Xin Chen, PhD

InstitutionUniversity of California San Francisco
Address513 Parnassus Avenue
San Francisco CA 94117
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    Collapse Biography 
    Collapse Awards and Honors
    1991First Prize Award, Beijing Medical University, Beijing, China
    1998Postdoctoral Fellowship Award, Life Science Research Foundation, Baltimore, MD

    Collapse Overview 
    Collapse Overview
    My lab studies molecular genetics and signaling pathways during hepatic carcinogenesis. Specifically, using genomic approaches including expression arrays and array based CGH, we have identified large numbers of genes which are deregulated during liver cancer development. Using murine models, we are studying how these genetic alterations contribute to malignant transformation and progression in vivo. Our current studies focus on AKT/mTOR and Notch pathways and how they regulate cancer metabolism and cancer cell proliferation. In addition, using the novel mouse models as preclinical models, we are testing the therapeutic potentials of PI3K/mTOR or Notch inhibitors in treating liver cancers.

    Collapse Research 
    Collapse Research Activities and Funding
    SWI/SNF complex in mouse HCC development
    NIH/NCI R03CA208215Aug 1, 2017 - Jul 31, 2019
    Role: Principal Investigator
    Inducible systems for studying liver tumor mainenance in vivo
    NIH/NCI R03CA208311Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Signaling cascades in cholangiocarcinoma development
    NIH/NCI R01CA190606Apr 5, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Yap and beta-catenin interactions in liver: Implications in Pathophysiology
    NIH/NCI R01CA204586Apr 5, 2016 - Mar 31, 2021
    Role: Co-Principal Investigator
    Glutamine catabolism in c-Myc driven liver tumor development
    NIH/NCI R21CA198490Jun 1, 2015 - May 31, 2017
    Role: Principal Investigator
    Fatty acid transporters in cholangiocarcinoma pathogenesis
    NIH/NCI R21CA187306Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Lipogenic inhibitors in prevention of oncogene induced liver cancer
    NIH/NCI R03CA165122Mar 1, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Virus-gene interactions during hepatic carcinogenesis
    NIH/NCI R21CA158508Sep 12, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Genetic Alterations Promoting Alcohol Induced Hepatic Carcinogenesis
    NIH/NIAAA R21AA020078Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Targeted siRNA Delivery to Liver with EIT guided Sonoporation
    NIH/NIAAA R43AA019638Sep 30, 2009 - Mar 31, 2011
    Role: Co-Principal Investigator
    Molecular Genetics of Liver Cancers
    NIH/NCI R01CA136606May 1, 2009 - Aug 31, 2017
    Role: Principal Investigator
    A flexible somatic and sporadic mouse model for liver cancers
    NIH/NCI R21CA131625Jul 1, 2008 - Jun 30, 2011
    Role: Principal Investigator
    Expression Programs of Intestinal Cell Differentiation
    NIH/NIDDK R21DK069309Sep 15, 2005 - Aug 31, 2008
    Role: Principal Investigator
    Hedgehog signaling in human hepatocellular carcinoma
    NIH/NCI R21CA113393Jul 1, 2005 - Jun 30, 2008
    Role: Principal Investigator
    Expression patterns of gastric premalignant lesions
    NIH/NCI R03CA112638Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Gene Expression Profiles in Human Liver Cancers
    NIH/NCI K01CA096774Sep 11, 2003 - Aug 31, 2009
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen X, Calvisi DF. Hydrodynamic transfection for generation of novel mouse models for liver cancer research. Am J Pathol. 2014 Apr; 184(4):912-923. PMID: 24480331; PMCID: PMC3969989.
    2. Cheung ST, Wong SY, Leung KL, Chen X, So S, Ng IO, Fan ST. Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma. Clin Cancer Res. 2004 Nov 15; 10(22):7629-36. PMID: 15569995.
      View in: PubMed
    3. Chen X, Higgins J, Cheung ST, Li R, Mason V, Montgomery K, Fan ST, van de Rijn M, So S. Novel endothelial cell markers in hepatocellular carcinoma. Mod Pathol. 2004 Oct; 17(10):1198-210. PMID: 15154008.
      View in: PubMed
    4. Leung SY, Yuen ST, Chu KM, Mathy JA, Li R, Chan AS, Law S, Wong J, Chen X, So S. Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer. Gastroenterology. 2004 Aug; 127(2):457-69. PMID: 15300578.
      View in: PubMed
    5. West RB, Corless CL, Chen X, Rubin BP, Subramanian S, Montgomery K, Zhu S, Ball CA, Nielsen TO, Patel R, Goldblum JR, Brown PO, Heinrich MC, van de Rijn M. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol. 2004 Jul; 165(1):107-13. PMID: 15215166; PMCID: PMC1618538.
    6. Cui K, Tailor P, Liu H, Chen X, Ozato K, Zhao K. The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol. 2004 May; 24(10):4476-86. PMID: 15121865; PMCID: PMC400460.
    7. Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13350-5. PMID: 14595015; PMCID: PMC263817.
    8. Chen X, Leung SY, Yuen ST, Chu KM, Ji J, Li R, Chan AS, Law S, Troyanskaya OG, Wong J, So S, Botstein D, Brown PO. Variation in gene expression patterns in human gastric cancers. Mol Biol Cell. 2003 Aug; 14(8):3208-15. PMID: 12925757; PMCID: PMC181561.
    9. Chua MS, Barry C, Chen X, Salvatierra O, Sarwal MM. Molecular profiling of anemia in acute renal allograft rejection using DNA microarrays. Am J Transplant. 2003 Jan; 3(1):17-22. PMID: 12492705.
      View in: PubMed
    10. Leung SY, Chen X, Chu KM, Yuen ST, Mathy J, Ji J, Chan AS, Li R, Law S, Troyanskaya OG, Tu IP, Wong J, So S, Botstein D, Brown PO. Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16203-8. PMID: 12456890; PMCID: PMC138589.
    11. Xu RH, Chen X, Li DS, Li R, Addicks GC, Glennon C, Zwaka TP, Thomson JA. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol. 2002 Dec; 20(12):1261-4. PMID: 12426580.
      View in: PubMed
    12. Ji J, Chen X, Leung SY, Chi JT, Chu KM, Yuen ST, Li R, Chan AS, Li J, Dunphy N, So S. Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines. Oncogene. 2002 Sep 19; 21(42):6549-56. PMID: 12226758.
      View in: PubMed
    13. Liu H, Kang H, Liu R, Chen X, Zhao K. Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol. 2002 Sep; 22(18):6471-9. PMID: 12192045; PMCID: PMC135632.
    14. Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IO, So S, Fan ST. Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor. Cancer Res. 2002 Aug 15; 62(16):4711-21. PMID: 12183430.
      View in: PubMed
    15. Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit S, Ng IO, Van De Rijn M, Botstein D, Brown PO. Gene expression patterns in human liver cancers. Mol Biol Cell. 2002 Jun; 13(6):1929-39. PMID: 12058060; PMCID: PMC117615.
    16. Liu R, Liu H, Chen X, Kirby M, Brown PO, Zhao K. Regulation of CSF1 promoter by the SWI/SNF-like BAF complex. Cell. 2001 Aug 10; 106(3):309-18. PMID: 11509180.
      View in: PubMed
    17. Sarwal M, Chang S, Barry C, Chen X, Alizadeh A, Salvatierra O, Brown P. Genomic analysis of renal allograft dysfunction using cDNA microarrays. Transplant Proc. 2001 Feb-Mar; 33(1-2):297-8. PMID: 11266826.
      View in: PubMed
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