Loading...

Takashi Mikawa, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-476-3230
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Atrioventricular Junction Development
    NIH/NHLBI R01HL132832Aug 1, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Heart Field Development
    NIH/NHLBI R01HL122375Apr 10, 2014 - Mar 31, 2018
    Role: Principal Investigator
    Cardiac Pacemaker Development
    NIH/NHLBI R01HL112268Dec 2, 2011 - Nov 30, 2016
    Role: Principal Investigator
    Vascular Differentiation and Patterning
    NIH/NHLBI R01HL092429Dec 1, 2008 - Nov 30, 2012
    Role: Principal Investigator
    Cardiac Conduction System Development
    NIH/NHLBI R01HL093566Jul 1, 2008 - Jun 30, 2013
    Role: Principal Investigator
    Coronary Vascular Cell Development
    NIH/NHLBI R37HL078921Dec 15, 2004 - Nov 30, 2019
    Role: Principal Investigator
    INDUCTION OF CORONARY ENDOTHELIAL CELL LINEAGE
    NIH/NHLBI R01HL078921Dec 15, 2004 - Nov 30, 2009
    Role: Principal Investigator
    NEGATIVE REGULATION OF BLOOD VESSEL FORMATION
    NIH/NHLBI R01HL076242Apr 1, 2004 - Feb 28, 2009
    Role: Principal Investigator
    Molecular Regulation of Coronary Vessel Development
    NIH P01HL067105May 1, 2001 - Apr 30, 2008
    Role: Co-Investigator
    REGULATION OF CARDIAC CONDUCTION SYSTEM DEVELOPMENT
    NIH/NHLBI R01HL062175Apr 1, 1999 - Mar 31, 2009
    Role: Principal Investigator
    REGULATION OF PURKINJE FIBER DEVELOPMENT IN THE HEART
    NIH/NHLBI R01HL054128Aug 1, 1996 - Jul 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Genuth MA, Allen CDC, Mikawa T, Weiner OD. Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol. 2018 Mar 06. PMID: 29501457.
      View in: PubMed
    2. Hua LL, Mikawa T. Chromosome Painting of Mouse Chromosomes. Methods Mol Biol. 2018; 1752:133-143. PMID: 29564769.
      View in: PubMed
    3. Bressan M, Mikawa T. Avians as a model system of vascular development. Methods Mol Biol. 2015; 1214:225-42. PMID: 25468608; PMCID: PMC4582444.
    4. Bressan MC, Louie JD, Mikawa T. Hemodynamic forces regulate developmental patterning of atrial conduction. PLoS One. 2014; 9(12):e115207. PMID: 25503944; PMCID: PMC4264946.
    5. Venters SJ, Mikawa T, Hyer J. Early divergence of central and peripheral neural retina precursors during vertebrate eye development. Dev Dyn. 2015 Mar; 244(3):266-76. PMID: 25329498; PMCID: PMC4351783.
    6. Bressan M, Yang PB, Louie JD, Navetta AM, Garriock RJ, Mikawa T. Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction. Development. 2014 Nov; 141(21):4149-57. PMID: 25273084; PMCID: PMC4302900.
    7. Yamaguchi H, Ikeda F, Iyoda T, Suzuki M, Mikawa T. [In vitro antifungal activity of ravuconazole against isolates of dermatophytes and Candida species from patients with dermatomycoses]. Med Mycol J. 2014; 55(4):J157-63. PMID: 25742996.
      View in: PubMed
    8. Czeisler C, Mikawa T. Microtubules coordinate VEGFR2 signaling and sorting. PLoS One. 2013; 8(9):e75833. PMID: 24073279; PMCID: PMC3779169.
    9. Maya-Ramos L, Cleland J, Bressan M, Mikawa T. Induction of the Proepicardium. J Dev Biol. 2013 Sep 01; 1(2):82-91. PMID: 23956959.
      View in: PubMed
    10. Garriock RJ, Mikawa T, Yamaguchi TP. Isolation and culture of mouse proepicardium using serum-free conditions. Methods. 2014 Apr 01; 66(3):365-9. PMID: 23816793.
      View in: PubMed
    11. Venters SJ, Mikawa T, Hyer J. Central and peripheral retina arise through distinct developmental paths. PLoS One. 2013; 8(4):e61422. PMID: 23613848; PMCID: PMC3628928.
    12. Bressan M, Liu G, Mikawa T. Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field. Science. 2013 May 10; 340(6133):744-8. PMID: 23519212; PMCID: PMC3651765.
    13. An KD, Degawa Y, Fujihara E, Mikawa T, Ohkuma M, Okada G. Molecular phylogenetic analyses based on the nuclear rRNA genes and the intron-exon structures of the nuSSU rRNA gene in Dictyocatenulata alba (anamorphic Ascomycota). Fungal Biol. 2012 Nov; 116(11):1134-45. PMID: 23153804.
      View in: PubMed
    14. Garriock RJ, Mikawa T. Early arterial differentiation and patterning in the avian embryo model. Semin Cell Dev Biol. 2011 Dec; 22(9):985-92. PMID: 22020129; PMCID: PMC3230727.
    15. Liu J, Bressan M, Hassel D, Huisken J, Staudt D, Kikuchi K, Poss KD, Mikawa T, Stainier DY. A dual role for ErbB2 signaling in cardiac trabeculation. Development. 2010 Nov; 137(22):3867-75. PMID: 20978078; PMCID: PMC3049280.
    16. Garriock RJ, Czeisler C, Ishii Y, Navetta AM, Mikawa T. An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis. Development. 2010 Nov; 137(21):3697-706. PMID: 20940228; PMCID: PMC2964099.
    17. Oda-Ishii I, Ishii Y, Mikawa T. Eph regulates dorsoventral asymmetry of the notochord plate and convergent extension-mediated notochord formation. PLoS One. 2010 Oct 29; 5(10):e13689. PMID: 21060822; PMCID: PMC2966392.
    18. Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T. BMP signals promote proepicardial protrusion necessary for recruitment of coronary vessel and epicardial progenitors to the heart. Dev Cell. 2010 Aug 17; 19(2):307-16. PMID: 20708592; PMCID: PMC2925255.
    19. Ishii Y, Weinberg K, Oda-Ishii I, Coughlin L, Mikawa T. Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes. Development. 2009 Aug; 136(15):2579-89. PMID: 19570849; PMCID: PMC2709064.
    20. Pennisi DJ, Mikawa T. FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation. Dev Biol. 2009 Apr 01; 328(1):148-59. PMID: 19389363; PMCID: PMC2724599.
    21. Bressan M, Davis P, Timmer J, Herzlinger D, Mikawa T. Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation. Dev Biol. 2009 Feb 01; 326(1):101-11. PMID: 19041859; PMCID: PMC2729169.
    22. Ishii Y, Langberg J, Rosborough K, Mikawa T. Endothelial cell lineages of the heart. Cell Tissue Res. 2009 Jan; 335(1):67-73. PMID: 18682987; PMCID: PMC2729171.
    23. Ikeda F, Saika T, Sato Y, Suzuki M, Hasegawa M, Mikawa T, Kobayashi I, Tsuji A. Antifungal activity of micafungin against Candida and Aspergillus spp. isolated from pediatric patients in Japan. Med Mycol. 2009 Mar; 47(2):145-8. PMID: 18668422.
      View in: PubMed
    24. Ishii Y, Langberg JD, Hurtado R, Lee S, Mikawa T. Induction of proepicardial marker gene expression by the liver bud. Development. 2007 Oct; 134(20):3627-37. PMID: 17855432.
      View in: PubMed
    25. Mikawa T, Hurtado R. Development of the cardiac conduction system. Semin Cell Dev Biol. 2007 Feb; 18(1):90-100. PMID: 17289407.
      View in: PubMed
    26. Dias da Silva MR, Tiffin N, Mima T, Mikawa T, Hyer J. FGF-mediated induction of ciliary body tissue in the chick eye. Dev Biol. 2007 Apr 01; 304(1):272-85. PMID: 17275804; PMCID: PMC1863121.
    27. Pallante BA, Duignan I, Okin D, Chin A, Bressan MC, Mikawa T, Edelberg JM. Bone marrow Oct3/4+ cells differentiate into cardiac myocytes via age-dependent paracrine mechanisms. Circ Res. 2007 Jan 05; 100(1):e1-11. PMID: 17122441.
      View in: PubMed
    28. Hurtado R, Mikawa T. Enhanced sensitivity and stability in two-color in situ hybridization by means of a novel chromagenic substrate combination. Dev Dyn. 2006 Oct; 235(10):2811-6. PMID: 16894600.
      View in: PubMed
    29. Turner BA, Sparrow J, Cai B, Monroe J, Mikawa T, Hempstead BL. TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions. Dev Biol. 2006 Nov 15; 299(2):455-65. PMID: 17005175; PMCID: PMC2623246.
    30. Tomanek RJ, Ishii Y, Holifield JS, Sjogren CL, Hansen HK, Mikawa T. VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo. Circ Res. 2006 Apr 14; 98(7):947-53. PMID: 16527987.
      View in: PubMed
    31. Pennisi DJ, Mikawa T. Normal patterning of the coronary capillary plexus is dependent on the correct transmural gradient of FGF expression in the myocardium. Dev Biol. 2005 Mar 15; 279(2):378-90. PMID: 15733666.
      View in: PubMed
    32. Ishii Y, Mikawa T. Somatic transgenesis in the avian model system. Birth Defects Res C Embryo Today. 2005 Mar; 75(1):19-27. PMID: 15838916.
      View in: PubMed
    33. Sedmera D, Reckova M, Bigelow MR, Dealmeida A, Stanley CP, Mikawa T, Gourdie RG, Thompson RP. Developmental transitions in electrical activation patterns in chick embryonic heart. Anat Rec A Discov Mol Cell Evol Biol. 2004 Oct; 280(2):1001-9. PMID: 15368341.
      View in: PubMed
    34. Hatcher CJ, Diman NY, Kim MS, Pennisi D, Song Y, Goldstein MM, Mikawa T, Basson CT. A role for Tbx5 in proepicardial cell migration during cardiogenesis. Physiol Genomics. 2004 Jul 08; 18(2):129-40. PMID: 15138308.
      View in: PubMed
    35. Reese DE, Hall CE, Mikawa T. Negative regulation of midline vascular development by the notochord. Dev Cell. 2004 May; 6(5):699-708. PMID: 15130494.
      View in: PubMed
    36. Mima T, Mikawa T. Folding of the tectal cortex by local remodeling of neural differentiation. Dev Dyn. 2004 Mar; 229(3):475-9. PMID: 14991703.
      View in: PubMed
    37. Ishii Y, Reese DE, Mikawa T. Somatic transgenesis using retroviral vectors in the chicken embryo. Dev Dyn. 2004 Mar; 229(3):630-42. PMID: 14991718.
      View in: PubMed
    38. Mikawa T, Poh AM, Kelly KA, Ishii Y, Reese DE. Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote. Dev Dyn. 2004 Mar; 229(3):422-32. PMID: 14991697.
      View in: PubMed
    39. Xaymardan M, Tang L, Zagreda L, Pallante B, Zheng J, Chazen JL, Chin A, Duignan I, Nahirney P, Rafii S, Mikawa T, Edelberg JM. Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes. Circ Res. 2004 Mar 19; 94(5):E39-45. PMID: 14963008.
      View in: PubMed
    40. Hall CE, Hurtado R, Hewett KW, Shulimovich M, Poma CP, Reckova M, Justus C, Pennisi DJ, Tobita K, Sedmera D, Gourdie RG, Mikawa T. Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart. Development. 2004 Feb; 131(3):581-92. PMID: 14711873.
      View in: PubMed
    41. Pennisi DJ, Ballard VL, Mikawa T. Epicardium is required for the full rate of myocyte proliferation and levels of expression of myocyte mitogenic factors FGF2 and its receptor, FGFR-1, but not for transmural myocardial patterning in the embryonic chick heart. Dev Dyn. 2003 Oct; 228(2):161-72. PMID: 14517988.
      View in: PubMed
    42. Nahirney PC, Mikawa T, Fischman DA. Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos. Dev Dyn. 2003 Aug; 227(4):511-23. PMID: 12889060.
      View in: PubMed
    43. Hyer J, Kuhlman J, Afif E, Mikawa T. Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation. Dev Biol. 2003 Jul 15; 259(2):351-63. PMID: 12871706.
      View in: PubMed
    44. Kumazawa S, Kanda M, Utagawa M, Chiba N, Ohtani H, Mikawa T. MK7924, a novel metabolite with nematocidal activity from Coronophora gregaria. J Antibiot (Tokyo). 2003 Jul; 56(7):652-4. PMID: 14513909.
      View in: PubMed
    45. Sugi Y, Ito N, Szebenyi G, Myers K, Fallon JF, Mikawa T, Markwald RR. Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation. Dev Biol. 2003 Jun 15; 258(2):252-63. PMID: 12798286.
      View in: PubMed
    46. Gourdie RG, Harris BS, Bond J, Edmondson AM, Cheng G, Sedmera D, O'Brien TX, Mikawa T, Thompson RP. His-Purkinje lineages and development. Novartis Found Symp. 2003; 250:110-22; discussion 122-4, 276-9. PMID: 12956326.
      View in: PubMed
    47. Mikawa T, Gourdie RG, Takebayashi-Suzuki K, Kanzawa N, Hyer J, Pennisi DJ, Poma CP, Shulimovich M, Diaz KG, Layliev J, Prasad A. Induction and patterning of the Purkinje fibre network. Novartis Found Symp. 2003; 250:142-53; discussion 153-6, 276-9. PMID: 12956328.
      View in: PubMed
    48. Reese DE, Mikawa T, Bader DM. Development of the coronary vessel system. Circ Res. 2002 Nov 01; 91(9):761-8. PMID: 12411389.
      View in: PubMed
    49. Ballard VL, Mikawa T. Constitutive expression of preproendothelin in the cardiac neural crest selectively promotes expansion of the adventitia of the great vessels in vivo. Dev Biol. 2002 Nov 01; 251(1):167-77. PMID: 12413906.
      View in: PubMed
    50. Pennisi DJ, Rentschler S, Gourdie RG, Fishman GI, Mikawa T. Induction and patterning of the cardiac conduction system. Int J Dev Biol. 2002 Sep; 46(6):765-75. PMID: 12382942.
      View in: PubMed
    51. Kanzawa N, Poma CP, Takebayashi-Suzuki K, Diaz KG, Layliev J, Mikawa T. Competency of embryonic cardiomyocytes to undergo Purkinje fiber differentiation is regulated by endothelin receptor expression. Development. 2002 Jul; 129(13):3185-94. PMID: 12070093.
      View in: PubMed
    52. Kelly KA, Wei Y, Mikawa T. Cell death along the embryo midline regulates left-right sidedness. Dev Dyn. 2002 Jun; 224(2):238-44. PMID: 12112476.
      View in: PubMed
    Takashi's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _