Wenhan Chang, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1700 Owens Street, #349
San Francisco CA 94158
ORCID ORCID Icon0000-0001-6583-7176 Additional info
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    Collapse Biography 
    Collapse Education and Training
    State University of New York, BuffaloPhDPhysiology/Electrophysiology
    University of California San Francisco, San FranciscoPost-docEndocrinology

    Collapse Overview 
    Collapse Overview
    My research investigates the roles of the extracellular Ca2+, gama-aminobutyric acid (GABA), insulin-like growth factor-1 (IGF1), parathyroid hormone (PTH), FGF23, and vitamin D, and their respective receptors (CaSR, GABBR1, IGF1R, PTH1R, Klotho, and VDR) in (1) controlling mineral homeostasis; (2) mediating skeletal development and facture healing; (3) regulating neuroendocrine functions; and (4) neuroprotection. We study mice with conditional knockout (KO) of genes encoding CaSR, GABBR1, IGF1, IGF1R, PTH1R, Cyp27b1, FGF23, Klotho, VDR, and their associated signaling molecules in parathyroid cells (PTC), intestinal epithelial cells, renal tubule cells, chondrocytes, bone cells, and/or neurons to determine their biological functions. These in vivo studies are complemented with in vitro cell/organ cultures of parathyroid cells/glands; primary intestinal and renal tubular cells and associated cell lines; primary chondrocyte, osteoblast, osteoclast, and related cell lines; and neurons to further delineate the underlying mechanisms. We perform union and nonunion bone fractures on the above KO mice and study the structural, biochemical, and biomechanics properties of the resulting callus to determine the functions of the CaSR, GABBR1, IGF1, IGF1R, PTH1R, Cyp27b1, VDR, and their associated signaling molecules in fracture healing. Based on the above study, we are developing new pharmacological regimens for more robust skeletal anabolism to treat osteoporosis and to repair bone. We also perform brain ischemia and traumatic brain injury protocols on the KO mice to assess the role of those molecules in the development of neuronal injury and to develop new therapies for neuroprotection against ischemia- and TBI-induced brain injury.
    Dr. Chang is also the director of the SF-VAMC Bone Imaging Core facility.

    Collapse Research 
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    Vitamin D and beta-amyloid signaling in hyperparathyroidism
    NIH/NIA 1RF1AG075742-01A1Apr 1, 2023 - Mar 31, 2028
    Role: Co-Principal Investigator
    Description: This study seeks to examine a previously unrecognized connection between the vitamin D receptor, the ?-amyloid peptide signaling, and hyperparathyroidism, an increasingly common disease of calcium metabolism.
    ShEEP Request for NanoString GeoMx Digital Spatial Profiling System
    VA BLR&D 1IS1BX006330-01Oct 1, 2022 - Sep 30, 2023
    Role: Principal Investigator
    Description: The goal of this application is to adopt a critical technical platform for spatially-defined cell type-specific profiling of gene and protein expression to evaluate, with high fidelity and resolution, molecular changes in bone, skin, lung, cardiovascular, endocrine, kidney and brain diseases in order to advance our basic and translational biomedical research and to facilitate development of treatments for the diseases. Since molecular and cellular changes accompany and drive disease progression, this tool will not only facilitate translational studies using animal models and patients’ biopsies, but also provide a robust means in delineating pathological pathways that cause the diseases which afflict large populations of VA patients.
    FRACTURE CURB: Combined long-acting PTH and calcimimetics actions on skeletal anabolism
    VA BLR&D I01 BX005851-01Oct 1, 2021 - Sep 30, 2025
    Role: Principal Investigator
    Description: The goals of this VA Collaborative Merit Review project are to study the impact of long-acting PTH and its combination with calcimimetics on bones in the context of aging and estrogen-deficiency and to delineate the underlying cellular and molecular mechanisms of those skeletal effects.
    Regulation of parathyroid function by the amyloid precursor protein
    NIH R21AG070721May 1, 2021 - Jan 31, 2023
    Role: Co-Principal Investigator
    Description: The goal of this application is to examine a previously unrecognized connection between the beta amyloid protein associated with aging and cognitive decline, and primary hyperparathyroidism, an increasingly common disease of calcium metabolism that disproportionately affects the elderly and causes a spectrum of clinical problems particularly burdensome to this vulnerable population.
    The 4th Symposium on The Extracellular Calcium-Sensing Receptor
    NIH R13DK124999Mar 1, 2020 - Feb 28, 2021
    Role: Principal Investigator
    UCSF Core Center for Musculoskeletal Biology in Medicine
    NIH NIAMS 6P30AR066262Oct 1, 2019 - Sep 30, 2024
    Role: Director of Skeletal Biology and Biomechanics Core
    Description: The UCSF Core Center for Musculoskeletal Biology in Medicine (CCMBM) is an interdisciplinary consortium of 39 basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaboration among existing research programs at UCSF and to accelerate transdisciplinary research in osteoporosis and osteoarthritis. The CCMBM has 3 cores: Skeletal Biology, Musculoskeletal and Quantitative Imaging Core, and Epidemiology and Biostatistics Core.
    BLR&D Research Career Scientist Award
    NIH IK6BX004835Oct 1, 2019 - Sep 30, 2024
    Role: Principal Investigator
    Regulation of Parathyroid Functions By G-Protein Coupled Receptors
    NIH R01DK122259Sep 12, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Description: This project will define a new process by which heterodimerization of the calcium-sensing receptor (CaSR) and the metabotropic type B1 beta-aminobutyric acid (GABA) receptor (GABAB1R) and GABA-synthesizing enzymes regulate PTH secretion from the parathyroid glands. The information to be obtained could result in a promising pharmacological target for treating parathyroid diseases, including different forms of hyperparathyroidism.
    ShEEP Equipment Request for GeoMx? Digital Spatial Profiler System
    NIH IS1BX005042Sep 1, 2019 - Sep 30, 2020
    Role: Principal Investigator
    Regulation of PTH secretion by TRPC1
    NIH R01DK121656Apr 1, 2019 - Mar 31, 2023
    Role: Co-Principal Investigator
    ShEEP Equipment Request for nCounter Max Analysis System
    NIH IS1BX004813Jan 1, 2019 - Sep 30, 2019
    Role: Principal Investigator
    ShEEP Request for Atomic Force Microscope (BRUKER INNOVA2-SYS)
    NIH IS1BX004391Jan 1, 2018 - Sep 30, 2018
    Role: Principal Investigator
    A novel treatment for bone fracture repair
    NIH I01BX003453Oct 1, 2017 - Sep 30, 2021
    Role: Principal Investigator
    ShEEP Request for SCANCO Medical VivaCT 80 preclinical micro-computed tomography (pCT) system
    NIH IS1BX003589May 1, 2016 - Sep 30, 2016
    Role: Principal Investigator
    Combined PTH and Calcimimetic Therapy and Its Mechanisms for Osteoanabolism
    NIH R01AR067291Feb 11, 2015 - Jun 30, 2020
    Role: Principal Investigator
    UCSF Core Center for Musculoskeletal Biology and Medicine
    NIH P30AR066262Jul 1, 2014 - Mar 31, 2020
    Role: Co-director of Skeletal Biology Core
    Description: The UCSF Core Center for Musculoskeletal Biology in Medicine (CCMBM) is an interdisciplinary consortium of 39 basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaboration among existing research programs at UCSF and to accelerate transdisciplinary research in osteoporosis and osteoarthritis. The CCMBM has 3 cores: Skeletal Biology, Musculoskeletal and Quantitative Imaging Core, and Epidemiology and Biostatistics Core.
    The Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain Injury
    NIH I01BX001960Apr 1, 2013 - Mar 31, 2017
    Role: Principal Investigator
    NIH R21AR054441Mar 6, 2007 - Feb 28, 2010
    Role: Principal Investigator
    Resolution of Stage-Specific Growth Plate Chondrocytes
    NIH R21AR050662Sep 25, 2003 - Jun 30, 2006
    Role: Principal Investigator
    NIH R01AG021353Feb 15, 2002 - Mar 31, 2014
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice. JCI Insight. 2023 Dec 22; 8(24). Courbon G, Kentrup D, Thomas JJ, Wang X, Tsai HH, Spindler J, Von Drasek J, Ndjonko LM, Martinez-Calle M, Lynch S, Hivert L, Wang X, Chang W, Feng JQ, David V, Martin A. PMID: 37943605; PMCID: PMC10807721.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation. Blood. 2023 07 06; 142(1):106-118. Courbon G, Thomas JJ, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, Hunt-Tobey B, Mehta R, Isakova T, Chang W, Creemers JWM, Ji P, Martin A, David V. PMID: 37053547; PMCID: PMC10356820.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    3. Digital spatial profiling of human parathyroid tumors reveals cellular and molecular alterations linked to vitamin D deficiency. PNAS Nexus. 2023 Mar; 2(3):pgad073. Tu CL, Chang W, Sosa JA, Koh J. PMID: 36992820; PMCID: PMC10042281.
      View in: PubMed   Mentions:
    4. Immune Reconstitution Bone Loss Exacerbates Bone Degeneration Due to Natural Aging in a Mouse Model. J Infect Dis. 2022 08 12; 226(1):38-48. Weitzmann MN, Weiss D, Vikulina T, Roser-Page S, Yu K, McGee-Lawrence ME, Tu CL, Chang W, Ofotokun I. PMID: 34962571; PMCID: PMC9373144.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells. J Am Soc Nephrol. 2022 07; 33(7):1323-1340. Schepelmann M, Ranieri M, Lopez-Fernandez I, Webberley TS, Brennan SC, Yarova PL, Graca J, Hanif UK, Müller C, Manhardt T, Salzmann M, Quasnichka H, Price SA, Ward DT, Gilbert T, Matchkov VV, Fenton RA, Herberger A, Hwong J, Santa Maria C, Tu CL, Kallay E, Valenti G, Chang W, Riccardi D. PMID: 35581010; PMCID: PMC9257819.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Precise druggability of the PTH type 1 receptor. Nat Chem Biol. 2022 03; 18(3):272-280. Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP. PMID: 34949836; PMCID: PMC8891041.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    7. Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation. Sci Signal. 2021 Oct 05; 14(703):eabc5944. White AD, Peña KA, Clark LJ, Maria CS, Liu S, Jean-Alphonse FG, Lee JY, Lei S, Cheng Z, Tu CL, Fang F, Szeto N, Gardella TJ, Xiao K, Gellman SH, Bahar I, Sutkeviciute I, Chang W, Vilardaga JP. PMID: 34609896; PMCID: PMC8682804.
      View in: PubMed   Mentions: 19     Fields:    
    8. FBW7 couples structural integrity with functional output of primary cilia. Commun Biol. 2021 09 13; 4(1):1066. Petsouki E, Gerakopoulos V, Szeto N, Chang W, Humphrey MB, Tsiokas L. PMID: 34518642; PMCID: PMC8438042.
      View in: PubMed   Mentions: 2  Translation:AnimalsCells
    9. The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells. Int J Mol Sci. 2021 Jun 17; 22(12). Rybchyn MS, Brennan-Speranza TC, Mor D, Cheng Z, Chang W, Conigrave AD, Mason RS. PMID: 34204449; PMCID: PMC8234890.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels. Elife. 2021 05 11; 10. Martiszus BJ, Tsintsadze T, Chang W, Smith SM. PMID: 33973519; PMCID: PMC8163501.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    11. Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice. Pediatr Res. 2022 05; 91(6):1391-1398. Mayer CA, Roos B, Teske J, Wells N, Martin RJ, Chang W, Pabelick CM, Prakash YS, MacFarlane PM. PMID: 33958714; PMCID: PMC8571113.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    12. Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling. Sci Rep. 2021 03 17; 11(1):6175. Egli-Spichtig D, Zhang MYH, Li A, Pastor Arroyo EM, Hernando N, Wagner CA, Chang W, Perwad F. PMID: 33731726; PMCID: PMC7969776.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis. Nat Commun. 2020 08 25; 11(1):4243. Jäger E, Murthy S, Schmidt C, Hahn M, Strobel S, Peters A, Stäubert C, Sungur P, Venus T, Geisler M, Radusheva V, Raps S, Rothe K, Scholz R, Jung S, Wagner S, Pierer M, Seifert O, Chang W, Estrela-Lopis I, Raulien N, Krohn K, Sträter N, Hoeppener S, Schöneberg T, Rossol M, Wagner U. PMID: 32843625; PMCID: PMC7447633.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    14. Control of PTH secretion by the TRPC1 ion channel. JCI Insight. 2020 04 23; 5(8). Onopiuk M, Eby B, Nesin V, Ngo P, Lerner M, Gorvin CM, Stokes VJ, Thakker RV, Brandi ML, Chang W, Humphrey MB, Tsiokas L, Lau K. PMID: 32213715; PMCID: PMC7205425.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism. Nat Metab. 2020 03; 2(3):243-255. Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP. PMID: 32694772; PMCID: PMC7377265.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    16. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 03 02; 130(3):1513-1526. Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. PMID: 32065590; PMCID: PMC7269595.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    17. Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice. J Bone Miner Res. 2020 01; 35(1):143-154. Cheng Z, Li A, Tu CL, Maria CS, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W. PMID: 31498905; PMCID: PMC7700777.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. Nat Commun. 2019 10 16; 10(1):4693. Centeno PP, Herberger A, Mun HC, Tu C, Nemeth EF, Chang W, Conigrave AD, Ward DT. PMID: 31619668; PMCID: PMC6795806.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    19. Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent β-catenin stabilization in osteoblasts. J Biol Chem. 2019 11 01; 294(44):16337-16350. Rybchyn MS, Islam KS, Brennan-Speranza TC, Cheng Z, Brennan SC, Chang W, Mason RS, Conigrave AD. PMID: 31527082; PMCID: PMC6827303.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport. J Endocr Soc. 2019 Nov 01; 3(11):1993-2011. Munson S, Wang Y, Chang W, Bikle DD. PMID: 31620669; PMCID: PMC6789431.
      View in: PubMed   Mentions: 3  
    21. Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR. J Bone Miner Res. 2019 04; 34(4):726-738. Zhang M, Yang H, Wan X, Lu L, Zhang J, Zhang H, Ye T, Liu Q, Xie M, Liu X, Yu S, Guo S, Chang W, Wang M. PMID: 30496623; PMCID: PMC6482062.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    22. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Nat Rev Endocrinol. 2018 12; 15(1):33-51. Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. PMID: 30443043; PMCID: PMC6535143.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    23. Calcium-Sensing Receptor Regulates Epidermal Intracellular Ca2+ Signaling and Re-Epithelialization after Wounding. J Invest Dermatol. 2019 04; 139(4):919-929. Tu CL, Celli A, Mauro T, Chang W. PMID: 30404020; PMCID: PMC6431556.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    24. Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons. Life Sci. 2018 Feb 01; 194:49-58. Sun X, Tang L, Winesett S, Chang W, Cheng SX. PMID: 29247746; PMCID: PMC5794538.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234. Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. PMID: 28096214; PMCID: PMC5394763.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    26. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Res. 2016 09 15; 76(18):5348-60. Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. PMID: 27450451; PMCID: PMC5026591.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    27. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 07; 88:170-179. Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. PMID: 27130872; PMCID: PMC4899137.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone. J Cell Biochem. 2016 07; 117(7):1556-67. Al-Dujaili SA, Koh AJ, Dang M, Mi X, Chang W, Ma PX, McCauley LK. PMID: 26579618; PMCID: PMC4856537.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    29. Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats. Osteoarthritis Cartilage. 2016 May; 24(5):921-31. Zhang M, Wang H, Zhang J, Zhang H, Yang H, Wan X, Jing L, Lu L, Liu X, Yu S, Chang W, Wang M. PMID: 26746151; PMCID: PMC5699887.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Semin Cell Dev Biol. 2016 Jan; 49:11-23. Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W. PMID: 26688334; PMCID: PMC4761456.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    31. Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney. Am J Physiol Renal Physiol. 2016 Mar 15; 310(6):F518-33. Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA. PMID: 26661650; PMCID: PMC5005276.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    32. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. Am J Physiol Cell Physiol. 2016 Feb 01; 310(3):C193-204. Schepelmann M, Yarova PL, Lopez-Fernandez I, Davies TS, Brennan SC, Edwards PJ, Aggarwal A, Graça J, Rietdorf K, Matchkov V, Fenton RA, Chang W, Krssak M, Stewart A, Broadley KJ, Ward DT, Price SA, Edwards DH, Kemp PJ, Riccardi D. PMID: 26538090; PMCID: PMC5243220.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    33. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. PMID: 26453498; PMCID: PMC4600536.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    34. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. PMID: 25801198; PMCID: PMC5690481.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    35. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. 2015 Apr 22; 7(284):284ra60. Yarova PL, Stewart AL, Sathish V, Britt RD, Thompson MA, P Lowe AP, Freeman M, Aravamudan B, Kita H, Brennan SC, Schepelmann M, Davies T, Yung S, Cholisoh Z, Kidd EJ, Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, T Ward JP, Kemp PJ, Pabelick CM, Prakash YS, Riccardi D. PMID: 25904744; PMCID: PMC4725057.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    36. Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon. Am J Physiol Gastrointest Liver Physiol. 2015 May 15; 308(10):G874-83. Tang L, Peng M, Liu L, Chang W, Binder HJ, Cheng SX. PMID: 25792563; PMCID: PMC4437021.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    37. The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon. Mol Cancer. 2015 Mar 18; 14:61. Aggarwal A, Prinz-Wohlgenannt M, Gröschel C, Tennakoon S, Meshcheryakova A, Chang W, Brown EM, Mechtcheriakova D, Kállay E. PMID: 25879211; PMCID: PMC4405849.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    38. Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling. J Dent Res. 2015 Jun; 94(6):803-12. Yang T, Zhang J, Cao Y, Zhang M, Jing L, Jiao K, Yu S, Chang W, Chen D, Wang M. PMID: 25749876; PMCID: PMC6728679.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    39. Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection. Ann Clin Transl Neurol. 2014 Nov; 1(11):851-66. Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari MA, Chang W. PMID: 25540800; PMCID: PMC4265057.
      View in: PubMed   Mentions: 27     Fields:    
    40. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. PMID: 24677183; PMCID: PMC4108521.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    41. Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One. 2014; 9(5):e94989. Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC. PMID: 24788917; PMCID: PMC4006800.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    42. Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis. J Orthop Res. 2014 Feb; 32(2):318-23. Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB. PMID: 24167068; PMCID: PMC4462343.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    43. Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. Bone Res. 2013 Sep; 1(3):249-59. Wang Y, Bikle DD, Chang W. PMID: 26273506; PMCID: PMC4472106.
      View in: PubMed   Mentions: 36  
    44. Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury. J Neurotrauma. 2013 Jul 01; 30(13):1170-6. Kim JY, Kim N, Yenari MA, Chang W. PMID: 23360235; PMCID: PMC3700438.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    45. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. PMID: 23782944; PMCID: PMC3749485.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    46. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. PMID: 23239173; PMCID: PMC3617088.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    47. The extracellular calcium-sensing receptor, CaSR, in fetal development. Best Pract Res Clin Endocrinol Metab. 2013 Jun; 27(3):443-53. Riccardi D, Brennan SC, Chang W. PMID: 23856271; PMCID: PMC4462341.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    48. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-2359. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. PMID: 22622426; PMCID: PMC3434298.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    49. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. PMID: 21956637; PMCID: PMC3222747.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    50. Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium. J Biol Chem. 2012 Jan 06; 287(2):1158-67. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. PMID: 22094462; PMCID: PMC3256874.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    51. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res. 2011 Jul; 26(7):1437-46. Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W. PMID: 21312270; PMCID: PMC3530140.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    52. Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression. Transl Stroke Res. 2011 Jun 01; 2(2):195-201. Kim JY, Kim N, Yenari MA, Chang W. PMID: 21731589; PMCID: PMC3124781.
      View in: PubMed   Mentions: 26     Fields:    
    53. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol. 2011 May; 131(5):1119-28. Tu CL, Chang W, Bikle DD. PMID: 21209619; PMCID: PMC3078217.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    54. Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function. J Clin Endocrinol Metab. 2010 Oct; 95(10):E245-52. Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL. PMID: 20631026; PMCID: PMC3050095.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    55. Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone. Methods Enzymol. 2010; 484:253-66. Chang W, Dvorak M, Shoback D. PMID: 21036236; PMCID: PMC3528079.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    56. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008 Sep 02; 1(35):ra1. Chang W, Tu C, Chen TH, Bikle D, Shoback D. PMID: 18765830; PMCID: PMC3538864.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    57. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J Biol Chem. 2008 Feb 08; 283(6):3519-3528. Tu CL, Chang W, Xie Z, Bikle DD. PMID: 18065418.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    58. Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Endocrinology. 2007 Oct; 148(10):4984-92. Cheng Z, Tu C, Rodriguez L, Chen TH, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. PMID: 17615148.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    59. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J Biol Chem. 2007 Aug 24; 282(34):25030-40. Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D. PMID: 17591780.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    60. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology. 2007 Jul; 148(7):3156-63. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. PMID: 17412806.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    61. The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes. J Invest Dermatol. 2007 May; 127(5):1074-83. Tu CL, Chang W, Bikle DD. PMID: 17124506.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    62. WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes. Endocrinology. 2006 Sep 05. Cheng Z, Tu C, Rodriguez L, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. PMID: 16728489.
      View in: PubMed   Mentions:    Fields:    
    63. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology. 2006 Oct; 147(10):4753-61. Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD. PMID: 16857753; PMCID: PMC10645399.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    64. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology. 2005 Dec; 146(12):5294-303. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. PMID: 16166224.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    65. Extracellular calcium and parathyroid hormone-related peptide signaling modulate the pace of growth plate chondrocyte differentiation. Endocrinology. 2005 Nov; 146(11):4597-608. Rodriguez L, Cheng Z, Chen TH, Tu C, Chang W. PMID: 16099862.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    66. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. J Invest Dermatol. 2005 Jan; 124(1):187-97. Tu CL, Chang W, Bikle DD. PMID: 15654973.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    67. Extracellular Ca2+-sensing in cartilage. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):410-1. Chang W, Rodriguez L, Chen TH, Tu C, Shoback D. PMID: 15758285.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    68. cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus). J Biol Chem. 2004 Dec 17; 279(51):53288-97. Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W, Shoback D. PMID: 15456780.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    69. Extracellular Ca2+-sensing receptors--an overview. Cell Calcium. 2004 Mar; 35(3):183-96. Chang W, Shoback D. PMID: 15200142.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    70. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol. 2002 Jul; 192(1):45-54. Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. PMID: 12115735.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    71. Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells. Endocrinology. 2002 Apr; 143(4):1467-74. Chang W, Tu C, Pratt S, Chen TH, Shoback D. PMID: 11897705.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    72. Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation. J Biol Chem. 2001 Nov 23; 276(47):44129-36. Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D. PMID: 11535593.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    73. Starvation amidst plenty--rickets and hypercalcemia in calcium receptor knockout mice. Endocrinology. 2001 Sep; 142(9):3733-5. Shoback D, Chang W. PMID: 11517147.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    74. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. J Biol Chem. 2001 Nov 02; 276(44):41079-85. Tu CL, Chang W, Bikle DD. PMID: 11500521.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    75. Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E180-9. Chang W, Pratt SA, Chen TH, Tu CL, Mikala G, Schwartz A, Shoback D. PMID: 11404236.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    76. Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis. DNA Cell Biol. 2001 Jan; 20(1):41-52. Gross C, De Baere E, Lo A, Chang W, Messiaen L. PMID: 11242542.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    77. Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C. J Biol Chem. 2000 Jun 30; 275(26):19955-63. Chang W, Chen TH, Pratt S, Shoback D. PMID: 10764812.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    78. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem. 2000 Jan 14; 275(2):1183-90. Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD. PMID: 10625662.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    79. Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes. Mol Cell Endocrinol. 1999 Dec 20; 158(1-2):13-23. Chang W, Pratt S, Chen TH, Shoback D. PMID: 10630401.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    80. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology. 1999 Dec; 140(12):5883-93. Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D. PMID: 10579354.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    81. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology. 1999 Apr; 140(4):1911-9. Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. PMID: 10098531.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    82. Regulation of extracellular calcium-activated cation currents by cAMP in parathyroid cells. Am J Physiol. 1998 08; 275(2):E213-21. Chang W, Chen TH, Pratt S, Shoback D. PMID: 9688621.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    83. Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera. J Bone Miner Res. 1998 Apr; 13(4):570-80. Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D. PMID: 9556057.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    84. Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists. Am J Physiol. 1997 11; 273(5):E880-90. Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D. PMID: 9374672.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    85. [Acute hepatic porphyria and its neurological syndrome]. Schweiz Med Wochenschr. 1996 Jan 09; 126(1-2):6-14. Bont A, Steck AJ, Meyer UA. PMID: 8571113.
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    86. Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers. Am J Physiol. 1995 Nov; 269(5 Pt 1):E864-77. Chang W, Chen TH, Gardner P, Shoback D. PMID: 7491938.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    87. DPC blockade of transepithelial chloride absorption and single anion channels in teleost urinary bladder. Am J Physiol. 1993 Jul; 265(1 Pt 2):R66-75. Chang W, Loretz CA. PMID: 7688192.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    88. Identification of a stretch-activated monovalent cation channel from teleost urinary bladder cells. J Exp Zool. 1991 Sep; 259(3):304-15. Chang WH, Loretz CA. PMID: 1717636.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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