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Xu Chen, PhD

Title(s)Associate Professor, Dermatology
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
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    Collapse Biography 
    Collapse Education and Training
    Tsinghua University, Beijing, ChinaB.S.biology
    Tsinghua University, Beijing, ChinaM.SBiochemistry
    Cornell University Weill Medical College, New York, USAPh.D.Biochemistry
    Cornell University Weill Medical College, New YorkPostdocNeuroscience
    Memorial Sloan Kettering Cancer Center, New YorkPostdocHuman Oncology & Pathogenesis
    Collapse Awards and Honors
    Memorial Sloan Kettering Cancer Center2007  - 2009Tri-Institute T32 Endocrine Research Fellow
    Melanoma Research Alliance2014  - 2017Young Investigator Award

    Collapse Overview 
    Collapse Overview
    I am a biomedical scientist with special expertise in the development of mouse models, biochemistry and cell biology, and signal transduction of cancer-relevant signaling pathways. My research interest has been on understanding the mechanisms of tumor initiation and progression by oncogenes, with the goal to identify therapeutic targets for patients with cancer. My current research interests lie in the following fields: (1) To dissect the downstream signaling pathways of oncogenic GNAQ and GNA11 to identify therapeutic targets for human uveal melanoma; (2) To develop uveal melanoma mouse models to validate the role of candidate melanoma genes in tumor formation and progression and to evaluate potential therapies in a preclinical setting; (3) To investigate the underlying mechainsm of uveal melanoma liver metastasis.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Functional characterization of uveal melanoma oncogenes. Oncogene. 2020 Dec 01. Ma J, Weng L, Bastian BC, Chen X. PMID: 33262460.
      View in: PubMed   Mentions:    Fields:    
    2. The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2020 04 15; 80(8):1656-1668. Lee HJ, Pham T, Chang MT, Barnes D, Cai AG, Noubade R, Totpal K, Chen X, Tran C, Hagenbeek T, Wu X, Eastham-Anderson J, Tao J, Lee W, Bastian BC, Carbone M, Webster JD, Dey A. PMID: 31988076.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Combined activation of MAP kinase pathway and ß-catenin signaling cause deep penetrating nevi. Nat Commun. 2017 09 21; 8(1):644. Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A. PMID: 28935960.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    4. Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene. Proc Natl Acad Sci U S A. 2017 06 20; 114(25):E4951-E4960. Montero-Conde C, Leandro-Garcia LJ, Chen X, Oler G, Ruiz-Llorente S, Ryder M, Landa I, Sanchez-Vega F, La K, Ghossein RA, Bajorin DF, Knauf JA, Riordan JD, Dupuy AJ, Fagin JA. PMID: 28584132.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017 05 08; 31(5):685-696.e6. Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC. PMID: 28486107.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    6. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. PMID: 24882516.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    7. Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition. Oncogene. 2014 Nov 20; 33(47):5442-9. Chen X, Makarewicz JM, Knauf JA, Johnson LK, Fagin JA. PMID: 24240680.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    8. Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations. Oncogene. 2014 Sep 25; 33(39):4724-34. Chen X, Wu Q, Tan L, Porter D, Jager MJ, Emery C, Bastian BC. PMID: 24141786.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    9. Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7979-84. Chen X, Mitsutake N, LaPerle K, Akeno N, Zanzonico P, Longo VA, Mitsutake S, Kimura ET, Geiger H, Santos E, Wendel HG, Franco A, Knauf JA, Fagin JA. PMID: 19416908.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    10. RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR. Cancer Res. 2008 Jun 01; 68(11):4183-91. Croyle M, Akeno N, Knauf JA, Fabbro D, Chen X, Baumgartner JE, Lane HA, Fagin JA. PMID: 18519677.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    11. Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12843-8. Carter M, Chen X, Slowinska B, Minnerath S, Glickstein S, Shi L, Campagne F, Weinstein H, Ross ME. PMID: 16126904.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    12. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20; 277(51):49631-7. Chen X, Resh MD. PMID: 12397069.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    13. Activation of mitogen-activated protein kinase by membrane-targeted Raf chimeras is independent of raft localization. J Biol Chem. 2001 Sep 14; 276(37):34617-23. Chen X, Resh MD. PMID: 11457834.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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