Tracy McKnight, PhD

TitleAssoc. Professor in Residence
SchoolUCSF School of Medicine
Address185 Berry Street
San Francisco CA 94143
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    Collapse Biography 
    Collapse Awards and Honors
    American Society of Neuroradiology2007Outstanding Presentation Award
    Alliance for Graduate Education and the Professoriate (AGEP) Colloquium, San Francisco2006Keynote Address
    American Society of Neuroradiology2001Outstanding Presentation Award
    National Institutes of Health Diagnostic Oncology1998Training Fellowship
    National Institutes of Health Cardiovascular and Neurophysiology1994Training Fellowship
    University of California, Davis1991Patricia Roberts Harris Fellowship

    Collapse Overview 
    Collapse Overview
    Tracy R. McKnight, PhD, is an Associate Professor in Residence, Director of the Center for Molecular and Functional Imaging Tissue Lab, and Co-Chair of the Safety and Compliance Committee in the Department of Radiology. Also, she is the Director of the UCSF – Tuskegee Summer Internship in Bioengineering and she is Co-Director of the UCSF Tumor Microenvironment Network Imaging and Tissue Procurement Core in Neurosurgery. Dr. McKnight received her BS in Physics from Spelman College in Atlanta, Georgia, in 1988, and she obtained her MS in Physics from Polytechnic University in Brooklyn, New York, in 1990. She completed her PhD in Biomedical Engineering from the University of California, Davis in 1998, followed by a visiting postdoctoral scholar at UCSF.

    Dr. McKnight’s research program is focused on improving the monitoring and treatment of patients with brain tumors through the use of advanced imaging technologies. A primary goal of her research is to investigate the biomedical mechanisms associated with the malignant progression of brain tumors using techniques that can be incorporated into patient management tools. Dr. McKnight’s recent research program is the study of cell and animal models of glioma. The purpose of this study is to probe the relationship between MR signals and subcellular mechanisms involved in tumor progression, and to characterize the structural and fluid mobility properties of tumors.

    Dr. McKnight is a member of the International Society of Magnetic Resonance in Medicine, the American Association for Cancer Research, and the American Society of Neuroradiology. Dr. McKnight is a member of several UCSF committees and departmental committees, and she is a reviewer for five scientific journals. She has 27 published articles and she has written 26 peer-reviewed articles, 45 abstracts, and 5 significant publications.

    Neuroradiology and Neurosurgery

    Neurosurgery, brain tumors, MRS

    Professional Interests:
    Cancer, magnetic resonance imaging, magnetic resonance spectroscopy, brain tumor, tumor biology, cancer progression, metabolism

    Education and Training:
    • Bachelor of Science: Spelman College, Atlanta, Georgia - Physics
    • Masters of Science: Polytechnic University, Brooklyn, New York - Physics
    • Doctor of Philosophy: University of California, Davis - Biomedical Engineering
    • Visiting Postdoctoral Scholar: University of California, San Francisco Department of Radiology

    Collapse Research 
    Collapse Research Activities and Funding
    Impact of molecular phenotype on glioma metabolism and growth
    NIH/NCI R01CA159869Apr 1, 2011 - Mar 31, 2016
    Role: Co-Principal Investigator
    The effect of p53 signaling on the metabolism and therapeutic response of glioma
    NIH/NCI R21CA154049Jun 29, 2010 - May 31, 2012
    Role: Principal Investigator
    Identification of MRS Markers of Glioma Progression
    NIH/NCI R01CA116041Jul 1, 2006 - May 31, 2011
    Role: Principal Investigator
    MRI / MRSI and Molecular Analysis of Low Grade Gliomas
    NIH/NCI K01CA090244Jun 7, 2001 - May 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight T, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Dec; 18(12):1336-1345. PMID: 27820599.
      View in: PubMed
    2. McKnight T, Yoshihara HA, Sitole LJ, Martin JN, Steffens F, Meyer D. A combined chemometric and quantitative NMR analysis of HIV/AIDS serum discloses metabolic alterations associated with disease status. Mol Biosyst. 2014 Nov; 10(11):2889-97. PMID: 25105420; PMCID: PMC4492936.
    3. Hashizume R, Smirnov I, Liu S, Phillips JJ, Hyer J, McKnight T, Wendland M, Prados M, Banerjee A, Nicolaides T, Mueller S, James CD, Gupta N. Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment. J Neurooncol. 2012 Dec; 110(3):305-13. PMID: 22983601.
      View in: PubMed
    4. Khayal IS, Vandenberg SR, Smith KJ, Cloyd CP, Chang SM, Cha S, Nelson SJ, McKnight T. MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas. Neuro Oncol. 2011 Nov; 13(11):1192-201. PMID: 21865401; PMCID: PMC3199150.
    5. McKnight T, Smith KJ, Chu PW, Chiu KS, Cloyd CP, Chang SM, Phillips JJ, Berger MS. Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma. J Magn Reson Imaging. 2011 Apr; 33(4):808-16. PMID: 21448944; PMCID: PMC3076678.
    6. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight T, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82. PMID: 21156288; PMCID: PMC3031116.
    7. Khayal IS, McKnight T, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson SJ. Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomas. NMR Biomed. 2009 May; 22(4):449-55. PMID: 19125391; PMCID: PMC3772178.
    8. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. PMID: 19095069; PMCID: PMC2730220.
    9. Haas-Kogan DA, Banerjee A, Kocak M, Prados MD, Geyer JR, Fouladi M, McKnight T, Poussaint TY, Broniscer A, Blaney SM, Boyett JM, Kun LE. Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma. Neuro Oncol. 2008 Jun; 10(3):341-7. PMID: 18417739; PMCID: PMC2563056.
    10. Khayal IS, Crawford FW, Saraswathy S, Lamborn KR, Chang SM, Cha S, McKnight T, Nelson SJ. Relationship between choline and apparent diffusion coefficient in patients with gliomas. J Magn Reson Imaging. 2008 Apr; 27(4):718-25. PMID: 18383265; PMCID: PMC3030277.
    11. Laprie A, Catalaa I, Cassol E, McKnight T, Berchery D, Marre D, Bachaud JM, Berry I, Moyal EC. Proton magnetic resonance spectroscopic imaging in newly diagnosed glioblastoma: predictive value for the site of postradiotherapy relapse in a prospective longitudinal study. Int J Radiat Oncol Biol Phys. 2008 Mar 01; 70(3):773-81. PMID: 18262090.
      View in: PubMed
    12. McKnight T, Lamborn KR, Love TD, Berger MS, Chang S, Dillon WP, Bollen A, Nelson SJ. Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas. J Neurosurg. 2007 Apr; 106(4):660-6. PMID: 17432719.
      View in: PubMed
    13. Catalaa I, Henry R, Dillon WP, Graves EE, McKnight T, Lu Y, Vigneron DB, Nelson SJ. Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas. NMR Biomed. 2006 Jun; 19(4):463-75. PMID: 16763973.
      View in: PubMed
    14. Saito R, Krauze MT, Bringas JR, Noble C, McKnight T, Jackson P, Wendland MF, Mamot C, Drummond DC, Kirpotin DB, Hong K, Berger MS, Park JW, Bankiewicz KS. Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol. 2005 Dec; 196(2):381-9. PMID: 16197944.
      View in: PubMed
    15. Krauze MT, Mcknight TR, Yamashita Y, Bringas J, Noble CO, Saito R, Geletneky K, Forsayeth J, Berger MS, Jackson P, Park JW, Bankiewicz KS. Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging. Brain Res Brain Res Protoc. 2005 Dec; 16(1-3):20-6. PMID: 16181805.
      View in: PubMed
    16. Krauze MT, Saito R, Noble C, Bringas J, Forsayeth J, McKnight T, Park J, Bankiewicz KS. Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen. Exp Neurol. 2005 Nov; 196(1):104-11. PMID: 16109410.
      View in: PubMed
    17. Laprie A, Pirzkall A, Haas-Kogan DA, Cha S, Banerjee A, Le TP, Lu Y, Nelson S, McKnight T. Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2005 May 01; 62(1):20-31. PMID: 15850898.
      View in: PubMed
    18. McKnight T. Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism. Semin Oncol. 2004 Oct; 31(5):605-17. PMID: 15497114.
      View in: PubMed
    19. Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, Drummond DC, Hong K, Kirpotin DB, McKnight T, Berger MS, Park JW, Bankiewicz KS. Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol. 2004 May; 68(1):1-9. PMID: 15174514.
      View in: PubMed
    20. Lee MC, Pirzkall A, McKnight T, Nelson SJ. 1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification. J Magn Reson Imaging. 2004 Apr; 19(4):379-88. PMID: 15065160.
      View in: PubMed
    21. Saito R, Bringas JR, McKnight T, Wendland MF, Mamot C, Drummond DC, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS. Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res. 2004 Apr 01; 64(7):2572-9. PMID: 15059914.
      View in: PubMed
    22. McKnight T, Curry FE. Mechanisms of heterogeneous endothelial cytoplasmic calcium increases in venular microvessels. Microcirculation. 2002 Dec; 9(6):537-50. PMID: 12483550.
      View in: PubMed
    23. Nelson SJ, McKnight T, Henry RG. Characterization of untreated gliomas by magnetic resonance spectroscopic imaging. Neuroimaging Clin N Am. 2002 Nov; 12(4):599-613. PMID: 12687914.
      View in: PubMed
    24. Nelson SJ, Graves E, Pirzkall A, Li X, Antiniw Chan A, Vigneron DB, McKnight T. In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J Magn Reson Imaging. 2002 Oct; 16(4):464-76. PMID: 12353260.
      View in: PubMed
    25. McKnight T, von dem Bussche MH, Vigneron DB, Lu Y, Berger MS, McDermott MW, Dillon WP, Graves EE, Pirzkall A, Nelson SJ. Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. J Neurosurg. 2002 Oct; 97(4):794-802. PMID: 12405365.
      View in: PubMed
    26. Li X, Lu Y, Pirzkall A, McKnight T, Nelson SJ. Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients. J Magn Reson Imaging. 2002 Sep; 16(3):229-37. PMID: 12205577.
      View in: PubMed
    27. Pirzkall A, Nelson SJ, McKnight T, Takahashi MM, Li X, Graves EE, Verhey LJ, Wara WW, Larson DA, Sneed PK. Metabolic imaging of low-grade gliomas with three-dimensional magnetic resonance spectroscopy. Int J Radiat Oncol Biol Phys. 2002 Aug 01; 53(5):1254-64. PMID: 12128127.
      View in: PubMed
    28. Pirzkall A, McKnight T, Graves EE, Carol MP, Sneed PK, Wara WW, Nelson SJ, Verhey LJ, Larson DA. MR-spectroscopy guided target delineation for high-grade gliomas. Int J Radiat Oncol Biol Phys. 2001 Jul 15; 50(4):915-28. PMID: 11429219.
      View in: PubMed
    29. McKnight T, Noworolski SM, Vigneron DB, Nelson SJ. An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma. J Magn Reson Imaging. 2001 Feb; 13(2):167-77. PMID: 11169821.
      View in: PubMed
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