Xin Chen | UCSF Profiles

Xin Chen, PhD

Title	Professor
Institution	University of California San Francisco
Department	Bioengineering
Address	513 Parnassus Avenue San Francisco CA 94117
Phone	415-502-6526
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Biography

Awards and Honors

	1991		First Prize Award, Beijing Medical University, Beijing, China
	1998		Postdoctoral Fellowship Award, Life Science Research Foundation, Baltimore, MD

Overview

My lab studies molecular genetics and signaling pathways during hepatic carcinogenesis. Specifically, using genomic approaches including expression arrays and array based CGH, we have identified large numbers of genes which are deregulated during liver cancer development. Using murine models, we are studying how these genetic alterations contribute to malignant transformation and progression in vivo. Our current studies focus on AKT/mTOR and Notch pathways and how they regulate cancer metabolism and cancer cell proliferation. In addition, using the novel mouse models as preclinical models, we are testing the therapeutic potentials of PI3K/mTOR or Notch inhibitors in treating liver cancers.

Research

Research Activities and Funding

Role of Cancer-Associated Fibroblasts in Cholangiocarcinoma
NIH/NCI R01CA228483Jun 19, 2018 - May 31, 2023
Role: Co-Principal Investigator

SWI/SNF complex in mouse HCC development
NIH/NCI R03CA208215Aug 1, 2017 - Jul 31, 2019
Role: Principal Investigator

Inducible systems for studying liver tumor mainenance in vivo
NIH/NCI R03CA208311Jul 1, 2017 - Jun 30, 2019
Role: Principal Investigator

Signaling cascades in cholangiocarcinoma development
NIH/NCI R01CA190606Apr 5, 2016 - Mar 31, 2021
Role: Principal Investigator

Yap and beta-catenin interactions in liver: Implications in Pathophysiology
NIH/NCI R01CA204586Apr 5, 2016 - Mar 31, 2021
Role: Co-Principal Investigator

Glutamine catabolism in c-Myc driven liver tumor development
NIH/NCI R21CA198490Jun 1, 2015 - May 31, 2017
Role: Principal Investigator

Fatty acid transporters in cholangiocarcinoma pathogenesis
NIH/NCI R21CA187306Jul 1, 2014 - Jun 30, 2016
Role: Principal Investigator

Lipogenic inhibitors in prevention of oncogene induced liver cancer
NIH/NCI R03CA165122Mar 1, 2012 - Feb 28, 2014
Role: Principal Investigator

Virus-gene interactions during hepatic carcinogenesis
NIH/NCI R21CA158508Sep 12, 2011 - Aug 31, 2014
Role: Principal Investigator

Genetic Alterations Promoting Alcohol Induced Hepatic Carcinogenesis
NIH/NIAAA R21AA020078Sep 1, 2011 - Aug 31, 2014
Role: Principal Investigator

Targeted siRNA Delivery to Liver with EIT guided Sonoporation
NIH/NIAAA R43AA019638Sep 30, 2009 - Mar 31, 2011
Role: Co-Principal Investigator

Molecular Genetics of Liver Cancers
NIH/NCI R01CA136606May 1, 2009 - Aug 31, 2017
Role: Principal Investigator

A flexible somatic and sporadic mouse model for liver cancers
NIH/NCI R21CA131625Jul 1, 2008 - Jun 30, 2011
Role: Principal Investigator

Expression Programs of Intestinal Cell Differentiation
NIH/NIDDK R21DK069309Sep 15, 2005 - Aug 31, 2008
Role: Principal Investigator

Hedgehog signaling in human hepatocellular carcinoma
NIH/NCI R21CA113393Jul 1, 2005 - Jun 30, 2008
Role: Principal Investigator

Expression patterns of gastric premalignant lesions
NIH/NCI R03CA112638Sep 30, 2004 - Aug 31, 2007
Role: Principal Investigator

Gene Expression Profiles in Human Liver Cancers
NIH/NCI K01CA096774Sep 11, 2003 - Aug 31, 2009
Role: Principal Investigator

ORNG Applications

Global Health

Websites

In The News

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

Wang J, Dong M, Xu Z, Song X, Zhang S, Qiao Y, Che L, Gordan J, Hu K, Liu Y, Calvisi DF, Chen X. Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. Oncogene. 2018 Mar 16. PMID: 29545603.

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Zhang S, Wang J, Wang H, Fan L, Fan B, Zeng B, Tao J, Li X, Che L, Cigliano A, Ribback S, Dombrowski F, Chen B, Cong W, Wei L, Calvisi DF, Chen X. Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans. Am J Pathol. 2018 Apr; 188(4):995-1006. PMID: 29378174.

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Dong M, Liu X, Evert K, Utpatel K, Peters M, Zhang S, Xu Z, Che L, Cigliano A, Ribback S, Dombrowski F, Cossu A, Gordan J, Calvisi DF, Evert M, Liu Y, Chen X. Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model. Cell Death Dis. 2018 Jan 18; 9(2):31. PMID: 29348467.

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Xu Z, Hu J, Cao H, Pilo MG, Cigliano A, Shao Z, Xu M, Ribback S, Dombrowski F, Calvisi DF, Chen X. Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway. Exp Mol Med. 2018 Jan 05; 50(1):e417. PMID: 29303510.

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Jia J, Qiao Y, Pilo MG, Cigliano A, Liu X, Shao Z, Calvisi DF, Chen X. Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade. PLoS One. 2017; 12(9):e0184068. PMID: 28877210.

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Liu P, Calvisi DF, Kiss A, Cigliano A, Schaff Z, Che L, Ribback S, Dombrowski F, Zhao D, Chen X. Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development. Oncotarget. 2017 Sep 26; 8(43):73433-73447. PMID: 29088718.

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Zhang S, Song X, Cao D, Xu Z, Fan B, Che L, Hu J, Chen B, Dong M, Pilo MG, Cigliano A, Evert K, Ribback S, Dombrowski F, Pascale RM, Cossu A, Vidili G, Porcu A, Simile MM, Pes GM, Giannelli G, Gordan J, Wei L, Evert M, Cong W, Calvisi DF, Chen X. Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice. J Hepatol. 2017 Dec; 67(6):1194-1203. PMID: 28733220.

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Méndez-Lucas A, Li X, Hu J, Che L, Song X, Jia J, Wang J, Xie C, Driscoll PC, Tschaharganeh DF, Calvisi DF, Yuneva M, Chen X. Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities. Cancer Res. 2017 08 15; 77(16):4355-4364. PMID: 28630053.

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Liu P, Ge M, Hu J, Li X, Che L, Sun K, Cheng L, Huang Y, Pilo MG, Cigliano A, Pes GM, Pascale RM, Brozzetti S, Vidili G, Porcu A, Cossu A, Palmieri G, Sini MC, Ribback S, Dombrowski F, Tao J, Calvisi DF, Chen L, Chen X. A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis. Hepatology. 2017 07; 66(1):167-181. PMID: 28370287.

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Che L, Pilo MG, Cigliano A, Latte G, Simile MM, Ribback S, Dombrowski F, Evert M, Chen X, Calvisi DF. Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma. Cell Cycle. 2017 Mar 19; 16(6):499-507. PMID: 28118080.

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Che L, Fan B, Pilo MG, Xu Z, Liu Y, Cigliano A, Cossu A, Palmieri G, Pascale RM, Porcu A, Vidili G, Serra M, Dombrowski F, Ribback S, Calvisi DF, Chen X. Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans. Oncogenesis. 2016 Dec 05; 5(12):e274. PMID: 27918553.

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Cao D, Song X, Che L, Li X, Pilo MG, Vidili G, Porcu A, Solinas A, Cigliano A, Pes GM, Ribback S, Dombrowski F, Chen X, Li L, Calvisi DF. Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells. Liver Int. 2017 01; 37(1):80-89. PMID: 27264722.

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Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y. [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. Mol Imaging Biol. 2016 06; 18(3):360-7. PMID: 26567114; PMCID: PMC4866912.

View in: PubMed, PubMed Central
Li L, Che L, Tharp KM, Park HM, Pilo MG, Cao D, Cigliano A, Latte G, Xu Z, Ribback S, Dombrowski F, Evert M, Gores GJ, Stahl A, Calvisi DF, Chen X. Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans. Hepatology. 2016 06; 63(6):1900-13. PMID: 26910791; PMCID: PMC4874885 [Available on 06/01/17].

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Hu J, Che L, Li L, Pilo MG, Cigliano A, Ribback S, Li X, Latte G, Mela M, Evert M, Dombrowski F, Zheng G, Chen X, Calvisi DF. Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice. Sci Rep. 2016 Feb 09; 6:20484. PMID: 26857837; PMCID: PMC4746674.

View in: PubMed, PubMed Central
Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, Demartis MI, Tao J, Gui B, Pilo MG, Ribback S, Dombrowski F, Evert M, Calvisi DF, Chen X. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016 08; 36(8):1176-86. PMID: 26716908; PMCID: PMC4929046 [Available on 08/01/17].

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Li L, Pilo GM, Li X, Cigliano A, Latte G, Che L, Joseph C, Mela M, Wang C, Jiang L, Ribback S, Simile MM, Pascale RM, Dombrowski F, Evert M, Semenkovich CF, Chen X, Calvisi DF. Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans. J Hepatol. 2016 Feb; 64(2):333-341. PMID: 26476289.

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Chen DG, Lin F, Chen XJ, Tang W, Kitzman H. Cusp catastrophe model: a nonlinear model for health outcomes in nursing research. Nurs Res. 2014 May-Jun; 63(3):211-20. PMID: 24785249; PMCID: PMC4066972.

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Chen X, Calvisi DF. Hydrodynamic transfection for generation of novel mouse models for liver cancer research. Am J Pathol. 2014 Apr; 184(4):912-923. PMID: 24480331; PMCID: PMC3969989.

View in: PubMed, PubMed Central