Tara Sigdel, PhD

Title(s)Associate Professor, Surgery
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #525E
San Francisco CA 94143
Phone415-502-3561
ORCID ORCID Icon0000-0001-8448-0328 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Stanford University, Stanford, CA2009  - 2010Pediatric Research Fund – CHRP Award
    Stanford University, Stanford, CA2008  - 2009Pediatric Research Fund – CHRP Award
    Stanford University, Stanford, CA2007  - 2008Deans Postdoctoral Fellowship
    Miami University, Oxford, OH2003  - 2005Doctoral-Undergraduate Opportunities in Scholarship (DUOS) award for two consecutive years (2003 and
    Miami University, Oxford, OH2002  - 2003William Hale Charch Graduate Fellowship

    Collapse Overview 
    Collapse Overview
    My research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Proteome Analysis for Inflammation Related to Acute and Convalescent Infection. Inflammation. 2024 Feb; 47(1):346-362. Sigdel TK, Sur S, Boada P, McDermott SM, Arlehamn CSL, Murray KO, Bockenstedt LK, Kerwin M, Reed EF, Harris E, Stuart K, Peters B, Sesma A, Montgomery RR, Sarwal MM. PMID: 37831367; PMCID: PMC10799112.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection. Nat Commun. 2023 07 19; 14(1):4359. Lamarthée B, Callemeyn J, Van Herck Y, Antoranz A, Anglicheau D, Boada P, Becker JU, Debyser T, De Smet F, De Vusser K, Eloudzeri M, Franken A, Gwinner W, Koshy P, Kuypers D, Lambrechts D, Marquet P, Mathias V, Rabant M, Sarwal MM, Senev A, Sigdel TK, Sprangers B, Thaunat O, Tinel C, Van Brussel T, Van Craenenbroeck A, Van Loon E, Vaulet T, Bosisio F, Naesens M. PMID: 37468466; PMCID: PMC10356785.
      View in: PubMed   Mentions: 6     Fields:    
    3. Plasma proteome perturbation for CMV DNAemia in kidney transplantation. PLoS One. 2023; 18(5):e0285870. Sigdel TK, Boada P, Kerwin M, Rashmi P, Gjertson D, Rossetti M, Sur S, Munar D, Cimino J, Ahn R, Pickering H, Sen S, Parmar R, Fatou B, Steen H, Schaenman J, Bunnapradist S, Reed EF, Sarwal MM, CMV Systems Immunobiology Group. PMID: 37205661; PMCID: PMC10198483.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors. Ann Transl Med. 2023 Jun 30; 11(9):315. Rashmi P, Sigdel TK, Rychkov D, Damm I, Da Silva AA, Vincenti F, Lourenco AL, Craik CS, Reiser J, Sarwal MM. PMID: 37404982; PMCID: PMC10316099.
      View in: PubMed   Mentions:
    5. Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection. Front Immunol. 2022; 13:1012824. Boada P, Fatou B, Belperron AA, Sigdel TK, Smolen KK, Wurie Z, Levy O, Ronca SE, Murray KO, Liberto JM, Rashmi P, Kerwin M, Montgomery RR, Bockenstedt LK, Steen H, Sarwal MM. PMID: 36569838; PMCID: PMC9784464.
      View in: PubMed   Mentions: 3     Fields:    
    6. Perturbations of the T-cell immune repertoire in kidney transplant rejection. Front Immunol. 2022; 13:1012042. Sigdel TK, Fields PA, Liberto J, Damm I, Kerwin M, Hood J, Towfighi P, Sirota M, Robins HS, Sarwal MM. PMID: 36466928; PMCID: PMC9709472.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. A reference tissue atlas for the human kidney. Sci Adv. 2022 06 10; 8(23):eabn4965. Hansen J, Sealfon R, Menon R, Eadon MT, Lake BB, Steck B, Anjani K, Parikh S, Sigdel TK, Zhang G, Velickovic D, Barwinska D, Alexandrov T, Dobi D, Rashmi P, Otto EA, Rivera M, Rose MP, Anderton CR, Shapiro JP, Pamreddy A, Winfree S, Xiong Y, He Y, de Boer IH, Hodgin JB, Barisoni L, Naik AS, Sharma K, Sarwal MM, Zhang K, Himmelfarb J, Rovin B, El-Achkar TM, Laszik Z, He JC, Dagher PC, Valerius MT, Jain S, Satlin LM, Troyanskaya OG, Kretzler M, Iyengar R, Azeloglu EU, Kidney Precision Medicine Project. PMID: 35675394; PMCID: PMC9176741.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    8. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL, CMV Systems Immunobiology Group. PMID: 35181606; PMCID: PMC8872722.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    9. Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney. Am J Transplant. 2022 03; 22(3):876-885. Rashmi P, Sur S, Sigdel TK, Boada P, Schroeder AW, Damm I, Kretzler M, Hodgin J, Hartoularos G, Jimmie Ye C, Sarwal MM, Kidney Precision Medicine Project. PMID: 34687145; PMCID: PMC8897263.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease. Front Immunol. 2021; 12:769972. Sur S, Nguyen M, Boada P, Sigdel TK, Sollinger H, Sarwal MM. PMID: 34925339; PMCID: PMC8672419.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. A Comprehensive Urine Proteome Database Generated From Patients With Various Renal Conditions and Prostate Cancer. Front Med (Lausanne). 2021; 8:548212. Swensen AC, He J, Fang AC, Ye Y, Nicora CD, Shi T, Liu AY, Sigdel TK, Sarwal MM, Qian WJ. PMID: 33928097; PMCID: PMC8076675.
      View in: PubMed   Mentions: 16  
    12. Use of the Tissue Common Rejection Module Score in Kidney Transplant as an Objective Measure of Allograft Inflammation. Front Immunol. 2020; 11:614343. Zarinsefat A, Guerra JMA, Sigdel T, Damm I, Sarwal R, Chan-On C, Szabo G, Aguilar-Frasco JL, Ixtlapale-Carmona X, Salinas-Ramos C, Ramirez-Martinez L, Ramirez C, Vilatoba M, Morales Buenrostro LE, Alberu JM, Sarwal MM. PMID: 33613539; PMCID: PMC7886808.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Corrigendum: Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney. Front Med (Lausanne). 2020; 7:625788. Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, Sarwal MM. PMID: 33511148; PMCID: PMC7835930.
      View in: PubMed   Mentions: 1  
    14. A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project. Physiol Genomics. 2021 01 01; 53(1):1-11. El-Achkar TM, Eadon MT, Menon R, Lake BB, Sigdel TK, Alexandrov T, Parikh S, Zhang G, Dobi D, Dunn KW, Otto EA, Anderton CR, Carson JM, Luo J, Park C, Hamidi H, Zhou J, Hoover P, Schroeder A, Joanes M, Azeloglu EU, Sealfon R, Winfree S, Steck B, He Y, D'Agati V, Iyengar R, Troyanskaya OG, Barisoni L, Gaut J, Zhang K, Laszik Z, Rovin BH, Dagher PC, Sharma K, Sarwal MM, Hodgin JB, Alpers CE, Kretzler M, Jain S. PMID: 33197228; PMCID: PMC7847045.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    15. Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney. Front Med (Lausanne). 2020; 7:499. Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, Sarwal MM, Kidney Precision Medicine Project (KPMP) Consortium. PMID: 33072769; PMCID: PMC7533534.
      View in: PubMed   Mentions: 4  
    16. Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection. Kidney Int Rep. 2020 Oct; 5(10):1706-1721. Pineda S, Sur S, Sigdel T, Nguyen M, Crespo E, Torija A, Meneghini M, Gomà M, Sirota M, Bestard O, Sarwal MM. PMID: 33102963; PMCID: PMC7569686.
      View in: PubMed   Mentions: 8  
    17. Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients. J Clin Med. 2020 Jul 22; 9(8). Sigdel TK, Schroeder AW, Yang JYC, Sarwal RD, Liberto JM, Sarwal MM. PMID: 32707952; PMCID: PMC7465632.
      View in: PubMed   Mentions: 7  
    18. Avoidance of CNI and steroids using belatacept-Results of the Clinical Trials in Organ Transplantation 16 trial. Am J Transplant. 2020 12; 20(12):3599-3608. Mannon RB, Armstrong B, Stock PG, Mehta AK, Farris AB, Watson N, Morrison Y, Sarwal M, Sigdel T, Bridges N, Robien M, Newell KA, Larsen CP. PMID: 32558199; PMCID: PMC7710570.
      View in: PubMed   Mentions: 9     Fields:    
    19. A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection. Sci Transl Med. 2020 03 18; 12(535). Yang JYC, Sarwal RD, Sigdel TK, Damm I, Rosenbaum B, Liberto JM, Chan-On C, Arreola-Guerra JM, Alberu J, Vincenti F, Sarwal MM. PMID: 32188722; PMCID: PMC8289390.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    20. Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies. Front Med (Lausanne). 2019; 6:213. Sigdel T, Nguyen M, Liberto J, Dobi D, Junger H, Vincenti F, Laszik Z, Sarwal MM. PMID: 31632976; PMCID: PMC6781675.
      View in: PubMed   Mentions: 13  
    21. A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring. PLoS One. 2019; 14(7):e0220052. Sigdel TK, Yang JYC, Bestard O, Schroeder A, Hsieh SC, Liberto JM, Damm I, Geraedts ACM, Sarwal MM. PMID: 31365568; PMCID: PMC6668802.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    22. A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer. Cytometry A. 2019 09; 95(9):1019-1030. Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D, Peters B, Sette A, Rahman AH. PMID: 31364278; PMCID: PMC6750971.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    23. Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing. Nat Commun. 2019 04 23; 10(1):1906. Pineda S, Sigdel TK, Liberto JM, Vincenti F, Sirota M, Sarwal MM. PMID: 31015506; PMCID: PMC6479061.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    24. A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury. J Clin Med. 2019 Apr 12; 8(4). Watson D, Yang JYC, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Louie V, Sigdel S, Livingstone D, Soh K, Chakraborty A, Liang M, Lin PC, Sarwal MM. PMID: 31013714; PMCID: PMC6517941.
      View in: PubMed   Mentions: 21  
    25. Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival. J Clin Med. 2019 Feb 13; 8(2). Yang JYC, Verleden SE, Zarinsefat A, Vanaudenaerde BM, Vos R, Verleden GM, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Watson D, Sarwal MM. PMID: 30781765; PMCID: PMC6406976.
      View in: PubMed   Mentions: 16  
    26. Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR. J Clin Med. 2018 Dec 23; 8(1). Sigdel TK, Archila FA, Constantin T, Prins SA, Liberto J, Damm I, Towfighi P, Navarro S, Kirkizlar E, Demko ZP, Ryan A, Sigurjonsson S, Sarwal RD, Hseish SC, Chan-On C, Zimmermann B, Billings PR, Moshkevich S, Sarwal MM. PMID: 30583588; PMCID: PMC6352163.
      View in: PubMed   Mentions: 63  
    27. The common rejection module in chronic rejection post lung transplantation. PLoS One. 2018; 13(10):e0205107. Sacreas A, Yang JYC, Vanaudenaerde BM, Sigdel TK, Liberto JM, Damm I, Verleden GM, Vos R, Verleden SE, Sarwal MM. PMID: 30289917; PMCID: PMC6173434.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Urinary Virome Perturbations in Kidney Transplantation. Front Med (Lausanne). 2018; 5:72. Sigdel TK, Mercer N, Nandoe S, Nicora CD, Burnum-Johnson K, Qian WJ, Sarwal MM. PMID: 29725592; PMCID: PMC5916966.
      View in: PubMed   Mentions: 5  
    29. Targeted Transcriptional Profiling of Kidney Transplant Biopsies. Kidney Int Rep. 2018 May; 3(3):722-731. Sigdel TK, Nguyen M, Dobi D, Hsieh SC, Liberto JM, Vincenti F, Sarwal MM, Laszik Z. PMID: 29854981; PMCID: PMC5976814.
      View in: PubMed   Mentions: 13  
    30. Corrigendum: Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant. Front Immunol. 2018; 9:107. Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM. PMID: 29406538; PMCID: PMC5797733.
      View in: PubMed   Mentions: 2     Fields:    
    31. Optimization for Peptide Sample Preparation for Urine Peptidomics. Methods Mol Biol. 2018; 1788:63-72. Sigdel TK, Nicora CD, Qian WJ, Sarwal MM. PMID: 29623538.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA. Methods Mol Biol. 2018; 1788:11-21. Sigdel TK, Sarwal MM. PMID: 29116566.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. LC-SRM-Based Targeted Quantification of Urinary Protein Biomarkers. Methods Mol Biol. 2018; 1788:145-156. Gao Y, Wang H, Nicora CD, Shi T, Smith RD, Sigdel TK, Sarwal MM, Camp DG, Qian WJ. PMID: 29116567; PMCID: PMC7224550.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    34. Fractionation of Soluble Proteins Using DEAE-Sepharose, SP-Sepharose, and Phenyl Sepharose Chromatographies for Proteomics. Methods Mol Biol. 2018; 1788:157-164. Towfighi P, Shaw J, Sigdel T. PMID: 29196897.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    35. Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant. Front Immunol. 2017; 8:1687. Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM. PMID: 29259604; PMCID: PMC5723302.
      View in: PubMed   Mentions: 18     Fields:    
    36. Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection. Front Med (Lausanne). 2017; 4:185. Roedder S, Sigdel T, Hsieh SC, Cheeseman J, Metes D, Macedo C, Reed EF, Gritsch HA, Zeevi A, Shapiro R, Kirk AD, Sarwal MM. PMID: 29164120; PMCID: PMC5671971.
      View in: PubMed   Mentions: 4  
    37. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Nov; 17(11):2945-2954. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. PMID: 28675676; PMCID: PMC5662482.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCellsCTClinical Trials
    38. Assessment of Circulating Protein Signatures for Kidney Transplantation in Pediatric Recipients. Front Med (Lausanne). 2017; 4:80. Sigdel TK, Sarwal MM. PMID: 28670579; PMCID: PMC5472654.
      View in: PubMed   Mentions: 2  
    39. Molecular and Functional Noninvasive Immune Monitoring in the ESCAPE Study for Prediction of Subclinical Renal Allograft Rejection. Transplantation. 2017 06; 101(6):1400-1409. Crespo E, Roedder S, Sigdel T, Hsieh SC, Luque S, Cruzado JM, Tran TQ, Grinyó JM, Sarwal MM, Bestard O. PMID: 27362314.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    40. Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes. BMC Res Notes. 2017 Apr 04; 10(1):146. Pokharel DR, Khadka D, Sigdel M, Yadav NK, Acharya S, Kafle R, Sapkota RM, Sigdel T. PMID: 28376848; PMCID: PMC5379598.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    41. A combined biomarker and clinical panel for chronic graft versus host disease diagnosis. J Pathol Clin Res. 2017 Jan; 3(1):3-16. Pidala J, Sigdel TK, Wang A, Hsieh S, Inamoto Y, Martin PJ, Flowers ME, Hansen JA, Lee SJ, Sarwal MM. PMID: 28138397; PMCID: PMC5259564.
      View in: PubMed   Mentions: 12     Fields:    
    42. Intragraft Antiviral-Specific Gene Expression as a Distinctive Transcriptional Signature for Studies in Polyomavirus-Associated Nephropathy. Transplantation. 2016 10; 100(10):2062-70. Sigdel TK, Bestard O, Salomonis N, Hsieh SC, Torras J, Naesens M, Tran TQ, Roedder S, Sarwal MM. PMID: 27140517; PMCID: PMC5235336.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    43. Advances in diagnostics for transplant rejection. Expert Rev Mol Diagn. 2016 10; 16(10):1121-1132. Nasr M, Sigdel T, Sarwal M. PMID: 27677432; PMCID: PMC5303063.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    44. Self-antigens and rejection: a proteomic analysis. Curr Opin Organ Transplant. 2016 08; 21(4):362-7. Yang JY, Sigdel TK, Sarwal MM. PMID: 27214090.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    45. Mining the human urine proteome for monitoring renal transplant injury. Kidney Int. 2016 06; 89(6):1244-52. Sigdel TK, Gao Y, He J, Wang A, Nicora CD, Fillmore TL, Shi T, Webb-Robertson BJ, Smith RD, Qian WJ, Salvatierra O, Camp DG, Sarwal MM. PMID: 27165815; PMCID: PMC5221536.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    46. Circulating CD40 autoantibody and suPAR synergy drives glomerular injury. Ann Transl Med. 2015 Nov; 3(19):300. Wei C, Sigdel TK, Sarwal MM, Reiser J. PMID: 26697460; PMCID: PMC4671868.
      View in: PubMed   Mentions: 8  
    47. A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts. PLoS One. 2015; 10(9):e0138133. Sigdel TK, Bestard O, Tran TQ, Hsieh SC, Roedder S, Damm I, Vincenti F, Sarwal MM. PMID: 26367000; PMCID: PMC4569485.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    48. Transcriptional Perturbations in Graft Rejection. Transplantation. 2015 Sep; 99(9):1882-93. Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM. PMID: 26154388; PMCID: PMC5221567.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    49. Perturbations in the urinary exosome in transplant rejection. Front Med (Lausanne). 2014; 1:57. Sigdel TK, Ng YW, Lee S, Nicora CD, Qian WJ, Smith RD, Camp DG, Sarwal MM. PMID: 25593928; PMCID: PMC4292055.
      View in: PubMed   Mentions: 34  
    50. Mapping novel immunogenic epitopes in IgA nephropathy. Clin J Am Soc Nephrol. 2015 Mar 06; 10(3):372-81. Woo SH, Sigdel TK, Dinh VT, Vu MT, Sarwal MM, Lafayette RA. PMID: 25542908; PMCID: PMC4348675.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    51. A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation. J Am Soc Nephrol. 2015 Aug; 26(8):2042-53. Roedder S, Li L, Alonso MN, Hsieh SC, Vu MT, Dai H, Sigdel TK, Bostock I, Macedo C, Metes D, Zeevi A, Shapiro R, Salvatierra O, Scandling J, Alberu J, Engleman E, Sarwal MM. PMID: 25429124; PMCID: PMC4520154.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    52. The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study. PLoS Med. 2014 Nov; 11(11):e1001759. Roedder S, Sigdel T, Salomonis N, Hsieh S, Dai H, Bestard O, Metes D, Zeevi A, Zeevi A, Gritsch A, Cheeseman J, Macedo C, Peddy R, Medeiros M, Vincenti F, Asher N, Salvatierra O, Shapiro R, Kirk A, Reed EF, Reed E, Sarwal MM. PMID: 25386950; PMCID: PMC4227654.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    53. Endothelial cell antibodies associated with novel targets and increased rejection. J Am Soc Nephrol. 2015 May; 26(5):1161-71. Jackson AM, Sigdel TK, Delville M, Hsieh SC, Dai H, Bagnasco S, Montgomery RA, Sarwal MM. PMID: 25381426; PMCID: PMC4413753.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    54. A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation. Sci Transl Med. 2014 Oct 01; 6(256):256ra136. Delville M, Sigdel TK, Wei C, Li J, Hsieh SC, Fornoni A, Burke GW, Bruneval P, Naesens M, Jackson A, Alachkar N, Canaud G, Legendre C, Anglicheau D, Reiser J, Sarwal MM. PMID: 25273097; PMCID: PMC4394366.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    55. Optimization for peptide sample preparation for urine peptidomics. Clin Proteomics. 2014 Feb 25; 11(1):7. Sigdel TK, Nicora CD, Hsieh SC, Dai H, Qian WJ, Camp DG, Sarwal MM. PMID: 24568099; PMCID: PMC3944950.
      View in: PubMed   Mentions: 15  
    56. Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection. PLoS One. 2013; 8(12):e82153. Li L, Khush K, Hsieh SC, Ying L, Luikart H, Sigdel T, Roedder S, Yang A, Valantine H, Sarwal MM. PMID: 24358149; PMCID: PMC3864873.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    57. The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics. Mol Cell Proteomics. 2014 Feb; 13(2):621-31. Sigdel TK, Salomonis N, Nicora CD, Ryu S, He J, Dinh V, Orton DJ, Moore RJ, Hsieh SC, Dai H, Thien-Vu M, Xiao W, Smith RD, Qian WJ, Camp DG, Sarwal MM. PMID: 24335474; PMCID: PMC3916658.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    58. Moving beyond HLA: a review of nHLA antibodies in organ transplantation. Hum Immunol. 2013 Nov; 74(11):1486-90. Sigdel TK, Sarwal MM. PMID: 23876683; PMCID: PMC5221517.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    59. A rapid noninvasive assay for the detection of renal transplant injury. Transplantation. 2013 Jul 15; 96(1):97-101. Sigdel TK, Vitalone MJ, Tran TQ, Dai H, Hsieh SC, Salvatierra O, Sarwal MM. PMID: 23756769; PMCID: PMC4472435.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCellsCTClinical Trials
    60. Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling. Am J Transplant. 2013 Jul; 13(7):1891-7. Keslar KS, Lin M, Zmijewska AA, Sigdel TK, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL. PMID: 23802725; PMCID: PMC3781926.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    61. Immune response profiling identifies autoantibodies specific to Moyamoya patients. Orphanet J Rare Dis. 2013 Mar 21; 8:45. Sigdel TK, Shoemaker LD, Chen R, Li L, Butte AJ, Sarwal MM, Steinberg GK. PMID: 23518061; PMCID: PMC3648437.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    62. The clinical impact of humoral immunity in pediatric renal transplantation. J Am Soc Nephrol. 2013 Mar; 24(4):655-64. Chaudhuri A, Ozawa M, Everly MJ, Ettenger R, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Li L, Sigdel TK, Hsieh SC, Dai H, Naesens M, Waskerwitz J, Salvatierra O, Terasaki PI, Sarwal MM. PMID: 23449533; PMCID: PMC3609135.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    63. Discovery and customized validation of antibody targets by protein arrays and indirect ELISA. Methods Mol Biol. 2013; 1034:373-84. Sigdel TK, Sarwal MM. PMID: 23775752; PMCID: PMC4476239.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    64. A common blood gene assay predates clinical and histological rejection in kidney and heart allografts. Clin Transpl. 2013; 241-7. Sarwal M, Sigdel T. PMID: 25095514.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    65. A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant. 2012 Oct; 12(10):2710-8. Li L, Khatri P, Sigdel TK, Tran T, Ying L, Vitalone MJ, Chen A, Hsieh S, Dai H, Zhang M, Naesens M, Zarkhin V, Sansanwal P, Chen R, Mindrinos M, Xiao W, Benfield M, Ettenger RB, Dharnidharka V, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Davis R, Butte AJ, Salvatierra O, Sarwal MM. PMID: 23009139; PMCID: PMC4148014.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    66. Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up. Am J Transplant. 2012 Oct; 12(10):2719-29. Sarwal MM, Ettenger RB, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Tang L, Liu J, Li L, Naesens M, Sigdel T, Waskerwitz J, Salvatierra O. PMID: 22694755; PMCID: PMC3681527.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    67. Protein and peptide biomarkers in organ transplantation. Biomark Med. 2012 Jun; 6(3):259-71. Sigdel TK, Gao X, Sarwal MM. PMID: 22731899.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    68. Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury. J Am Soc Nephrol. 2012 Apr; 23(4):750-63. Sigdel TK, Li L, Tran TQ, Khatri P, Naesens M, Sansanwal P, Dai H, Hsieh SC, Sarwal MM. PMID: 22302197.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    69. Cell-free DNA as a measure of transplant injury. Clin Transpl. 2012; 201-5. Sigdel TK, Sarwal MM. PMID: 23721023.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    70. Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli. J Inorg Biochem. 2012 Jun; 111:164-72. Hensley MP, Gunasekera TS, Easton JA, Sigdel TK, Sugarbaker SA, Klingbeil L, Breece RM, Tierney DL, Crowder MW. PMID: 22196016; PMCID: PMC3325339.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    71. Recent advances in biomarker discovery in solid organ transplant by proteomics. Expert Rev Proteomics. 2011 Dec; 8(6):705-15. Sigdel TK, Sarwal MM. PMID: 22087656; PMCID: PMC3282122.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    72. Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach. Clin J Am Soc Nephrol. 2011 Dec; 6(12):2775-84. Sigdel TK, Woo SH, Dai H, Khatri P, Li L, Myers B, Sarwal MM, Lafayette RA. PMID: 22157707; PMCID: PMC3255376.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    73. The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation. Transplantation. 2011 Oct 15; 92(7):787-95. Vitalone MJ, Naesens M, Sigdel T, Li L, Hseih S, Sarwal MM. PMID: 21952304.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    74. Functional proteogenomics--embracing complexity. Semin Immunol. 2011 Aug; 23(4):235-51. Sarwal MM, Sigdel TK, Salomon DR. PMID: 21908202.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    75. Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int. 2011 Dec; 80(12):1364-76. Naesens M, Khatri P, Li L, Sigdel TK, Vitalone MJ, Chen R, Butte AJ, Salvatierra O, Sarwal MM. PMID: 21881554; PMCID: PMC4492284.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    76. Profiling the proteome in renal transplantation. Proteomics Clin Appl. 2011 Jun; 5(5-6):269-80. Sigdel TK, Lee S, Sarwal MM. PMID: 21520424; PMCID: PMC3681534.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    77. Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease. Mol Cell Proteomics. 2011 Mar; 10(3):M110.000497. Butte AJ, Sigdel TK, Wadia PP, Miklos DB, Sarwal MM. PMID: 21183621; PMCID: PMC3047141.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    78. Differential immunogenicity and clinical relevance of kidney compartment specific antigens after renal transplantation. J Proteome Res. 2010 Dec 03; 9(12):6715-21. Li L, Sigdel T, Vitalone M, Lee SH, Sarwal M. PMID: 20923235.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    79. Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions. PLoS Comput Biol. 2010 Sep 23; 6(9). Chen R, Sigdel TK, Li L, Kambham N, Dudley JT, Hsieh SC, Klassen RB, Chen A, Caohuu T, Morgan AA, Valantine HA, Khush KK, Sarwal MM, Butte AJ. PMID: 20885780; PMCID: PMC2944782.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    80. Compartmental localization and clinical relevance of MICA antibodies after renal transplantation. Transplantation. 2010 Feb 15; 89(3):312-9. Li L, Chen A, Chaudhuri A, Kambham N, Sigdel T, Chen R, Sarwal MM. PMID: 20145522; PMCID: PMC2820825.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    81. Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection. J Am Soc Nephrol. 2010 Apr; 21(4):646-53. Ling XB, Sigdel TK, Lau K, Ying L, Lau I, Schilling J, Sarwal MM. PMID: 20150539; PMCID: PMC2844301.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    82. Shotgun proteomics identifies proteins specific for acute renal transplant rejection. Proteomics Clin Appl. 2010 Jan; 4(1):32-47. Sigdel TK, Kaushal A, Gritsenko M, Norbeck AD, Qian WJ, Xiao W, Camp DG, Smith RD, Sarwal MM. PMID: 20543976; PMCID: PMC2883247.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    83. Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int. 2009 Dec; 76(12):1277-83. Sutherland SM, Li L, Sigdel TK, Wadia PP, Miklos DB, Butte AJ, Sarwal MM. PMID: 19812540; PMCID: PMC4464694.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    84. Expression of complement components differs between kidney allografts from living and deceased donors. J Am Soc Nephrol. 2009 Aug; 20(8):1839-51. Naesens M, Li L, Ying L, Sansanwal P, Sigdel TK, Hsieh SC, Kambham N, Lerut E, Salvatierra O, Butte AJ, Sarwal MM. PMID: 19443638; PMCID: PMC2723986.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    85. Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4148-53. Li L, Wadia P, Chen R, Kambham N, Naesens M, Sigdel TK, Miklos DB, Sarwal MM, Butte AJ. PMID: 19251643; PMCID: PMC2657434.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    86. Interpreting the proteome and peptidome in transplantation. Adv Clin Chem. 2009; 47:139-69. Sigdel TK, Klassen RB, Sarwal MM. PMID: 19634780.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    87. A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation. Am J Transplant. 2008 Dec; 8(12):2607-17. Zarkhin V, Li L, Kambham N, Sigdel T, Salvatierra O, Sarwal MM. PMID: 18808404.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    88. The proteogenomic path towards biomarker discovery. Pediatr Transplant. 2008 Nov; 12(7):737-47. Sigdel TK, Sarwal MM. PMID: 18764911; PMCID: PMC2574627.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    89. Optimizing protein recovery for urinary proteomics, a tool to monitor renal transplantation. Clin Transplant. 2008 Sep-Oct; 22(5):617-23. Sigdel TK, Lau K, Schilling J, Sarwal M. PMID: 18459997.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    90. Interference of globin genes with biomarker discovery for allograft rejection in peripheral blood samples. Physiol Genomics. 2008 Jan 17; 32(2):190-7. Li L, Ying L, Naesens M, Xiao W, Sigdel T, Hsieh S, Martin J, Chen R, Liu K, Mindrinos M, Davis R, Sarwal M. PMID: 17971501.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    91. Probing the adaptive response of Escherichia coli to extracellular Zn(II). Biometals. 2006 Oct; 19(5):461-71. Sigdel TK, Cilliers R, Gursahaney PR, Thompson P, Easton JA, Crowder MW. PMID: 16937252.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    92. Transcriptional response of Escherichia coli to TPEN. J Bacteriol. 2006 Sep; 188(18):6709-13. Sigdel TK, Easton JA, Crowder MW. PMID: 16952965; PMCID: PMC1595494.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    93. Phosphinate, sulfonate, and sulfonamidate dipeptides as potential inhibitors of Escherichia coli aminopeptidase N. Bioorg Med Chem Lett. 2005 Dec 01; 15(23):5150-3. Yang KW, Golich FC, Sigdel TK, Crowder MW. PMID: 16168644.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    94. A five-coordinate metal center in Co(II)-substituted VanX. J Biol Chem. 2005 Mar 25; 280(12):11074-81. Breece RM, Costello A, Bennett B, Sigdel TK, Matthews ML, Tierney DL, Crowder MW. PMID: 15657055.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    95. Fractionation of soluble proteins in Escherichia coli using DEAE-, SP-, and phenyl sepharose chromatographies. J Biomol Tech. 2004 Sep; 15(3):199-207. Sigdel TK, Cilliers R, Gursahaney PR, Crowder MW. PMID: 15331586; PMCID: PMC2291686.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    96. L-alanine-p-nitroanilide is not a substrate for VanX. Anal Biochem. 2004 Aug 15; 331(2):398-400. Golich FC, Sigdel T, Breece RM, Detar L, Herron LR, Crowder MW. PMID: 15265748.
      View in: PubMed   Mentions: 1     Fields:    
    97. Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria. Protein Expr Purif. 2004 Aug; 36(2):272-9. Crawford PA, Sharma N, Chandrasekar S, Sigdel T, Walsh TR, Spencer J, Crowder MW. PMID: 15249050.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    98. In vivo folding of recombinant metallo-beta-lactamase L1 requires the presence of Zn(II). Protein Sci. 2004 Aug; 13(8):2236-43. Periyannan G, Shaw PJ, Sigdel T, Crowder MW. PMID: 15238636; PMCID: PMC2279831.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
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