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Xu Chen, PhD

Title(s)Assistant Professor, Dermatology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Tsinghua University, Beijing, ChinaB.S.06/1992biology
    Tsinghua University, Beijing, ChinaM.S06/1995Biochemistry
    Cornell University Weill Medical College, New York, USAPh.D.01/2003Biochemistry
    Collapse Awards and Honors
    Tsinghua University1990Excellent student scholarship (third class)
    Tsinghua University1988 Mathematic Contest third class prize
    Tsinghua University1993Guanghua Scholarship
    Memorial Sloan Kettering Cancer Center2007  - 2009Tri-Institute T32 Endocrine Research Fellow
    Melanoma Research Alliance2014  - 2017Young Investigator Award

    Collapse Overview 
    Collapse Overview
    I am a biomedical scientist with training and experience in cancer biology, biochemistry, cell biology, mouse modeling, and translational research. My current research interests lie in the following fields: (1) To dissect the downstream signaling pathways of oncogenic GNAQ and GNA11 to identify therapeutic targets for human uveal melanoma; (2) To develop uveal melanoma mouse models to validate the role of candidate melanoma genes in tumor formation and progression and to evaluate potential therapies in a preclinical setting; (3) To investigate the role of liver microenvironment in uveal melanoma liver metastasis.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee HJ, Pham T, Chang MT, Barnes D, Cai AG, Noubade R, Totpal K, Chen X, Tran C, Hagenbeek T, Wu X, Eastham-Anderson J, Tao J, Lee W, Bastian BC, Carbone M, Webster JD, Dey A. The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2020 Apr 15; 80(8):1656-1668. PMID: 31988076.
      View in: PubMed
    2. Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A. Combined activation of MAP kinase pathway and ß-catenin signaling cause deep penetrating nevi. Nat Commun. 2017 09 21; 8(1):644. PMID: 28935960.
      View in: PubMed
    3. Montero-Conde C, Leandro-Garcia LJ, Chen X, Oler G, Ruiz-Llorente S, Ryder M, Landa I, Sanchez-Vega F, La K, Ghossein RA, Bajorin DF, Knauf JA, Riordan JD, Dupuy AJ, Fagin JA. Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene. Proc Natl Acad Sci U S A. 2017 06 20; 114(25):E4951-E4960. PMID: 28584132.
      View in: PubMed
    4. Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017 05 08; 31(5):685-696.e6. PMID: 28486107.
      View in: PubMed
    5. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30. PMID: 24882516.
      View in: PubMed
    6. Chen X, Makarewicz JM, Knauf JA, Johnson LK, Fagin JA. Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition. Oncogene. 2014 Nov 20; 33(47):5442-9. PMID: 24240680.
      View in: PubMed
    7. Chen X, Wu Q, Tan L, Porter D, Jager MJ, Emery C, Bastian BC. Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations. Oncogene. 2014 Sep 25; 33(39):4724-34. PMID: 24141786.
      View in: PubMed
    8. Chen X, Mitsutake N, LaPerle K, Akeno N, Zanzonico P, Longo VA, Mitsutake S, Kimura ET, Geiger H, Santos E, Wendel HG, Franco A, Knauf JA, Fagin JA. Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7979-84. PMID: 19416908.
      View in: PubMed
    9. Croyle M, Akeno N, Knauf JA, Fabbro D, Chen X, Baumgartner JE, Lane HA, Fagin JA. RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR. Cancer Res. 2008 Jun 01; 68(11):4183-91. PMID: 18519677.
      View in: PubMed
    10. Carter M, Chen X, Slowinska B, Minnerath S, Glickstein S, Shi L, Campagne F, Weinstein H, Ross ME. Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12843-8. PMID: 16126904.
      View in: PubMed
    11. Chen X, Resh MD. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20; 277(51):49631-7. PMID: 12397069.
      View in: PubMed
    12. Chen X, Resh MD. Activation of mitogen-activated protein kinase by membrane-targeted Raf chimeras is independent of raft localization. J Biol Chem. 2001 Sep 14; 276(37):34617-23. PMID: 11457834.
      View in: PubMed