Wesley McKeithan, PhD

Title(s)Postdoctoral Scholar, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone--
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    Collapse Research Activities and Funding
    Rebuilding a Micro-Organ: Using Synthetic Morphological Tools to Probe and Engineer the Structure and Function of Pancreatic Islets
    NIH F32DK123939May 1, 2020 - Apr 30, 2023
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human iPSC-derived Cardiomyocytes and Pyridyl-Phenyl Mexiletine Analogs. Bioorg Med Chem Lett. 2021 May 29; 128162. Johnson M, Gomez-Galeno J, Ryan D, Okolotowicz K, McKeithan WL, Sampson KJ, Kass RS, Mercola M, Cashman JR. PMID: 34062251.
      View in: PubMed   Mentions:    Fields:    
    2. Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes. J Med Chem. 2021 May 13; 64(9):5384-5403. Cashman JR, Ryan D, McKeithan WL, Okolotowicz K, Gomez-Galeno J, Johnson M, Sampson KJ, Kass RS, Pezhouman A, Karagueuzian HS, Mercola M. PMID: 33942619.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes. Sci Rep. 2021 Feb 04; 11(1):3026. Chirikian O, Goodyer WR, Dzilic E, Serpooshan V, Buikema JW, McKeithan W, Wu H, Li G, Lee S, Merk M, Galdos F, Beck A, Ribeiro AJS, Paige S, Mercola M, Wu JC, Pruitt BL, Wu SM. PMID: 33542270.
      View in: PubMed   Mentions: 3     Fields:    
    4. Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness. Cell Chem Biol. 2021 May 20; 28(5):625-635.e5. Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway PJ, Colas AR, Lancman JJ, Schade D, Perea-Gil I, Bruyneel AAN, Lee J, Vadgama N, Quach J, McKeithan WL, Biechele TL, Wu JC, Moon RT, Si Dong PD, Karakikes I, Cashman JR, Mercola M. PMID: 33503403.
      View in: PubMed   Mentions:    Fields:    
    5. Engineering synthetic morphogen systems that can program multicellular patterning. Science. 2020 10 16; 370(6514):327-331. Toda S, McKeithan WL, Hakkinen TJ, Lopez P, Klein OD, Lim WA. PMID: 33060357.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    6. Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity. Cell Stem Cell. 2020 11 05; 27(5):813-821.e6. McKeithan WL, Feyen DAM, Bruyneel AAN, Okolotowicz KJ, Ryan DA, Sampson KJ, Potet F, Savchenko A, Gómez-Galeno J, Vu M, Serrano R, George AL, Kass RS, Cashman JR, Mercola M. PMID: 32931730.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Rep. 2020 07 21; 32(3):107925. Feyen DAM, McKeithan WL, Bruyneel AAN, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen RP, Ginsburg KS, Lam CK, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya PL, Behrens CS, Ranjbarvaziri S, Maas RGC, Greenhaw M, Bernstein D, Wu JC, Bers DM, Eschenhagen T, Metallo CM, Mercola M. PMID: 32697997.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    8. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation. 2019 02 05; 139(6):799-811. Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. PMID: 30586709.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    9. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nat Protoc. 2018 12; 13(12):3018-3041. Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC. PMID: 30413796.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    10. Will iPSC-cardiomyocytes revolutionize the discovery of drugs for heart disease? Curr Opin Pharmacol. 2018 10; 42:55-61. Bruyneel AA, McKeithan WL, Feyen DA, Mercola M. PMID: 30081259.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function. Curr Cardiol Rep. 2018 05 25; 20(7):57. Bruyneel AAN, McKeithan WL, Feyen DAM, Mercola M. PMID: 29802473.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017; 8:766. McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M. PMID: 29075196.
      View in: PubMed   Mentions:
    13. Id genes are essential for early heart formation. Genes Dev. 2017 07 01; 31(13):1325-1338. Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR. PMID: 28794185.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    14. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med. 2017 02 15; 9(377). Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. PMID: 28202772.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    15. Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev. 2012 Dec 01; 26(23):2567-79. Colas AR, McKeithan WL, Cunningham TJ, Bushway PJ, Garmire LX, Duester G, Subramaniam S, Mercola M. PMID: 23152446.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    16. Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening. Curr Protoc Stem Cell Biol. 2012 Nov; Chapter 1:Unit 1F.13. McKeithan WL, Colas AR, Bushway PJ, Ray S, Mercola M. PMID: 23154934.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells