie RG, Fishman GI, Mikawa T. PMID: 12382942.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    52. Competency of embryonic cardiomyocytes to undergo Purkinje fiber differentiation is regulated by endothelin receptor expression. Development. 2002 Jul; 129(13):3185-94. Kanzawa N, Poma CP, Takebayashi-Suzuki K, Diaz KG, Layliev J, Mikawa T. PMID: 12070093.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    53. Cell death along the embryo midline regulates left-right sidedness. Dev Dyn. 2002 Jun; 224(2):238-44. Kelly KA, Wei Y, Mikawa T. PMID: 12112476.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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