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Integrin avß8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Cell Rep. 2021 Jul 06; 36(1):109309.
Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D. PMID: 34233193.
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1 Fields:
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Enhanced Efficiency of flySAM by Optimization of sgRNA Parameters in Drosophila. G3 (Bethesda). 2020 12 03; 10(12):4483-4488.
Mao D, Jia Y, Peng P, Shen D, Ren X, Zhu R, Qiu Y, Han Y, Yu J, Che Q, Li Y, Lu X, Liu LP, Wang Z, Liu Q, Sun J, Ni JQ. PMID: 33020192.
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AnimalsCells
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Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Nat Genet. 2019 08; 51(8):1252-1262.
Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y. PMID: 31367015.
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PubMed Mentions:
26 Fields:
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HumansCells
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Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 11 02; 3(21).
Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M. PMID: 30385725.
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PubMed Mentions:
2 Fields:
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HumansAnimals
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An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila. Nat Commun. 2018 10 08; 9(1):4160.
Qiao HH, Wang F, Xu RG, Sun J, Zhu R, Mao D, Ren X, Wang X, Jia Y, Peng P, Shen D, Liu LP, Chang Z, Wang G, Li S, Ji JY, Liu Q, Ni JQ. PMID: 30297884.
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9 Fields:
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HumansAnimalsCells
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The Lysine Demethylase dKDM2 Is Non-essential for Viability, but Regulates Circadian Rhythms in Drosophila. Front Genet. 2018; 9:354.
Zheng Y, Xue Y, Ren X, Liu M, Li X, Jia Y, Niu Y, Ni JQ, Zhang Y, Ji JY. PMID: 30233643.
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Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):4719-4724.
Jia Y, Xu RG, Ren X, Ewen-Campen B, Rajakumar R, Zirin J, Yang-Zhou D, Zhu R, Wang F, Mao D, Peng P, Qiao HH, Wang X, Liu LP, Xu B, Ji JY, Liu Q, Sun J, Perrimon N, Ni JQ. PMID: 29666231.
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17 Fields:
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Animals
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Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function. . 2017 Nov 01; 313(5):L878-L888.
Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D. PMID: 28818870.
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Optimized strategy for in vivo Cas9-activation in Drosophila. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):9409-9414.
Ewen-Campen B, Yang-Zhou D, Fernandes VR, González DP, Liu LP, Tao R, Ren X, Sun J, Hu Y, Zirin J, Mohr SE, Ni JQ, Perrimon N. PMID: 28808002.
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23 Fields:
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Animals
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Genome editing in Drosophila melanogaster: from basic genome engineering to the multipurpose CRISPR-Cas9 system. Sci China Life Sci. 2017 May; 60(5):476-489.
Ren X, Holsteens K, Li H, Sun J, Zhang Y, Liu LP, Liu Q, Ni JQ. PMID: 28527116.
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PubMed Mentions:
2 Fields:
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Animals
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Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693.
Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. PMID: 27977701.
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6 Fields:
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Animals
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Transforming growth factor-ß plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma. . 2017 01 01; 312(1):L22-L31.
Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D. PMID: 27864286.
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A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70.
Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. PMID: 25362490.
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PubMed Mentions:
85 Fields:
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HumansAnimalsCells
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Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila. Cell Rep. 2014 Nov 06; 9(3):1151-62.
Ren X, Yang Z, Xu J, Sun J, Mao D, Hu Y, Yang SJ, Qiao HH, Wang X, Hu Q, Deng P, Liu LP, Ji JY, Li JB, Ni JQ. PMID: 25437567.
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PubMed Mentions:
85 Fields:
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AnimalsCells
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Performance of the Cas9 nickase system in Drosophila melanogaster. G3 (Bethesda). 2014 Aug 15; 4(10):1955-62.
Ren X, Yang Z, Mao D, Chang Z, Qiao HH, Wang X, Sun J, Hu Q, Cui Y, Liu LP, Ji JY, Xu J, Ni JQ. PMID: 25128437.
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PubMed Mentions:
13 Fields:
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AnimalsCells
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Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19012-7.
Ren X, Sun J, Housden BE, Hu Y, Roesel C, Lin S, Liu LP, Yang Z, Mao D, Sun L, Wu Q, Ji JY, Xi J, Mohr SE, Xu J, Perrimon N, Ni JQ. PMID: 24191015.
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PubMed Mentions:
149 Fields:
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AnimalsCells
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IL-17A produced by aß T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med. 2012 Mar 04; 18(4):547-54.
Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. PMID: 22388091.
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PubMed Mentions:
169 Fields:
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HumansAnimalsCells
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The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb; 122(2):748-58.
Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. PMID: 22232213.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells