Frederic Hopf, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Cornell UniversityBA1985Neurobiology
    University of California, BerkeleyPhD1994Molecular Biology
    University of California, Berkeley/Athena Postdoctoral Fellow1996Neuroscience
    Stanford UniversityPostdoctoral Fellow1998Neuroscience

    Collapse Overview 
    Collapse Overview
    Woody Hopf He is a widely recognized leader in the use of innovative methodologies, including the combination of optogenetics, in vitro electrophysiology and novel behavioral paradigms of pathological drinking, to uncover the molecular and circuit mechanisms that drive the excessive alcohol intake that make alcoholism so destructive. His main research goal is to identify specific molecular changes within particular brain areas that anchor binge-like and compulsive alcohol drinking, which will allow development of novel and potent pharmacological and behavioral interventions in human alcoholics. He presently focuses on frontal cortical areas (including the Insula) and downstream targets (nucleus accumbens, central amygdala), and how alcohol-related adaptations and other neuromodulators (dopamine, orexin, CRF) in these regions interact to drive pathological drinking. His work has been published in high impact factor journals such as Neuron, Nature Neuroscience, Journal of Neuroscience and Biological Psychiatry, and he has made major contributions to our understanding of molecular adaptations and brain circuits that promote pathological alcohol and cocaine intake, which could facilitate development of novel therapeutic interventions for the treatment of addiction.

    Collapse Research 
    Collapse Research Activities and Funding
    Encoding and regulation of compulsion-like alcohol drinking by subtypes of nucleus accumbens core neurons
    NIH/NIAAA R21AA027157Jul 1, 2018 - Jun 30, 2020
    Role: Principal Investigator
    Insula Circuitry and Compulsive Alcohol Drinking
    NIH/NIAAA R01AA024109Jun 8, 2016 - May 31, 2021
    Role: Principal Investigator
    Opto/Chemo-genetic Analysis of Locus Coeruleus CRF and Compulsive Ethanol Intake
    NIH/NIAAA R21AA023223Sep 1, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Optogenetic Analysis of Different Forms of Aversion-Resistant Ethanol Intake
    NIH/NIAAA R21AA021445Sep 1, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Alcohol Center for Translational Genetics (ACTG)
    NIH/NIAAA P50AA017072May 20, 2008 - Jun 30, 2018
    Role: Co-Investigator
    Altered Accumbens Signaling Following Ethanol Exposure
    NIH/NIAAA R01AA015358Sep 1, 2006 - Jun 30, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lei K, Kwok C, Darevsky D, Wegner SA, Yu J, Nakayama L, Pedrozo V, Anderson L, Ghotra S, Fouad M, Hopf FW. Nucleus Accumbens Shell Orexin-1 Receptors Are Critical Mediators of Binge Intake in Excessive-Drinking Individuals. Front Neurosci. 2019; 13:88. PMID: 30814925.
      View in: PubMed
    2. Goltseker K, Hopf FW, Barak S. Advances in behavioral animal models of alcohol use disorder. Alcohol. 2019 Feb; 74:73-82. PMID: 30424979.
      View in: PubMed
    3. Woodward Hopf F, Mangieri RA. Do Alcohol-Related AMPA-Type Glutamate Receptor Adaptations Promote Intake? Handb Exp Pharmacol. 2018 Apr 20. PMID: 29675583.
      View in: PubMed
    4. Darevsky D, Gill TM, Vitale KR, Hu B, Wegner SA, Hopf FW. Drinking despite adversity: behavioral evidence for a head down and push strategy of conflict-resistant alcohol drinking in rats. Addict Biol. 2018 Mar 08. PMID: 29516676.
      View in: PubMed
    5. Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW. Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 02; 41(2):345-358. PMID: 28103636.
      View in: PubMed
    6. Lei K, Wegner SA, Yu JH, Mototake A, Hu B, Hopf FW. Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking. Front Neurosci. 2016; 10:400. PMID: 27625592.
      View in: PubMed
    7. Hopf FW. Commentary: alcohol depletion of magnesium: a new mechanism for tolerance to alcohol activation of BK channels? Alcohol Clin Exp Res. 2015 Nov; 39(11):2095-6. PMID: 26332707.
      View in: PubMed
    8. Zuo W, Fu R, Hopf FW, Xie G, Krnjevic K, Li J, Ye JH. Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons. Addict Biol. 2017 Jan; 22(1):103-116. PMID: 26283508.
      View in: PubMed
    9. Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW. D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. Neuropsychopharmacology. 2015 Sep; 40(10):2357-67. PMID: 25801502; PMCID: PMC4538350.
    10. Hopf FW, Lesscher HM. Rodent models for compulsive alcohol intake. Alcohol. 2014 May; 48(3):253-64. PMID: 24731992; PMCID: PMC4993047.
    11. Chatterjee S, Santos N, Holgate J, Haass-Koffler CL, Hopf FW, Kharazia V, Lester H, Bonci A, Bartlett SE. The a5 subunit regulates the expression and function of a4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. PLoS One. 2013; 8(7):e68300. PMID: 23869214; PMCID: PMC3712017.
    12. Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug; 16(8):1094-100. PMID: 23817545.
      View in: PubMed
    13. Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A. Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res. 2013 Oct; 37(10):1680-7. PMID: 23763790; PMCID: PMC3985436.
    14. Hopf FW, Seif T, Chung S, Civelli O. MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro. PeerJ. 2013; 1:e61. PMID: 23646281; PMCID: PMC3642701.
    15. Chen BT, Yau HJ, Hatch C, Kusumoto-Yoshida I, Cho SL, Hopf FW, Bonci A. Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature. 2013 Apr 18; 496(7445):359-62. PMID: 23552889.
      View in: PubMed
    16. Srinivasan S, Simms JA, Nielsen CK, Lieske SP, Bito-Onon JJ, Yi H, Hopf FW, Bonci A, Bartlett SE. The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. PLoS One. 2012; 7(9):e44726. PMID: 23028593; PMCID: PMC3448615.
    17. Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonci A, Sulzer D, Borrelli E. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci. 2012 Jun 27; 32(26):9023-34. PMID: 22745501; PMCID: PMC3752062.
    18. Addolorato G, Leggio L, Hopf FW, Diana M, Bonci A. Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation. Neuropsychopharmacology. 2012 Jan; 37(1):163-77. PMID: 22030714.
      View in: PubMed
    19. Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M. Endocytosis promotes rapid dopaminergic signaling. Neuron. 2011 Jul 28; 71(2):278-90. PMID: 21791287; PMCID: PMC3417347.
    20. Seif T, Makriyannis A, Kunos G, Bonci A, Hopf FW. The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing. Neuroscience. 2011 Oct 13; 193:21-33. PMID: 21821098; PMCID: PMC3579619.
    21. Hopf FW, Seif T, Bonci A. The SK channel as a novel target for treating alcohol use disorders. Channels (Austin). 2011 Jul-Aug; 5(4):289-92. PMID: 21712648.
      View in: PubMed
    22. Hopf FW, Sparta DR, Bonci A. Translational models of interactions between stress and alcohol consumption: strengths and limitations. ILAR J. 2011; 52(3):239-50. PMID: 23382142.
      View in: PubMed
    23. Hopf FW, Simms JA, Chang SJ, Seif T, Bartlett SE, Bonci A. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry. 2011 Apr 01; 69(7):618-24. PMID: 21195386; PMCID: PMC3062269.
    24. Hopf FW, Bonci A. Dnmt3a: addiction's molecular forget-me-not? Nat Neurosci. 2010 Sep; 13(9):1041-3. PMID: 20740031.
      View in: PubMed
    25. Kapfhamer D, Berger KH, Hopf FW, Seif T, Kharazia V, Bonci A, Heberlein U. Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. J Neurosci. 2010 Jun 30; 30(26):8830-40. PMID: 20592205; PMCID: PMC3842471.
    26. Hopf FW, Chang SJ, Sparta DR, Bowers MS, Bonci A. Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration. Alcohol Clin Exp Res. 2010 Sep 01; 34(9):1565-73. PMID: 20586757; PMCID: PMC2997761.
    27. Hopf FW, Seif T, Mohamedi ML, Chen BT, Bonci A. The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum. Eur J Neurosci. 2010 Jun; 31(11):1946-59. PMID: 20497469; PMCID: PMC3077989.
    28. Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye K, Bonci A. Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. Neuron. 2010 Mar 11; 65(5):682-94. PMID: 20223203; PMCID: PMC2847608.
    29. Chen BT, Hopf FW, Bonci A. Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse. Ann N Y Acad Sci. 2010 Feb; 1187:129-39. PMID: 20201850; PMCID: PMC2886008.
    30. Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Curr Top Behav Neurosci. 2010; 3:3-27. PMID: 21161748.
      View in: PubMed
    31. Abdallah L, Bonasera SJ, Hopf FW, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci. 2009 Jun 24; 29(25):8156-65. PMID: 19553455; PMCID: PMC3077993.
    32. Hahn J, Hopf FW, Bonci A. Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. J Neurosci. 2009 May 20; 29(20):6535-44. PMID: 19458224; PMCID: PMC3077990.
    33. Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ. Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. Alcohol Clin Exp Res. 2009 Jul; 33(7):1125-35. PMID: 19389201; PMCID: PMC2760381.
    34. Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O. The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6772-7. PMID: 19342492; PMCID: PMC2672513.
    35. Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, Kharazia V, Waldhoer M, Mailliard WS, Armstrong R, Bonci A, Whistler JL. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11521-6. PMID: 16049099; PMCID: PMC1183554.