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Tara Tracy

Title(s)Postdoctoral Fellow, Gladstone Institutes
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Impact of KIBRA signaling on memory in tauopathy
    NIH/NIA R03AG063248Jun 1, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Synaptic mechanisms of tau-mediated pathogenesis in human iPSC-derived neurons
    NIH/NIA K01AG057862Apr 15, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Pathogenic events triggered by tau acetylation in neurodegenerative tauopathy
    NIH/NIA F32AG043301Aug 1, 2012 - Jul 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. 2019 Sep 04. PMID: 31542321.
      View in: PubMed
    2. Tracy TE, Gan L. Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease. Curr Opin Neurobiol. 2018 08; 51:134-138. PMID: 29753269.
      View in: PubMed
    3. Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 2018 04 04; 98(1):75-89.e5. PMID: 29551491.
      View in: PubMed
    4. Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017 10 10; 9(4):1221-1233. PMID: 28966121.
      View in: PubMed
    5. Tracy TE, Gan L. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. Bioessays. 2017 04; 39(4). PMID: 28083916.
      View in: PubMed
    6. Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016 06 29; 11(1):47. PMID: 27356871.
      View in: PubMed
    7. Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL, Gan L. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 04 20; 90(2):245-60. PMID: 27041503.
      View in: PubMed
    8. Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015 Oct; 21(10):1154-62. PMID: 26390242.
      View in: PubMed
    9. Tracy TE, Yan JJ, Chen L. Acute knockdown of AMPA receptors reveals a trans-synaptic signal for presynaptic maturation. EMBO J. 2011 Apr 20; 30(8):1577-92. PMID: 21378752.
      View in: PubMed