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Wilian Cortopassi Coelho, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Oxford UniversityDPhilChemistry
    Pontifical Catholic University of Rio de janeiroBScChemistry
    Collapse Awards and Honors
    Royal Society of Chemistry2018Travel Grant Scholarship
    Tv Globo (Caldeirão do Huck)2018Top 5 most inspirational Brazilians
    Merck kGaA2017Runner up prize in the Biopharma Innovation Cup 2017
    Fundacao Estudar2017One of the characters of the book "Cultura de Excelencia" (Culture of Excellence), by David Cohen
    SciFinder2016Future Leaders in Chemistry
    Chemical Information Division of the American Chemical Society2016Scholarship for Scientific Excellence
    Royal Society of Chemistry2016Travel Grant Scholarship
    UK’s National Service for Computational Chemistry Software (NSCCS) 2015Poster prize
    German Chemical Society2015Travel Grant Scholarship
    2013One of the characters of the documentary "Romance de Formacao", by Julia de Simone
    PUC Rio2011Bronze medal at the Challenges in Chemistry Competition
    Annual Meeting of the Brazilian Chemical Society2011Poster prize
    Regional meeting of the Brazilian Chemical Society - Rio de Janeiro2011Poster prize
    Fundação Estudar2010Scholarship for Youth Leadership
    Brazilian Chemistry Olympiad2006Honorable mention

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cortopassi WA, Celmar Costa Franca T, Krettli AU. A systems biology approach to antimalarial drug discovery. Expert Opin Drug Discov. 2018 Jul; 13(7):617-626. PMID: 29737894.
      View in: PubMed
    2. Kumar K, Woo SM, Siu T, Cortopassi WA, Duarte F, Paton RS. Cation-Ï€ interactions in protein-ligand binding: theory and data-mining reveal different roles for lysine and arginine. Chem Sci. 2018 Mar 14; 9(10):2655-2665. PMID: 29719674.
      View in: PubMed
    3. Pliotas C, Grayer SC, Ekkerman S, Chan AKN, Healy J, Marius P, Bartlett W, Khan A, Cortopassi WA, Chandler SA, Rasmussen T, Benesch JLP, Paton RS, Claridge TDW, Miller S, Booth IR, Naismith JH, Conway SJ. Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System. Biochemistry. 2017 08 15; 56(32):4219-4234. PMID: 28656748.
      View in: PubMed
    4. Lin WK, Bolton EL, Cortopassi WA, Wang Y, O'Brien F, Maciejewska M, Jacobson MP, Garnham C, Ruas M, Parrington J, Lei M, Sitsapesan R, Galione A, Terrar DA. Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in ß-adrenoceptor signaling. J Biol Chem. 2017 08 11; 292(32):13243-13257. PMID: 28539361.
      View in: PubMed
    5. Cortopassi WA, Kumar K, Paton RS. Cation-p interactions in CREBBP bromodomain inhibition: an electrostatic model for small-molecule binding affinity and selectivity. Org Biomol Chem. 2016 Nov 22; 14(46):10926-10938. PMID: 27814427.
      View in: PubMed
    6. Cortopassi WA, Kumar K, Duarte F, Pimentel AS, Paton RS. Mechanisms of histone lysine-modifying enzymes: A computational perspective on the role of the protein environment. J Mol Graph Model. 2016 06; 67:69-84. PMID: 27258188.
      View in: PubMed
    7. Brand M, Measures AR, Wilson BG, Cortopassi WA, Alexander R, Höss M, Hewings DS, Rooney TP, Paton RS, Conway SJ. Correction to Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions. ACS Chem Biol. 2016 Apr 15; 11(4):1148. PMID: 26756254.
      View in: PubMed
    8. Cortopassi WA, Simion R, Honsby CE, França TC, Paton RS. Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment. Chemistry. 2015 Dec 21; 21(52):18869. PMID: 26663343.
      View in: PubMed
    9. Cortopassi WA, Simion R, Honsby CE, França TC, Paton RS. Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment. Chemistry. 2015 Dec 21; 21(52):18983-92. PMID: 26577067.
      View in: PubMed
    10. Brand M, Measures AR, Measures AM, Wilson BG, Cortopassi WA, Alexander R, Höss M, Hewings DS, Rooney TP, Paton RS, Conway SJ. Small molecule inhibitors of bromodomain-acetyl-lysine interactions. ACS Chem Biol. 2015 Jan 16; 10(1):22-39. PMID: 25549280.
      View in: PubMed
    11. Rooney TP, Filippakopoulos P, Fedorov O, Picaud S, Cortopassi WA, Hay DA, Martin S, Tumber A, Rogers CM, Philpott M, Wang M, Thompson AL, Heightman TD, Pryde DC, Cook A, Paton RS, Müller S, Knapp S, Brennan PE, Conway SJ. A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-p interaction. Angew Chem Int Ed Engl. 2014 Jun 10; 53(24):6126-30. PMID: 24821300.
      View in: PubMed
    12. Cortopassi WA, Penna-Coutinho J, Aguiar AC, Pimentel AS, Buarque CD, Costa PR, Alves BR, França TC, Krettli AU. Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum. PLoS One. 2014; 9(3):e91191. PMID: 24651068; PMCID: PMC3961230.
    13. Aguiar AC, Santos Rde M, Figueiredo FJ, Cortopassi WA, Pimentel AS, França TC, Meneghetti MR, Krettli AU. Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites. PLoS One. 2012; 7(5):e37259. PMID: 22649514; PMCID: PMC3359361.
    14. Cortopassi WA, Oliveira AA, Guimarães AP, Rennó MN, Krettli AU, França TC. Docking studies on the binding of quinoline derivatives and hematin to Plasmodium falciparum lactate dehydrogenase. J Biomol Struct Dyn. 2011 Aug; 29(1):207-18. PMID: 21696234.
      View in: PubMed
    15. Penna-Coutinho J, Cortopassi WA, Oliveira AA, França TC, Krettli AU. Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies. PLoS One. 2011; 6(7):e21237. PMID: 21779323; PMCID: PMC3136448.