Trent Balius, PhD

TitleAssociate Specialist
InstitutionUniversity of California San Francisco
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
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    Collapse Research 
    Collapse Research Activities and Funding
    Docking the Proteome for New Ligands and Functional Associations
    NIH/NIGMS F32GM108161Jan 1, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Characterizing the Mechanism of Cancer-Causing and Resistance Mutation of EGFR
    NIH/NCI F31CA134201May 24, 2008 - May 23, 2013
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N. Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. J Chem Inf Model. 2018 Feb 26; 58(2):464-471. PMID: 29320178.
      View in: PubMed
    2. Allen WJ, Fochtman BC, Balius TE, Rizzo RC. Customizable de novo design strategies for DOCK: Application to HIVgp41 and other therapeutic targets. J Comput Chem. 2017 Nov 15; 38(30):2641-2663. PMID: 28940386.
      View in: PubMed
    3. Balius TE, Fischer M, Stein RM, Adler TB, Nguyen CN, Cruz A, Gilson MK, Kurtzman T, Shoichet BK. Testing inhomogeneous solvation theory in structure-based ligand discovery. Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33):E6839-E6846. PMID: 28760952.
      View in: PubMed
    4. Teng YH, Berger WT, Nesbitt NM, Kumar K, Balius TE, Rizzo RC, Tonge PJ, Ojima I, Swaminathan S. Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A. Bioorg Med Chem. 2015 Sep 01; 23(17):5489-95. PMID: 26275678.
      View in: PubMed
    5. Allen WJ, Balius TE, Mukherjee S, Brozell SR, Moustakas DT, Lang PT, Case DA, Kuntz ID, Rizzo RC. DOCK 6: Impact of new features and current docking performance. J Comput Chem. 2015 Jun 05; 36(15):1132-56. PMID: 25914306; PMCID: PMC4469538.
    6. Merski M, Fischer M, Balius TE, Eidam O, Shoichet BK. Homologous ligands accommodated by discrete conformations of a buried cavity. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5039-44. PMID: 25847998; PMCID: PMC4413287.
    7. Balius TE, Allen WJ, Mukherjee S, Rizzo RC. Grid-based molecular footprint comparison method for docking and de novo design: application to HIVgp41. J Comput Chem. 2013 May 30; 34(14):1226-1240. PMID: 23436713; PMCID: PMC4016043.
    8. Berger WT, Ralph BP, Kaczocha M, Sun J, Balius TE, Rizzo RC, Haj-Dahmane S, Ojima I, Deutsch DG. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. PLoS One. 2012; 7(12):e50968. PMID: 23236415; PMCID: PMC3517626.
    9. Brozell SR, Mukherjee S, Balius TE, Roe DR, Case DA, Rizzo RC. Evaluation of DOCK 6 as a pose generation and database enrichment tool. J Comput Aided Mol Des. 2012 Jun; 26(6):749-73. PMID: 22569593; PMCID: PMC3902891.
    10. Balius TE, Mukherjee S, Rizzo RC. Implementation and evaluation of a docking-rescoring method using molecular footprint comparisons. J Comput Chem. 2011 Jul 30; 32(10):2273-89. PMID: 21541962; PMCID: PMC3181325.
    11. Mukherjee S, Balius TE, Rizzo RC. Docking validation resources: protein family and ligand flexibility experiments. J Chem Inf Model. 2010 Nov 22; 50(11):1986-2000. PMID: 21033739; PMCID: PMC3058392.
    12. McGillick BE, Balius TE, Mukherjee S, Rizzo RC. Origins of resistance to the HIVgp41 viral entry inhibitor T20. Biochemistry. 2010 May 04; 49(17):3575-92. PMID: 20230061; PMCID: PMC2867330.
    13. Owonikoko TK, Ramalingam SS, Kanterewicz B, Balius TE, Belani CP, Hershberger PA. Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells. Int J Cancer. 2010 Feb 01; 126(3):743-55. PMID: 19621389; PMCID: PMC2795066.
    14. Balius TE, Rizzo RC. Quantitative prediction of fold resistance for inhibitors of EGFR. Biochemistry. 2009 Sep 08; 48(35):8435-48. PMID: 19627157; PMCID: PMC2741091.
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