Tiffany Ho, PhD

TitleAssociate Researcher
SchoolUCSF School of Medicine
Address401 Parnassus Ave.
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyB.A.2006Cognitive Science
    University of California, San DiegoPh.D.2012Psychology
    Collapse Awards and Honors
    Society for Neuroscience2014Postdoctoral Fellow Travel Award
    Society of Biological Psychiatry2015Travel Award
    Career Development Institute for Psychiatry2016  - 2018Trainee
    American College of Neuropsychopharmacology2016Travel Award
    Klingenstein Third Generation Foundation2017  - 2019Fellow in Child and Adolescent Depression

    Collapse Overview 
    Collapse Overview
    I am a translational neuroscientist broadly interested in brain development and mental health. Specifically, I study neurobiological risk factors and mechanisms of adolescent depression from an affective and developmental lens using cognitive neuroscience and computational methods. My goal is to leverage the rich information from an individual (brain, cognition, life experiences, etc), with the hope that my research will guide the development of more personalized and effective interventions in adolescents.

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding the Course of Adolescent Depression: Cytokines, Glutamate, Glutathione
    Klingenstein Third Generation Foundation Sep 1, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Functional Magnetic Resonance Imaging of Suicidal Ideation and Behavior in Adolescents
    American Foundation for Suicide Prevention Oct 1, 2014 - Mar 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Fischer AS, Camacho MC, Ho T, Whitfield-Gabrieli S, Gotlib IH. Neural Markers of Resilience in Adolescent Females at Familial Risk for Major Depressive Disorder. JAMA Psychiatry. 2018 Mar 21. PMID: 29562053.
      View in: PubMed
    2. Tymofiyeva O, Henje Blom E, Ho T, Connolly CG, Lindqvist D, Wolkowitz OM, Lin J, LeWinn KZ, Sacchet MD, Han LKM, Yuan JP, Bhandari SP, Xu D, Yang TT. High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression. J Affect Disord. 2018 Feb 17; 232:283-290. PMID: 29500956.
      View in: PubMed
    3. Colich NL, Williams ES, Ho T, King LS, Humphreys KL, Price AN, Ordaz SJ, Gotlib IH. The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence. Dev Psychopathol. 2017 Dec; 29(5):1851-1864. PMID: 29162186.
      View in: PubMed
    4. Ho T, Auerbach RP. Toward an Improved Understanding of Corticobasal Ganglia Reward Circuitry in Adolescent Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct; 2(7):554-555. PMID: 29560908.
      View in: PubMed
    5. Ordaz SJ, Goyer MS, Ho T, Singh MK, Gotlib IH. Network basis of suicidal ideation in depressed adolescents. J Affect Disord. 2018 Jan 15; 226:92-99. PMID: 28968564.
      View in: PubMed
    6. Colich NL, Ho T, Foland-Ross LC, Eggleston C, Ordaz SJ, Singh MK, Gotlib IH. Hyperactivation in Cognitive Control and Visual Attention Brain Regions During Emotional Interference in Adolescent Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jul; 2(5):388-395. PMID: 28890942.
      View in: PubMed
    7. Colich NL, Ho T, Ellwood-Lowe M, Foland-Ross LC, Sacchet MD, LeMoult JL, Gotlib IH. Like Mother Like Daughter: Putamen Activation as a Mechanism Underlying Intergenerational Risk for Depression. Soc Cogn Affect Neurosci. 2017 May 29. PMID: 28575505.
      View in: PubMed
    8. Ho T, Sacchet MD, Connolly CG, Margulies DS, Tymofiyeva O, Paulus MP, Simmons AN, Gotlib IH, Yang TT. Inflexible Functional Connectivity of the Dorsal Anterior Cingulate Cortex in Adolescent Major Depressive Disorder. Neuropsychopharmacology. 2017 May 29. PMID: 28553837.
      View in: PubMed
    9. Ho T, King LS, Leong JK, Colich NL, Humphreys KL, Ordaz SJ, Gotlib IH. Effects of Sensitivity to Life Stress on Uncinate Fasciculus Segments in Early Adolescence. Soc Cogn Affect Neurosci. 2017 Apr 28. PMID: 28460088.
      View in: PubMed
    10. Henje Blom E, Tymofiyeva O, Chesney MA, Ho T, Moran P, Connolly CG, Duncan LG, Baldini L, Weng HY, Acree M, Goldman V, Hecht FM, Yang TT. Feasibility and Preliminary Efficacy of a Novel RDoC-Based Treatment Program for Adolescent Depression: "Training for Awareness Resilience and Action" (TARA)-A Pilot Study. Front Psychiatry. 2016; 7:208. PMID: 28138319.
      View in: PubMed
    11. Connolly CG, Ho T, Blom EH, LeWinn KZ, Sacchet MD, Tymofiyeva O, Simmons AN, Yang TT. Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression. J Affect Disord. 2017 Jan 01; 207:86-94. PMID: 27716542.
      View in: PubMed
    12. Colich NL, Ho T, Foland-Ross LC, Eggleston C, Ordaz SJ, Singh MK, Gotlib IH. Hyperactivation in Cognitive Control and Visual Attention Brain Regions During Emotional Interference in Adolescent Depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2016.
    13. Tymofiyeva O, Connolly CG, Ho T, Sacchet MD, Henje Blom E, LeWinn KZ, Xu D, Yang TT, et al. DTI-based connectome analysis of adolescents with major depressive disorder reveals hypoconnectivity of the right caudate. J Affect Disord. 2017 Jan 01; 207:18-25. PMID: 27673479.
      View in: PubMed
    14. Ho T, Sanders SJ, Gotlib IH, Hoeft F, et al. Intergenerational Neuroimaging of Human Brain Circuitry. Trends Neurosci. 2016 Oct; 39(10):644-648. PMID: 27623194.
      View in: PubMed
    15. Sacchet MD, Ho T, Connolly CG, Tymofiyeva O, Lewinn KZ, Han LK, Blom EH, Tapert SF, Max JE, Frank GK, Paulus MP, Simmons AN, Gotlib IH, Yang TT, et al. Large-Scale Hypoconnectivity Between Resting-State Functional Networks in Unmedicated Adolescent Major Depressive Disorder. Neuropsychopharmacology. 2016 Nov; 41(12):2951-2960. PMID: 27238621.
      View in: PubMed
    16. Ho T, Zhang S, Sacchet MD, Weng H, Connolly CG, Henje Blom E, Han LK, Mobayed NO, Yang TT. Fusiform Gyrus Dysfunction is Associated with Perceptual Processing Efficiency to Emotional Faces in Adolescent Depression: A Model-Based Approach. Front Psychol. 2016; 7:40. PMID: 26869950; PMCID: PMC4740953.
    17. Henje-Blom E, Ho T, Connolly CG, LeWinn KZ, Sacchet MD, Tymofiyeva O, Weng HY, Yang TT. The neuroscience and context of adolescent depression. Acta Paediatr. 2016 Apr; 105(4):358-65. PMID: 26663379; PMCID: PMC4779656.
    18. Henje Blom E, Han LK, Connolly CG, Ho T, Lin J, LeWinn KZ, Simmons AN, Sacchet MD, Mobayed N, Luna ME, Paulus M, Epel ES, Blackburn EH, Wolkowitz OM, Yang TT. Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder. Transl Psychiatry. 2015 Nov 10; 5:e676. PMID: 26556285.
      View in: PubMed
    19. Henje Blom E, Connolly CG, Ho T, LeWinn KZ, Mobayed N, Han L, Paulus MP, Wu J, Simmons AN, Yang TT. Altered insular activation and increased insular functional connectivity during sad and happy face processing in adolescent major depressive disorder. J Affect Disord. 2015 Jun 01; 178:215-23. PMID: 25827506; PMCID: PMC4412607.
    20. Ho T, Connolly CG, Henje Blom E, LeWinn KZ, Strigo IA, Paulus MP, Frank G, Max JE, Wu J, Chan M, Tapert SF, Simmons AN, Yang TT. Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression. Biol Psychiatry. 2015 Nov 01; 78(9):635-46. PMID: 25483399; PMCID: PMC4362932 [Available on 11/01/16].
    21. Henje Blom E, Duncan LG, Ho T, Connolly CG, LeWinn KZ, Chesney M, Hecht FM, Yang TT. The development of an RDoC-based treatment program for adolescent depression: "Training for Awareness, Resilience, and Action" (TARA). Front Hum Neurosci. 2014; 8:630. PMID: 25191250; PMCID: PMC4137278.
    22. LeWinn KZ, Connolly CG, Wu J, Drahos M, Hoeft F, Ho T, Simmons AN, Yang TT. White matter correlates of adolescent depression: structural evidence for frontolimbic disconnectivity. J Am Acad Child Adolesc Psychiatry. 2014 Aug; 53(8):899-909, 909.e1-7. PMID: 25062597; PMCID: PMC4112055.
    23. Ester EF, Ho T, Brown SD, Serences JT. Variability in visual working memory ability limits the efficiency of perceptual decision making. J Vis. 2014 Apr 02; 14(4). PMID: 24695991; PMCID: PMC3974583.
    24. Ho T, Yang G, Wu J, Cassey P, Brown SD, Hoang N, Chan M, Connolly CG, Henje-Blom E, Duncan LG, Chesney MA, Paulus MP, Max JE, Patel R, Simmons AN, Yang TT. Functional connectivity of negative emotional processing in adolescent depression. J Affect Disord. 2014 Feb; 155:65-74. PMID: 24268546; PMCID: PMC4961511.
    25. Connolly CG, Wu J, Ho T, Hoeft F, Wolkowitz O, Eisendrath S, Frank G, Hendren R, Max JE, Paulus MP, Tapert SF, Banerjee D, Simmons AN, Yang TT. Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents. Biol Psychiatry. 2013 Dec 15; 74(12):898-907. PMID: 23910949; PMCID: PMC4103629.
    26. Ho T, Wu J, Shin DD, Liu TT, Tapert SF, Yang G, Connolly CG, Frank GK, Max JE, Wolkowitz O, Eisendrath S, Hoeft F, Banerjee D, Hood K, Hendren RL, Paulus MP, Simmons AN, Yang TT. Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression. J Am Acad Child Adolesc Psychiatry. 2013 Oct; 52(10):1076-1091.e2. PMID: 24074474; PMCID: PMC3825460.
    27. Ho T, Ester EF. Target enhancement and distractor suppression in naturalistic visual search. J Neurosci. 2012 Nov 21; 32(47):16539-40. PMID: 23175809; PMCID: PMC3535462.
    28. Ho T, Brown S, Abuyo NA, Ku EH, Serences JT. Perceptual consequences of feature-based attentional enhancement and suppression. J Vis. 2012 Aug 24; 12(8):15. PMID: 22923726; PMCID: PMC4503215.
    29. Ho T, Horn NA, Huynh T, Kelava L, Lansman JB. Evidence TRPV4 contributes to mechanosensitive ion channels in mouse skeletal muscle fibers. Channels (Austin). 2012 Jul-Aug; 6(4):246-54. PMID: 22785252; PMCID: PMC3508903.
    30. Ho T, Brown S, van Maanen L, Forstmann BU, Wagenmakers EJ, Serences JT. The optimality of sensory processing during the speed-accuracy tradeoff. J Neurosci. 2012 Jun 06; 32(23):7992-8003. PMID: 22674274; PMCID: PMC3388609.
    31. van Maanen L, Brown SD, Eichele T, Wagenmakers EJ, Ho T, Serences J, Forstmann BU. Neural correlates of trial-to-trial fluctuations in response caution. J Neurosci. 2011 Nov 30; 31(48):17488-95. PMID: 22131410.
      View in: PubMed
    32. Ho T, Brown S, Serences JT. Domain general mechanisms of perceptual decision making in human cortex. J Neurosci. 2009 Jul 08; 29(27):8675-87. PMID: 19587274; PMCID: PMC2719543.
    33. Serences JT, Saproo S, Scolari M, Ho T, Muftuler LT. Estimating the influence of attention on population codes in human visual cortex using voxel-based tuning functions. Neuroimage. 2009 Jan 01; 44(1):223-31. PMID: 18721888.
      View in: PubMed
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