Wenhan Chang, PhD
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Title(s) | Professor, Medicine |
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School | School of Medicine |
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Address | 4150 Clement St San Francisco CA 94121
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Phone | 415-750-2089 ext. 3880 |
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ORCID
.gif) | 0000-0001-6583-7176  |
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vCard | Download vCard |
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Overview My research investigates the roles of the extracellular Ca2+, gama-aminobutyric acid (GABA), insulin-like growth factor-1 (IGF1), parathyroid hormone (PTH), FGF23, and vitamin D, and their respective receptors (CaSR, GABBR1, IGF1R, PTH1R, Klotho, and VDR) in (1) controlling mineral homeostasis; (2) mediating skeletal development and facture healing; (3) regulating neuroendocrine functions; and (4) neuroprotection. We study mice with conditional knockout (KO) of genes encoding CaSR, GABBR1, IGF1, IGF1R, PTH1R, Cyp27b1, FGF23, Klotho, VDR, and their associated signaling molecules in parathyroid cells (PTC), intestinal epithelial cells, renal tubule cells, chondrocytes, bone cells, and/or neurons to determine their biological functions. These in vivo studies are complemented with in vitro cell/organ cultures of parathyroid cells/glands; primary intestinal and renal tubular cells and associated cell lines; primary chondrocyte, osteoblast, osteoclast, and related cell lines; and neurons to further delineate the underlying mechanisms. We perform union and nonunion bone fractures on the above KO mice and study the structural, biochemical, and biomechanics properties of the resulting callus to determine the functions of the CaSR, GABBR1, IGF1, IGF1R, PTH1R, Cyp27b1, VDR, and their associated signaling molecules in fracture healing. Based on the above study, we are developing new pharmacological regimens for more robust skeletal anabolism to treat osteoporosis and to repair bone. We also perform brain ischemia and traumatic brain injury protocols on the KO mice to assess the role of those molecules in the development of neuronal injury and to develop new therapies for neuroprotection against ischemia- and TBI-induced brain injury. Dr. Chang is also the director of the SF-VAMC Bone Imaging Core facility.
Research ORNG Applications Bibliographic
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Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis. Nat Commun. 2020 08 25; 11(1):4243.
Jäger E, Murthy S, Schmidt C, Hahn M, Strobel S, Peters A, Stäubert C, Sungur P, Venus T, Geisler M, Radusheva V, Raps S, Rothe K, Scholz R, Jung S, Wagner S, Pierer M, Seifert O, Chang W, Estrela-Lopis I, Raulien N, Krohn K, Sträter N, Hoeppener S, Schöneberg T, Rossol M, Wagner U. PMID: 32843625.
View in: PubMed Mentions:
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PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism. Nat Metab. 2020 03; 2(3):243-255.
Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP. PMID: 32694772.
View in: PubMed Mentions:
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Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 03 02; 130(3):1513-1526.
Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. PMID: 32065590.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice. J Bone Miner Res. 2020 01; 35(1):143-154.
Cheng Z, Li A, Tu CL, Maria CS, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W. PMID: 31498905.
View in: PubMed Mentions: 2 Fields:
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Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. Nat Commun. 2019 10 16; 10(1):4693.
Centeno PP, Herberger A, Mun HC, Tu C, Nemeth EF, Chang W, Conigrave AD, Ward DT. PMID: 31619668.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent ß-catenin stabilization in osteoblasts. J Biol Chem. 2019 11 01; 294(44):16337-16350.
Rybchyn MS, Islam KS, Brennan-Speranza TC, Cheng Z, Brennan SC, Chang W, Mason RS, Conigrave AD. PMID: 31527082.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport. J Endocr Soc. 2019 Nov 01; 3(11):1993-2011.
Munson S, Wang Y, Chang W, Bikle DD. PMID: 31620669.
View in: PubMed Mentions:
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Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR. J Bone Miner Res. 2019 04; 34(4):726-738.
Zhang M, Yang H, Wan X, Lu L, Zhang J, Zhang H, Ye T, Liu Q, Xie M, Liu X, Yu S, Guo S, Chang W, Wang M. PMID: 30496623.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Nat Rev Endocrinol. 2018 12; 15(1):33-51.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. PMID: 30443043.
View in: PubMed Mentions: 22 Fields: Translation: Humans
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Calcium-Sensing Receptor Regulates Epidermal Intracellular Ca2+ Signaling and Re-Epithelialization after Wounding. J Invest Dermatol. 2019 04; 139(4):919-929.
Tu CL, Celli A, Mauro T, Chang W. PMID: 30404020.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons. Life Sci. 2018 Feb 01; 194:49-58.
Sun X, Tang L, Winesett S, Chang W, Cheng SX. PMID: 29247746.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234.
Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. PMID: 28096214.
View in: PubMed Mentions: 49 Fields: Translation: HumansAnimalsCells
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Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Res. 2016 09 15; 76(18):5348-60.
Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. PMID: 27450451.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimals
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Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 07; 88:170-179.
Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. PMID: 27130872.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone. J Cell Biochem. 2016 07; 117(7):1556-67.
Al-Dujaili SA, Koh AJ, Dang M, Mi X, Chang W, Ma PX, McCauley LK. PMID: 26579618.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats. Osteoarthritis Cartilage. 2016 May; 24(5):921-31.
Zhang M, Wang H, Zhang J, Zhang H, Yang H, Wan X, Jing L, Lu L, Liu X, Yu S, Chang W, Wang M. PMID: 26746151.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Semin Cell Dev Biol. 2016 Jan; 49:11-23.
Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W. PMID: 26688334.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney. Am J Physiol Renal Physiol. 2016 Mar 15; 310(6):F518-33.
Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA. PMID: 26661650.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimals
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The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. . 2016 Feb 01; 310(3):C193-204.
Schepelmann M, Yarova PL, Lopez-Fernandez I, Davies TS, Brennan SC, Edwards PJ, Aggarwal A, Graça J, Rietdorf K, Matchkov V, Fenton RA, Chang W, Krssak M, Stewart A, Broadley KJ, Ward DT, Price SA, Edwards DH, Kemp PJ, Riccardi D. PMID: 26538090.
View in: PubMed Mentions:
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Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88.
Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. PMID: 26453498.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimalsCells
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Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84.
Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. PMID: 25801198.
View in: PubMed Mentions: 20 Fields: Translation: AnimalsCells
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Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. 2015 Apr 22; 7(284):284ra60.
Yarova PL, Stewart AL, Sathish V, Britt RD, Thompson MA, P Lowe AP, Freeman M, Aravamudan B, Kita H, Brennan SC, Schepelmann M, Davies T, Yung S, Cholisoh Z, Kidd EJ, Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, T Ward JP, Kemp PJ, Pabelick CM, Prakash YS, Riccardi D. PMID: 25904744.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
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Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon. Am J Physiol Gastrointest Liver Physiol. 2015 May 15; 308(10):G874-83.
Tang L, Peng M, Liu L, Chang W, Binder HJ, Cheng SX. PMID: 25792563.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
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The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon. Mol Cancer. 2015 Mar 18; 14:61.
Aggarwal A, Prinz-Wohlgenannt M, Gröschel C, Tennakoon S, Meshcheryakova A, Chang W, Brown EM, Mechtcheriakova D, Kállay E. PMID: 25879211.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling. J Dent Res. 2015 Jun; 94(6):803-12.
Yang T, Zhang J, Cao Y, Zhang M, Jing L, Jiao K, Yu S, Chang W, Chen D, Wang M. PMID: 25749876.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection. Ann Clin Transl Neurol. 2014 Nov; 1(11):851-66.
Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari MA, Chang W. PMID: 25540800.
View in: PubMed Mentions: 18 Fields:
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Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13.
Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. PMID: 24677183.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One. 2014; 9(5):e94989.
Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC. PMID: 24788917.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis. J Orthop Res. 2014 Feb; 32(2):318-23.
Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB. PMID: 24167068.
View in: PubMed Mentions: 14 Fields: Translation: Animals
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Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. Bone Res. 2013 Sep; 1(3):249-59.
Wang Y, Bikle DD, Chang W. PMID: 26273506.
View in: PubMed Mentions:
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Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury. J Neurotrauma. 2013 Jul 01; 30(13):1170-6.
Kim JY, Kim N, Yenari MA, Chang W. PMID: 23360235.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42.
Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. PMID: 23782944.
View in: PubMed Mentions: 16 Fields: Translation: Animals
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Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100.
Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. PMID: 23239173.
View in: PubMed Mentions: 11 Fields: Translation: Animals
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The extracellular calcium-sensing receptor, CaSR, in fetal development. Best Pract Res Clin Endocrinol Metab. 2013 Jun; 27(3):443-53.
Riccardi D, Brennan SC, Chang W. PMID: 23856271.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-2359.
Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. PMID: 22622426.
View in: PubMed Mentions: 31 Fields: Translation: AnimalsCells
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Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47.
Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. PMID: 21956637.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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Negative cross-talk between calcium-sensing receptor and ß-catenin signaling systems in colonic epithelium. J Biol Chem. 2012 Jan 06; 287(2):1158-67.
Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. PMID: 22094462.
View in: PubMed Mentions: 27 Fields: Translation: HumansAnimalsCells
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IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res. 2011 Jul; 26(7):1437-46.
Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W. PMID: 21312270.
View in: PubMed Mentions: 49 Fields: Translation: AnimalsCells
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Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression. Transl Stroke Res. 2011 Jun 01; 2(2):195-201.
Kim JY, Kim N, Yenari MA, Chang W. PMID: 21731589.
View in: PubMed Mentions: 17 Fields:
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The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol. 2011 May; 131(5):1119-28.
Tu CL, Chang W, Bikle DD. PMID: 21209619.
View in: PubMed Mentions: 16 Fields: Translation: HumansCells
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Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function. J Clin Endocrinol Metab. 2010 Oct; 95(10):E245-52.
Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL. PMID: 20631026.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone. Methods Enzymol. 2010; 484:253-66.
Chang W, Dvorak M, Shoback D. PMID: 21036236.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008 Sep 02; 1(35):ra1.
Chang W, Tu C, Chen TH, Bikle D, Shoback D. PMID: 18765830.
View in: PubMed Mentions: 84 Fields: Translation: HumansAnimalsCells
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Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J Biol Chem. 2008 Feb 08; 283(6):3519-28.
Tu CL, Chang W, Xie Z, Bikle DD. PMID: 18065418.
View in: PubMed Mentions: 44 Fields: Translation: HumansCells
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Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Endocrinology. 2007 Oct; 148(10):4984-92.
Cheng Z, Tu C, Rodriguez L, Chen TH, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. PMID: 17615148.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J Biol Chem. 2007 Aug 24; 282(34):25030-40.
Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D. PMID: 17591780.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
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Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology. 2007 Jul; 148(7):3156-63.
Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. PMID: 17412806.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes. J Invest Dermatol. 2007 May; 127(5):1074-83.
Tu CL, Chang W, Bikle DD. PMID: 17124506.
View in: PubMed Mentions: 29 Fields: Translation: HumansCells
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WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes. Endocrinology. 2006 Sep 05.
Cheng Z, Tu C, Rodriguez L, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. PMID: 16728489.
View in: PubMed Mentions: Fields:
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Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology. 2006 Oct; 147(10):4753-61.
Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD. PMID: 16857753.
View in: PubMed Mentions: 47 Fields: Translation: AnimalsCells
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Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology. 2005 Dec; 146(12):5294-303.
Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. PMID: 16166224.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimalsCells
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Extracellular calcium and parathyroid hormone-related peptide signaling modulate the pace of growth plate chondrocyte differentiation. Endocrinology. 2005 Nov; 146(11):4597-608.
Rodriguez L, Cheng Z, Chen TH, Tu C, Chang W. PMID: 16099862.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimalsCells
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Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. J Invest Dermatol. 2005 Jan; 124(1):187-97.
Tu CL, Chang W, Bikle DD. PMID: 15654973.
View in: PubMed Mentions: 29 Fields: Translation: HumansCells
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Extracellular Ca2+-sensing in cartilage. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):410-1.
Chang W, Rodriguez L, Chen TH, Tu C, Shoback D. PMID: 15758285.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus). J Biol Chem. 2004 Dec 17; 279(51):53288-97.
Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W, Shoback D. PMID: 15456780.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Extracellular Ca2+-sensing receptors--an overview. Cell Calcium. 2004 Mar; 35(3):183-96.
Chang W, Shoback D. PMID: 15200142.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol. 2002 Jul; 192(1):45-54.
Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. PMID: 12115735.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells. Endocrinology. 2002 Apr; 143(4):1467-74.
Chang W, Tu C, Pratt S, Chen TH, Shoback D. PMID: 11897705.
View in: PubMed Mentions: 21 Fields: Translation: AnimalsCells
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Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation. J Biol Chem. 2001 Nov 23; 276(47):44129-36.
Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D. PMID: 11535593.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Starvation amidst plenty--rickets and hypercalcemia in calcium receptor knockout mice. Endocrinology. 2001 Sep; 142(9):3733-5.
Shoback D, Chang W. PMID: 11517147.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. J Biol Chem. 2001 Nov 02; 276(44):41079-85.
Tu CL, Chang W, Bikle DD. PMID: 11500521.
View in: PubMed Mentions: 42 Fields: Translation: HumansCells
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Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E180-9.
Chang W, Pratt SA, Chen TH, Tu CL, Mikala G, Schwartz A, Shoback D. PMID: 11404236.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis. DNA Cell Biol. 2001 Jan; 20(1):41-52.
Gross C, De Baere E, Lo A, Chang W, Messiaen L. PMID: 11242542.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C. J Biol Chem. 2000 Jun 30; 275(26):19955-63.
Chang W, Chen TH, Pratt S, Shoback D. PMID: 10764812.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem. 2000 Jan 14; 275(2):1183-90.
Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD. PMID: 10625662.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
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Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes. Mol Cell Endocrinol. 1999 Dec 20; 158(1-2):13-23.
Chang W, Pratt S, Chen TH, Shoback D. PMID: 10630401.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology. 1999 Dec; 140(12):5883-93.
Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D. PMID: 10579354.
View in: PubMed Mentions: 40 Fields: Translation: HumansAnimalsCells
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Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology. 1999 Apr; 140(4):1911-9.
Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. PMID: 10098531.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Regulation of extracellular calcium-activated cation currents by cAMP in parathyroid cells. Am J Physiol. 1998 08; 275(2):E213-21.
Chang W, Chen TH, Pratt S, Shoback D. PMID: 9688621.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera. J Bone Miner Res. 1998 Apr; 13(4):570-80.
Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D. PMID: 9556057.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
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Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists. Am J Physiol. 1997 11; 273(5):E880-90.
Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D. PMID: 9374672.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers. Am J Physiol. 1995 Nov; 269(5 Pt 1):E864-77.
Chang W, Chen TH, Gardner P, Shoback D. PMID: 7491938.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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DPC blockade of transepithelial chloride absorption and single anion channels in teleost urinary bladder. Am J Physiol. 1993 Jul; 265(1 Pt 2):R66-75.
Chang W, Loretz CA. PMID: 7688192.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Identification of a stretch-activated monovalent cation channel from teleost urinary bladder cells. J Exp Zool. 1991 Sep; 259(3):304-15.
Chang WH, Loretz CA. PMID: 1717636.
View in: PubMed Mentions: Fields: Translation: Animals
This graph shows the total number of publications by year. To see the data as text, click here.
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Year | Publications |
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1991 | 1 | 1993 | 1 | 1995 | 1 | 1997 | 1 | 1998 | 2 | 1999 | 3 | 2000 | 2 | 2001 | 5 | 2002 | 2 | 2004 | 3 | 2005 | 3 | 2006 | 3 | 2007 | 4 | 2008 | 1 | 2010 | 2 | 2011 | 5 | 2012 | 1 | 2013 | 6 | 2014 | 3 | 2015 | 10 | 2016 | 3 | 2017 | 2 | 2018 | 2 | 2019 | 5 | 2020 | 3 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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