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Tara Sigdel, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentSurgery
Address513 Parnassus Ave, Med Sci
San Francisco CA 94122
Phone415-502-3561
Emailtara.sigdel@ucsf.edu
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    Collapse Biography 
    Collapse Awards and Honors
    Stanford University, Stanford, CA2009  - 2010Pediatric Research Fund – CHRP Award
    Stanford University, Stanford, CA2008  - 2009Pediatric Research Fund – CHRP Award
    Stanford University, Stanford, CA2007  - 2008Deans Postdoctoral Fellowship
    Miami University, Oxford, OH2003  - 2005Doctoral-Undergraduate Opportunities in Scholarship (DUOS) award for two consecutive years (2003 and
    Miami University, Oxford, OH2002  - 2003William Hale Charch Graduate Fellowship

    Collapse Overview 
    Collapse Overview
    My research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.


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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. Polyclonal Regulatory T cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Jul 04. PMID: 28675676.
      View in: PubMed
    2. Nasr M, Sigdel T, Sarwal M. Advances in diagnostics for transplant rejection. Expert Rev Mol Diagn. 2016 Oct; 16(10):1121-1132. PMID: 27677432.
      View in: PubMed
    3. Yang JY, Sigdel T, Sarwal MM. Self-antigens and rejection: a proteomic analysis. Curr Opin Organ Transplant. 2016 Aug; 21(4):362-7. PMID: 27214090.
      View in: PubMed
    4. Sigdel T, Gao Y, He J, Wang A, Nicora CD, Fillmore TL, Shi T, Webb-Robertson BJ, Smith RD, Qian WJ, Salvatierra O, Camp DG, Sarwal MM. Mining the human urine proteome for monitoring renal transplant injury. Kidney Int. 2016 Jun; 89(6):1244-52. PMID: 27165815.
      View in: PubMed
    5. Wei C, Sigdel T, Sarwal MM, Reiser J. Circulating CD40 autoantibody and suPAR synergy drives glomerular injury. Ann Transl Med. 2015 Nov; 3(19):300. PMID: 26697460.
      View in: PubMed
    6. Sigdel T, Bestard O, Tran TQ, Hsieh SC, Roedder S, Damm I, Vincenti F, Sarwal MM. A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts. PLoS One. 2015; 10(9):e0138133. PMID: 26367000; PMCID: PMC4569485.
    7. Vitalone MJ, Sigdel T, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM. Transcriptional Perturbations in Graft Rejection. Transplantation. 2015 Sep; 99(9):1882-93. PMID: 26154388.
      View in: PubMed
    8. Sigdel T, Ng YW, Lee S, Nicora CD, Qian WJ, Smith RD, Camp DG, Sarwal MM. Perturbations in the urinary exosome in transplant rejection. Front Med (Lausanne). 2014; 1:57. PMID: 25593928; PMCID: PMC4292055.
    9. Woo SH, Sigdel T, Dinh VT, Vu MT, Sarwal MM, Lafayette RA. Mapping novel immunogenic epitopes in IgA nephropathy. Clin J Am Soc Nephrol. 2015 Mar 6; 10(3):372-81. PMID: 25542908; PMCID: PMC4348675 [Available on 03/06/16].
    10. Roedder S, Li L, Alonso MN, Hsieh SC, Vu MT, Dai H, Sigdel T, Bostock I, Macedo C, Metes D, Zeevi A, Shapiro R, Salvatierra O, Scandling J, Alberu J, Engleman E, Sarwal MM. A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation. J Am Soc Nephrol. 2015 Aug; 26(8):2042-53. PMID: 25429124; PMCID: PMC4520154 [Available on 08/01/16].
    11. Roedder S, Sigdel T, Salomonis N, Hsieh S, Dai H, Bestard O, Metes D, Zeevi A, Gritsch A, Cheeseman J, Macedo C, Peddy R, Medeiros M, Vincenti F, Asher N, Salvatierra O, Shapiro R, Kirk A, Reed E, Sarwal MM. The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study. PLoS Med. 2014 Nov; 11(11):e1001759. PMID: 25386950; PMCID: PMC4227654.
    12. Jackson AM, Sigdel T, Delville M, Hsieh SC, Dai H, Bagnasco S, Montgomery RA, Sarwal MM. Endothelial cell antibodies associated with novel targets and increased rejection. J Am Soc Nephrol. 2015 May; 26(5):1161-71. PMID: 25381426; PMCID: PMC4413753 [Available on 05/01/16].
    13. Delville M, Sigdel T, Wei C, Li J, Hsieh SC, Fornoni A, Burke GW, Bruneval P, Naesens M, Jackson A, Alachkar N, Canaud G, Legendre C, Anglicheau D, Reiser J, Sarwal MM. A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation. Sci Transl Med. 2014 Oct 1; 6(256):256ra136. PMID: 25273097; PMCID: PMC4394366.
    14. Sigdel T, Nicora CD, Hsieh SC, Dai H, Qian WJ, Camp DG, Sarwal MM. Optimization for peptide sample preparation for urine peptidomics. Clin Proteomics. 2014; 11(1):7. PMID: 24568099; PMCID: PMC3944950.
    15. Li L, Khush K, Hsieh SC, Ying L, Luikart H, Sigdel T, Roedder S, Yang A, Valantine H, Sarwal MM. Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection. PLoS One. 2013; 8(12):e82153. PMID: 24358149; PMCID: PMC3864873.
    16. Sigdel T, Salomonis N, Nicora CD, Ryu S, He J, Dinh V, Orton DJ, Moore RJ, Hsieh SC, Dai H, Thien-Vu M, Xiao W, Smith RD, Qian WJ, Camp DG, Sarwal MM. The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics. Mol Cell Proteomics. 2014 Feb; 13(2):621-31. PMID: 24335474; PMCID: PMC3916658.
    17. Sigdel T, Sarwal MM. Moving beyond HLA: a review of nHLA antibodies in organ transplantation. Hum Immunol. 2013 Nov; 74(11):1486-90. PMID: 23876683.
      View in: PubMed
    18. Sigdel T, Vitalone MJ, Tran TQ, Dai H, Hsieh SC, Salvatierra O, Sarwal MM. A rapid noninvasive assay for the detection of renal transplant injury. Transplantation. 2013 Jul 15; 96(1):97-101. PMID: 23756769; PMCID: PMC4472435.
    19. Keslar KS, Lin M, Zmijewska AA, Sigdel T, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL. Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling. Am J Transplant. 2013 Jul; 13(7):1891-7. PMID: 23802725; PMCID: PMC3781926.
    20. Sigdel T, Shoemaker LD, Chen R, Li L, Butte AJ, Sarwal MM, Steinberg GK. Immune response profiling identifies autoantibodies specific to Moyamoya patients. Orphanet J Rare Dis. 2013; 8:45. PMID: 23518061; PMCID: PMC3648437.
    21. Chaudhuri A, Ozawa M, Everly MJ, Ettenger R, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Li L, Sigdel T, Hsieh SC, Dai H, Naesens M, Waskerwitz J, Salvatierra O, Terasaki PI, Sarwal MM. The clinical impact of humoral immunity in pediatric renal transplantation. J Am Soc Nephrol. 2013 Mar; 24(4):655-64. PMID: 23449533; PMCID: PMC3609135.
    22. Sigdel T, Sarwal MM. Discovery and customized validation of antibody targets by protein arrays and indirect ELISA. Methods Mol Biol. 2013; 1034:373-84. PMID: 23775752; PMCID: PMC4476239.
    23. Sarwal M, Sigdel T. A common blood gene assay predates clinical and histological rejection in kidney and heart allografts. Clin Transpl. 2013; 241-7. PMID: 25095514.
      View in: PubMed
    24. Li L, Khatri P, Sigdel T, Tran T, Ying L, Vitalone MJ, Chen A, Hsieh S, Dai H, Zhang M, Naesens M, Zarkhin V, Sansanwal P, Chen R, Mindrinos M, Xiao W, Benfield M, Ettenger RB, Dharnidharka V, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Davis R, Butte AJ, Salvatierra O, Sarwal MM. A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant. 2012 Oct; 12(10):2710-8. PMID: 23009139; PMCID: PMC4148014.
    25. Sarwal MM, Ettenger RB, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Tang L, Liu J, Li L, Naesens M, Sigdel T, Waskerwitz J, Salvatierra O. Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up. Am J Transplant. 2012 Oct; 12(10):2719-29. PMID: 22694755; PMCID: PMC3681527.
    26. Sigdel T, Gao X, Sarwal MM. Protein and peptide biomarkers in organ transplantation. Biomark Med. 2012 Jun; 6(3):259-71. PMID: 22731899.
      View in: PubMed
    27. Sigdel T, Li L, Tran TQ, Khatri P, Naesens M, Sansanwal P, Dai H, Hsieh SC, Sarwal MM. Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury. J Am Soc Nephrol. 2012 Apr; 23(4):750-63. PMID: 22302197.
      View in: PubMed
    28. Sigdel T, Sarwal MM. Cell-free DNA as a measure of transplant injury. Clin Transpl. 2012; 201-5. PMID: 23721023.
      View in: PubMed
    29. Hensley MP, Gunasekera TS, Easton JA, Sigdel T, Sugarbaker SA, Klingbeil L, Breece RM, Tierney DL, Crowder MW. Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli. J Inorg Biochem. 2012 Jun; 111:164-72. PMID: 22196016; PMCID: PMC3325339.
    30. Sigdel T, Sarwal MM. Recent advances in biomarker discovery in solid organ transplant by proteomics. Expert Rev Proteomics. 2011 Dec; 8(6):705-15. PMID: 22087656; PMCID: PMC3282122.
    31. Sigdel T, Woo SH, Dai H, Khatri P, Li L, Myers B, Sarwal MM, Lafayette RA. Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach. Clin J Am Soc Nephrol. 2011 Dec; 6(12):2775-84. PMID: 22157707; PMCID: PMC3255376.
    32. Vitalone MJ, Naesens M, Sigdel T, Li L, Hseih S, Sarwal MM. The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation. Transplantation. 2011 Oct 15; 92(7):787-95. PMID: 21952304.
      View in: PubMed
    33. Sarwal MM, Sigdel T, Salomon DR. Functional proteogenomics--embracing complexity. Semin Immunol. 2011 Aug; 23(4):235-51. PMID: 21908202.
      View in: PubMed
    34. Naesens M, Khatri P, Li L, Sigdel T, Vitalone MJ, Chen R, Butte AJ, Salvatierra O, Sarwal MM. Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int. 2011 Dec; 80(12):1364-76. PMID: 21881554; PMCID: PMC4492284.
    35. Sigdel T, Lee S, Sarwal MM. Profiling the proteome in renal transplantation. Proteomics Clin Appl. 2011 Jun; 5(5-6):269-80. PMID: 21520424; PMCID: PMC3681534.
    36. Butte AJ, Sigdel T, Wadia PP, Miklos DB, Sarwal MM. Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease. Mol Cell Proteomics. 2011 Mar; 10(3):M110.000497. PMID: 21183621; PMCID: PMC3047141.
    37. Li L, Sigdel T, Vitalone M, Lee SH, Sarwal M. Differential immunogenicity and clinical relevance of kidney compartment specific antigens after renal transplantation. J Proteome Res. 2010 Dec 3; 9(12):6715-21. PMID: 20923235.
      View in: PubMed
    38. Chen R, Sigdel T, Li L, Kambham N, Dudley JT, Hsieh SC, Klassen RB, Chen A, Caohuu T, Morgan AA, Valantine HA, Khush KK, Sarwal MM, Butte AJ. Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions. PLoS Comput Biol. 2010; 6(9). PMID: 20885780; PMCID: PMC2944782.
    39. Li L, Chen A, Chaudhuri A, Kambham N, Sigdel T, Chen R, Sarwal MM. Compartmental localization and clinical relevance of MICA antibodies after renal transplantation. Transplantation. 2010 Feb 15; 89(3):312-9. PMID: 20145522; PMCID: PMC2820825.
    40. Ling XB, Sigdel T, Lau K, Ying L, Lau I, Schilling J, Sarwal MM. Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection. J Am Soc Nephrol. 2010 Apr; 21(4):646-53. PMID: 20150539; PMCID: PMC2844301.
    41. Sigdel T, Kaushal A, Gritsenko M, Norbeck AD, Qian WJ, Xiao W, Camp DG, Smith RD, Sarwal MM. Shotgun proteomics identifies proteins specific for acute renal transplant rejection. Proteomics Clin Appl. 2010 Jan; 4(1):32-47. PMID: 20543976.
      View in: PubMed
    42. Sutherland SM, Li L, Sigdel T, Wadia PP, Miklos DB, Butte AJ, Sarwal MM. Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int. 2009 Dec; 76(12):1277-83. PMID: 19812540; PMCID: PMC4464694.
    43. Naesens M, Li L, Ying L, Sansanwal P, Sigdel T, Hsieh SC, Kambham N, Lerut E, Salvatierra O, Butte AJ, Sarwal MM. Expression of complement components differs between kidney allografts from living and deceased donors. J Am Soc Nephrol. 2009 Aug; 20(8):1839-51. PMID: 19443638; PMCID: PMC2723986.
    44. Li L, Wadia P, Chen R, Kambham N, Naesens M, Sigdel T, Miklos DB, Sarwal MM, Butte AJ. Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4148-53. PMID: 19251643; PMCID: PMC2657434.
    45. Sigdel T, Klassen RB, Sarwal MM. Interpreting the proteome and peptidome in transplantation. Adv Clin Chem. 2009; 47:139-69. PMID: 19634780.
      View in: PubMed
    46. Zarkhin V, Li L, Kambham N, Sigdel T, Salvatierra O, Sarwal MM. A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation. Am J Transplant. 2008 Dec; 8(12):2607-17. PMID: 18808404.
      View in: PubMed
    47. Sigdel T, Sarwal MM. The proteogenomic path towards biomarker discovery. Pediatr Transplant. 2008 Nov; 12(7):737-47. PMID: 18764911; PMCID: PMC2574627.
    48. Sigdel T, Lau K, Schilling J, Sarwal M. Optimizing protein recovery for urinary proteomics, a tool to monitor renal transplantation. Clin Transplant. 2008 Sep-Oct; 22(5):617-23. PMID: 18459997.
      View in: PubMed
    49. Li L, Ying L, Naesens M, Xiao W, Sigdel T, Hsieh S, Martin J, Chen R, Liu K, Mindrinos M, Davis R, Sarwal M. Interference of globin genes with biomarker discovery for allograft rejection in peripheral blood samples. Physiol Genomics. 2008 Jan 17; 32(2):190-7. PMID: 17971501.
      View in: PubMed
    50. Sigdel T, Cilliers R, Gursahaney PR, Thompson P, Easton JA, Crowder MW. Probing the adaptive response of Escherichia coli to extracellular Zn(II). Biometals. 2006 Oct; 19(5):461-71. PMID: 16937252.
      View in: PubMed
    51. Sigdel T, Easton JA, Crowder MW. Transcriptional response of Escherichia coli to TPEN. J Bacteriol. 2006 Sep; 188(18):6709-13. PMID: 16952965; PMCID: PMC1595494.
    52. Yang KW, Golich FC, Sigdel T, Crowder MW. Phosphinate, sulfonate, and sulfonamidate dipeptides as potential inhibitors of Escherichia coli aminopeptidase N. Bioorg Med Chem Lett. 2005 Dec 1; 15(23):5150-3. PMID: 16168644.
      View in: PubMed
    53. Breece RM, Costello A, Bennett B, Sigdel T, Matthews ML, Tierney DL, Crowder MW. A five-coordinate metal center in Co(II)-substituted VanX. J Biol Chem. 2005 Mar 25; 280(12):11074-81. PMID: 15657055.
      View in: PubMed
    54. Sigdel T, Cilliers R, Gursahaney PR, Crowder MW. Fractionation of soluble proteins in Escherichia coli using DEAE-, SP-, and phenyl sepharose chromatographies. J Biomol Tech. 2004 Sep; 15(3):199-207. PMID: 15331586; PMCID: PMC2291686.
    55. Golich FC, Sigdel T, Breece RM, Detar L, Herron LR, Crowder MW. L-alanine-p-nitroanilide is not a substrate for VanX. Anal Biochem. 2004 Aug 15; 331(2):398-400. PMID: 15265748.
      View in: PubMed
    56. Crawford PA, Sharma N, Chandrasekar S, Sigdel T, Walsh TR, Spencer J, Crowder MW. Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria. Protein Expr Purif. 2004 Aug; 36(2):272-9. PMID: 15249050.
      View in: PubMed
    57. Periyannan G, Shaw PJ, Sigdel T, Crowder MW. In vivo folding of recombinant metallo-beta-lactamase L1 requires the presence of Zn(II). Protein Sci. 2004 Aug; 13(8):2236-43. PMID: 15238636; PMCID: PMC2279831.
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