Theodore Miclau, MD

InstitutionUniversity of California San Francisco
DepartmentOrthopaedic Surgery
Address1001 Potrero Ave
San Francisco CA 94110
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    Collapse Research Activities and Funding
    A Murine Model of Polytrauma: Understanding the molecular basis of accelerated bone repair with concomitant traumatic brain injury
    NIH/NIAMS R21AR066847Mar 1, 2015 - Dec 31, 2016
    Role: Principal Investigator
    Functional roles of muscle in bone repair
    NIH/NIAMS R01AR057344Mar 1, 2010 - Dec 31, 2014
    Role: Principal Investigator
    Biology of stable and non-stable fracture repair
    NIH/NIAMS R01AR053645Feb 1, 2006 - Nov 30, 2011
    Role: Principal Investigator
    NIH/NIAMS K08AR002164Apr 4, 2000 - Mar 31, 2006
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hanke A, Bäumlein M, Lang S, Gueorguiev B, Nerlich M, Perren T, Rillmann P, Ryf C, Miclau T, Loibl M. Long-term radiographic appearance of calcium-phosphate synthetic bone grafts after surgical treatment of tibial plateau fractures. Injury. 2017 Dec; 48(12):2807-2813. PMID: 29096930.
      View in: PubMed
    2. Toogood P, Miclau T. Critical-Sized Bone Defects: Sequence and Planning. J Orthop Trauma. 2017 Oct; 31 Suppl 5:S23-S26. PMID: 28938387.
      View in: PubMed
    3. Cunningham BP, Brazina S, Morshed S, Miclau T. Fracture healing: A review of clinical, imaging and laboratory diagnostic options. Injury. 2017 Jun; 48 Suppl 1:S69-S75. PMID: 28483359.
      View in: PubMed
    4. Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T. Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? Front Cell Dev Biol. 2017; 5:45. PMID: 28523266.
      View in: PubMed
    5. Wu HH, Liu M, Patel KR, Turner W, Baltus L, Caldwell AM, Hahn JC, Coughlin RR, Morshed S, Miclau T, Shearer DW. Impact of academic collaboration and quality of clinical orthopaedic research conducted in low- and middle-income countries. SICOT J. 2017; 3:6. PMID: 28134090.
      View in: PubMed
    6. Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234. PMID: 28096214.
      View in: PubMed
    7. Cheung WH, Miclau T, Chow SK, Yang FF, Alt V. Fracture healing in osteoporotic bone. Injury. 2016 Jun; 47 Suppl 2:S21-6. PMID: 27338222.
      View in: PubMed
    8. Kammerlander C, Neuerburg C, Verlaan JJ, Schmoelz W, Miclau T, Larsson S. The use of augmentation techniques in osteoporotic fracture fixation. Injury. 2016 Jun; 47 Suppl 2:S36-43. PMID: 27338226.
      View in: PubMed
    9. Alt V, Miclau T. Osteoporotic fractures - the biological perspective. Injury. 2016 Jan; 47 Suppl 1:S1-2. PMID: 26768281.
      View in: PubMed
    10. Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T. Stem Cell Therapies in Orthopaedic Trauma. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S24-7. PMID: 26584262; PMCID: PMC4845034 [Available on 12/01/16].
    11. Marmor M, Alt V, Latta L, Lane J, Rebolledo B, Egol KA, Miclau T. Osteoporotic Fracture Care: Are We Closer to Gold Standards? J Orthop Trauma. 2015 Dec; 29 Suppl 12:S53-6. PMID: 26584268.
      View in: PubMed
    12. Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016 Feb; 83:197-209. PMID: 26608518.
      View in: PubMed
    13. Bara JJ, Herrmann M, Evans CH, Miclau T, Ratcliffe A, Richards RG. Improving translation success of cell-based therapies in orthopaedics. J Orthop Res. 2016 Jan; 34(1):17-21. PMID: 26403666.
      View in: PubMed
    14. Abou-Khalil R, Yang F, Lieu S, Julien A, Perry J, Pereira C, Relaix F, Miclau T, Marcucio R, Colnot C. Role of muscle stem cells during skeletal regeneration. Stem Cells. 2015 May; 33(5):1501-11. PMID: 25594525.
      View in: PubMed
    15. Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S. The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells. Acta Biomater. 2015 May; 18:100-11. PMID: 25735800.
      View in: PubMed
    16. Bahney CS, Hu DP, Miclau T, Marcucio RS. The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne). 2015; 6:4. PMID: 25699016; PMCID: PMC4318416.
    17. Abou-Khalil R, Yang F, Mortreux M, Lieu S, Yu YY, Wurmser M, Pereira C, Relaix F, Miclau T, Marcucio RS, Colnot C. Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy. J Bone Miner Res. 2014 Feb; 29(2):304-15. PMID: 23857747; PMCID: PMC3893315.
    18. Shearer D, Morshed S, Miclau T. Status of road safety and injury burden: North America. J Orthop Trauma. 2014; 28 Suppl 1:S37-8. PMID: 24857996.
      View in: PubMed
    19. Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS. Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation. J Bone Miner Res. 2014; 29(5):1269-82. PMID: 24259230; PMCID: PMC4802866.
    20. Slade Shantz JA, Yu YY, Andres W, Miclau T, Marcucio R. Modulation of macrophage activity during fracture repair has differential effects in young adult and elderly mice. J Orthop Trauma. 2014; 28 Suppl 1:S10-4. PMID: 24378434; PMCID: PMC3965608.
    21. Matityahu A, Marmor M, Elson JK, Lieber C, Rogalski G, Lin C, Belaye T, Miclau T, Kandemir U. Acute complications of patients with pelvic fractures after pelvic angiographic embolization. Clin Orthop Relat Res. 2013 Sep; 471(9):2906-11. PMID: 23846601; PMCID: PMC3734434.
    22. Marcucio R, Hunt TK, Miclau T. Beneficial effects of oxygen- and lactate-production in scaffold designs. Bone. 2013 Nov; 57(1):324. PMID: 23895996.
      View in: PubMed
    23. Richards RG, Moriarty TF, Miclau T, McClellan RT, Grainger DW. Advances in biomaterials and surface technologies. J Orthop Trauma. 2012 Dec; 26(12):703-7. PMID: 22913967.
      View in: PubMed
    24. Nauth A, Giles E, Potter BK, Nesti LJ, O'brien FP, Bosse MJ, Anglen JO, Mehta S, Ahn J, Miclau T, Schemitsch EH. Heterotopic ossification in orthopaedic trauma. J Orthop Trauma. 2012 Dec; 26(12):684-8. PMID: 23010648.
      View in: PubMed
    25. Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, Hou H, Williams B, Swartz HM, Hunt TK, Miclau T, Marcucio RS. The role of oxygen during fracture healing. Bone. 2013 Jan; 52(1):220-9. PMID: 23063782; PMCID: PMC4827706.
    26. Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C. MMP9 regulates the cellular response to inflammation after skeletal injury. Bone. 2013 Jan; 52(1):111-9. PMID: 23010105; PMCID: PMC3513654.
    27. Lu C, Xing Z, Wang X, Mao J, Marcucio RS, Miclau T. Anti-inflammatory treatment increases angiogenesis during early fracture healing. Arch Orthop Trauma Surg. 2012 Aug; 132(8):1205-13. PMID: 22622792.
      View in: PubMed
    28. Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T. Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. J Vis Exp. 2012 Apr 11; (62). PMID: 22525683; PMCID: PMC3466651.
    29. Yu YY, Lieu S, Hu D, Miclau T, Colnot C. Site specific effects of zoledronic acid during tibial and mandibular fracture repair. PLoS One. 2012; 7(2):e31771. PMID: 22359627; PMCID: PMC3281002.
    30. Bahney CS, Miclau T. Therapeutic potential of stem cells in orthopedics. Indian J Orthop. 2012 Jan; 46(1):4-9. PMID: 22345800; PMCID: PMC3270604.
    31. Ogilvie CM, Lu C, Marcucio R, Lee M, Thompson Z, Hu D, Helms JA, Miclau T. Vascular endothelial growth factor improves bone repair in a murine nonunion model. Iowa Orthop J. 2012; 32:90-4. PMID: 23576927; PMCID: PMC3565421.
    32. Lu C, Saless N, Hu D, Wang X, Xing Z, Hou H, Williams B, Swartz HM, Colnot C, Miclau T, Marcucio RS. Mechanical stability affects angiogenesis during early fracture healing. J Orthop Trauma. 2011 Aug; 25(8):494-9. PMID: 21738063; PMCID: PMC3167470.
    33. Nauth A, Miclau T, Bhandari M, Schemitsch EH. Use of osteobiologics in the management of osteoporotic fractures. J Orthop Trauma. 2011 Jun; 25 Suppl 2:S51-5. PMID: 21566475.
      View in: PubMed
    34. Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C. Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Dis Model Mech. 2011 Mar; 4(2):203-11. PMID: 21135056; PMCID: PMC3046093.
    35. Miclau T, Schmidt AH, Wenke JC, Webb LX, Harro JM, Prabhakara R, Shirtliff ME. Infection. J Orthop Trauma. 2010 Sep; 24(9):583-6. PMID: 20736799; PMCID: PMC4408554.
    36. Morshed S, Corrales LA, Lin K, Miclau T. Femoral nailing during serum bicarbonate-defined hypo-perfusion predicts pulmonary organ dysfunction in multi-system trauma patients. Injury. 2011 Jul; 42(7):643-9. PMID: 20678765.
      View in: PubMed
    37. Xing Z, Lu C, Hu D, Miclau T, Marcucio RS. Rejuvenation of the inflammatory system stimulates fracture repair in aged mice. J Orthop Res. 2010 Aug; 28(8):1000-6. PMID: 20108320; PMCID: PMC2892015.
    38. Lange J, Sapozhnikova A, Lu C, Hu D, Li X, Miclau T, Marcucio RS. Action of IL-1beta during fracture healing. J Orthop Res. 2010 Jun; 28(6):778-84. PMID: 20041490; PMCID: PMC2858256.
    39. Lu C, Xing Z, Yu YY, Colnot C, Miclau T, Marcucio RS. Recombinant human bone morphogenetic protein-7 enhances fracture healing in an ischemic environment. J Orthop Res. 2010 May; 28(5):687-96. PMID: 19918910; PMCID: PMC2845727.
    40. Xing Z, Lu C, Hu D, Yu YY, Wang X, Colnot C, Nakamura M, Wu Y, Miclau T, Marcucio RS. Multiple roles for CCR2 during fracture healing. Dis Model Mech. 2010 Jul-Aug; 3(7-8):451-8. PMID: 20354109; PMCID: PMC2898536.
    41. Nauth A, Miclau T, Li R, Schemitsch EH. Gene therapy for fracture healing. J Orthop Trauma. 2010 Mar; 24 Suppl 1:S17-24. PMID: 20182229.
      View in: PubMed
    42. Hu D, Lu C, Sapozhnikova A, Barnett M, Sparrey C, Miclau T, Marcucio RS. Absence of beta3 integrin accelerates early skeletal repair. J Orthop Res. 2010 Jan; 28(1):32-7. PMID: 19637214; PMCID: PMC2811376.
    43. Yu YY, Lieu S, Lu C, Miclau T, Marcucio RS, Colnot C. Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair. Bone. 2010 Mar; 46(3):841-51. PMID: 19913648.
      View in: PubMed
    44. Lu C, Buckley JM, Colnot C, Marcucio R, Miclau T. Basic research in orthopedic surgery: Current trends and future directions. Indian J Orthop. 2009 Oct; 43(4):318-23. PMID: 19838378; PMCID: PMC2762563.
    45. Morshed S, Miclau T, Bembom O, Cohen M, Knudson MM, Colford JM. Delayed internal fixation of femoral shaft fracture reduces mortality among patients with multisystem trauma. J Bone Joint Surg Am. 2009 Jan; 91(1):3-13. PMID: 19122073; PMCID: PMC2663326.
    46. Lu C, Hansen E, Sapozhnikova A, Hu D, Miclau T, Marcucio RS. Effect of age on vascularization during fracture repair. J Orthop Res. 2008 Oct; 26(10):1384-9. PMID: 18464248; PMCID: PMC2846969.
    47. Corrales LA, Morshed S, Bhandari M, Miclau T. Variability in the assessment of fracture-healing in orthopaedic trauma studies. J Bone Joint Surg Am. 2008 Sep; 90(9):1862-8. PMID: 18762645; PMCID: PMC2663323.
    48. Firoozabadi R, Morshed S, Engelke K, Prevrhal S, Fierlinger A, Miclau T, Genant HK. Qualitative and quantitative assessment of bone fragility and fracture healing using conventional radiography and advanced imaging technologies--focus on wrist fracture. J Orthop Trauma. 2008 Sep; 22(8 Suppl):S83-90. PMID: 18753895.
      View in: PubMed
    49. Morshed S, Corrales L, Genant H, Miclau T. Outcome assessment in clinical trials of fracture-healing. J Bone Joint Surg Am. 2008 Feb; 90 Suppl 1:62-7. PMID: 18292359.
      View in: PubMed
    50. Lu C, Rollins M, Hou H, Swartz HM, Hopf H, Miclau T, Marcucio RS. Tibial fracture decreases oxygen levels at the site of injury. Iowa Orthop J. 2008; 28:14-21. PMID: 19223943; PMCID: PMC2603344.
    51. Miclau T, Lu C, Thompson Z, Choi P, Puttlitz C, Marcucio R, Helms JA. Effects of delayed stabilization on fracture healing. J Orthop Res. 2007 Dec; 25(12):1552-8. PMID: 17593540; PMCID: PMC2844641.
    52. Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C. Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS One. 2007 Nov 07; 2(11):e1150. PMID: 17987127; PMCID: PMC2063465.
    53. Cole PA, Miclau T, Bhandari M. What's new in orthopaedic trauma. J Bone Joint Surg Am. 2007 Nov; 89(11):2560-77. PMID: 17974910.
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    54. Kusuma SK, Mehta S, Sirkin M, Yates AJ, Miclau T, Templeton KJ, Friedlaender GE. Measuring the attitudes and impact of the eighty-hour workweek rules on orthopaedic surgery residents. J Bone Joint Surg Am. 2007 Mar; 89(3):679-85. PMID: 17332119.
      View in: PubMed
    55. Lu C, Miclau T, Hu D, Marcucio RS. Ischemia leads to delayed union during fracture healing: a mouse model. J Orthop Res. 2007 Jan; 25(1):51-61. PMID: 17019699; PMCID: PMC2848995.
    56. Kim T, Ayturk UM, Haskell A, Miclau T, Puttlitz CM. Fixation of osteoporotic distal fibula fractures: A biomechanical comparison of locking versus conventional plates. J Foot Ankle Surg. 2007 Jan-Feb; 46(1):2-6. PMID: 17198946.
      View in: PubMed
    57. Ogilvie CM, Miclau T. Necrotizing soft tissue infections of the extremities and back. Clin Orthop Relat Res. 2006 Jun; 447:179-86. PMID: 16672902.
      View in: PubMed
    58. Mullis BH, Copland ST, Weinhold PS, Miclau T, Lester GE, Bos GD. Effect of COX-2 inhibitors and non-steroidal anti-inflammatory drugs on a mouse fracture model. Injury. 2006 Sep; 37(9):827-37. PMID: 16497308.
      View in: PubMed
    59. Lu C, Marcucio R, Miclau T. Assessing angiogenesis during fracture healing. Iowa Orthop J. 2006; 26:17-26. PMID: 16789443; PMCID: PMC1888583.
    60. Lu C, Miclau T, Hu D, Hansen E, Tsui K, Puttlitz C, Marcucio RS. Cellular basis for age-related changes in fracture repair. J Orthop Res. 2005 Nov; 23(6):1300-7. PMID: 15936915; PMCID: PMC2844440.
    61. Lu C, Huang S, Miclau T, Helms JA, Colnot C. Mepe is expressed during skeletal development and regeneration. Histochem Cell Biol. 2004 Jun; 121(6):493-9. PMID: 15221418; PMCID: PMC2845917.
    62. Colnot C, Thompson Z, Miclau T, Werb Z, Helms JA. Altered fracture repair in the absence of MMP9. Development. 2003 Sep; 130(17):4123-33. PMID: 12874132; PMCID: PMC2778064.
    63. Box GG, Lindsey RW, Curylo L, Miclau T, Alexander JW, Perren SM. The effect of delayed autogenous bone grafting on the healing of diaphyseal defects in a canine model. Orthopedics. 2003 Mar; 26(3):311-5. PMID: 12650324.
      View in: PubMed
    64. Caprise PA, Miclau T, Dahners LE, Dirschl DR. High-pressure pulsatile lavage irrigation of contaminated fractures: effects on fracture healing. J Orthop Res. 2002 Nov; 20(6):1205-9. PMID: 12472230.
      View in: PubMed
    65. Thompson Z, Miclau T, Hu D, Helms JA. A model for intramembranous ossification during fracture healing. J Orthop Res. 2002 Sep; 20(5):1091-8. PMID: 12382977.
      View in: PubMed
    66. Lee EW, Dirschl DR, Duff G, Dahners LE, Miclau T. High-pressure pulsatile lavage irrigation of fresh intraarticular fractures: effectiveness at removing particulate matter from bone. J Orthop Trauma. 2002 Mar; 16(3):162-5. PMID: 11880778.
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