Tammy T. Chang, MD, PhD

Title(s)Associate Professor, Surgery
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
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    Collapse Overview 
    Collapse Overview
    Tissue engineering and regeneration are the next evolutionary step in surgical practice. Today, surgeons resect, reconstruct, and transplant to treat a diverse array of diseases. In the near future, our armamentarium will increase to include using our surgical skills to induce tissue regeneration in situ or to implant ex vivo engineered organs. Accelerating advances in biotechnology, stem cell biology, and minimally invasive surgery are ripe for convergence, which will lead to the creation of novel surgical treatments to replace diseased or dysfunctional tissues. Our lab's goal is to make significant contributions to bringing these regenerative surgical therapies from the lab into the operating room.

    In order to translate regenerative surgery from concept to therapeutic reality, our lab focuses on a complex and vital solid organ, the liver, for several reasons. First, there is great clinical need to develop alternative therapies for end stage liver disease, which is currently treated by liver transplantation and severely limited by the shortage of donor organs. Second, the liver has enormous innate capacity to regenerate in response to injury and metabolic demand, a feature that can be exploited to facilitate development of regenerative surgical approaches. Finally, building a solid organ such as the liver ex vivo remains the most challenging goal in tissue engineering and a problem of sufficient difficulty that is worthy of intense focus.

    Our lab has 3 major areas of investigation aimed at advancing the field of liver tissue engineering:

    1) Understanding the role of the physical environment and mechano-signal transduction in regulating hepatocyte function in healthy and diseased liver.
    2) Elucidating the importance of dimensionality in promoting the generation of highly-functional human stem cell-derived liver organoids.
    3) Developing surgical strategies for efficient orthotopic engraftment of hepatocytes and hepatic organoids into the liver.

    Collapse Research 
    Collapse Research Activities and Funding
    Liver tissue engineering in space
    NSF/CASIS 18-514Sep 1, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Using organoids to determine gravity effects on organogenesis and vasculogenesis
    NASA 16-16ROSBDFP-0030Sep 1, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Pioneering regenerative surgery - Mechanisms of cell death and regeneration in liver treated with non-thermal irreversible electroporation (NTIRE)
    NIH R21EB024135Jan 1, 2018 - Dec 31, 2019
    Role: Principal Investigator
    The Role of Matrix Rigidity and Hepatocyte Mechanotransduction in Fibrotic Liver Disease
    NIH R01DK114311Jul 15, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Defining the mechanism of function and engraftment potential of human hepatocyte organoids
    American College of Surgeons Clowes Research Career Development AwardJul 1, 2017 - Jun 30, 2022
    Innovating a method of in situ decellularization followed by organoid engraftment
    Open Philanthropy Project Transformational Research ProposalJul 1, 2017 - Jun 30, 2020
    Role: PI

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Focal Adhesion Kinase (FAK) promotes cholangiocarcinoma development and progression via YAP activation. J Hepatol. 2021 May 27. Song X, Xu H, Wang P, Wang J, Affo S, Wang H, Xu M, Liang B, Che L, Qiu W, Schwabe RF, Chang TT, Vogl M, Pes GM, Ribback S, Evert M, Chen X, Calvisi DF. PMID: 34052254.
      View in: PubMed   Mentions:    Fields:    
    2. Jejunal prolapse and incarceration following feeding tube exchange. J Trauma Acute Care Surg. 2020 12; 89(6):e175-e176. Conroy PC, Colley A, Bongiovanni T, Chang TT, Harris H. PMID: 32925576.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Liver epithelial focal adhesion kinase modulates fibrogenesis and hedgehog signaling. JCI Insight. 2020 10 15; 5(20). Weng Y, Lieberthal TJ, Zhou VX, Lopez-Ichikawa M, Armas-Phan M, Bond TK, Yoshida MC, Choi WT, Chang TT. PMID: 32910808.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Intra-Vital Imaging Demonstrates Robust Recruitment of Neutrophils after Irreversible Electroporation Tissue Ablation. Journal of the American College of Surgeons. 2019 Oct 1; 229(4):e117-e118. Maya A. Lopez-Ichikawa, Tammy T. Chang. .
      View in: Publisher Site   Mentions:
    5. Normal and fibrotic liver parenchyma respond differently to irreversible electroporation. HPB (Oxford). 2019 10; 21(10):1344-1353. Lyu C, Lopez-Ichikawa M, Rubinsky B, Chang TT. PMID: 30879992.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Liver Fibrosis: Current Approaches and Future Directions for Diagnosis and Treatment. Fibrosis in Disease. 2019 Jan 1; 387-417. Jennifer Y. Chen, Dhruv Thakar, Tammy T. Chang. .
      View in: Publisher Site   Mentions:
    7. Molecular and histological study on the effects of non-thermal irreversible electroporation on the liver. Biochem Biophys Res Commun. 2018 06 07; 500(3):665-670. Zhang Y, Lyu C, Liu Y, Lv Y, Chang TT, Rubinsky B. PMID: 29678581.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Using non-thermal irreversible electroporation to create an in vivo niche for exogenous cell engraftment. Biotechniques. 2017 05 01; 62(5):229-231. Chang TT, Zhou VX, Rubinsky B. PMID: 28528576.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Reply. Hepatology. 2017 05; 65(5):1781-1782. Chang TT. PMID: 28027581.
      View in: PubMed   Mentions:    Fields:    
    10. Direct orthotopic implantation of hepatic organoids. J Surg Res. 2017 05 01; 211:251-260. Zhou VX, Lolas M, Chang TT. PMID: 28501125.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    11. Force-dependent breaching of the basement membrane. Matrix Biol. 2017 01; 57-58:178-189. Chang TT, Thakar D, Weaver VM. PMID: 28025167.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    12. Hepatic Focal Adhesion Kinase Signaling Modulates Development of Liver Fibrosis. Journal of the American College of Surgeons. 2016 Oct 1; 223(4):e25. Tammy T. Chang, Vivian X. Zhou. .
      View in: Publisher Site   Mentions:
    13. Gastrointestinal Zygomycosis Masquerading as Acute Appendicitis. Case Rep Gastroenterol. 2016 Jan-Apr; 10(1):81-7. Choi WT, Chang TT, Gill RM. PMID: 27403107.
      View in: PubMed   Mentions:
    14. Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha. Hepatology. 2016 07; 64(1):261-75. Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT. PMID: 26755329.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    15. Spaceflight alters expression of microRNA during T-cell activation. FASEB J. 2015 Dec; 29(12):4893-900. Hughes-Fulford M, Chang TT, Martinez EM, Li CF. PMID: 26276131.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    16. Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. FASEB J. 2015 Oct; 29(10):4122-32. Chang TT, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M. PMID: 26085131.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. Biomaterials. 2014 Feb; 35(7):2162-71. Chang TT, Hughes-Fulford M. PMID: 24332390.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    18. The Rel/NF-?B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J Leukoc Biol. 2012 Dec; 92(6):1133-45. Chang TT, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M. PMID: 22750545.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    19. Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng Part A. 2009 Mar; 15(3):559-67. Chang TT, Hughes-Fulford M. PMID: 18724832.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    20. Caudate split for open and laparoscopic liver resections. J Am Coll Surg. 2008 Dec; 207(6):e7-9. Chang TT, Corvera CU. PMID: 19183523.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival. HPB (Oxford). 2008; 10(6):405-11. Chang TT, Sawhney R, Monto A, Davoren JB, Kirkland JG, Stewart L, Corvera CU. PMID: 19088925.
      View in: PubMed   Mentions: 20     Fields:    
    22. Injury in the elderly and end-of-life decisions. Surg Clin North Am. 2007 Feb; 87(1):229-45, viii. Chang TT, Schecter WP. PMID: 17127130.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. Eur J Immunol. 2003 Jul; 33(7):2022-2032. Chang TT, Sobel RA, Wei T, Ransohoff RM, Kuchroo VK, Sharpe AH. PMID: 12884869.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol. 2002 Sep; 32(9):2687-97. Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK. PMID: 12207354.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    25. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32. Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. PMID: 12145647.
      View in: PubMed   Mentions: 207     Fields:    Translation:AnimalsCells
    26. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Curr Dir Autoimmun. 2002; 5:113-30. Chang TT, Kuchroo VK, Sharpe AH. PMID: 11826754.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
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