Thomas Cirino, PhD

Title(s)Postdoctoral Scholar, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
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    University of Florida, Gainesville, FloridaPh.D05/2020Pharmaceutical Sciences: Pharmacodynamics
    Florida State University, Tallahassee, FloridaB.S05/2015Biochemistry and Chemistry

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    I am currently working under Dr. Elyssa Margolis studying how pathological states such as chronic pain, stress and addiction alter motivational circuitry. My dissertation work under Dr. Jay McLaughlin at the University of Florida investigated how exposure to viral proteins during HIV infection such as the transactivator of transcription protein, Tat, contributes to HIV-associated comorbities including cognitive impairment, chronic pain, addiction and affective disorders. I utilize behavioral, anatomical and electrophysiological techniques to determine relevant circuitry underlying these maladaptive conditions, and collaborate with medicinal chemists to evaluate novel therapeutics to restore function.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mini review: Promotion of substance abuse in HIV patients: Biological mediation by HIV-1 Tat protein. Neurosci Lett. 2021 May 14; 753:135877. Cirino TJ, McLaughlin JP. PMID: 33838257.
      View in: PubMed   Mentions:    Fields:    
    2. Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-Tat1-86) Protein Alters Nociceptive Processing that is Sensitive to Anti-Oxidant and Anti-Inflammatory Interventions. J Neuroimmune Pharmacol. 2021 Feb 22. Cirino TJ, Alleyne AR, Duarte V, Figueroa A, Simons CA, Anceaume EM, Kendrick J, Wallman O, Eans SO, Stacy HM, Medina JM, McLaughlin JP. PMID: 33619645.
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    3. Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal. Cell Mol Neurobiol. 2021 Jul; 41(5):1131-1143. Wilson LL, Chakraborty S, Eans SO, Cirino TJ, Stacy HM, Simons CA, Uprety R, Majumdar S, McLaughlin JP. PMID: 33433723.
      View in: PubMed   Mentions: 4     Fields:    
    4. HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration. Mol Neurobiol. 2021 Feb; 58(2):490-504. Sivalingam K, Cirino TJ, McLaughlin JP, Samikkannu T. PMID: 32978730.
      View in: PubMed   Mentions: 3     Fields:    
    5. Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence. Drug Alcohol Depend. 2020 11 01; 216:108310. Wilson LL, Harris HM, Eans SO, Brice-Tutt AC, Cirino TJ, Stacy HM, Simons CA, León F, Sharma A, Boyer EW, Avery BA, McLaughlin JP, McCurdy CR. PMID: 33017752.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus. J Neurophysiol. 2020 04 01; 123(4):1332-1341. Cirino TJ, Harden SW, McLaughlin JP, Frazier CJ. PMID: 32101482.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain. Front Pharmacol. 2019; 10:678. Cirino TJ, Eans SO, Medina JM, Wilson LL, Mottinelli M, Intagliata S, McCurdy CR, McLaughlin JP. PMID: 31258480.
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    8. Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct; 2(7):599-609. McLaughlin JP, Paris JJ, Mintzopoulos D, Hymel KA, Kim JK, Cirino TJ, Gillis TE, Eans SO, Vitaliano GD, Medina JM, Krapf RC, Stacy HM, Kaufman MJ. PMID: 29057370.
      View in: PubMed   Mentions: 6     Fields:    
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