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Valerie Weaver, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentSurgery
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-3826
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    Collapse Research 
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    Inside-Out Approaches to Improve Wound Repair by HoxB3
    NIH/NIAMS R21AR069495Jul 15, 2016 - Apr 30, 2018
    Role: Principal Investigator
    ECM geometrical and mechanical properties modulate RTK signaling
    NIH/NCI U01CA202241Sep 22, 2015 - Aug 31, 2020
    Role: Co-Principal Investigator
    2015 Fibronectin, Integrins &Related Molecules Gordon Research Conference &Gordon Research Seminar
    NIH/NIAMS R13AR068188May 1, 2015 - Apr 30, 2016
    Role: Principal Investigator
    Tension-Stat3-miR-mediated metastasis
    NIH/NCI R01CA192914Apr 1, 2015 - Mar 31, 2020
    Role: Principal Investigator
    A biophysical stromal basis for radiation sensitivity in ductal carcinoma in situ
    NIH/NCI R01CA174929May 5, 2014 - Feb 28, 2019
    Role: Co-Principal Investigator
    Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor M
    NIH/NCI R33CA183685May 2, 2014 - Apr 30, 2017
    Role: Co-Principal Investigator
    2013 Fibronectin, Integrins &Related Molecules GRC/GRS
    NIH/NCI R13CA174204Feb 6, 2013 - Jan 31, 2014
    Role: Principal Investigator
    Biophysical and molecular dialogue of glioma cells and the brain microenvironment
    NIH/NCI U54CA163155Sep 26, 2011 - Jul 31, 2016
    Role: Co-Principal Investigator
    Role of Fibroblasts, Myeloid Cells and Matrix in PDAC
    NIH/NCI U01CA151925Sep 30, 2010 - Aug 31, 2015
    Role: Co-Principal Investigator
    Collagen remodeling and tumor progression
    NIH/NCI R01CA138818May 7, 2010 - Feb 28, 2015
    Role: Principal Investigator
    Fundamental Mechanobiology of Tumor Progression
    NIH U54CA143836Sep 29, 2009 - Jul 31, 2015
    Role: Co-Investigator
    NFkB, tissue polarity and apoptosis resistance
    NIH/NCI R01CA078731Jul 1, 2000 - Jun 30, 2010
    Role: Principal Investigator
    TGF-beta Suppression and Promotion of Mammary Carcinomas
    NIH/NCI R01CA085492May 20, 2000 - Feb 29, 2016
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Elloumi-Hannachi I, Gooch K, Sarang-Sieminski AL, García AJ, Weaver V. a5ß1-integrinpromotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Mol Biol Cell. 2017 Sep 06. PMID: 28877984.
      View in: PubMed
    2. Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver V, Kalluri R, Moses HL, Novitskiy SV. Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells. Cancer Immunol Res. 2017 Sep; 5(9):718-729. PMID: 28775207.
      View in: PubMed
    3. Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vazquez-Naharro A, Santamaría PG, Morales S, Dubus P, Muinelo-Romay L, López López R, Tung JC, Weaver V, Portillo F, Cano A. Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer. Cancer Res. 2017 Jul 18. PMID: 28720577.
      View in: PubMed
    4. Weaver V. Cell and tissue mechanics: the new cell biology frontier. Mol Biol Cell. 2017 Jul 07; 28(14):1815-1818. PMID: 28684606.
      View in: PubMed
    5. Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver V, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science. 2017 May 12; 356(6338). PMID: 28495700.
      View in: PubMed
    6. Oudin MJ, Weaver V. Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis. Cold Spring Harb Symp Quant Biol. 2016; 81:189-205. PMID: 28424337.
      View in: PubMed
    7. Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver V, Hwang DG, Chan MF. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy. PLoS One. 2017; 12(4):e0175112. PMID: 28384203.
      View in: PubMed
    8. Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver V. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017 Jun 01; 28(11):1467-1488. PMID: 28381423.
      View in: PubMed
    9. Barnes JM, Przybyla L, Weaver V. Tissue mechanics regulate brain development, homeostasis and disease. J Cell Sci. 2017 Jan 01; 130(1):71-82. PMID: 28043968.
      View in: PubMed
    10. Chang TT, Thakar D, Weaver V. Force-dependent breaching of the basement membrane. Matrix Biol. 2017 Jan; 57-58:178-189. PMID: 28025167.
      View in: PubMed
    11. Takai K, Le A, Weaver V, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016 Dec 13; 7(50):82889-82901. PMID: 27756881.
      View in: PubMed
    12. Kaushik S, Pickup MW, Weaver V. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer. Cancer Metastasis Rev. 2016 Dec; 35(4):655-667. PMID: 27914000.
      View in: PubMed
    13. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver V. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Dec; 18(12):1336-1345. PMID: 27820599.
      View in: PubMed
    14. Gilbert PM, Weaver V. Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease. Semin Cell Dev Biol. 2017 Jul; 67:141-152. PMID: 27641825.
      View in: PubMed
    15. Przybyla L, Lakins JN, Weaver V. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Cell Stem Cell. 2016 Oct 06; 19(4):462-475. PMID: 27452175.
      View in: PubMed
    16. Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver V. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb). 2016 Jul 11; 8(7):795-804. PMID: 27334548; PMCID: PMC4980125 [Available on 07/11/17].
    17. Przybyla L, Muncie JM, Weaver V. Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer. Annu Rev Cell Dev Biol. 2016 Oct 06; 32:527-554. PMID: 27298087.
      View in: PubMed
    18. Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver V, Kumar S. Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes. Langmuir. 2016 Jun 14; 32(23):5990-6. PMID: 27203736.
      View in: PubMed
    19. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver V. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 May; 22(5):497-505. PMID: 27089513; PMCID: PMC4860133 [Available on 10/18/16].
    20. Kai F, Laklai H, Weaver V. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends Cell Biol. 2016 Jul; 26(7):486-497. PMID: 27056543; PMCID: PMC4970516 [Available on 07/01/17].
    21. Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver V, Hinck L. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness. J Cell Biol. 2016 Mar 14; 212(6):707-19. PMID: 26975850; PMCID: PMC4792073.
    22. Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver V, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 2015 Dec 14; 28(6):831-833. PMID: 28843279.
      View in: PubMed
    23. Ou G, Weaver V. Tumor-induced solid stress activates ß-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells. Bioessays. 2015 Dec; 37(12):1293-7. PMID: 26439949; PMCID: PMC4731088.
    24. Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver V, Park C, LaBarge MA. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors. Mol Biol Cell. 2015 Nov 05; 26(22):3946-53. PMID: 26337386; PMCID: PMC4710228.
    25. Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver V. Monitoring developmental force distributions in reconstituted embryonic epithelia. Methods. 2016 Feb 01; 94:101-13. PMID: 26342256; PMCID: PMC4761493 [Available on 02/01/17].
    26. Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver V, Weiss WA, Persson AI. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. Cancer Res. 2015 Oct 15; 75(20):4302-11. PMID: 26282165; PMCID: PMC4609277 [Available on 10/15/16].
    27. Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver V. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integr Biol (Camb). 2015 Oct; 7(10):1120-34. PMID: 25959051; PMCID: PMC4593730.
    28. Northcott JM, Northey JJ, Barnes JM, Weaver V. Fighting the force: Potential of homeobox genes for tumor microenvironment regulation. Biochim Biophys Acta. 2015 Apr; 1855(2):248-53. PMID: 25818365; PMCID: PMC4433566.
    29. Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver V. Tumor mechanics and metabolic dysfunction. Free Radic Biol Med. 2015 Feb; 79:269-80. PMID: 25532934; PMCID: PMC4339308.
    30. Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver V. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype. J Biotechnol. 2015 Jan 10; 193:66-9. PMID: 25435379; PMCID: PMC4454500.
    31. Pickup MW, Mouw JK, Weaver V. The extracellular matrix modulates the hallmarks of cancer. EMBO Rep. 2014 Dec; 15(12):1243-53. PMID: 25381661; PMCID: PMC4264927.
    32. Mouw JK, Ou G, Weaver V. Extracellular matrix assembly: a multiscale deconstruction. Nat Rev Mol Cell Biol. 2014 Dec; 15(12):771-85. PMID: 25370693.
      View in: PubMed
    33. Weaver V. The microenvironment matters. Mol Biol Cell. 2014 Nov 01; 25(21):3254-8. PMID: 25360044; PMCID: PMC4214768.
    34. Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver V. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res. 2014 Sep 01; 74(17):4597-611. PMID: 25183785; PMCID: PMC4191931.
    35. Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver V, Fletcher DA, El-Samad H, Rycroft CH. Multicellular architecture of malignant breast epithelia influences mechanics. PLoS One. 2014; 9(8):e101955. PMID: 25111489; PMCID: PMC4128597.
    36. Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver V. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 2014 Jul 17; 511(7509):319-25. PMID: 25030168; PMCID: PMC4487551.
    37. Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver V, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014 Jun 16; 25(6):719-34. PMID: 24856586; PMCID: PMC4180632.
    38. Michor F, Weaver V. Understanding tissue context influences on intratumour heterogeneity. Nat Cell Biol. 2014 Apr; 16(4):301-2. PMID: 24691256; PMCID: PMC4180082.
    39. Rubashkin MG, Ou G, Weaver V. Deconstructing signaling in three dimensions. Biochemistry. 2014 Apr 08; 53(13):2078-90. PMID: 24649923; PMCID: PMC3985742.
    40. Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver V. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med. 2014 Apr; 20(4):360-7. PMID: 24633304; PMCID: PMC3981899.
    41. Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver V, Liphardt JT. Rapid disorganization of mechanically interacting systems of mammary acini. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):658-63. PMID: 24379367; PMCID: PMC3896145.
    42. Bainer R, Weaver V. Cell biology. Strength under tension. Science. 2013 Aug 30; 341(6149):965-6. PMID: 23990548.
      View in: PubMed
    43. Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver V, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-ß-deficient mouse mammary carcinomas. Cancer Res. 2013 Sep 01; 73(17):5336-46. PMID: 23856251; PMCID: PMC3766496.
    44. Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver V, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. J Cell Sci. 2013 Sep 15; 126(Pt 18):4108-10. PMID: 23843613; PMCID: PMC3772386.
    45. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver V. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 08; 33(19):2441-53. PMID: 23770848; PMCID: PMC3960370.
    46. Maller O, DuFort CC, Weaver V. YAP forces fibroblasts to feel the tension. Nat Cell Biol. 2013 Jun; 15(6):570-2. PMID: 23728464.
      View in: PubMed
    47. Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver V, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ. MT1-MMP-dependent control of skeletal stem cell commitment via a ß1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28; 25(4):402-16. PMID: 23685250; PMCID: PMC3736823.
    48. Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver V, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449. PMID: 23618955; PMCID: PMC3636513.
    49. Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver V, Tsai KK. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. Am J Pathol. 2013 Feb; 182(2):363-74. PMID: 23219426; PMCID: PMC3562735.
    50. Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver V. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nat Methods. 2012 Jul 01; 9(8):825-7. PMID: 22751201; PMCID: PMC3454456.
    51. Cassereau L, DuFort CC, Weaver V. Morphogenesis: Laying down the tracks. Nat Mater. 2012 May 22; 11(6):490-2. PMID: 22614514.
      View in: PubMed
    52. Lu P, Weaver V, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012 Feb 20; 196(4):395-406. PMID: 22351925; PMCID: PMC3283993.
    53. Lakins JN, Chin AR, Weaver V. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels. Methods Mol Biol. 2012; 916:317-50. PMID: 22914951.
      View in: PubMed
    54. Lu P, Takai K, Weaver V, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011 Dec 01; 3(12). PMID: 21917992; PMCID: PMC3225943.
    55. Lopez JI, Kang I, You WK, McDonald DM, Weaver V. In situ force mapping of mammary gland transformation. Integr Biol (Camb). 2011 Sep; 3(9):910-21. PMID: 21842067; PMCID: PMC3564969.
    56. Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver V, Olson MF. Actomyosin-mediated cellular tension drives increased tissue stiffness and ß-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell. 2011 Jun 14; 19(6):776-91. PMID: 21665151; PMCID: PMC3115541.
    57. Weaver V. Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick. J Cell Biol. 2011 May 30; 193(5):802-3. PMID: 21624950; PMCID: PMC3105548.
    58. DuFort CC, Paszek MJ, Weaver V. Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol. 2011 May; 12(5):308-19. PMID: 21508987; PMCID: PMC3564968.
    59. Dvorak HF, Weaver V, Tlsty TD, Bergers G. Tumor microenvironment and progression. J Surg Oncol. 2011 May 01; 103(6):468-74. PMID: 21480238; PMCID: PMC3277953.
    60. Miroshnikova YA, Jorgens DM, Spirio L, Auer M, Sarang-Sieminski AL, Weaver V. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Phys Biol. 2011 Apr; 8(2):026013. PMID: 21441648; PMCID: PMC3401181.
    61. Frantz C, Stewart KM, Weaver V. The extracellular matrix at a glance. J Cell Sci. 2010 Dec 15; 123(Pt 24):4195-200. PMID: 21123617; PMCID: PMC2995612.
    62. Yu H, Mouw JK, Weaver V. Forcing form and function: biomechanical regulation of tumor evolution. Trends Cell Biol. 2011 Jan; 21(1):47-56. PMID: 20870407; PMCID: PMC3014395.
    63. Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver V, Wong JY. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. J Cell Physiol. 2010 Oct; 225(1):115-22. PMID: 20648629; PMCID: PMC2920297.
    64. Egeblad M, Rasch MG, Weaver V. Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol. 2010 Oct; 22(5):697-706. PMID: 20822891; PMCID: PMC2948601.
    65. Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver V, Imbalzano AN, Nickerson JA. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. J Cell Physiol. 2010 Jun; 223(3):667-78. PMID: 20333683; PMCID: PMC3320666.
    66. Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver V. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest. 2010 May; 120(5):1535-50. PMID: 20389018; PMCID: PMC2860938.
    67. Paszek M, Weaver V. Biophysics. Enforcing order on signaling. Science. 2010 Mar 12; 327(5971):1335-6. PMID: 20223974.
      View in: PubMed
    68. Paszek MJ, Boettiger D, Weaver V, Hammer DA. Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLoS Comput Biol. 2009 Dec; 5(12):e1000604. PMID: 20011123; PMCID: PMC2782178.
    69. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver V. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009 Nov 25; 139(5):891-906. PMID: 19931152; PMCID: PMC2788004.
    70. Kumar S, Weaver V. Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev. 2009 Jun; 28(1-2):113-27. PMID: 19153673; PMCID: PMC2658728.
    71. Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver V, Calderwood DA, Keely PJ. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell. 2009 Jul; 20(14):3224-38. PMID: 19458194; PMCID: PMC2710838.
    72. Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J. The tissue diagnostic instrument. Rev Sci Instrum. 2009 May; 80(5):054303. PMID: 19485522; PMCID: PMC2832056.
    73. Engler AJ, Humbert PO, Wehrle-Haller B, Weaver V. Multiscale modeling of form and function. Science. 2009 Apr 10; 324(5924):208-12. PMID: 19359578; PMCID: PMC4527531.
    74. Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver V, Seewaldt VL. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2009 Mar; 18(3):901-14. PMID: 19258476; PMCID: PMC2667866.
    75. Butcher DT, Alliston T, Weaver V. A tense situation: forcing tumour progression. Nat Rev Cancer. 2009 Feb; 9(2):108-22. PMID: 19165226; PMCID: PMC2649117.
    76. Lopez JI, Mouw JK, Weaver V. Biomechanical regulation of cell orientation and fate. Oncogene. 2008 Nov 24; 27(55):6981-93. PMID: 19029939; PMCID: PMC2648514.
    77. Erler JT, Weaver V. Three-dimensional context regulation of metastasis. Clin Exp Metastasis. 2009; 26(1):35-49. PMID: 18814043; PMCID: PMC2648515.
    78. Rizki A, Weaver V, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW, Bissell MJ. A human breast cell model of preinvasive to invasive transition. Cancer Res. 2008 Mar 01; 68(5):1378-87. PMID: 18316601; PMCID: PMC2662716.
    79. Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver V, Chen CS, Assoian RK. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. J Cell Sci. 2008 Jan 15; 121(Pt 2):226-33. PMID: 18187454; PMCID: PMC2662746.
    80. Hebner C, Weaver V, Debnath J. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annu Rev Pathol. 2008; 3:313-39. PMID: 18039125.
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    81. Yee KL, Weaver V, Hammer DA. Integrin-mediated signalling through the MAP-kinase pathway. IET Syst Biol. 2008 Jan; 2(1):8-15. PMID: 18248081.
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    82. Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver V. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci. 2007 Oct 15; 120(Pt 20):3700-12. PMID: 17911169.
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    83. Weaver V, Werb Z. G'rab'bing the microenvironment for invasion. Dev Cell. 2007 Oct; 13(4):462-3. PMID: 17925222.
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    84. Kass L, Erler JT, Dembo M, Weaver V. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. Int J Biochem Cell Biol. 2007; 39(11):1987-94. PMID: 17719831; PMCID: PMC2658720.
    85. Johnson KR, Leight JL, Weaver V. Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods Cell Biol. 2007; 83:547-83. PMID: 17613324; PMCID: PMC2658721.
    86. Underwood JM, Imbalzano KM, Weaver V, Fischer AH, Imbalzano AN, Nickerson JA. The ultrastructure of MCF-10A acini. J Cell Physiol. 2006 Jul; 208(1):141-8. PMID: 16607610.
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    87. Boudreau N, Weaver V. Forcing the third dimension. Cell. 2006 May 05; 125(3):429-31. PMID: 16678088.
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    88. Yan Y, Weaver V, Blair IA. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard. J Proteome Res. 2005 Nov-Dec; 4(6):2007-14. PMID: 16335945.
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    89. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver V. Tensional homeostasis and the malignant phenotype. Cancer Cell. 2005 Sep; 8(3):241-54. PMID: 16169468.
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    90. Yang C, Liu Y, Leskow FC, Weaver V, Kazanietz MG. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. J Biol Chem. 2005 Jul 01; 280(26):24363-70. PMID: 15863513.
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    91. Cowden Dahl KD, Robertson SE, Weaver V, Simon MC. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell. 2005 Apr; 16(4):1901-12. PMID: 15689487; PMCID: PMC1073670.
    92. Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton. 2005 Jan; 60(1):24-34. PMID: 15573414.
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    93. Paszek MJ, Weaver V. The tension mounts: mechanics meets morphogenesis and malignancy. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):325-42. PMID: 15838603.
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    94. Weaver V, Gilbert P. Watch thy neighbor: cancer is a communal affair. J Cell Sci. 2004 Mar 15; 117(Pt 8):1287-90. PMID: 15020668.
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    95. Zahir N, Weaver V. Death in the third dimension: apoptosis regulation and tissue architecture. Curr Opin Genet Dev. 2004 Feb; 14(1):71-80. PMID: 15108808.
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    96. Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver V. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. J Cell Biol. 2003 Dec 22; 163(6):1397-407. PMID: 14691145; PMCID: PMC2173718.
    97. Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver V, Marinkovich MP. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J Cell Sci. 2003 Sep 01; 116(Pt 17):3543-56. PMID: 12865436.
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    98. Unger M, Weaver V. The tissue microenvironment as an epigenetic tumor modifier. Methods Mol Biol. 2003; 223:315-47. PMID: 12777739.
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    99. Bissell MJ, Radisky DC, Rizki A, Weaver V, Petersen OW. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation. 2002 Dec; 70(9-10):537-46. PMID: 12492495; PMCID: PMC2933198.
    100. Weaver V, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002 Sep; 2(3):205-16. PMID: 12242153; PMCID: PMC2788997.
    101. Weaver V. Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins? Dev Cell. 2002 Jan; 2(1):6-7. PMID: 11782309.
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    102. Chrenek MA, Wong P, Weaver V. Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation. Breast Cancer Res. 2001; 3(4):224-9. PMID: 11434873; PMCID: PMC138686.
    103. Weaver V, Buckley T, Groopman JD. Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods. Cancer Epidemiol Biomarkers Prev. 2000 Jul; 9(7):749-55. PMID: 10919747.
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    104. Spancake KM, Anderson CB, Weaver V, Matsunami N, Bissell MJ, White RL. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture. Cancer Res. 1999 Dec 15; 59(24):6042-5. PMID: 10626787.
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    105. Guerra-Vladusic FK, Scott G, Weaver V, Vladusic EA, Tsai MS, Benz CC, Lupu R. Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3. Int J Oncol. 1999 Nov; 15(5):883-92. PMID: 10536169.
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    106. Weaver V, Bissell MJ. Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia. 1999 Apr; 4(2):193-201. PMID: 10426398; PMCID: PMC2933214.
    107. Bissell MJ, Weaver V, Lelièvre SA, Wang F, Petersen OW, Schmeichel KL. Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res. 1999 Apr 01; 59(7 Suppl):1757-1763s; discussion 1763s-1764s. PMID: 10197593.
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    108. Wang F, Weaver V, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14821-6. PMID: 9843973; PMCID: PMC24533.
    109. Lelièvre SA, Weaver V, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14711-6. PMID: 9843954; PMCID: PMC24514.
    110. Schmeichel KL, Weaver V, Bissell MJ. Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype. J Mammary Gland Biol Neoplasia. 1998 Apr; 3(2):201-13. PMID: 10819528; PMCID: PMC2933208.
    111. Petersen OW, Rønnov-Jessen L, Weaver V, Bissell MJ. Differentiation and cancer in the mammary gland: shedding light on an old dichotomy. Adv Cancer Res. 1998; 75:135-61. PMID: 9709809; PMCID: PMC3867313.
    112. Weaver V, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol. 1997 Apr 07; 137(1):231-45. PMID: 9105051; PMCID: PMC2139858.
    113. Weaver V, Roskelley CD. Extracellular matrix: the central regulator of cell and tissue homeostasis. Trends Cell Biol. 1997 Jan; 7(1):40-2. PMID: 17708898.
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    114. Weaver V, Fischer AH, Peterson OW, Bissell MJ. The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochem Cell Biol. 1996; 74(6):833-51. PMID: 9164652; PMCID: PMC2933195.
    115. Weaver V, Carson CE, Walker PR, Chaly N, Lach B, Raymond Y, Brown DL, Sikorska M. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes. J Cell Sci. 1996 Jan; 109 ( Pt 1):45-56. PMID: 8834789.
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    116. Lelièvre S, Weaver V, Bissell MJ. Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation. Recent Prog Horm Res. 1996; 51:417-32. PMID: 8701089; PMCID: PMC2937008.
    117. Weaver V, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ. The development of a functionally relevant cell culture model of progressive human breast cancer. Semin Cancer Biol. 1995 Jun; 6(3):175-84. PMID: 7495986.
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    118. Weaver V, Lach B, Walker PR, Sikorska M. Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes. Biochem Cell Biol. 1993 Sep-Oct; 71(9-10):488-500. PMID: 8192901.
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