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Tammy T. Chang, MD, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentSurgery
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-6069
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    Collapse Research 
    Collapse Research Activities and Funding
    Pioneering regenerative surgery - Mechanisms of cell death and regeneration in liver treated with non-thermal irreversible electroporation (NTIRE)
    NIH R21EB024135Jan 1, 2018 - Dec 31, 2019
    Role: Principal Investigator
    The Role of Matrix Rigidity and Hepatocyte Mechanotransduction in Fibrotic Liver Disease
    NIH R01DK114311Jul 15, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Defining the mechanism of function and engraftment potential of human hepatocyte organoids
    American College of Surgeons Clowes Research Career Development AwardJul 1, 2017 - Jun 30, 2022
    Innovating a method of in situ decellularization followed by organoid engraftment
    Open Philanthropy Project Transformational Research ProposalJul 1, 2017 - Jun 30, 2020
    Role: PI

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang Y, Lyu C, Liu Y, Lv Y, Chang T, Rubinsky B. Molecular and histological study on the effects of non-thermal irreversible electroporation on the liver. Biochem Biophys Res Commun. 2018 Jun 07; 500(3):665-670. PMID: 29678581.
      View in: PubMed
    2. Chang T, Zhou VX, Rubinsky B.Using non-thermal irreversible electroporation to create an in vivo niche for exogenous cell engraftment. BioTechniques. 2017; 62:229-231.
    3. Chang T, Zhou VX, Rubinsky B. Using non-thermal irreversible electroporation to create an in vivo niche for exogenous cell engraftment. Biotechniques. 2017 05 01; 62(5):229-231. PMID: 28528576.
      View in: PubMed
    4. Chang T. Reply. Hepatology. 2017 05; 65(5):1781-1782. PMID: 28027581.
      View in: PubMed
    5. Zhou VX, Lolas M, Chang T. Direct orthotopic implantation of hepatic organoids. J Surg Res. 2017 May 01; 211:251-260. PMID: 28501125.
      View in: PubMed
    6. Chang T, Thakar D, Weaver VM. Force-dependent breaching of the basement membrane. Matrix Biol. 2017 01; 57-58:178-189. PMID: 28025167.
      View in: PubMed
    7. Choi WT, Chang T, Gill RM. Gastrointestinal Zygomycosis Masquerading as Acute Appendicitis. Case Rep Gastroenterol. 2016 Jan-Apr; 10(1):81-7. PMID: 27403107; PMCID: PMC4929359.
    8. Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang T. Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha. Hepatology. 2016 07; 64(1):261-75. PMID: 26755329.
      View in: PubMed
    9. Hughes-Fulford M, Chang T, Martinez EM, Li CF. Spaceflight alters expression of microRNA during T-cell activation. FASEB J. 2015 Dec; 29(12):4893-900. PMID: 26276131; PMCID: PMC4653058 [Available on 12/01/16].
    10. Chang T, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M. Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. FASEB J. 2015 Oct; 29(10):4122-32. PMID: 26085131.
      View in: PubMed
    11. Chang T, Hughes-Fulford M. Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. Biomaterials. 2014 Feb; 35(7):2162-71. PMID: 24332390; PMCID: PMC4012541.
    12. Chang T, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M. The Rel/NF-?B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J Leukoc Biol. 2012 Dec; 92(6):1133-45. PMID: 22750545; PMCID: PMC3501893.
    13. Chang T, Hughes-Fulford M. Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng Part A. 2009 Mar; 15(3):559-67. PMID: 18724832.
      View in: PubMed
    14. Chang T, Corvera CU. Caudate split for open and laparoscopic liver resections. J Am Coll Surg. 2008 Dec; 207(6):e7-9. PMID: 19183523.
      View in: PubMed
    15. Chang T, Sawhney R, Monto A, Davoren JB, Kirkland JG, Stewart L, Corvera CU. Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival. HPB (Oxford). 2008; 10(6):405-11. PMID: 19088925; PMCID: PMC2597312.
    16. Chang T, Schecter WP. Injury in the elderly and end-of-life decisions. Surg Clin North Am. 2007 Feb; 87(1):229-45, viii. PMID: 17127130.
      View in: PubMed
    17. Chang T, Sobel RA, Wei T, Ransohoff RM, Kuchroo VK, Sharpe AH. Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. Eur J Immunol. 2003 Jul; 33(7):2022-2032. PMID: 12884869.
      View in: PubMed
    18. Jabs C, Greve B, Chang T, Sobel RA, Sharpe AH, Kuchroo VK. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol. 2002 Sep; 32(9):2687-97. PMID: 12207354.
      View in: PubMed
    19. Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang T, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32. PMID: 12145647.
      View in: PubMed
    20. Chang T, Kuchroo VK, Sharpe AH. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Curr Dir Autoimmun. 2002; 5:113-30. PMID: 11826754.
      View in: PubMed