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Xiao Hu, PhD

Title(s)Professor, Physiological Nursing
SchoolSchool of Nursing
Phone415-476-4412
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    Collapse Biography 
    Collapse Awards and Honors
    UCLA2008  - 2010Clinical and Translational Science Institute Scholar
    Innocentive 2013  - 2013Winner of NASA-Innocentive Challenge on Noninvasive Intracranial Pressure

    Collapse Overview 
    Collapse Overview
    My research program’s goal is to innovate intelligent informatics systems to enhance healthcare professionals’ ability in utilizing Big Clinical Data to achieve more precise assessment and anticipation of patient state changes. Our team’s core expertise lies in various physiological signal modeling and processing and developing machine learning models. Our projects are interdisciplinary in nature. We are keen in learning new clinical/physiological problems that can be approached using our core engineering expertise. We are capable of developing and validating prototypes of intelligent systems equipped with our algorithms. Our current projects cover problems derived from neurocritical care and neurosurgical care of patients as well as from general in-hospital patient monitoring.

    Collapse Research 
    Collapse Research Activities and Funding
    Development and Validation of a Novel Noninvasive Intracranial Pressure Approach
    NIH/NINDS R01NS089771A1Aug 16, 2018 - Aug 15, 2023
    Role: Principal Investigator
    Integrate Dynamic System Model and Machine Learning for Calibration-Free Noninvasive ICP
    NIH/NINDS R01NS106905Aug 15, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Develop&validate SuperAlarm to detect patient deterioration with few false alarms
    NIH/NHLBI R01HL128679Jul 20, 2015 - Apr 30, 2019
    Role: Principal Investigator
    ICP Elevation Alerting Based on a Predictive Model Hosting Platform
    NIH/NINDS R01NS076738May 15, 2012 - Jan 31, 2016
    Role: Principal Investigator
    Continuous-Signal Driven Predictive Models in Neurological Intensive Care Units
    NIH/NINDS R01NS066008May 15, 2009 - Apr 30, 2013
    Role: Principal Investigator
    Intracranial Pressure Latency as a Biomarker of Cerebral Vasculature Status
    NIH/NINDS R21NS059797Feb 15, 2008 - Jan 31, 2011
    Role: Principal Investigator
    Data Mining Based Noninvasive Intracranial Pressure Assessment
    NIH/NINDS R21NS055998Mar 1, 2007 - Feb 28, 2010
    Role: Principal Investigator
    A Data Fusion Method for Bedside Monitoring of Lumped Cerebral Arterial Radii
    NIH/NINDS R21NS055045Jan 15, 2007 - Dec 31, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xiao R, Malekmohammadi M, Pouratian N, Hu X. Characterization of pallidocortical motor network in Parkinson disease through complex network analysis. J Neural Eng. 2019 Sep 10. PMID: 31505469.
      View in: PubMed
    2. Liu X, Zimmermann L, Vespa P, Hu X. Response to Letter to the Editor: Evaluation of a New Catheter for Simultaneous Intracranial Pressure Monitoring and Cerebral Spinal Fluid Drainage: A Pilot Study. Neurocrit Care. 2019 Aug; 31(1):227-228. PMID: 31172401.
      View in: PubMed
    3. Do DH, Kuo A, Lee ES, Mortara D, Elashoff D, Hu X, Boyle NG. Usefulness of Trends in Continuous Electrocardiographic Telemetry Monitoring to Predict In-Hospital Cardiac Arrest. Am J Cardiol. 2019 Oct 01; 124(7):1149-1158. PMID: 31405547.
      View in: PubMed
    4. Liu X, Zimmermann LL, Ho N, Vespa P, Liao X, Hu X. Evaluation of a New Catheter for Simultaneous Intracranial Pressure Monitoring and Cerebral Spinal Fluid Drainage: A Pilot Study. Neurocrit Care. 2019 06; 30(3):617-625. PMID: 30511345.
      View in: PubMed
    5. Liu X, Zimmermann LL, Ho N, Vespa P, Liao X, Hu X. Cerebral Vascular Changes During Acute Intracranial Pressure Drop. Neurocrit Care. 2019 06; 30(3):635-644. PMID: 30523541.
      View in: PubMed
    6. Suba S, Sandoval CP, Zègre-Hemsey JK, Hu X, Pelter MM. Contribution of Electrocardiographic Accelerated Ventricular Rhythm Alarms to Alarm Fatigue. Am J Crit Care. 2019 May; 28(3):222-229. PMID: 31043402.
      View in: PubMed
    7. Hu X. An algorithm strategy for precise patient monitoring in a connected healthcare enterprise. NPJ Digit Med. 2019; 2:30. PMID: 31304377.
      View in: PubMed
    8. Pereira T, Gadhoumi K, Ma M, Xiuyun L, Xiao R, Colorado RA, Keenan KJ, Meisel K, Hu X. A Supervised Approach to Robust Photoplethysmography Quality Assessment. IEEE J Biomed Health Inform. 2019 Apr 03. PMID: 30951482.
      View in: PubMed
    9. Liu X, Pu Y, Wu D, Zhang Z, Hu X, Liu L. Cross-Frequency Coupling Between Cerebral Blood Flow Velocity and EEG in Ischemic Stroke Patients With Large Vessel Occlusion. Front Neurol. 2019; 10:194. PMID: 30915019.
      View in: PubMed
    10. Linnen DT, Escobar GJ, Hu X, Scruth E, Liu V, Stephens C. Statistical Modeling and Aggregate-Weighted Scoring Systems in Prediction of Mortality and ICU Transfer: A Systematic Review. J Hosp Med. 2019 Mar; 14(3):161-169. PMID: 30811322.
      View in: PubMed
    11. Liu X, Gadhoumi K, Xiao R, Tran N, Smielewski P, Czosnyka M, Hetts SW, Ko N, Hu X. Continuous monitoring of cerebrovascular reactivity through pulse transit time and intracranial pressure. Physiol Meas. 2019 01 23; 40(1):01LT01. PMID: 30577032.
      View in: PubMed
    12. Hamilton RB, Scalzo F, Baldwin K, Dorn A, Vespa P, Hu X, Bergsneider M. Opposing CSF hydrodynamic trends found in the cerebral aqueduct and prepontine cistern following shunt treatment in patients with normal pressure hydrocephalus. Fluids Barriers CNS. 2019 Jan 22; 16(1):2. PMID: 30665428.
      View in: PubMed
    13. Megjhani M, Alkhachroum A, Terilli K, Ford J, Rubinos C, Kromm J, Wallace BK, Connolly ES, Roh D, Agarwal S, Claassen J, Padmanabhan R, Hu X, Park S. An active learning framework for enhancing identification of non-artifactual intracranial pressure waveforms. Physiol Meas. 2019 01 18; 40(1):015002. PMID: 30562165.
      View in: PubMed
    14. Wang JX, Hu X, Shadden SC. Data-Augmented Modeling of Intracranial Pressure. Ann Biomed Eng. 2019 Mar; 47(3):714-730. PMID: 30607645.
      View in: PubMed
    15. Papachristou N, Puschmann D, Barnaghi P, Cooper B, Hu X, Maguire R, Apostolidis K, Conley YP, Hammer M, Katsaragakis S, Kober KM, Levine JD, McCann L, Patiraki E, Furlong EP, Fox PA, Paul SM, Ream E, Wright F, Miaskowski C. Learning from data to predict future symptoms of oncology patients. PLoS One. 2018; 13(12):e0208808. PMID: 30596658.
      View in: PubMed
    16. Tinoco A, Mortara DW, Hu X, Sandoval CP, Pelter MM. ECG derived Cheyne-Stokes respiration and periodic breathing are associated with cardiorespiratory arrest in intensive care unit patients. Heart Lung. 2019 Mar - Apr; 48(2):114-120. PMID: 30340809.
      View in: PubMed
    17. Gadhoumi K, Do D, Badilini F, Pelter MM, Hu X. Wavelet leader multifractal analysis of heart rate variability in atrial fibrillation. J Electrocardiol. 2018 Nov - Dec; 51(6S):S83-S87. PMID: 30177367.
      View in: PubMed
    18. Xiao R, Xu Y, Pelter MM, Fidler R, Badilini F, Mortara DW, Hu X. Monitoring significant ST changes through deep learning. J Electrocardiol. 2018 Nov - Dec; 51(6S):S78-S82. PMID: 30082087.
      View in: PubMed
    19. Malekmohammadi M, Shahriari Y, AuYong N, O'Keeffe A, Bordelon Y, Hu X, Pouratian N. Pallidal stimulation in Parkinson disease differentially modulates local and network ß activity. J Neural Eng. 2018 10; 15(5):056016. PMID: 29972146.
      View in: PubMed
    20. Xiao R, King J, Villaroman A, Do DH, Boyle NG, Hu X. Predict In-Hospital Code Blue Events using Monitor Alarms through Deep Learning Approach. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:3717-3720. PMID: 30441177.
      View in: PubMed
    21. Liu X, Czosnyka M, Donnelly J, Cardim D, Cabeleira M, Hutchinson PJ, Hu X, Smielewski P, Brady K. Wavelet pressure reactivity index: a validation study. J Physiol. 2018 07; 596(14):2797-2809. PMID: 29665012.
      View in: PubMed
    22. Xiao R, Xu Y, Pelter MM, Mortara DW, Hu X. A Deep Learning Approach to Examine Ischemic ST Changes in Ambulatory ECG Recordings. AMIA Jt Summits Transl Sci Proc. 2018; 2017:256-262. PMID: 29888083.
      View in: PubMed
    23. Winters BD, Cvach MM, Bonafide CP, Hu X, Konkani A, O'Connor MF, Rothschild JM, Selby NM, Pelter MM, McLean B, Kane-Gill SL. Technological Distractions (Part 2): A Summary of Approaches to Manage Clinical Alarms With Intent to Reduce Alarm Fatigue. Crit Care Med. 2018 01; 46(1):130-137. PMID: 29112077.
      View in: PubMed
    24. Fidler RL, Pelter MM, Drew BJ, Palacios JA, Bai Y, Stannard D, Aldrich JM, Hu X. Understanding heart rate alarm adjustment in the intensive care units through an analytical approach. PLoS One. 2017; 12(11):e0187855. PMID: 29176776.
      View in: PubMed
    25. Kane-Gill SL, O'Connor MF, Rothschild JM, Selby NM, McLean B, Bonafide CP, Cvach MM, Hu X, Konkani A, Pelter MM, Winters BD. Technologic Distractions (Part 1): Summary of Approaches to Manage Alert Quantity With Intent to Reduce Alert Fatigue and Suggestions for Alert Fatigue Metrics. Crit Care Med. 2017 Sep; 45(9):1481-1488. PMID: 28682835.
      View in: PubMed
    26. Papachristou N, Barnaghi P, Cooper BA, Hu X, Maguire R, Apostolidis K, Armes J, Conley YP, Hammer M, Katsaragakis S, Kober KM, Levine JD, McCann L, Patiraki E, Paul SM, Ream E, Wright F, Miaskowski C. Congruence Between Latent Class and K-Modes Analyses in the Identification of Oncology Patients With Distinct Symptom Experiences. J Pain Symptom Manage. 2018 02; 55(2):318-333.e4. PMID: 28859882.
      View in: PubMed
    27. Shahriari Y, Fidler R, Pelter MM, Bai Y, Villaroman A, Hu X. Electrocardiogram Signal Quality Assessment Based on Structural Image Similarity Metric. IEEE Trans Biomed Eng. 2018 04; 65(4):745-753. PMID: 28644794.
      View in: PubMed
    28. Laurie SS, Vizzeri G, Taibbi G, Ferguson CR, Hu X, Lee SMC, Ploutz-Snyder R, Smith SM, Zwart SR, Stenger MB. Effects of short-term mild hypercapnia during head-down tilt on intracranial pressure and ocular structures in healthy human subjects. Physiol Rep. 2017 Jun; 5(11). PMID: 28611153.
      View in: PubMed
    29. Harris PR, Zègre-Hemsey JK, Schindler D, Bai Y, Pelter MM, Hu X. Patient characteristics associated with false arrhythmia alarms in intensive care. Ther Clin Risk Manag. 2017; 13:499-513. PMID: 28458554.
      View in: PubMed
    30. Meng L, Xiao J, Gudelunas K, Yu Z, Zhong Z, Hu X. Association of intraoperative cerebral and muscular tissue oxygen saturation with postoperative complications and length of hospital stay after major spine surgery: an observational study. Br J Anaesth. 2017 Apr 01; 118(4):551-562. PMID: 28403400.
      View in: PubMed
    31. Ryu J, Ko N, Hu X, Shadden SC. Numerical Investigation of Vasospasm Detection by Extracranial Blood Velocity Ratios. Cerebrovasc Dis. 2017; 43(5-6):214-222. PMID: 28241122.
      View in: PubMed
    32. Pelter MM, Stotts J, Spolini K, Nguyen J, Sin E, Hu X. Developing a Clinical Alarms Management Committee at an Academic Medical Center. Biomed Instrum Technol. 2017 02; 51(s2):21-29. PMID: 28296458.
      View in: PubMed
    33. Arroyo-Palacios J, Rudz M, Fidler R, Smith W, Ko N, Park S, Bai Y, Hu X. Characterization of Shape Differences Among ICP Pulses Predicts Outcome of External Ventricular Drainage Weaning Trial. Neurocrit Care. 2016 12; 25(3):424-433. PMID: 27106888.
      View in: PubMed
    34. Prudente CN, Stilla R, Singh S, Buetefisch C, Evatt M, Factor SA, Freeman A, Hu XP, Hess EJ, Sathian K, Jinnah HA. A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia. Front Neurol. 2016; 7:201. PMID: 27895619.
      View in: PubMed
    35. Ding Q, Bai Y, Erol YB, Salas-Boni R, Zhang X, Hu X. Robust QRS peak detection by multimodal information fusion of ECG and blood pressure signals. Physiol Meas. 2016 11; 37(11):N84-N95. PMID: 27734807.
      View in: PubMed
    36. Pelter MM, Fidler R, Hu X. Research: Association of Low-Amplitude QRSs with False-Positive Asystole Alarms. Biomed Instrum Technol. 2016 Sep-Oct; 50(5):329-35. PMID: 27632038.
      View in: PubMed
    37. Pelter MM, Loranger D, Kozik TM, Fidler R, Hu X, Carey MG. Unplanned transfer from the telemetry unit to the intensive care unit in hospitalized patients with suspected acute coronary syndrome. J Electrocardiol. 2016 Nov - Dec; 49(6):775-783. PMID: 27623400.
      View in: PubMed
    38. Bai Y, Do D, Ding Q, Palacios JA, Shahriari Y, Pelter MM, Boyle N, Fidler R, Hu X. Is the Sequence of SuperAlarm Triggers More Predictive Than Sequence of the Currently Utilized Patient Monitor Alarms? IEEE Trans Biomed Eng. 2017 05; 64(5):1023-1032. PMID: 27390164.
      View in: PubMed
    39. Miaskowski C, Cooper BA, Aouizerat B, Melisko M, Chen LM, Dunn L, Hu X, Kober KM, Mastick J, Levine JD, Hammer M, Wright F, Harris J, Armes J, Furlong E, Fox P, Ream E, Maguire R, Kearney N. The symptom phenotype of oncology outpatients remains relatively stable from prior to through 1 week following chemotherapy. Eur J Cancer Care (Engl). 2017 May; 26(3). PMID: 26777053.
      View in: PubMed
    40. Bai Y, Sow D, Vespa P, Hu X. Real-Time Processing of Continuous Physiological Signals in a Neurocritical Care Unit on a Stream Data Analytics Platform. Acta Neurochir Suppl. 2016; 122:75-80. PMID: 27165881.
      View in: PubMed
    41. Hamilton R, Fuller J, Baldwin K, Vespa P, Hu X, Bergsneider M. Relative Position of the Third Characteristic Peak of the Intracranial Pressure Pulse Waveform Morphology Differentiates Normal-Pressure Hydrocephalus Shunt Responders and Nonresponders. Acta Neurochir Suppl. 2016; 122:339-45. PMID: 27165933.
      View in: PubMed
    42. Connolly M, Vespa P, Hu X. Characterization of Cerebral Vascular Response to EEG Bursts Using ICP Pulse Waveform Template Matching. Acta Neurochir Suppl. 2016; 122:291-4. PMID: 27165924.
      View in: PubMed
    43. Connolly M, Liou R, Vespa P, Hu X. Identification of an Intracranial Pressure (ICP) Response Function from Continuously Acquired Electroencephalographic and ICP Signals in Burst-Suppressed Patients. Acta Neurochir Suppl. 2016; 122:225-8. PMID: 27165911.
      View in: PubMed
    44. Connolly M, He X, Gonzalez N, Hu X. Reproduction of ICP Waveform Changes in a Mathematical Model of the Cerebrospinal Circulatory System. Acta Neurochir Suppl. 2016; 122:313-6. PMID: 27165928.
      View in: PubMed
    45. Ding Q, Bai Y, Tinoco A, Mortara D, Do D, Boyle NG, Pelter MM, Hu X. Developing new predictive alarms based on ECG metrics for bradyasystolic cardiac arrest. Physiol Meas. 2015 Dec; 36(12):2405-22. PMID: 26502065.
      View in: PubMed
    46. Ryu J, Hu X, Shadden SC. A Coupled Lumped-Parameter and Distributed Network Model for Cerebral Pulse-Wave Hemodynamics. J Biomech Eng. 2015 Oct; 137(10):101009. PMID: 26287937.
      View in: PubMed
    47. Fidler R, Bond R, Finlay D, Guldenring D, Gallagher A, Pelter M, Drew B, Hu X. Human factors approach to evaluate the user interface of physiologic monitoring. J Electrocardiol. 2015 Nov-Dec; 48(6):982-7. PMID: 26375330.
      View in: PubMed
    48. Do DH, Hayase J, Tiecher RD, Bai Y, Hu X, Boyle NG. ECG changes on continuous telemetry preceding in-hospital cardiac arrests. J Electrocardiol. 2015 Nov-Dec; 48(6):1062-8. PMID: 26362882.
      View in: PubMed
    49. Connolly M, Vespa P, Pouratian N, Gonzalez NR, Hu X. Characterization of the relationship between intracranial pressure and electroencephalographic monitoring in burst-suppressed patients. Neurocrit Care. 2015 Apr; 22(2):212-20. PMID: 25142827.
      View in: PubMed
    50. Salas-Boni R, Bai Y, Hu X. Cumulative Time Series Representation for Code Blue prediction in the Intensive Care Unit. AMIA Jt Summits Transl Sci Proc. 2015; 2015:162-7. PMID: 26306261.
      View in: PubMed
    51. Kim S, Scalzo F, Telesca D, Hu X. Ensemble of sparse classifiers for high-dimensional biological data. Int J Data Min Bioinform. 2015; 12(2):167-83. PMID: 26510301.
      View in: PubMed
    52. Drew BJ, Harris P, Zègre-Hemsey JK, Mammone T, Schindler D, Salas-Boni R, Bai Y, Tinoco A, Ding Q, Hu X. Insights into the problem of alarm fatigue with physiologic monitor devices: a comprehensive observational study of consecutive intensive care unit patients. PLoS One. 2014; 9(10):e110274. PMID: 25338067.
      View in: PubMed
    53. Bai Y, Do DH, Harris PR, Schindler D, Boyle NG, Drew BJ, Hu X. Integrating monitor alarms with laboratory test results to enhance patient deterioration prediction. J Biomed Inform. 2015 Feb; 53:81-92. PMID: 25240252.
      View in: PubMed
    54. Salas-Boni R, Bai Y, Harris PR, Drew BJ, Hu X. False ventricular tachycardia alarm suppression in the ICU based on the discrete wavelet transform in the ECG signal. J Electrocardiol. 2014 Nov-Dec; 47(6):775-80. PMID: 25172188.
      View in: PubMed
    55. Connolly M, He X, Gonzalez N, Vespa P, DiStefano J, Hu X. Reproduction of consistent pulse-waveform changes using a computational model of the cerebral circulatory system. Med Eng Phys. 2014 Mar; 36(3):354-63. PMID: 24389244.
      View in: PubMed
    56. Hu X, Do D, Bai Y, Boyle NG. A case-control study of non-monitored ECG metrics preceding in-hospital bradyasystolic cardiac arrest: implication for predictive monitor alarms. J Electrocardiol. 2013 Nov-Dec; 46(6):608-15. PMID: 24034301.
      View in: PubMed
    57. Asgari S, Vespa P, Hu X. Is there any association between cerebral vasoconstriction/vasodilatation and microdialysis Lactate to Pyruvate ratio increase? Neurocrit Care. 2013 Aug; 19(1):56-64. PMID: 23733172.
      View in: PubMed
    58. Scalzo F, Alger JR, Hu X, Saver JL, Dani KA, Muir KW, Demchuk AM, Coutts SB, Luby M, Warach S, Liebeskind DS. Multi-center prediction of hemorrhagic transformation in acute ischemic stroke using permeability imaging features. Magn Reson Imaging. 2013 Jul; 31(6):961-9. PMID: 23587928.
      View in: PubMed
    59. Scalzo F, Hu X. Semi-supervised detection of intracranial pressure alarms using waveform dynamics. Physiol Meas. 2013 Apr; 34(4):465-78. PMID: 23524637.
      View in: PubMed
    60. Xu P, Hu X, Yao D. Improved wavelet entropy calculation with window functions and its preliminary application to study intracranial pressure. Comput Biol Med. 2013 Jun; 43(5):425-33. PMID: 23566389.
      View in: PubMed
    61. Tsiokos C, Hu X, Pouratian N. 200-300Hz movement modulated oscillations in the internal globus pallidus of patients with Parkinson's Disease. Neurobiol Dis. 2013 Jun; 54:464-74. PMID: 23388190.
      View in: PubMed
    62. Gonzalez NR, Hamilton R, Bilgin-Freiert A, Dusick J, Vespa P, Hu X, Asgari S. Cerebral hemodynamic and metabolic effects of remote ischemic preconditioning in patients with subarachnoid hemorrhage. Acta Neurochir Suppl. 2013; 115:193-8. PMID: 22890668.
      View in: PubMed
    63. Asgari S, Gonzalez N, Subudhi AW, Hamilton R, Vespa P, Bergsneider M, Roach RC, Hu X. Continuous detection of cerebral vasodilatation and vasoconstriction using intracranial pulse morphological template matching. PLoS One. 2012; 7(11):e50795. PMID: 23226385.
      View in: PubMed
    64. Kim S, Hamilton R, Pineles S, Bergsneider M, Hu X. Noninvasive intracranial hypertension detection utilizing semisupervised learning. IEEE Trans Biomed Eng. 2013 Apr; 60(4):1126-33. PMID: 23193303.
      View in: PubMed
    65. Hu X, Gonzalez N, Bergsneider M. Steady-state indicators of the intracranial pressure dynamic system using geodesic distance of the ICP pulse waveform. Physiol Meas. 2012 Dec; 33(12):2017-31. PMID: 23151442.
      View in: PubMed
    66. Hamilton R, Baldwin K, Fuller J, Vespa P, Hu X, Bergsneider M. Intracranial pressure pulse waveform correlates with aqueductal cerebrospinal fluid stroke volume. J Appl Physiol (1985). 2012 Nov; 113(10):1560-6. PMID: 22995390.
      View in: PubMed
    67. Lu J, Speier W, Hu X, Pouratian N. The effects of stimulus timing features on P300 speller performance. Clin Neurophysiol. 2013 Feb; 124(2):306-14. PMID: 22939456.
      View in: PubMed
    68. Scalzo F, Liebeskind D, Hu X. Reducing false intracranial pressure alarms using morphological waveform features. IEEE Trans Biomed Eng. 2013 Jan; 60(1):235-9. PMID: 22851230.
      View in: PubMed
    69. Scalzo F, Hao Q, Alger JR, Hu X, Liebeskind DS. Regional prediction of tissue fate in acute ischemic stroke. Ann Biomed Eng. 2012 Oct; 40(10):2177-87. PMID: 22592291.
      View in: PubMed
    70. Hu X, Sapo M, Nenov V, Barry T, Kim S, Do DH, Boyle N, Martin N. Predictive combinations of monitor alarms preceding in-hospital code blue events. J Biomed Inform. 2012 Oct; 45(5):913-21. PMID: 22465785.
      View in: PubMed
    71. Scalzo F, Hamilton R, Asgari S, Kim S, Hu X. Intracranial hypertension prediction using extremely randomized decision trees. Med Eng Phys. 2012 Oct; 34(8):1058-65. PMID: 22401795.
      View in: PubMed
    72. Scalzo F, Bergsneider M, Vespa PM, Martin NA, Hu X. Intracranial pressure signal morphology: real-time tracking. IEEE Pulse. 2012 Mar; 3(2):49-52. PMID: 22481746.
      View in: PubMed
    73. Glenn TC, Sherma AK, McArthur DL, Hu X, Hanuscin CR, Furreedan MS, Hovda DA, Vespa PM, Martin NA. The linear relationship between transcranial Doppler pulsatility indices and intracranial pressure is influenced by traumatic brain injury and vasospasm. Acta Neurochir Suppl. 2012; 114:11-5. PMID: 22327657.
      View in: PubMed
    74. Hamilton R, Dye J, Frew A, Baldwin K, Hu X, Bergsneider M. Quantification of pulsatile cerebrospinal fluid flow within the prepontine cistern. Acta Neurochir Suppl. 2012; 114:191-5. PMID: 22327691.
      View in: PubMed
    75. Asgari S, Vespa PM, Bergsneider M, Hu X. Latency relationships between cerebral blood flow velocity and intracranial pressure. Acta Neurochir Suppl. 2012; 114:5-9. PMID: 22327656.
      View in: PubMed
    76. Kasprowicz M, Bergsneider M, Czosnyka M, Hu X. Association between ICP pulse waveform morphology and ICP B waves. Acta Neurochir Suppl. 2012; 114:29-34. PMID: 22327660.
      View in: PubMed
    77. Hu X, Hamilton R, Baldwin K, Vespa PM, Bergsneider M. Automated extraction of decision rules for predicting lumbar drain outcome by analyzing overnight intracranial pressure. Acta Neurochir Suppl. 2012; 114:207-12. PMID: 22327694.
      View in: PubMed
    78. Hamilton RB, Baldwin K, Vespa P, Bergsneider M, Hu X. Subpeak regional analysis of intracranial pressure waveform morphology based on cerebrospinal fluid hydrodynamics in the cerebral aqueduct and prepontine cistern. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:3935-8. PMID: 23366788.
      View in: PubMed
    79. Scalzo F, Asgari S, Kim S, Bergsneider M, Hu X. Bayesian tracking of intracranial pressure signal morphology. Artif Intell Med. 2012 Feb; 54(2):115-23. PMID: 21968205.
      View in: PubMed
    80. Asgari S, Vespa P, Bergsneider M, Hu X. Lack of consistent intracranial pressure pulse morphological changes during episodes of microdialysis lactate/pyruvate ratio increase. Physiol Meas. 2011 Oct; 32(10):1639-51. PMID: 21904021.
      View in: PubMed
    81. Asgari S, Bergsneider M, Hamilton R, Vespa P, Hu X. Consistent changes in intracranial pressure waveform morphology induced by acute hypercapnic cerebral vasodilatation. Neurocrit Care. 2011 Aug; 15(1):55-62. PMID: 21052864.
      View in: PubMed
    82. Yang L, Zhao M, Peng C, Hu X, Feng H, Ji Z. Waveform descriptor for pulse onset detection of intracranial pressure signal. Med Eng Phys. 2012 Mar; 34(2):179-86. PMID: 21807549.
      View in: PubMed
    83. Asgari S, Subudhi AW, Roach RC, Liebeskind DS, Bergsneider M, Hu X. An extended model of intracranial latency facilitates non-invasive detection of cerebrovascular changes. J Neurosci Methods. 2011 Apr 15; 197(1):171-9. PMID: 21310179.
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    84. Kim S, Bergsneider M, Hu X. A systematic study of linear dynamic modeling of intracranial pressure dynamics. Physiol Meas. 2011 Mar; 32(3):319-36. PMID: 21285483.
      View in: PubMed
    85. Kim S, Hu X, McArthur D, Hamilton R, Bergsneider M, Glenn T, Martin N, Vespa P. Inter-subject correlation exists between morphological metrics of cerebral blood flow velocity and intracranial pressure pulses. Neurocrit Care. 2011 Apr; 14(2):229-37. PMID: 21136207.
      View in: PubMed
    86. Kim S, Scalzo F, Bergsneider M, Vespa P, Martin N, Hu X. Noninvasive intracranial pressure assessment based on a data-mining approach using a nonlinear mapping function. IEEE Trans Biomed Eng. 2012 Mar; 59(3):619-26. PMID: 21097375.
      View in: PubMed
    87. Scalzo F, Asgari S, Kim S, Bergsneider M, Hu X. Robust peak recognition in intracranial pressure signals. Biomed Eng Online. 2010 Oct 19; 9:61. PMID: 20959014.
      View in: PubMed
    88. Kasprowicz M, Asgari S, Bergsneider M, Czosnyka M, Hamilton R, Hu X. Pattern recognition of overnight intracranial pressure slow waves using morphological features of intracranial pressure pulse. J Neurosci Methods. 2010 Jul 15; 190(2):310-8. PMID: 20566403.
      View in: PubMed
    89. Hu X, Xu P, Asgari S, Vespa P, Bergsneider M. Forecasting ICP elevation based on prescient changes of intracranial pressure waveform morphology. IEEE Trans Biomed Eng. 2010 May; 57(5):1070-8. PMID: 20659820.
      View in: PubMed
    90. Hu X, Glenn T, Scalzo F, Bergsneider M, Sarkiss C, Martin N, Vespa P. Intracranial pressure pulse morphological features improved detection of decreased cerebral blood flow. Physiol Meas. 2010 May; 31(5):679-95. PMID: 20348611.
      View in: PubMed
    91. Hu X, Xu P, Wu S, Asgari S, Bergsneider M. A data mining framework for time series estimation. J Biomed Inform. 2010 Apr; 43(2):190-9. PMID: 19900575.
      View in: PubMed
    92. Asgari S, Bergsneider M, Hu X. A robust approach toward recognizing valid arterial-blood-pressure pulses. IEEE Trans Inf Technol Biomed. 2010 Jan; 14(1):166-72. PMID: 19884099.
      View in: PubMed
    93. Asgari S, Xu P, Bergsneider M, Hu X. A subspace decomposition approach toward recognizing valid pulsatile signals. Physiol Meas. 2009 Nov; 30(11):1211-25. PMID: 19794232.
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    94. Xu P, Kasprowicz M, Bergsneider M, Hu X. Improved noninvasive intracranial pressure assessment with nonlinear kernel regression. IEEE Trans Inf Technol Biomed. 2010 Jul; 14(4):971-8. PMID: 19643711.
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    95. Sapo M, Wu S, Asgari S, McNair N, Buxey F, Martin N, Hu X. A comparison of vital signs charted by nurses with automated acquired values using waveform quality indices. J Clin Monit Comput. 2009 Oct; 23(5):263-71. PMID: 19629728.
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    96. Scalzo F, Xu P, Asgari S, Bergsneider M, Hu X. Regression analysis for peak designation in pulsatile pressure signals. Med Biol Eng Comput. 2009 Sep; 47(9):967-77. PMID: 19578916.
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    97. Hu X, Subudhi AW, Xu P, Asgari S, Roach RC, Bergsneider M. Inferring cerebrovascular changes from latencies of systemic and intracranial pulses: a model-based latency subtraction algorithm. J Cereb Blood Flow Metab. 2009 Apr; 29(4):688-97. PMID: 19142194.
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    98. Hamilton R, Xu P, Asgari S, Kasprowicz M, Vespa P, Bergsneider M, Hu X. Forecasting intracranial pressure elevation using pulse waveform morphology. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4331-4. PMID: 19963821.
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    99. Hu X, Xu P, Scalzo F, Vespa P, Bergsneider M. Morphological clustering and analysis of continuous intracranial pressure. IEEE Trans Biomed Eng. 2009 Mar; 56(3):696-705. PMID: 19272879.
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    100. Xu P, Tian Y, Lei X, Hu X, Yao D. Equivalent charge source model based iterative maximum neighbor weight for sparse EEG source localization. Ann Biomed Eng. 2008 Dec; 36(12):2051-67. PMID: 18830695.
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    101. Xu P, Bergsneider M, Hu X. Pulse onset detection using neighbor pulse-based signal enhancement. Med Eng Phys. 2009 Apr; 31(3):337-45. PMID: 18632299.
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    102. Hu X, Xu P, Lee DJ, Vespa P, Baldwin K, Bergsneider M. An algorithm for extracting intracranial pressure latency relative to electrocardiogram R wave. Physiol Meas. 2008 Apr; 29(4):459-71. PMID: 18354246.
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    103. Bergsneider M, Miller C, Vespa PM, Hu X. Surgical management of adult hydrocephalus. Neurosurgery. 2008 Feb; 62 Suppl 2:643-59; discussion 659-60. PMID: 18596440.
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    104. Xu P, Scalzo F, Bergsneider M, Vespa P, Chad M, Hu X. Wavelet entropy characterization of elevated intracranial pressure. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:2924-7. PMID: 19163318.
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    105. Scalzo F, Xu P, Bergsneider M, Hu X. Nonlinear regression for sub-peak detection of intracranial pressure signals. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:5411-4. PMID: 19163941.
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    106. Cattivelli FS, Sayed AH, Hu X, Lee D, Vespa P. Mathematical models of cerebral hemodynamics for detection of vasospasm in major cerebral arteries. Acta Neurochir Suppl. 2008; 102:63-9. PMID: 19388290.
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    107. Hu X, Xu P, Lee DJ, Paul V, Bergsneider M. Morphological changes of intracranial pressure pulses are correlated with acute dilatation of ventricles. Acta Neurochir Suppl. 2008; 102:131-6. PMID: 19388304.
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    108. Hu X, Miller C, Vespa P, Bergsneider M. Adaptive computation of approximate entropy and its application in integrative analysis of irregularity of heart rate variability and intracranial pressure signals. Med Eng Phys. 2008 Jun; 30(5):631-9. PMID: 17714974.
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    109. Hu X, Nenov V, Vespa P, Bergsneider M. Characterization of interdependency between intracranial pressure and heart variability signals: a causal spectral measure and a generalized synchronization measure. IEEE Trans Biomed Eng. 2007 Aug; 54(8):1407-17. PMID: 17694861.
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    110. Hu X, Nenov V, Bergsneider M, Glenn TC, Vespa P, Martin N. Estimation of hidden state variables of the Intracranial system using constrained nonlinear Kalman filters. IEEE Trans Biomed Eng. 2007 Apr; 54(4):597-610. PMID: 17405367.
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    111. Vespa PM, Miller C, Hu X, Nenov V, Buxey F, Martin NA. Intensive care unit robotic telepresence facilitates rapid physician response to unstable patients and decreased cost in neurointensive care. Surg Neurol. 2007 Apr; 67(4):331-7. PMID: 17350395.
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    112. Hu X, Nenov V, Glenn TC, Steiner LA, Czosnyka M, Bergsneider M, Martin N. Nonlinear analysis of cerebral hemodynamic and intracranial pressure signals for characterization of autoregulation. IEEE Trans Biomed Eng. 2006 Feb; 53(2):195-209. PMID: 16485748.
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    113. Hu X, Nenov V. A single-lead ECG enhancement algorithm using a regularized data-driven filter. IEEE Trans Biomed Eng. 2006 Feb; 53(2):347-51. PMID: 16485766.
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    114. Hu X, Nenov V, Bergsneider M. Integrative analysis of intracranial pressure and R-R interval signals: a study of ICP B-wave using causal coherence. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:464-7. PMID: 17945587.
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    115. Hu X, Alwan AA, Rubinstein EH, Bergsneider M. Reduction of compartment compliance increases venous flow pulsatility and lowers apparent vascular compliance: implications for cerebral blood flow hemodynamics. Med Eng Phys. 2006 May; 28(4):304-14. PMID: 16112597.
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    116. Hu X, Nenov V, Vespa P, Bergsneider M. Estimation of hidden state variables of the intracranial system using constrained nonlinear Kalman filters. Conf Proc IEEE Eng Med Biol Soc. 2005; 6:5631-4. PMID: 17281533.
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    117. Hu X, Nenov V, Bergsneider M. Phase Coordination between Intracranial Pressure and Electrocardiogram Signals. Conf Proc IEEE Eng Med Biol Soc. 2005; 1:45-8. PMID: 17282107.
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    118. Bergsneider M, Yang I, Hu X, McArthur DL, Cook SW, Boscardin WJ. Relationship between valve opening pressure, body position, and intracranial pressure in normal pressure hydrocephalus: paradigm for selection of programmable valve pressure setting. Neurosurgery. 2004 Oct; 55(4):851-8; discussion 858-9. PMID: 15458593.
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    119. Hu X, Nenov V. Multivariate AR modeling of electromyography for the classification of upper arm movements. Clin Neurophysiol. 2004 Jun; 115(6):1276-87. PMID: 15134694.
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    120. Hu X, Nenov V. Robust measure for characterizing generalized synchronization. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Feb; 69(2 Pt 2):026206. PMID: 14995547.
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