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Wenhan Chang, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-750-2089 ext. 3880
ORCID ORCID Icon0000-0001-6583-7176 Additional info
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    Collapse Biography 
    Collapse Education and Training
    State University of New York, BuffaloPhD1992Physiology/Electrophysiology
    University of California San Francisco, San FranciscoPost-doc1996Endocrinology
    Collapse Awards and Honors
    Department of Vaterans Affairs2019BLR&D Research Career Scientist

    Collapse Overview 
    Collapse Overview
    My research investigates the roles of the extracellular Ca2+, gama-aminobutyric acid (GABA), insulin-like growth factor-1 (IGF1), parathyroid hormone (PTH), FGF23, and vitamin D, and their respective receptors (CaSR, GABBR1, IGF1R, PTH1R, Klotho, and VDR) in (1) controlling mineral homeostasis; (2) mediating skeletal development and facture healing; (3) regulating neuroendocrine functions; and (4) neuroprotection. We study mice with conditional knockout (KO) of genes encoding CaSR, GABBR1, IGF1, IGF1R, PTH1R, Cyp27b1, FGF23, Klotho, VDR, and their associated signaling molecules in parathyroid cells (PTC), intestinal epithelial cells, renal tubule cells, chondrocytes, bone cells, and/or neurons to determine their biological functions. These in vivo studies are complemented with in vitro cell/organ cultures of parathyroid cells/glands; primary intestinal and renal tubular cells and associated cell lines; primary chondrocyte, osteoblast, osteoclast, and related cell lines; and neurons to further delineate the underlying mechanisms. We perform union and nonunion bone fractures on the above KO mice and study the structural, biochemical, and biomechanics properties of the resulting callus to determine the functions of the CaSR, GABBR1, IGF1, IGF1R, PTH1R, Cyp27b1, VDR, and their associated signaling molecules in fracture healing. Based on the above study, we are developing new pharmacological regimens for more robust skeletal anabolism to treat osteoporosis and to repair bone. We also perform brain ischemia and traumatic brain injury protocols on the KO mice to assess the role of those molecules in the development of neuronal injury and to develop new therapies for neuroprotection against ischemia- and TBI-induced brain injury.
    Dr. Chang is also the director of the SF-VAMC Bone Imaging Core facility.

    Collapse Research 
    Collapse Research Activities and Funding
    The 4th Symposium on The Extracellular Calcium-Sensing Receptor
    NIH/NIDDK R13DK124999Mar 1, 2020 - Feb 28, 2021
    Role: Principal Investigator
    BLR&D Research Career Scientist Award
    VA IK6BX004835Oct 1, 2019 - Sep 30, 2024
    Role: Principal Investigator
    ShEEP Equipment Request for GeoMx? Digital Spatial Profiler System
    VA IS1BX005042Sep 1, 2019 - Sep 30, 2020
    Role: Principal Investigator
    Regulation of Parathyroid Functions By G-Protein Coupled Receptors
    NIH/NIDDK R01DK122259Jul 1, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Regulation of PTH secretion by TRPC1
    NIH/NIDDK R01DK121656Apr 1, 2019 - Mar 31, 2023
    Role: Co-Principal Investigator
    ShEEP Equipment Request for nCounter Max Analysis System
    VA IS1BX004813Jan 1, 2019 - Sep 30, 2019
    Role: Principal Investigator
    ShEEP Request for Atomic Force Microscope (BRUKER INNOVA2-SYS)
    VA IS1BX004391Jan 1, 2018 - Sep 30, 2018
    Role: Principal Investigator
    A novel treatment for bone fracture repair
    VA I01BX003453Oct 1, 2017 - Sep 30, 2021
    Role: Principal Investigator
    ShEEP Request for SCANCO Medical VivaCT 80 preclinical micro-computed tomography (pCT) system
    VA IS1BX003589May 1, 2016 - Sep 30, 2016
    Role: Principal Investigator
    Combined PTH and Calcimimetic Therapy and Its Mechanisms for Osteoanabolism
    NIH/NIAMS R01AR067291Feb 11, 2015 - Dec 31, 2019
    Role: Principal Investigator
    UCSF Core Center for Musculoskeletal Biology and Medicine
    NIH/NIAMS P30AR066262Jul 1, 2014 - Jun 30, 2019
    Role: Co-Investigator
    The Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain Injury
    VA I01BX001960Apr 1, 2013 - Mar 31, 2017
    Role: Principal Investigator
    INTERACTIONS BETWEEN GABA B AND CA2+-SENSING RECEPTORS
    NIH/NIAMS R21AR054441Mar 6, 2007 - Feb 28, 2010
    Role: Principal Investigator
    Resolution of Stage-Specific Growth Plate Chondrocytes
    NIH/NIAMS R21AR050662Sep 25, 2003 - Jun 30, 2006
    Role: Principal Investigator
    CALCIUM-SENSING RECEPTORS AND GROWTH PLATE DEVELOPMENT
    NIH/NIA R01AG021353Feb 15, 2002 - Mar 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism. Nat Metab. 2020 Mar; 2(3):243-255. Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP. PMID: 32694772.
      View in: PubMed   Mentions:
    2. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 Mar 02; 130(3):1513-1526. Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. PMID: 32065590.
      View in: PubMed   Mentions: 4     Fields:    
    3. Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice. J Bone Miner Res. 2020 01; 35(1):143-154. Cheng Z, Li A, Tu CL, Maria CS, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W. PMID: 31498905.
      View in: PubMed   Mentions:    Fields:    
    4. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. Nat Commun. 2019 10 16; 10(1):4693. Centeno PP, Herberger A, Mun HC, Tu C, Nemeth EF, Chang W, Conigrave AD, Ward DT. PMID: 31619668.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent ß-catenin stabilization in osteoblasts. J Biol Chem. 2019 11 01; 294(44):16337-16350. Rybchyn MS, Islam KS, Brennan-Speranza TC, Cheng Z, Brennan SC, Chang W, Mason RS, Conigrave AD. PMID: 31527082.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport. J Endocr Soc. 2019 Nov 01; 3(11):1993-2011. Munson S, Wang Y, Chang W, Bikle DD. PMID: 31620669.
      View in: PubMed   Mentions:
    7. Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR. J Bone Miner Res. 2019 04; 34(4):726-738. Zhang M, Yang H, Wan X, Lu L, Zhang J, Zhang H, Ye T, Liu Q, Xie M, Liu X, Yu S, Guo S, Chang W, Wang M. PMID: 30496623.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Nat Rev Endocrinol. 2018 12; 15(1):33-51. Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. PMID: 30443043.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    9. Calcium-Sensing Receptor Regulates Epidermal Intracellular Ca2+ Signaling and Re-Epithelialization after Wounding. J Invest Dermatol. 2019 04; 139(4):919-929. Tu CL, Celli A, Mauro T, Chang W. PMID: 30404020.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons. Life Sci. 2018 Feb 01; 194:49-58. Sun X, Tang L, Winesett S, Chang W, Cheng SX. PMID: 29247746.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234. Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. PMID: 28096214.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    12. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Res. 2016 09 15; 76(18):5348-60. Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. PMID: 27450451.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    13. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 07; 88:170-179. Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. PMID: 27130872.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone. J Cell Biochem. 2016 07; 117(7):1556-67. Al-Dujaili SA, Koh AJ, Dang M, Mi X, Chang W, Ma PX, McCauley LK. PMID: 26579618.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats. Osteoarthritis Cartilage. 2016 May; 24(5):921-31. Zhang M, Wang H, Zhang J, Zhang H, Yang H, Wan X, Jing L, Lu L, Liu X, Yu S, Chang W, Wang M. PMID: 26746151.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Semin Cell Dev Biol. 2016 Jan; 49:11-23. Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W. PMID: 26688334.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney. Am J Physiol Renal Physiol. 2016 Mar 15; 310(6):F518-33. Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA. PMID: 26661650.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    18. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. Am J Physiol Cell Physiol. 2016 Feb 01; 310(3):C193-204. Schepelmann M, Yarova PL, Lopez-Fernandez I, Davies TS, Brennan SC, Edwards PJ, Aggarwal A, Graça J, Rietdorf K, Matchkov V, Fenton RA, Chang W, Krssak M, Stewart A, Broadley KJ, Ward DT, Price SA, Edwards DH, Kemp PJ, Riccardi D. PMID: 26538090.
      View in: PubMed   Mentions:
    19. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. PMID: 26453498.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. PMID: 25801198.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    21. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. 2015 Apr 22; 7(284):284ra60. Yarova PL, Stewart AL, Sathish V, Britt RD, Thompson MA, P Lowe AP, Freeman M, Aravamudan B, Kita H, Brennan SC, Schepelmann M, Davies T, Yung S, Cholisoh Z, Kidd EJ, Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, T Ward JP, Kemp PJ, Pabelick CM, Prakash YS, Riccardi D. PMID: 25904744.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    22. Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon. Am J Physiol Gastrointest Liver Physiol. 2015 May 15; 308(10):G874-83. Tang L, Peng M, Liu L, Chang W, Binder HJ, Cheng SX. PMID: 25792563.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon. Mol Cancer. 2015 Mar 18; 14:61. Aggarwal A, Prinz-Wohlgenannt M, Gröschel C, Tennakoon S, Meshcheryakova A, Chang W, Brown EM, Mechtcheriakova D, Kállay E. PMID: 25879211.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling. J Dent Res. 2015 Jun; 94(6):803-12. Yang T, Zhang J, Cao Y, Zhang M, Jing L, Jiao K, Yu S, Chang W, Chen D, Wang M. PMID: 25749876.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection. Ann Clin Transl Neurol. 2014 Nov; 1(11):851-66. Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari MA, Chang W. PMID: 25540800.
      View in: PubMed   Mentions: 17     Fields:    
    26. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. PMID: 24677183.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    27. Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One. 2014; 9(5):e94989. Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC. PMID: 24788917.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis. J Orthop Res. 2014 Feb; 32(2):318-23. Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB. PMID: 24167068.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    29. Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. Bone Res. 2013 Sep; 1(3):249-59. Wang Y, Bikle DD, Chang W. PMID: 26273506.
      View in: PubMed   Mentions:
    30. Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury. J Neurotrauma. 2013 Jul 01; 30(13):1170-6. Kim JY, Kim N, Yenari MA, Chang W. PMID: 23360235.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    31. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. PMID: 23782944.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    32. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. PMID: 23239173.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    33. The extracellular calcium-sensing receptor, CaSR, in fetal development. Best Pract Res Clin Endocrinol Metab. 2013 Jun; 27(3):443-53. Riccardi D, Brennan SC, Chang W. PMID: 23856271.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    34. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-2359. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. PMID: 22622426.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    35. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. PMID: 21956637.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    36. Negative cross-talk between calcium-sensing receptor and ß-catenin signaling systems in colonic epithelium. J Biol Chem. 2012 Jan 06; 287(2):1158-67. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. PMID: 22094462.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    37. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res. 2011 Jul; 26(7):1437-46. Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W. PMID: 21312270.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    38. Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression. Transl Stroke Res. 2011 Jun 01; 2(2):195-201. Kim JY, Kim N, Yenari MA, Chang W. PMID: 21731589.
      View in: PubMed   Mentions: 16     Fields:    
    39. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol. 2011 May; 131(5):1119-28. Tu CL, Chang W, Bikle DD. PMID: 21209619.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    40. Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function. J Clin Endocrinol Metab. 2010 Oct; 95(10):E245-52. Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL. PMID: 20631026.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    41. Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone. Methods Enzymol. 2010; 484:253-66. Chang W, Dvorak M, Shoback D. PMID: 21036236.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    42. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008 Sep 02; 1(35):ra1. Chang W, Tu C, Chen TH, Bikle D, Shoback D. PMID: 18765830.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    43. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J Biol Chem. 2008 Feb 08; 283(6):3519-28. Tu CL, Chang W, Xie Z, Bikle DD. PMID: 18065418.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    44. Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Endocrinology. 2007 Oct; 148(10):4984-92. Cheng Z, Tu C, Rodriguez L, Chen TH, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. PMID: 17615148.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    45. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J Biol Chem. 2007 Aug 24; 282(34):25030-40. Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D. PMID: 17591780.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    46. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology. 2007 Jul; 148(7):3156-63. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. PMID: 17412806.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    47. The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes. J Invest Dermatol. 2007 May; 127(5):1074-83. Tu CL, Chang W, Bikle DD. PMID: 17124506.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    48. WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes. Endocrinology. 2006 Sep 05. Cheng Z, Tu C, Rodriguez L, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. PMID: 16728489.
      View in: PubMed   Mentions:    Fields:    
    49. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology. 2006 Oct; 147(10):4753-61. Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD. PMID: 16857753.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    50. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology. 2005 Dec; 146(12):5294-303. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. PMID: 16166224.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    51. Extracellular calcium and parathyroid hormone-related peptide signaling modulate the pace of growth plate chondrocyte differentiation. Endocrinology. 2005 Nov; 146(11):4597-608. Rodriguez L, Cheng Z, Chen TH, Tu C, Chang W. PMID: 16099862.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    52. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. J Invest Dermatol. 2005 Jan; 124(1):187-97. Tu CL, Chang W, Bikle DD. PMID: 15654973.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    53. Extracellular Ca2+-sensing in cartilage. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):410-1. Chang W, Rodriguez L, Chen TH, Tu C, Shoback D. PMID: 15758285.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    54. cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus). J Biol Chem. 2004 Dec 17; 279(51):53288-97. Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W, Shoback D. PMID: 15456780.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    55. Extracellular Ca2+-sensing receptors--an overview. Cell Calcium. 2004 Mar; 35(3):183-96. Chang W, Shoback D. PMID: 15200142.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    56. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol. 2002 Jul; 192(1):45-54. Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. PMID: 12115735.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    57. Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells. Endocrinology. 2002 Apr; 143(4):1467-74. Chang W, Tu C, Pratt S, Chen TH, Shoback D. PMID: 11897705.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    58. Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation. J Biol Chem. 2001 Nov 23; 276(47):44129-36. Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D. PMID: 11535593.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    59. Starvation amidst plenty--rickets and hypercalcemia in calcium receptor knockout mice. Endocrinology. 2001 Sep; 142(9):3733-5. Shoback D, Chang W. PMID: 11517147.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    60. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. J Biol Chem. 2001 Nov 02; 276(44):41079-85. Tu CL, Chang W, Bikle DD. PMID: 11500521.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    61. Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E180-9. Chang W, Pratt SA, Chen TH, Tu CL, Mikala G, Schwartz A, Shoback D. PMID: 11404236.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    62. Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis. DNA Cell Biol. 2001 Jan; 20(1):41-52. Gross C, De Baere E, Lo A, Chang W, Messiaen L. PMID: 11242542.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    63. Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C. J Biol Chem. 2000 Jun 30; 275(26):19955-63. Chang W, Chen TH, Pratt S, Shoback D. PMID: 10764812.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    64. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem. 2000 Jan 14; 275(2):1183-90. Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD. PMID: 10625662.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    65. Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes. Mol Cell Endocrinol. 1999 Dec 20; 158(1-2):13-23. Chang W, Pratt S, Chen TH, Shoback D. PMID: 10630401.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    66. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology. 1999 Dec; 140(12):5883-93. Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D. PMID: 10579354.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    67. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology. 1999 Apr; 140(4):1911-9. Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. PMID: 10098531.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    68. Regulation of extracellular calcium-activated cation currents by cAMP in parathyroid cells. Am J Physiol. 1998 08; 275(2):E213-21. Chang W, Chen TH, Pratt S, Shoback D. PMID: 9688621.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    69. Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera. J Bone Miner Res. 1998 Apr; 13(4):570-80. Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D. PMID: 9556057.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    70. Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists. Am J Physiol. 1997 11; 273(5):E880-90. Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D. PMID: 9374672.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    71. Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers. Am J Physiol. 1995 Nov; 269(5 Pt 1):E864-77. Chang W, Chen TH, Gardner P, Shoback D. PMID: 7491938.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    72. DPC blockade of transepithelial chloride absorption and single anion channels in teleost urinary bladder. Am J Physiol. 1993 Jul; 265(1 Pt 2):R66-75. Chang W, Loretz CA. PMID: 7688192.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    73. Identification of a stretch-activated monovalent cation channel from teleost urinary bladder cells. J Exp Zool. 1991 Sep; 259(3):304-15. Chang WH, Loretz CA. PMID: 1717636.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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