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Warren Gasper, MD

Title(s)Assistant Professor, Surgery
SchoolSchool of Medicine
Phone415-353-4366
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoVascular Surgeyr Fellowship2013School of Medicine
    University of California, San FranciscoGeneral Surgery Residency2010School of Medicine
    Univeristy of Maryland, BaltimoreM.D.2003School of Medicine
    University of California, San FranciscoVascular Surgery Fellowship2011School of Medicine
    Bowdoin CollegeA.B1999Biochemistry & German
    Collapse Awards and Honors
    Society for Vascular Surgery Annual Meeting2011First place, Poster Competition
    UCSF Haile T. Debas Academy of Medical Educators2017Excellence in Teaching Award
    UCSF Department of Surgery Chief Residents2018Lim/Thomas Excellence in Teaching Award

    Collapse Overview 
    Collapse Overview
    My current research interests fall broadly into the categories of vein / vein graft physiology and advanced endovascular aneurysm therapies. Over the past 4 years I have been working with Dr Michael Conte and Dr Christopher Owens in the UCSF Division of Vascular and Endovascular Surgery on several projects involving vein graft physiology, which have lead to several presentations at national meetings as well as publications. We have found that after lower extremity bypass surgery most luminal dilation occurs early (30 days) and is typically complete by 3 months. However, the response is not uniform and it appears that a mixture of local factors (e.g. vein diameter and quality), biologic factors (e.g. preoperative hsCRP levels) and systemic factors (e.g. race, indication for bypass surgery) are involved in the remodeling response.
    My second major area of research interest is advanced endovascular therapies for aortic aneurysms. The development and widespread adoption of endovascular stent-grafts for infrarenal aortic aneurysms and thoracic aortic aneurysms have dramatically reduced the physiologic demands, complication rates and length of hospitalization for patients undergoing infrarenal or thoracic aortic aneurysm repairs compared to open techniques. However, aneurysms of thoracoabdominal, paravisceral and/or pararenal aorta require even more demanding operations with a higher rate of complications and longer hospitalizations. For the past 4 years I have worked with Dr. Timothy Chuter and Dr. Linda Reilly in the UCSF Division of Vascular and Endovascular Surgery to develop the multi-branched endovascular thoracoabdominal aneurysm repair technique. The technique is being studied under an FDA IDE in a CHR-approved study at UCSF and the San Francisco VA. As the co-principal investigator, I am responsible for overseeing the regulatory and subject care activities for the study at the San Francisco VA. This work has included consultations in the outpatient clinic, planning and performing the multi-branched endovascular repairs and analyzing the results of the study.

    Collapse Research 
    Collapse Research Activities and Funding
    Transfusion Trigger after Operations in High Cardiac Risk Patients
    VA Cooperative Studies Program VA CSP 599Oct 1, 2017 - Feb 28, 2022
    Role: Co-local Site Investigator
    Role Description: I am the co-local site coordinator for this VA Cooperative Studies Trial. I oversee the conduct of the study and supervise 2 research coordinators.
    Imaging Substudy, part of "A Phase 2 Study for the Evaluation of Safety and Efficacy of Humacyte's Human Acellular Vessel for Use as a Vascular Prosthesis for Femoro-Popliteal Bypass in Patients With Peripheral Arterial Disease"
    Industry NCT02887859Jun 13, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Role Description: I am a site PI for the imaging sub-project of this trial. I provide core lab imaging services for the study.
    Targeted Endovascular Treatment of Inflammation for Vascular Healing in Humans
    NIH/NHLBI R01HL128816-01Aug 18, 2015 - Apr 30, 2020
    Role: Co-Investigator
    Role Description: I am the clinical PI for the study. I am responsible for all aspects of subject recruitment and treatment as well as maintaining regulatory approval with the UCSF IRB.
    Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST-CLI)
    NIH/NHLBI CHR 14-1440Dec 1, 2014 - Dec 31, 2019
    Role: Principal Investigator
    Role Description: I am the SFVA site PI for this NIH-sponsored multi-center randomized trial. I am responsible for all aspects of subject recruitment and treatment as well as maintaining regulatory approval with the UCSF IRB and SFVA R&D Committee.

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ramirez JL, Gasper WJ, Seib CD, Finlayson E, Conte MS, Sosa JA, Iannuzzi JC. Patient complexity by surgical specialty does not correlate with work relative value units. Surgery. 2020 Apr 24. PMID: 32336468.
      View in: PubMed
    2. Wang Y, Liu X, Haraldsson H, Zhu C, Ballweber M, Gasper W, Hatsukami T, Saloner D. Quantitative measurement of atheroma burden: reproducibility in serial studies of atherosclerotic femoral arteries. MAGMA. 2020 Apr 16. PMID: 32297164.
      View in: PubMed
    3. Ramirez JL, Zarkowsky DS, Sorrentino TA, Hicks CW, Vartanian SM, Gasper WJ, Conte MS, Iannuzzi JC. Antegrade common femoral artery closure device use is associated with decreased complications. J Vasc Surg. 2020 Mar 09. PMID: 32165058.
      View in: PubMed
    4. Wang Y, Zhu C, Leach J, Gasper W, Saloner D, Hope M. Growth of common iliac artery aneurysms coexisting with abdominal aortic aneurysms: associated factors and potential role of intraluminal thrombus. Quant Imaging Med Surg. 2020 Mar; 10(3):703-712. PMID: 32269930.
      View in: PubMed
    5. Zhu C, Leach JR, Wang Y, Gasper W, Saloner D, Hope MD. Intraluminal Thrombus Predicts Rapid Growth of Abdominal Aortic Aneurysms. Radiology. 2020 Mar; 294(3):707-713. PMID: 31990263.
      View in: PubMed
    6. Hiramoto JS, Elahi FM, Gasper WJ, Reilly LM, Chuter TA, Goetzl EJ. Acute Insulin Resistance and Rapid Alterations in Neuronal Derived Blood Exosome Concentration After Branched Endovascular Aortic Aneurysm Repair. Eur J Vasc Endovasc Surg. 2020 Mar; 59(3):457-463. PMID: 31866237.
      View in: PubMed
    7. Hiramoto JS, Hoffman M, Gasper W, Reilly L, Chuter T. Strict Control of Blood Glucose With an Intravenous Insulin Infusion Decreases the Risk of Post-operative Lower Extremity Weakness After Complex Endovascular Aortic Aneurysm Repair. Eur J Vasc Endovasc Surg. 2019 Dec; 58(6):848-853. PMID: 31636016.
      View in: PubMed
    8. Werlin EC, Kaushik S, Gasper WJ, Hoffman M, Reilly LM, Chuter TA, Hiramoto JS. Multibranched endovascular aortic aneurysm repair in patients with and without chronic aortic dissections. J Vasc Surg. 2019 Nov; 70(5):1419-1426. PMID: 31327618.
      View in: PubMed
    9. Ramirez JL, Zahner GJ, Spaulding KA, Khetani SA, Hills NK, Gasper WJ, Harris WS, Cohen BE, Grenon SM. Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n-3 Polyunsaturated Fatty Acids. Lipids. 2019 04; 54(4):211-219. PMID: 30883776.
      View in: PubMed
    10. Ramirez JL, Gasper WJ, Khetani SA, Zahner GJ, Hills NK, Mitchell PT, Sansbury BE, Conte MS, Spite M, Grenon SM. Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial). J Surg Res. 2019 06; 238:164-174. PMID: 30771686.
      View in: PubMed
    11. Zahner GJ, Ramirez JL, Spaulding KA, Khetani SA, Gasper WJ, Grunfeld C, Hills NK, Schafer AL, Grenon SM. Leptinemia is Associated With Peripheral Artery Disease. J Surg Res. 2019 06; 238:48-56. PMID: 30738358.
      View in: PubMed
    12. Walker J, Kaushik S, Hoffman M, Gasper W, Hiramoto J, Reilly L, Chuter T. Long-term durability of multibranched endovascular repair of thoracoabdominal and pararenal aortic aneurysms. J Vasc Surg. 2019 02; 69(2):341-347. PMID: 30683193.
      View in: PubMed
    13. Ramirez JL, Spaulding KA, Zahner GJ, Khetani SA, Schaller MS, Gasper WJ, Hills NK, Marlene Grenon S. Radial Artery Tonometry is Associated With Major Adverse Cardiac Events in Patients With Peripheral Artery Disease. J Surg Res. 2019 03; 235:250-257. PMID: 30691803.
      View in: PubMed
    14. Ramirez JL, Khetani SA, Zahner GJ, Spaulding KA, Schaller MS, Gasper WJ, Hills NK, Schafer AL, Grenon SM. Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease. J Vasc Surg. 2019 02; 69(2):497-506. PMID: 30292618.
      View in: PubMed
    15. Hernandez NV, Ramirez JL, Khetani SA, Spaulding KA, Gasper WJ, Hiramoto J, Lindqvist D, Wolkowitz OM, Hills NK, Grenon SM, Zahner GJ. Depression severity is associated with increased inflammation in veterans with peripheral artery disease. Vasc Med. 2018 10; 23(5):445-453. PMID: 30035700.
      View in: PubMed
    16. Schaller MS, Ramirez JL, Gasper WJ, Zahner GJ, Hills NK, Grenon SM. Frailty Is Associated with an Increased Risk of Major Adverse Cardiac Events in Patients with Stable Claudication. Ann Vasc Surg. 2018 Jul; 50:38-45. PMID: 29477684.
      View in: PubMed
    17. Kaushik S, Gasper WJ, Ramanan B, Vartanian SM, Reilly LM, Chuter TAM, Hiramoto JS. The impact of prior aortic surgery on outcomes after multibranched endovascular aortic aneurysm repair. J Vasc Surg. 2018 08; 68(2):325-330. PMID: 29523439.
      View in: PubMed
    18. Zahner GJ, Spaulding KA, Ramirez JL, Schaller MS, Walker SC, Hills NK, Gasper WJ, Grenon SM. Characterizing the relationship between flow-mediated vasodilation and radial artery tonometry in peripheral artery disease. J Surg Res. 2018 04; 224:121-131. PMID: 29506827.
      View in: PubMed
    19. Ramanan B, Ahmed A, Wu B, Causey MW, Gasper WJ, Vartanian SM, Reyzelman AM, Hiramoto JS, Conte MS. Determinants of midterm functional outcomes, wound healing, and resources used in a hospital-based limb preservation program. J Vasc Surg. 2017 12; 66(6):1765-1774. PMID: 28823866.
      View in: PubMed
    20. Zahner GJ, Gruendl MA, Spaulding KA, Schaller MS, Hills NK, Gasper WJ, Grenon SM. Association between arterial stiffness and peripheral artery disease as measured by radial artery tonometry. J Vasc Surg. 2017 11; 66(5):1518-1526. PMID: 28756044.
      View in: PubMed
    21. Schaller MS, Zahner GJ, Gasper WJ, Harris WS, Conte MS, Hills NK, Grenon SM. Relationship between the omega-3 index and specialized pro-resolving lipid mediators in patients with peripheral arterial disease taking fish oil supplements. J Clin Lipidol. 2017 Sep - Oct; 11(5):1289-1295. PMID: 28778393.
      View in: PubMed
    22. Loeffler JW, Obara H, Fujimura N, Bove P, Newton DH, Zettervall SL, van Petersen AS, Geelkerken RH, Charlton-Ouw KM, Shalhub S, Singh N, Roussel A, Glebova NO, Harlander-Locke MP, Gasper WJ, Humphries MD, Lawrence PF. Medical therapy and intervention do not improve uncomplicated isolated mesenteric artery dissection outcomes over observation alone. J Vasc Surg. 2017 07; 66(1):202-208. PMID: 28506477.
      View in: PubMed
    23. Hiramoto JS, Fernandez C, Gasper W, Vartanian S, Reilly L, Chuter T. Lower extremity weakness is associated with elevated blood and cerebrospinal fluid glucose levels following multibranched endovascular aortic aneurysm repair. J Vasc Surg. 2017 Feb; 65(2):311-317. PMID: 27876524.
      View in: PubMed
    24. Drudi LM, Schaller MS, Hiramoto J, Gasper W, Harris WS, Hills NK, Grenon SM. Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease. J Surg Res. 2017 04; 210:124-131. PMID: 28457318.
      View in: PubMed
    25. Causey MW, Ahmed A, Wu B, Gasper WJ, Reyzelman A, Vartanian SM, Hiramoto JS, Conte MS. Society for Vascular Surgery limb stage and patient risk correlate with outcomes in an amputation prevention program. J Vasc Surg. 2016 06; 63(6):1563-1573.e2. PMID: 27036309.
      View in: PubMed
    26. Grenon SM, Owens CD, Alley H, Perez S, Whooley MA, Neylan TC, Aschbacher K, Gasper WJ, Hilton JF, Cohen BE. Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans. J Am Heart Assoc. 2016 Mar 23; 5(3):e003010. PMID: 27009621.
      View in: PubMed
    27. Ramanan B, Fernandez CC, Sobel JD, Gasper WJ, Vartanian SM, Reilly LM, Chuter TA, Hiramoto JS. Low-profile versus standard-profile multibranched thoracoabdominal aortic stent grafts. J Vasc Surg. 2016 Jul; 64(1):39-45. PMID: 26994953.
      View in: PubMed
    28. Fernandez CC, Sobel JD, Gasper WJ, Vartanian SM, Reilly LM, Chuter TA, Hiramoto JS. Standard off-the-shelf versus custom-made multibranched thoracoabdominal aortic stent grafts. J Vasc Surg. 2016 May; 63(5):1208-15. PMID: 26817612.
      View in: PubMed
    29. Zhu C, Haraldsson H, Faraji F, Owens C, Gasper W, Ahn S, Liu J, Laub G, Hope MD, Saloner D. Isotropic 3D black blood MRI of abdominal aortic aneurysm wall and intraluminal thrombus. Magn Reson Imaging. 2016 Jan; 34(1):18-25. PMID: 26471514.
      View in: PubMed
    30. Hope MD, Gasper WJ, Rapp J, Owens CD, Haraldsson H, Saloner D. Vascular inflammation in a growing iliac artery aneurysm. Clin Nucl Med. 2015 Jun; 40(6):e323-4. PMID: 25674872.
      View in: PubMed
    31. Han SM, Gasper WJ, Chuter TA. Endovascular rescue after inadvertent false lumen stent graft implantation. J Vasc Surg. 2016 Feb; 63(2):518-22. PMID: 25595403.
      View in: PubMed
    32. Sobel JD, Vartanian SM, Gasper WJ, Hiramoto JS, Chuter TA, Reilly LM. Lower extremity weakness after endovascular aneurysm repair with multibranched thoracoabdominal stent grafts. J Vasc Surg. 2015 Mar; 61(3):623-8. PMID: 25457458.
      View in: PubMed
    33. Alley H, Owens CD, Gasper WJ, Grenon SM. Ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery in clinical research. J Vis Exp. 2014 Oct 22; (92):e52070. PMID: 25406739.
      View in: PubMed
    34. Chong KC, Owens CD, Park M, Alley HF, Boscardin WJ, Conte MS, Gasper WJ, Grenon SM. Relationship between kidney disease and endothelial function in peripheral artery disease. J Vasc Surg. 2014 Dec; 60(6):1605-11. PMID: 25441679.
      View in: PubMed
    35. Walker JP, Nosova E, Sigovan M, Rapp J, Grenon MS, Owens CD, Gasper WJ, Saloner DA. Ferumoxytol-enhanced magnetic resonance angiography is a feasible method for the clinical evaluation of lower extremity arterial disease. Ann Vasc Surg. 2015 Jan; 29(1):63-8. PMID: 25269682.
      View in: PubMed
    36. Walker JP, Hiramoto JS, Gasper WJ, Auyang P, Conte MS, Rapp JH, Lovett DH, Owens CD. Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with end-stage renal disease. J Vasc Surg. 2014 Jul; 60(1):176-83. PMID: 24582700.
      View in: PubMed
    37. Grenon SM, Chong K, Alley H, Nosova E, Gasper W, Hiramoto J, Boscardin WJ, Owens CD. Walking disability in patients with peripheral artery disease is associated with arterial endothelial function. J Vasc Surg. 2014 Apr; 59(4):1025-34. PMID: 24423479.
      View in: PubMed
    38. Owens CD, Gasper WJ, Walker JP, Alley HF, Conte MS, Grenon SM. Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization. J Vasc Surg. 2014 Apr; 59(4):1016-24. PMID: 24423476.
      View in: PubMed
    39. Gasper WJ, Jimenez CA, Walker J, Conte MS, Seward K, Owens CD. Adventitial nab-rapamycin injection reduces porcine femoral artery luminal stenosis induced by balloon angioplasty via inhibition of medial proliferation and adventitial inflammation. Circ Cardiovasc Interv. 2013 Dec; 6(6):701-9. PMID: 24221390.
      View in: PubMed
    40. Owens CD, Gasper WJ, Rahman AS, Conte MS. Vein graft failure. J Vasc Surg. 2015 Jan; 61(1):203-16. PMID: 24095042.
      View in: PubMed
    41. Gasper WJ, Reilly LM, Rapp JH, Grenon SM, Hiramoto JS, Sobel JD, Chuter TA. Assessing the anatomic applicability of the multibranched endovascular repair of thoracoabdominal aortic aneurysm technique. J Vasc Surg. 2013 Jun; 57(6):1553-8; discussion 1558. PMID: 23395201.
      View in: PubMed
    42. Conte MS, Owens CD, Belkin M, Creager MA, Edwards KL, Gasper WJ, Kenagy RD, LeBoeuf RC, Sobel M, Clowes A. A single nucleotide polymorphism in the p27(Kip1) gene is associated with primary patency of lower extremity vein bypass grafts. J Vasc Surg. 2013 May; 57(5):1179-85.e1-2. PMID: 23312942.
      View in: PubMed
    43. Sigovan M, Rayz V, Gasper W, Alley HF, Owens CD, Saloner D. Vascular remodeling in autogenous arterio-venous fistulas by MRI and CFD. Ann Biomed Eng. 2013 Apr; 41(4):657-68. PMID: 23188560.
      View in: PubMed
    44. Gasper WJ, Owens CD, Kim JM, Hills N, Belkin M, Creager MA, Conte MS. Thirty-day vein remodeling is predictive of midterm graft patency after lower extremity bypass. J Vasc Surg. 2013 Jan; 57(1):9-18. PMID: 22960020.
      View in: PubMed
    45. Sigovan M, Gasper W, Alley HF, Owens CD, Saloner D. USPIO-enhanced MR angiography of arteriovenous fistulas in patients with renal failure. Radiology. 2012 Nov; 265(2):584-90. PMID: 22875796.
      View in: PubMed
    46. Owens CD, Kim JM, Hevelone ND, Gasper WJ, Belkin M, Creager MA, Conte MS. An integrated biochemical prediction model of all-cause mortality in patients undergoing lower extremity bypass surgery for advanced peripheral artery disease. J Vasc Surg. 2012 Sep; 56(3):686-95. PMID: 22554422.
      View in: PubMed
    47. Gasper WJ, Runge SJ, Owens CD. Management of infrapopliteal peripheral arterial occlusive disease. Curr Treat Options Cardiovasc Med. 2012 Apr; 14(2):136-48. PMID: 22249766.
      View in: PubMed
    48. Dubin R, Owens C, Gasper W, Ganz P, Johansen K. Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension. Hemodial Int. 2011 Jul; 15(3):350-8. PMID: 21658174.
      View in: PubMed
    49. Owens CD, Gasper WJ, Conte MS. Assessing drug elution technologies in the superficial femoral artery. Panminerva Med. 2011 Mar; 53(1):37-49. PMID: 21346703.
      View in: PubMed
    50. Roll GR, Ma S, Gasper WJ, Patti M, Way LW, Carter J. Excellent outcomes of laparoscopic esophagomyotomy for achalasia in patients older than 60 years of age. Surg Endosc. 2010 Oct; 24(10):2562-6. PMID: 20361213.
      View in: PubMed
    51. Gasper WJ, Glidden DV, Jin C, Way LW, Patti MG. Has recognition of the relationship between mortality rates and hospital volume for major cancer surgery in California made a difference?: A follow-up analysis of another decade. Ann Surg. 2009 Sep; 250(3):472-83. PMID: 19730178.
      View in: PubMed
    52. Patti MG, Gasper WJ, Fisichella PM, Nipomnick I, Palazzo F. Gastroesophageal reflux disease and connective tissue disorders: pathophysiology and implications for treatment. J Gastrointest Surg. 2008 Nov; 12(11):1900-6. PMID: 18766408.
      View in: PubMed
    53. Jancelewicz T, Vu LT, Shawo AE, Yeh B, Gasper WJ, Harris HW. Predicting strangulated small bowel obstruction: an old problem revisited. J Gastrointest Surg. 2009 Jan; 13(1):93-9. PMID: 18685902.
      View in: PubMed
    54. Imhof I, Gasper WJ, Derynck R. Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization. J Cell Sci. 2008 Jul 01; 121(Pt 13):2265-74. PMID: 18544636.
      View in: PubMed
    55. Gasper WJ, Sweet MP, Golden JA, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Patti MG. Lung transplantation in patients with connective tissue disorders and esophageal dysmotility. Dis Esophagus. 2008; 21(7):650-5. PMID: 18459990.
      View in: PubMed
    56. Gasper WJ, Jamshidi R, Theodore PR. Palliation of thoracic malignancies. Surg Oncol. 2007 Dec; 16(4):259-65. PMID: 17904357.
      View in: PubMed
    57. Sweet MP, Nipomnick I, Gasper WJ, Bagatelos K, Ostroff JW, Fisichella PM, Way LW, Patti MG. The outcome of laparoscopic Heller myotomy for achalasia is not influenced by the degree of esophageal dilatation. J Gastrointest Surg. 2008 Jan; 12(1):159-65. PMID: 17710504.
      View in: PubMed
    58. Gasper WJ, Sweet MP, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Golden JA, Patti MG. Antireflux surgery for patients with end-stage lung disease before and after lung transplantation. Surg Endosc. 2008 Feb; 22(2):495-500. PMID: 17704875.
      View in: PubMed
    59. Zhang L, Gasper WJ, Stass SA, Ioffe OB, Davis MA, Mixson AJ. Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res. 2002 Oct 01; 62(19):5463-9. PMID: 12359754.
      View in: PubMed
    60. Chen QR, Zhang L, Gasper W, Mixson AJ. Targeting tumor angiogenesis with gene therapy. Mol Genet Metab. 2001 Sep-Oct; 74(1-2):120-7. PMID: 11592809.
      View in: PubMed