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Tomos Walters, PhD

TitleHS Clinical Instructor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address500 Parnassus Avenue
San Francisco CA 94117
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    Collapse Overview
    CLINICAL
    My particular clinical interest is the management of complex cardiac arrhythmias. I employ a patient-centered approach that seeks to understand how each individual patient experiences their heart rhythm disorder, and I work with each patient to develop a comprehensive management plan that address their particular concerns. With extensive training at leading centers in both Australia and the USA, I have particular expertise in catheter ablation of complex atrial and ventricular arrhythmias, and I also have expertise and great interest in the implantation and management of pacemakers, defibrillators and cardiac resynchronization devices.

    RESEARCH
    During my training in the management of heart rhythm disorders, I completed a PhD that focussed on the mechanisms underlying the persistence of atrial fibrillation, the most common sustained heart rhythm disorder encountered in clinical practice. I am now continuing this research, with the aim of identifying specific treatment targets in each individual patient with persistent atrial fibrillation. I am also heavily involved in research aimed at understanding the mechanisms through which ectopic heart beats from the ventricles of the heart can lead to heart failure, with the aim of developing therapies that might prevent heart failure.


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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stacy R, Huttner K, Watts J, Peace J, Wirta D, Walters T, Sall K, Seaman J, Ni X, Prasanna G, Mogi M, Adams C, Yan JH, Wald M, He Y, Newton R, Kolega R, Grosskreutz C. A randomized, controlled phase I/II study to evaluate the safety and efficacy of MGV354 for ocular hypertension or glaucoma. Am J Ophthalmol. 2018 May 23. PMID: 29802818.
      View in: PubMed
    2. McLellan AJA, Prabhu S, Voskoboinik A, Wong MCG, Walters T, Pathik B, Morris GM, Nisbet A, Lee G, Morton JB, Kalman JM, Kistler PM. Isolation of the posterior left atrium for patients with persistent atrial fibrillation: routine adenosine challenge for dormant posterior left atrial conduction improves long-term outcome. Europace. 2017 Dec 01; 19(12):1958-1966. PMID: 28204434.
      View in: PubMed
    3. Pathik B, Kalman JM, Walters T, Kuklik P, Zhao J, Madry A, Sanders P, Kistler PM, Lee G. Absence of rotational activity detected using 2-dimensional phase mapping in the corresponding 3-dimensional phase maps in human persistent atrial fibrillation. Heart Rhythm. 2018 Feb; 15(2):182-192. PMID: 28917553.
      View in: PubMed
    4. Pathik B, Kalman JM, Walters T, Kuklik P, Zhao J, Madry A, Prabhu S, Nalliah C, Kistler P, Lee G. Transient Rotor Activity During Prolonged 3-Dimensional Phase Mapping in Human Persistent Atrial Fibrillation. JACC Clin Electrophysiol. 2018 Jan; 4(1):72-83. PMID: 29600788.
      View in: PubMed
    5. Walters T, Kalman JM, Patel SK, Mearns M, Velkoska E, Burrell LM. Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling. Europace. 2017 Aug 01; 19(8):1280-1287. PMID: 27738071.
      View in: PubMed
    6. Szilágyi J, Marcus GM, Badhwar N, Lee BK, Lee RJ, Vedantham V, Tseng ZH, Walters T, Scheinman M, Olgin J, Gerstenfeld EP. Atrial fibrillation patients with isolated pulmonary veins: Is sinus rhythm achievable? J Cardiovasc Electrophysiol. 2017 Jul; 28(7):754-761. PMID: 28429499.
      View in: PubMed
    7. Nazer B, Walters T, Duggirala S, Gerstenfeld EP. Feasibility of Rapid Linear-Endocardial and Epicardial Ventricular Ablation Using an Irrigated Multipolar Radiofrequency Ablation Catheter. Circ Arrhythm Electrophysiol. 2017 Mar; 10(3). PMID: 28288961.
      View in: PubMed
    8. Gerstenfeld EP, Walters T. Amiodarone for Suppression of Ventricular Tachycardia: When Less Is More. JACC Clin Electrophysiol. 2017 May; 3(5):512-513. PMID: 29759608.
      View in: PubMed
    9. Janaswamy P, Walters T, Nazer B, Lee RJ. Current Treatment Strategies for Heart Failure: Role of Device Therapy and LV Reconstruction. Curr Treat Options Cardiovasc Med. 2016 Sep; 18(9):57. PMID: 27488313.
      View in: PubMed
    10. Walters T, Lee G, Spence S, Kalman JM. The effect of electrode density on the interpretation of atrial activation patterns in epicardial mapping of human persistent atrial fibrillation. Heart Rhythm. 2016 06; 13(6):1215-20. PMID: 26829116.
      View in: PubMed
    11. Walters T, Nisbet A, Morris GM, Tan G, Mearns M, Teo E, Lewis N, Ng A, Gould P, Lee G, Joseph S, Morton JB, Zentner D, Sanders P, Kistler PM, Kalman JM. Progression of atrial remodeling in patients with high-burden atrial fibrillation: Implications for early ablative intervention. Heart Rhythm. 2016 Feb; 13(2):331-9. PMID: 26484789.
      View in: PubMed
    12. Prabhu S, McLellan AJ, Walters T, Sharma M, Voskoboinik A, Kistler PM. Atrial structure and function and its implications for current and emerging treatments for atrial fibrillation. Prog Cardiovasc Dis. 2015 Sep-Oct; 58(2):152-67. PMID: 26247494.
      View in: PubMed
    13. Walters T, Ellims AH, Kalman JM. The role of left atrial imaging in the management of atrial fibrillation. Prog Cardiovasc Dis. 2015 Sep-Oct; 58(2):136-51. PMID: 26241303.
      View in: PubMed
    14. Walters T, Kalman JM. Human persistent atrial fibrillation is maintained by rotors: the jury is still out. Circ Arrhythm Electrophysiol. 2015 Jun; 8(3):517-9. PMID: 26082522.
      View in: PubMed
    15. McLellan AJ, Ling LH, Azzopardi S, Lee GA, Lee G, Kumar S, Wong MC, Walters T, Lee JM, Looi KL, Halloran K, Stiles MK, Lever NA, Fynn SP, Heck PM, Sanders P, Morton JB, Kalman JM, Kistler PM. A minimal or maximal ablation strategy to achieve pulmonary vein isolation for paroxysmal atrial fibrillation: a prospective multi-centre randomized controlled trial (the Minimax study). Eur Heart J. 2015 Jul 21; 36(28):1812-21. PMID: 25920401.
      View in: PubMed
    16. Walters T, Lee G, Morris G, Spence S, Larobina M, Atkinson V, Antippa P, Goldblatt J, Royse A, O'Keefe M, Sanders P, Morton JB, Kistler PM, Kalman JM. Temporal Stability of Rotors and Atrial Activation Patterns in Persistent Human Atrial Fibrillation: A High-Density Epicardial Mapping Study of Prolonged Recordings. JACC Clin Electrophysiol. 2015 Mar - Apr; 1(1-2):14-24. PMID: 29759334.
      View in: PubMed
    17. Walters T, Lee G, Spence S, Larobina M, Atkinson V, Antippa P, Goldblatt J, O'Keefe M, Sanders P, Kistler PM, Kalman JM. Acute atrial stretch results in conduction slowing and complex signals at the pulmonary vein to left atrial junction: insights into the mechanism of pulmonary vein arrhythmogenesis. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1189-97. PMID: 25516579.
      View in: PubMed
    18. Walters T, Teh AW, Spence S, Morton JB, Kistler PM, Kalman JM. Absence of gender-based differences in the atrial and pulmonary vein substrate: a detailed electroanatomic mapping study. J Cardiovasc Electrophysiol. 2014 Oct; 25(10):1065-70. PMID: 24902862.
      View in: PubMed
    19. Walters T, Kalman JM. Development of atrial fibrillation after atrial flutter ablation: more a question of when than whether. J Cardiovasc Electrophysiol. 2014 Aug; 25(8):821-823. PMID: 24762080.
      View in: PubMed
    20. Walters T, Teh AW, Spence S, Kistler PM, Morton JB, Kalman JM. Relationship between the electrocardiographic atrial fibrillation cycle length and left atrial remodeling: a detailed electroanatomic mapping study. Heart Rhythm. 2014 Apr; 11(4):670-6. PMID: 24378770.
      View in: PubMed
    21. McLellan AJ, Ling LH, Ruggiero D, Wong MC, Walters T, Nisbet A, Shetty AK, Azzopardi S, Taylor AJ, Morton JB, Kalman JM, Kistler PM. Pulmonary vein isolation: the impact of pulmonary venous anatomy on long-term outcome of catheter ablation for paroxysmal atrial fibrillation. Heart Rhythm. 2014 Apr; 11(4):549-56. PMID: 24342795.
      View in: PubMed
    22. Amerena JV, Walters T, Mirzaee S, Kalman JM. Update on the management of atrial fibrillation. Med J Aust. 2013 Nov 04; 199(9):592-7. PMID: 24182224.
      View in: PubMed
    23. Kumar S, Walters T, Halloran K, Morton JB, Hepworth G, Wong CX, Kistler PM, Sanders P, Kalman JM. Ten-year trends in the use of catheter ablation for treatment of atrial fibrillation vs. the use of coronary intervention for the treatment of ischaemic heart disease in Australia. Europace. 2013 Dec; 15(12):1702-9. PMID: 23796617.
      View in: PubMed
    24. Walters T, Kistler PM, Morton JB, Sparks PB, Halloran K, Kalman JM. Impact of collimation on radiation exposure during interventional electrophysiology. Europace. 2012 Nov; 14(11):1670-3. PMID: 22516059.
      View in: PubMed
    25. Walters T, Kistler PM, Kalman JM. Radiofrequency ablation for atrial tachycardia and atrial flutter. Heart Lung Circ. 2012 Jun; 21(6-7):386-94. PMID: 22464595.
      View in: PubMed
    26. Pattison DA, Walters T, Seal E. Exercise-associated hyponatraemia on the Kokoda Track. Med J Aust. 2011 Mar 07; 194(5):247-8. PMID: 21381998.
      View in: PubMed
    27. Wightman F, Walters T, Ayres A, Bowden S, Bartholomeusz A, Lau D, Locarnini S, Lewin SR. Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of Lamivudine-resistant hepatitis B virus strains. J Clin Microbiol. 2004 Aug; 42(8):3809-12. PMID: 15297535; PMCID: PMC497642.
    28. Lewin S, Walters T, Locarnini S. Hepatitis B treatment: rational combination chemotherapy based on viral kinetic and animal model studies. Antiviral Res. 2002 Sep; 55(3):381-96. PMID: 12206877.
      View in: PubMed
    29. Torresi J, Earnest-Silveira L, Civitico G, Walters T, Lewin SR, Fyfe J, Locarnini SA, Manns M, Trautwein C, Bock TC. Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene. Virology. 2002 Jul 20; 299(1):88-99. PMID: 12167344.
      View in: PubMed