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Frederic Hopf, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-7391
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    Collapse Biography 
    Collapse Education and Training
    Cornell UniversityBA1985Neurobiology
    University of California, BerkeleyPhD1994Molecular Biology
    University of California, Berkeley/Athena Postdoctoral Fellow1996Neuroscience
    Stanford UniversityPostdoctoral Fellow1998Neuroscience

    Collapse Overview 
    Collapse Overview
    Woody Hopf He is a widely recognized leader in the use of innovative methodologies, including the combination of optogenetics, in vitro electrophysiology and novel behavioral paradigms of pathological drinking, to uncover the molecular and circuit mechanisms that drive the excessive alcohol intake that make alcoholism so destructive. His main research goal is to identify specific molecular changes within particular brain areas that anchor binge-like and compulsive alcohol drinking, which will allow development of novel and potent pharmacological and behavioral interventions in human alcoholics. He presently focuses on frontal cortical areas (including the Insula) and downstream targets (nucleus accumbens, central amygdala), and how alcohol-related adaptations and other neuromodulators (dopamine, orexin, CRF) in these regions interact to drive pathological drinking. His work has been published in high impact factor journals such as Neuron, Nature Neuroscience, Journal of Neuroscience and Biological Psychiatry, and he has made major contributions to our understanding of molecular adaptations and brain circuits that promote pathological alcohol and cocaine intake, which could facilitate development of novel therapeutic interventions for the treatment of addiction.


    Collapse Research 
    Collapse Research Activities and Funding
    Insula Circuitry and Compulsive Alcohol Drinking
    NIH/NIAAA R01AA024109Jun 8, 2016 - May 31, 2021
    Role: Principal Investigator
    Opto/Chemo-genetic Analysis of Locus Coeruleus CRF and Compulsive Ethanol Intake
    NIH/NIAAA R21AA023223Sep 1, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Optogenetic Analysis of Different Forms of Aversion-Resistant Ethanol Intake
    NIH/NIAAA R21AA021445Sep 1, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Alcohol Center for Translational Genetics (ACTG)
    NIH/NIAAA P50AA017072May 20, 2008 - Jun 30, 2018
    Role: Co-Investigator
    Altered Accumbens Signaling Following Ethanol Exposure
    NIH/NIAAA R01AA015358Sep 1, 2006 - Jun 30, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf F. Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 Feb; 41(2):345-358. PMID: 28103636.
      View in: PubMed
    2. Hopf F. Do specific NMDA receptor subunits act as gateways for addictive behaviors? Genes Brain Behav. 2017 Jan; 16(1):118-138. PMID: 27706932.
      View in: PubMed
    3. Zuo W, Xiao C, Gao M, Hopf F, Krnjevic K, McIntosh JM, Fu R, Wu J, Bekker A, Ye JH. Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms. Sci Rep. 2016 Sep 06; 6:32937. PMID: 27596561; PMCID: PMC5011770.
    4. Lei K, Wegner SA, Yu JH, Mototake A, Hu B, Hopf F. Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking. Front Neurosci. 2016; 10:400. PMID: 27625592; PMCID: PMC5004043.
    5. Lei K, Wegner SA, Yu JH, Simms JA, Hopf F. A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice. Alcohol. 2016 Sep; 55:9-16. PMID: 27788780.
      View in: PubMed
    6. Lei K, Wegner SA, Yu JH, Hopf F. Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice. Neuropharmacology. 2016 Nov; 110(Pt A):431-437. PMID: 27523303.
      View in: PubMed
    7. Pomrenze MB, Millan EZ, Hopf F, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015; 9:487. PMID: 26733798; PMCID: PMC4689854.
    8. Hopf F. Commentary: alcohol depletion of magnesium: a new mechanism for tolerance to alcohol activation of BK channels? Alcohol Clin Exp Res. 2015 Nov; 39(11):2095-6. PMID: 26332707.
      View in: PubMed
    9. Zuo W, Fu R, Hopf F, Xie G, Krnjevic K, Li J, Ye JH. Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons. Addict Biol. 2017 Jan; 22(1):103-116. PMID: 26283508.
      View in: PubMed
    10. Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf F. D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. Neuropsychopharmacology. 2015 Sep; 40(10):2357-67. PMID: 25801502; PMCID: PMC4538350.
    11. Hopf F, Lesscher HM. Rodent models for compulsive alcohol intake. Alcohol. 2014 May; 48(3):253-64. PMID: 24731992; PMCID: PMC4993047.
    12. Chatterjee S, Santos N, Holgate J, Haass-Koffler CL, Hopf F, Kharazia V, Lester H, Bonci A, Bartlett SE. The a5 subunit regulates the expression and function of a4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. PLoS One. 2013; 8(7):e68300. PMID: 23869214; PMCID: PMC3712017.
    13. Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf F. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug; 16(8):1094-100. PMID: 23817545; PMCID: PMC3939030.
    14. Sparta DR, Hopf F, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A. Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res. 2013 Oct; 37(10):1680-7. PMID: 23763790; PMCID: PMC3985436.
    15. Hopf F, Seif T, Chung S, Civelli O. MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro. PeerJ. 2013; 1:e61. PMID: 23646281; PMCID: PMC3642701.
    16. Chen BT, Yau HJ, Hatch C, Kusumoto-Yoshida I, Cho SL, Hopf F, Bonci A. Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature. 2013 Apr 18; 496(7445):359-62. PMID: 23552889.
      View in: PubMed
    17. Srinivasan S, Simms JA, Nielsen CK, Lieske SP, Bito-Onon JJ, Yi H, Hopf F, Bonci A, Bartlett SE. The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. PLoS One. 2012; 7(9):e44726. PMID: 23028593; PMCID: PMC3448615.
    18. Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf F, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonci A, Sulzer D, Borrelli E. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci. 2012 Jun 27; 32(26):9023-34. PMID: 22745501; PMCID: PMC3752062.
    19. Addolorato G, Leggio L, Hopf F, Diana M, Bonci A. Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation. Neuropsychopharmacology. 2012 Jan; 37(1):163-77. PMID: 22030714; PMCID: PMC3238087.
    20. Kotowski SJ, Hopf F, Seif T, Bonci A, von Zastrow M. Endocytosis promotes rapid dopaminergic signaling. Neuron. 2011 Jul 28; 71(2):278-90. PMID: 21791287; PMCID: PMC3417347.
    21. Seif T, Makriyannis A, Kunos G, Bonci A, Hopf F. The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing. Neuroscience. 2011 Oct 13; 193:21-33. PMID: 21821098; PMCID: PMC3579619.
    22. Hopf F, Seif T, Bonci A. The SK channel as a novel target for treating alcohol use disorders. Channels (Austin). 2011 Jul-Aug; 5(4):289-92. PMID: 21712648.
      View in: PubMed
    23. Hopf F, Sparta DR, Bonci A. Translational models of interactions between stress and alcohol consumption: strengths and limitations. ILAR J. 2011; 52(3):239-50. PMID: 23382142.
      View in: PubMed
    24. Hopf F, Simms JA, Chang SJ, Seif T, Bartlett SE, Bonci A. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry. 2011 Apr 01; 69(7):618-24. PMID: 21195386; PMCID: PMC3062269.
    25. Hopf F, Bonci A. Dnmt3a: addiction's molecular forget-me-not? Nat Neurosci. 2010 Sep; 13(9):1041-3. PMID: 20740031.
      View in: PubMed
    26. Kapfhamer D, Berger KH, Hopf F, Seif T, Kharazia V, Bonci A, Heberlein U. Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. J Neurosci. 2010 Jun 30; 30(26):8830-40. PMID: 20592205; PMCID: PMC3842471.
    27. Hopf F, Chang SJ, Sparta DR, Bowers MS, Bonci A. Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration. Alcohol Clin Exp Res. 2010 Sep 01; 34(9):1565-73. PMID: 20586757; PMCID: PMC2997761.
    28. Hopf F, Seif T, Mohamedi ML, Chen BT, Bonci A. The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum. Eur J Neurosci. 2010 Jun; 31(11):1946-59. PMID: 20497469; PMCID: PMC3077989.
    29. Hopf F, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye K, Bonci A. Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. Neuron. 2010 Mar 11; 65(5):682-94. PMID: 20223203; PMCID: PMC2847608.
    30. Chen BT, Hopf F, Bonci A. Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse. Ann N Y Acad Sci. 2010 Feb; 1187:129-39. PMID: 20201850; PMCID: PMC2886008.
    31. Stuber GD, Hopf F, Tye KM, Chen BT, Bonci A. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Curr Top Behav Neurosci. 2010; 3:3-27. PMID: 21161748.
      View in: PubMed
    32. Abdallah L, Bonasera SJ, Hopf F, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci. 2009 Jun 24; 29(25):8156-65. PMID: 19553455; PMCID: PMC3077993.
    33. Hahn J, Hopf F, Bonci A. Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. J Neurosci. 2009 May 20; 29(20):6535-44. PMID: 19458224; PMCID: PMC3077990.
    34. Hopf F, Bonci A. Striatal-enriched protein-tyrosine-phosphatase, synaptic plasticity, and psychostimulant-induced stereotypies. Biol Psychiatry. 2009 Apr 15; 65(8):635-6. PMID: 19328273.
      View in: PubMed
    35. Mulholland PJ, Hopf F, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ. Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. Alcohol Clin Exp Res. 2009 Jul; 33(7):1125-35. PMID: 19389201; PMCID: PMC2760381.
    36. Chung S, Hopf F, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O. The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6772-7. PMID: 19342492; PMCID: PMC2672513.
    37. Wanat MJ, Sparta DR, Hopf F, Bowers MS, Melis M, Bonci A. Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure. Biol Psychiatry. 2009 Apr 15; 65(8):646-53. PMID: 19118821; PMCID: PMC3040034.
    38. Bowers MS, Hopf F, Chou JK, Guillory AM, Chang SJ, Janak PH, Bonci A, Diamond I. Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12533-8. PMID: 18719114; PMCID: PMC2527946.
    39. Chen BT, Bowers MS, Martin M, Hopf F, Guillory AM, Carelli RM, Chou JK, Bonci A. Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. Neuron. 2008 Jul 31; 59(2):288-97. PMID: 18667156; PMCID: PMC2593405.
    40. Stuber GD, Hopf F, Hahn J, Cho SL, Guillory A, Bonci A. Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental area. Alcohol Clin Exp Res. 2008 Oct; 32(10):1714-20. PMID: 18627359; PMCID: PMC3040033.
    41. Wanat MJ, Hopf F, Stuber GD, Phillips PE, Bonci A. Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih. J Physiol. 2008 Apr 15; 586(8):2157-70. PMID: 18308824; PMCID: PMC2465205.
    42. Hopf F, Martin M, Chen BT, Bowers MS, Mohamedi MM, Bonci A. Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro. J Neurophysiol. 2007 Oct; 98(4):2297-310. PMID: 17699688.
      View in: PubMed
    43. Inoue Y, Yao L, Hopf F, Fan P, Jiang Z, Bonci A, Diamond I. Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors. J Pharmacol Exp Ther. 2007 Jul; 322(1):23-9. PMID: 17468300.
      View in: PubMed
    44. Hopf F, Turner PR, Steinhardt RA. Calcium misregulation and the pathogenesis of muscular dystrophy. Subcell Biochem. 2007; 45:429-64. PMID: 18193647.
      View in: PubMed
    45. Martin M, Chen BT, Hopf F, Bowers MS, Bonci A. Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nat Neurosci. 2006 Jul; 9(7):868-9. PMID: 16732275.
      View in: PubMed
    46. Bonci A, Hopf F. The dopamine D2 receptor: new surprises from an old friend. Neuron. 2005 Aug 04; 47(3):335-8. PMID: 16055058.
      View in: PubMed
    47. Bartlett SE, Enquist J, Hopf F, Lee JH, Gladher F, Kharazia V, Waldhoer M, Mailliard WS, Armstrong R, Bonci A, Whistler JL. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11521-6. PMID: 16049099; PMCID: PMC1183554.
    48. Hopf F, Mailliard WS, Gonzalez GF, Diamond I, Bonci A. Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons. J Neurosci. 2005 Jan 26; 25(4):985-9. PMID: 15673680.
      View in: PubMed
    49. Nicola SM, Hopf F, Hjelmstad GO. Contrast enhancement: a physiological effect of striatal dopamine? Cell Tissue Res. 2004 Oct; 318(1):93-106. PMID: 15503151.
      View in: PubMed
    50. Hopf F, Cascini MG, Gordon AS, Diamond I, Bonci A. Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein betagamma subunits. J Neurosci. 2003 Jun 15; 23(12):5079-87. PMID: 12832531.
      View in: PubMed
    51. Hopf F, Waters J, Mehta S, Smith SJ. Stability and plasticity of developing synapses in hippocampal neuronal cultures. J Neurosci. 2002 Feb 01; 22(3):775-81. PMID: 11826107.
      View in: PubMed
    52. Hazuka CD, Foletti DL, Hsu SC, Kee Y, Hopf F, Scheller RH. The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. J Neurosci. 1999 Feb 15; 19(4):1324-34. PMID: 9952410.
      View in: PubMed
    53. Hopf F, Turner PR, Denetclaw WF, Reddy P, Steinhardt RA. A critical evaluation of resting intracellular free calcium regulation in dystrophic mdx muscle. Am J Physiol. 1996 Oct; 271(4 Pt 1):C1325-39. PMID: 8897840.
      View in: PubMed
    54. Hopf F, Reddy P, Hong J, Steinhardt RA. A capacitative calcium current in cultured skeletal muscle cells is mediated by the calcium-specific leak channel and inhibited by dihydropyridine compounds. J Biol Chem. 1996 Sep 13; 271(37):22358-67. PMID: 8798397.
      View in: PubMed
    55. Denetclaw WF, Hopf F, Cox GA, Chamberlain JS, Steinhardt RA. Myotubes from transgenic mdx mice expressing full-length dystrophin show normal calcium regulation. Mol Biol Cell. 1994 Oct; 5(10):1159-67. PMID: 7865881; PMCID: PMC301138.
    56. Hopf F, Steinhardt RA. Regulation of intracellular free calcium in normal and dystrophic mouse cerebellar neurons. Brain Res. 1992 Apr 24; 578(1-2):49-54. PMID: 1511288.
      View in: PubMed
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