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Yadong Huang, MD, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Phone415-734-2511
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship

    Collapse Research 
    Collapse Research Activities and Funding
    ApoE Genotype-Directed Drug Repositioning and Combination Therapy for Alzheimer's Disease
    NIH/NIA R01AG057683Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Study ApoE4's Effects on Hippocampal Network Activity in Alzheimer's Disease
    NIH/NIA R01AG055682Aug 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Modeling Alzheimer?s disease using directly reprogrammed isogenic neural cells
    NIH/NIA R01AG056305Aug 1, 2017 - Apr 30, 2022
    Role: Co-Principal Investigator
    Roles of ApoE4 in Brain Aging and Alzheimer's Disease
    NIH/NIA RF1AG055421Apr 15, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Apolipoprotein E in Alzheimer's Disease: Molecular Mechanism
    NIH/NIA R01AG048017Apr 15, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Studying Alzheimer's Disease Using Human iPS Cells
    NIH/NIA RF1AG048030Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Optogenetic Study of ApoE4-Related Alzheimers Disease
    NIH/NIA RF1AG047655Jun 15, 2014 - May 31, 2019
    Role: Principal Investigator
    Frontotemporal Dementia Induced Pluripotent Stem Cell Consortium
    NIH/NINDS R01NS079725Sep 30, 2013 - Jun 30, 2017
    Role: Principal Investigator
    New Approaches to Dementia Heterogeneity
    NIH/NIA P50AG023501Apr 1, 2004 - Mar 31, 2019
    Role: Co-Investigator
    Proteinopathies of the Aging Central Nervous System
    NIH/NIA P01AG022074Jun 15, 2003 - Nov 30, 2013
    Role: Co-Investigator
    APOE EXPRESSION LEVEL MODULATES VLDL METABOLISM
    NIH/NHLBI R01HL064162May 1, 2000 - Apr 30, 2005
    Role: Principal Investigator
    Regulation of Apolipoprotein Synthesis
    NIH/NHLBI R01HL037063Jul 1, 1986 - Mar 31, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Jones EA, Gillespie AK, Yoon SY, Frank LM, Huang Y. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model. Cell Rep. 2019 Nov 19; 29(8):2123-2133.e4. PMID: 31747587.
      View in: PubMed
    2. Zalocusky KA, Nelson MR, Huang Y. An Alzheimer's-disease-protective APOE mutation. Nat Med. 2019 11; 25(11):1648-1649. PMID: 31686033.
      View in: PubMed
    3. Najm R, Jones EA, Huang Y. Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. Mol Neurodegener. 2019 06 11; 14(1):24. PMID: 31186040.
      View in: PubMed
    4. Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018 05; 24(5):647-657. PMID: 29632371.
      View in: PubMed
    5. Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS. Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. PLoS Med. 2017 Mar; 14(3):e1002272. PMID: 28350795.
      View in: PubMed
    6. Gillespie AK, Jones EA, Huang Y. Approaching Alzheimer's disease from a network level. Oncotarget. 2017 Feb 07; 8(6):9003-9004. PMID: 28099927.
      View in: PubMed
    7. Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. 2016 09 13; 7(3):325-340. PMID: 27594585.
      View in: PubMed
    8. Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y. Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples. Neuron. 2016 05 18; 90(4):740-51. PMID: 27161522.
      View in: PubMed
    9. Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016 05 05; 18(5):653-67. PMID: 27133794.
      View in: PubMed
    10. Tong LM, Yoon SY, Andrews-Zwilling Y, Yang A, Lin V, Lei H, Huang Y. Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice. J Neurosci. 2016 Feb 17; 36(7):2316-22. PMID: 26888940.
      View in: PubMed
    11. Wang C, Fong H, Huang Y. Direct Reprogramming of RESTing Astrocytes. Cell Stem Cell. 2015 Jul 02; 17(1):1-3. PMID: 26140600.
      View in: PubMed
    12. Tong LM, Fong H, Huang Y. Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives. Exp Mol Med. 2015 Mar 13; 47:e151. PMID: 25766620.
      View in: PubMed
    13. Knoferle J, Yoon SY, Walker D, Leung L, Gillespie AK, Tong LM, Bien-Ly N, Huang Y. Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. J Neurosci. 2014 Oct 15; 34(42):14069-78. PMID: 25319703.
      View in: PubMed
    14. Huang Y, Mahley RW. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiol Dis. 2014 Dec; 72 Pt A:3-12. PMID: 25173806.
      View in: PubMed
    15. Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JL, Alvarez-Buylla A, Huang Y. Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aß accumulation. J Neurosci. 2014 Jul 16; 34(29):9506-15. PMID: 25031394.
      View in: PubMed
    16. Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y. Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(3):226-34. PMID: 24319659.
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    17. Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O'Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD. Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients. J Neurol Neurosurg Psychiatry. 2014 Mar; 85(3):266-73. PMID: 23965289.
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    18. Jain S, Yoon SY, Leung L, Knoferle J, Huang Y. Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development. PLoS One. 2013; 8(3):e59478. PMID: 23527202.
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    19. Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y. Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. PLoS One. 2012; 7(12):e53569. PMID: 23300939.
      View in: PubMed
    20. Mahley RW, Huang Y. Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron. 2012 Dec 06; 76(5):871-85. PMID: 23217737.
      View in: PubMed
    21. Mahley RW, Huang Y. Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology. J Med Chem. 2012 Nov 08; 55(21):8997-9008. PMID: 23013167.
      View in: PubMed
    22. Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y.. Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One. 2012; 7(9):e46340.
    23. Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y. Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One. 2012; 7(9):e46340. PMID: 23050017.
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    24. Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS One. 2012; 7(7):e40555. PMID: 22792368.
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    25. Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell. 2012 Jul 06; 11(1):100-9. PMID: 22683203.
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    26. Vossel KA, Bien-Ly N, Bernardo A, Rascovsky K, Karydas A, Rabinovici GD, Sidhu M, Huang EJ, Miller BL, Huang Y, Seeley WW. ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease. Neurocase. 2013; 19(3):295-301. PMID: 22512241.
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    27. Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y. Reducing human apolipoprotein E levels attenuates age-dependent Aß accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012 Apr 04; 32(14):4803-11. PMID: 22492035.
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    28. Huang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell. 2012 Mar 16; 148(6):1204-22. PMID: 22424230.
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    29. Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17; 287(8):5253-66. PMID: 22158868.
      View in: PubMed
    30. Huang Y. Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models. Biochem Soc Trans. 2011 Aug; 39(4):924-32. PMID: 21787325.
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    31. Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 2011 Jun 10; 145(6):863-74. PMID: 21640374.
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    32. Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13; 286(19):17217-26. PMID: 21454574.
      View in: PubMed
    33. Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4236-41. PMID: 21368138.
      View in: PubMed
    34. Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem. 2011 Feb 18; 286(7):5215-21. PMID: 21118811.
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    35. Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010 Oct 13; 30(41):13707-17. PMID: 20943911.
      View in: PubMed
    36. Huang Y. Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases. Curr Opin Lipidol. 2010 Aug; 21(4):337-45. PMID: 20531185.
      View in: PubMed
    37. Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. Am J Pathol. 2010 Aug; 177(2):563-9. PMID: 20595630.
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    38. Huang Y. Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease. Trends Mol Med. 2010 Jun; 16(6):287-94. PMID: 20537952.
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    39. Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell. 2009 Dec 04; 5(6):634-45. PMID: 19951691.
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    40. Tesseur I, Zhang H, Brecht W, Corn J, Gong JS, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T. Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. J Neurochem. 2009 Aug; 110(4):1254-62. PMID: 19549280.
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    41. Mahley RW, Huang Y. Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches. Ann Neurol. 2009 Jun; 65(6):623-5. PMID: 19557874.
      View in: PubMed
    42. Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res. 2009 Apr; 50 Suppl:S183-8. PMID: 19106071.
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    43. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8718-23. PMID: 18562290.
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    44. Xu Q, Walker D, Bernardo A, Brodbeck J, Balestra ME, Huang Y. Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS. J Neurosci. 2008 Feb 06; 28(6):1452-9. PMID: 18256266.
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    45. Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y. Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1343-6. PMID: 18212130.
      View in: PubMed
    46. Mahley RW, Huang Y, Weisgraber KH. Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease. Curr Alzheimer Res. 2007 Dec; 4(5):537-40. PMID: 18220516.
      View in: PubMed
    47. Mahley RW, Huang Y. Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing. J Clin Invest. 2007 Jan; 117(1):94-8. PMID: 17200713.
      View in: PubMed
    48. Huang Y. Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies. Curr Opin Drug Discov Devel. 2006 Sep; 9(5):627-41. PMID: 17002223.
      View in: PubMed
    49. Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW. Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease). Pharmacogenomics J. 2007 Feb; 7(1):10-28. PMID: 16770341.
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    50. Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y. Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci. 2006 May 10; 26(19):4985-94. PMID: 16687490.
      View in: PubMed
    51. Mahley RW, Huang Y, Weisgraber KH. Putting cholesterol in its place: apoE and reverse cholesterol transport. J Clin Invest. 2006 May; 116(5):1226-9. PMID: 16670767.
      View in: PubMed
    52. Huang Y, Mahley RW. Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis. Alzheimers Dement. 2006 Apr; 2(2):71-3. PMID: 19595858.
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    53. Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5644-51. PMID: 16567625.
      View in: PubMed
    54. Huang Y. Apolipoprotein E and Alzheimer disease. Neurology. 2006 Jan 24; 66(2 Suppl 1):S79-85. PMID: 16432152.
      View in: PubMed
    55. Mahley RW, Huang Y. Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta Neurol Scand Suppl. 2006; 185:8-14. PMID: 16866905.
      View in: PubMed
    56. Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18694-9. PMID: 16344479.
      View in: PubMed
    57. Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18700-5. PMID: 16344478.
      View in: PubMed
    58. Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW. Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration. J Biol Chem. 2006 Feb 03; 281(5):2683-92. PMID: 16298992.
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    59. Ramaswamy G, Xu Q, Huang Y, Weisgraber KH. Effect of domain interaction on apolipoprotein E levels in mouse brain. J Neurosci. 2005 Nov 16; 25(46):10658-63. PMID: 16291938.
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    60. Hodoglugil U, Tanyolaç S, Williamson DW, Huang Y, Mahley RW. Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks. J Lipid Res. 2006 Jan; 47(1):144-53. PMID: 16258166.
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    61. Hodoglugil U, Williamson DW, Huang Y, Mahley RW. Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks. Atherosclerosis. 2005 Dec; 183(2):199-212. PMID: 15935359.
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    62. Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem. 2004 Oct 22; 279(43):44795-801. PMID: 15322121.
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    63. Raber J, Huang Y, Ashford JW. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging. 2004 May-Jun; 25(5):641-50. PMID: 15172743.
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    64. Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. J Biol Chem. 2004 Jun 11; 279(24):25511-6. PMID: 15054100.
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    65. Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci. 2004 Mar 10; 24(10):2527-34. PMID: 15014128.
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    66. Huang Y, Weisgraber KH, Mucke L, Mahley RW. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci. 2004; 23(3):189-204. PMID: 15181247.
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    67. Harris FM, Tesseur I, Brecht WJ, Xu Q, Mullendorff K, Chang S, Wyss-Coray T, Mahley RW, Huang Y. Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. J Biol Chem. 2004 Jan 30; 279(5):3862-8. PMID: 14585838.
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    68. Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10966-71. PMID: 12939405.
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    69. Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci. 2002 Dec 15; 22(24):10539-48. PMID: 12486146.
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    70. Hopkins PC, Huang Y, McGuire JG, Pitas RE. Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J Lipid Res. 2002 Nov; 43(11):1881-9. PMID: 12401887.
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    71. Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem. 2002 Jun 14; 277(24):21821-8. PMID: 11912196.
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    72. Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW. Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8838-43. PMID: 11447277.
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    73. Langer C, Huang Y, Cullen P, Wiesenhütter B, Mahley RW, Assmann G, von Eckardstein A. Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages. J Mol Med (Berl). 2000; 78(4):217-27. PMID: 10933584.
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    74. Huang Y, Ji ZS, Brecht WJ, Rall SC, Taylor JM, Mahley RW. Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis. Arterioscler Thromb Vasc Biol. 1999 Dec; 19(12):2952-9. PMID: 10591675.
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    75. Mahley RW, Huang Y, Rall SC. Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes. J Lipid Res. 1999 Nov; 40(11):1933-49. PMID: 10552997.
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    76. Mahley RW, Huang Y. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr Opin Lipidol. 1999 Jun; 10(3):207-17. PMID: 10431657.
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    77. Huang Y, Liu XQ, Rall SC, Taylor JM, von Eckardstein A, Assmann G, Mahley RW. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem. 1998 Oct 09; 273(41):26388-93. PMID: 9756870.
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    78. Huang Y, Liu XQ, Rall SC, Mahley RW. Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. J Biol Chem. 1998 Jul 10; 273(28):17483-90. PMID: 9651338.
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    79. Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM. Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma. J Clin Invest. 1998 May 15; 101(10):2151-64. PMID: 9593771.
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    80. von Eckardstein A, Huang Y, Kastelein JJ, Geisel J, Real JT, Kuivenhoven JA, Miccoli R, Noseda G, Assmann G. Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients. Atherosclerosis. 1998 May; 138(1):25-34. PMID: 9678768.
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    81. Huang Y, Rall SC, Mahley RW. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):2817-24. PMID: 9409260.
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    82. Huang Y, Zhu Y, Langer C, Raabe M, Wu S, Wiesenhütter B, Seedorf U, Maeda N, Assmann G, von Eckardstein A. Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal, apolipoprotein A-I-, and apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 1997 Oct; 17(10):2010-9. PMID: 9351366.
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    83. Huang Y, Schwendner SW, Rall SC, Sanan DA, Mahley RW. Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. J Biol Chem. 1997 Sep 05; 272(36):22685-94. PMID: 9312550.
      View in: PubMed
    84. Miccoli R, Zhu Y, Daum U, Wessling J, Huang Y, Navalesi R, Assmann G, von Eckardstein A. A natural apolipoprotein A-I variant, apoA-I (L141R)Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta 1-HDL and influences efflux of cholesterol into plasma. J Lipid Res. 1997 Jun; 38(6):1242-53. PMID: 9215551.
      View in: PubMed
    85. Huang Y, Schwendner SW, Rall SC, Mahley RW. Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2. J Biol Chem. 1996 Nov 15; 271(46):29146-51. PMID: 8910571.
      View in: PubMed
    86. Assmann G, Schulte H, von Eckardstein A, Huang Y. High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis. 1996 Jul; 124 Suppl:S11-20. PMID: 8831911.
      View in: PubMed
    87. von Eckardstein A, Jauhiainen M, Huang Y, Metso J, Langer C, Pussinen P, Wu S, Ehnholm C, Assmann G. Phospholipid transfer protein mediated conversion of high density lipoproteins generates pre beta 1-HDL. Biochim Biophys Acta. 1996 Jun 11; 1301(3):255-62. PMID: 8664337.
      View in: PubMed
    88. von Eckardstein A, Huang Y, Wu S, Assmann G. Uptake, transfer, and esterification of cell-derived cholesterol in plasma of patients with familial HDL-deficiency. Z Gastroenterol. 1996 Jun; 34 Suppl 3:143-4. PMID: 8767492.
      View in: PubMed
    89. Huang Y, von Eckardstein A, Wu S, Assmann G. Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma. J Clin Invest. 1995 Dec; 96(6):2693-701. PMID: 8675636.
      View in: PubMed
    90. von Eckardstein A, Huang Y, Wu S, Sarmadi AS, Schwarz S, Steinmetz A, Assmann G. Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma. Arterioscler Thromb Vasc Biol. 1995 Oct; 15(10):1755-63. PMID: 7583553.
      View in: PubMed
    91. Huang Y, von Eckardstein A, Wu S, Langer C, Assmann G. Generation of pre-beta 1-HDL and conversion into alpha-HDL. Evidence for disturbed HDL conversion in Tangier disease. Arterioscler Thromb Vasc Biol. 1995 Oct; 15(10):1746-54. PMID: 7583552.
      View in: PubMed
    92. Huang Y, von Eckardstein A, Wu S, Assmann G. Cholesterol efflux, cholesterol esterification, and cholesteryl ester transfer by LpA-I and LpA-I/A-II in native plasma. Arterioscler Thromb Vasc Biol. 1995 Sep; 15(9):1412-8. PMID: 7670956.
      View in: PubMed
    93. von Eckardstein A, Huang Y, Wu S, Funke H, Noseda G, Assmann G. Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency. Arterioscler Thromb Vasc Biol. 1995 May; 15(5):691-703. PMID: 7749883.
      View in: PubMed
    94. von Eckardstein A, Huang Y, Assmann G. Physiological role and clinical relevance of high-density lipoprotein subclasses. Curr Opin Lipidol. 1994 Dec; 5(6):404-16. PMID: 7712045.
      View in: PubMed
    95. Huang Y, von Eckardstein A, Wu S, Maeda N, Assmann G. A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells. Proc Natl Acad Sci U S A. 1994 Mar 01; 91(5):1834-8. PMID: 8127890.
      View in: PubMed
    96. Huang Y, von Eckardstein A, Assmann G. Cell-derived unesterified cholesterol cycles between different HDLs and LDL for its effective esterification in plasma. Arterioscler Thromb. 1993 Mar; 13(3):445-58. PMID: 8443149.
      View in: PubMed