Vivek Durai, MD, PhD

Title(s)Clinical Fellow, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Northwestern University, Evanston, ILBA06/2011History
    Washington University in St. Louis, St. Louis, MOMD05/2020
    Washington University in St. Louis, St. Louis, MOPhD05/2020Immunology
    Collapse Awards and Honors
    2011summa cum laude
    2020Alpha Omega Alpha

    Collapse Research 
    Collapse Research Activities and Funding
    The role of cross-presentation of self-antigens by dendritic cells in type 1 diabetes
    NIH F30DK108498Sep 1, 2015 - Aug 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain. Cancer Immunol Res. 2023 Jan 03; 11(1):20-37. Bowman-Kirigin JA, Desai R, Saunders BT, Wang AZ, Schaettler MO, Liu CJ, Livingstone AJ, Kobayashi DK, Durai V, Kretzer NM, Zipfel GJ, Leuthardt EC, Osbun JW, Chicoine MR, Kim AH, Murphy KM, Johanns TM, Zinselmeyer BH, Dunn GP. PMID: 36409838.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Statin therapy for the primary prevention of cardiovascular disease: Cons. Atherosclerosis. 2022 09; 356:46-49. Durai V, Redberg RF. PMID: 35934533.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    3. Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication. Immunity. 2022 06 14; 55(6):1032-1050.e14. Gargaro M, Scalisi G, Manni G, Brise?o CG, Bagadia P, Durai V, Theisen DJ, Kim S, Castelli M, Xu CA, Meyer Zu H?rste G, Servillo G, Della Fazia MA, Mencarelli G, Ricciuti D, Padiglioni E, Giacch? N, Colliva C, Pellicciari R, Calvitti M, Zelante T, Fuchs D, Orabona C, Boon L, Bessede A, Colonna M, Puccetti P, Murphy TL, Murphy KM, Fallarino F. PMID: 35704993; PMCID: PMC9220322.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections. Immunity. 2021 11 09; 54(11):2547-2564.e7. Russler-Germain EV, Jung J, Miller AT, Young S, Yi J, Wehmeier A, Fox LE, Monte KJ, Chai JN, Kulkarni DH, Funkhouser-Jones LJ, Wilke G, Durai V, Zinselmeyer BH, Czepielewski RS, Greco S, Murphy KM, Newberry RD, Sibley LD, Hsieh CS. PMID: 34715017; PMCID: PMC8716016.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation. Elife. 2021 02 03; 10. Russler-Germain EV, Yi J, Young S, Nutsch K, Wong HS, Ai TL, Chai JN, Durai V, Kaplan DH, Germain RN, Murphy KM, Hsieh CS. PMID: 33533717; PMCID: PMC7877908.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity. Nature. 2020 08; 584(7822):624-629. Ferris ST, Durai V, Wu R, Theisen DJ, Ward JP, Bern MD, Davidson JT, Bagadia P, Liu T, Brise?o CG, Li L, Gillanders WE, Wu GF, Yokoyama WM, Murphy TL, Schreiber RD, Murphy KM. PMID: 32788723; PMCID: PMC7469755.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    7. An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development. Nat Immunol. 2019 09; 20(9):1174-1185. Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschk? M, Modrusan Z, Granja JM, Satpathy AT, Brise?o CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM. PMID: 31406377; PMCID: PMC6707889.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    8. Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Nat Immunol. 2019 09; 20(9):1161-1173. Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Brise?o CG, Grajales-Reyes GE, W?hner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM. PMID: 31406378; PMCID: PMC6707878.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    9. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science. 2018 11 09; 362(6415):694-699. Theisen DJ, Davidson JT, Brise?o CG, Gargaro M, Lauron EJ, Wang Q, Desai P, Durai V, Bagadia P, Brickner JR, Beatty WL, Virgin HW, Gillanders WE, Mosammaparast N, Diamond MS, Sibley LD, Yokoyama W, Schreiber RD, Murphy TL, Murphy KM. PMID: 30409884; PMCID: PMC6655551.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    10. Notch2-dependent DC2s mediate splenic germinal center responses. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):10726-10731. Brise?o CG, Satpathy AT, Davidson JT, Ferris ST, Durai V, Bagadia P, O'Connor KW, Theisen DJ, Murphy TL, Murphy KM. PMID: 30279176; PMCID: PMC6196531.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    11. Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4+ T Cells during an Immune Response. J Immunol. 2018 05 15; 200(10):3429-3437. Milam AAV, Bartleson JM, Donermeyer DL, Horvath S, Durai V, Raju S, Yu H, Redmann V, Zinselmeyer B, White JM, Murphy KM, Allen PM. PMID: 29618523; PMCID: PMC5940509.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice. J Exp Med. 2018 05 07; 215(5):1417-1435. Durai V, Bagadia P, Briseño CG, Theisen DJ, Iwata A, Davidson JT, Gargaro M, Fremont DH, Murphy TL, Murphy KM. PMID: 29572360; PMCID: PMC5940266.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    13. Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex. Nat Immunol. 2017 05; 18(5):563-572. Iwata A, Durai V, Tussiwand R, Brise?o CG, Wu X, Grajales-Reyes GE, Egawa T, Murphy TL, Murphy KM. PMID: 28346410; PMCID: PMC5401770.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    14. Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):3957-3962. Briseño CG, Gargaro M, Durai V, Davidson JT, Theisen DJ, Anderson DA, Novack DV, Murphy TL, Murphy KM. PMID: 28348230; PMCID: PMC5393217.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. RAB43 facilitates cross-presentation of cell-associated antigens by CD8a+ dendritic cells. J Exp Med. 2016 12 12; 213(13):2871-2883. Kretzer NM, Theisen DJ, Tussiwand R, Brise?o CG, Grajales-Reyes GE, Wu X, Durai V, Albring J, Bagadia P, Murphy TL, Murphy KM. PMID: 27899443; PMCID: PMC5154939.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    16. Functions of Murine Dendritic Cells. Immunity. 2016 10 18; 45(4):719-736. Durai V, Murphy KM. PMID: 27760337; PMCID: PMC5145312.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    17. Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells. J Exp Med. 2016 11 14; 213(12):2553-2565. Wu X, Briseño CG, Durai V, Albring JC, Haldar M, Bagadia P, Kim KW, Randolph GJ, Murphy TL, Murphy KM. PMID: 27810926; PMCID: PMC5110021.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    18. Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic Cells. Cell Rep. 2016 06 14; 15(11):2462-74. Brise?o CG, Haldar M, Kretzer NM, Wu X, Theisen DJ, Kc W, Durai V, Grajales-Reyes GE, Iwata A, Bagadia P, Murphy TL, Murphy KM. PMID: 27264183; PMCID: PMC4941620.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    19. Transcriptional Control of Dendritic Cell Development. Annu Rev Immunol. 2016 05 20; 34:93-119. Murphy TL, Grajales-Reyes GE, Wu X, Tussiwand R, Brise?o CG, Iwata A, Kretzer NM, Durai V, Murphy KM. PMID: 26735697; PMCID: PMC5135011.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    20. Batf3 maintains autoactivation of Irf8 for commitment of a CD8a(+) conventional DC clonogenic progenitor. Nat Immunol. 2015 Jul; 16(7):708-17. Grajales-Reyes GE, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, Kretzer NM, Brise?o CG, Durai V, Bagadia P, Haldar M, Sch?nheit J, Rosenbauer F, Murphy TL, Murphy KM. PMID: 26054719; PMCID: PMC4507574.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    21. L-Myc expression by dendritic cells is required for optimal T-cell priming. Nature. 2014 Mar 13; 507(7491):243-7. KC W, Satpathy AT, Rapaport AS, Brise?o CG, Wu X, Albring JC, Russler-Germain EV, Kretzer NM, Durai V, Persaud SP, Edelson BT, Loschko J, Cella M, Allen PM, Nussenzweig MC, Colonna M, Sleckman BP, Murphy TL, Murphy KM. PMID: 24509714; PMCID: PMC3954917.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    22. Short chain fatty acids and their receptors: new metabolic targets. Transl Res. 2013 Mar; 161(3):131-40. Layden BT, Angueira AR, Brodsky M, Durai V, Lowe WL. PMID: 23146568.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
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