Yan Li, PhD

Title(s)Assistant Professor, Radiology
SchoolSchool of Medicine
AddressLocation Required
Phone415-514-2104
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    Collapse Biography 
    Collapse Education and Training
    Shanghai Jiao Tong University, Shanghai, ChinaBachelor of Medicine2002Clinical Medicine
    McGill University, Montreal, Quebec, CanadaMS2004Biochemistry
    University of California, Berkeley & San Francisco, California, USAPh.D.2008Bioengineering
    University of California, San Francisco, CA2021Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    UCSF Brain Tumor SPORE 2021  - 2022Developmental Research Program Award

    Collapse Overview 
    Collapse Overview
    Dr. Yan Li is an Assistant Professor in the Department of Radiology and Biomedical Imaging. Dr. Li received her medical degree from Shanghai Jiao Tong University in China, Master of Science in Biochemistry from McGill University in Canada, and Ph.D. from the UCSF/UC Berkeley Joint Graduate Program in Bioengineering.

    Dr. Yan Li’s research focuses on developing methods for obtaining reliable metabolic information from the brain to characterize spatial and temporal heterogeneity and the biological behavior during disease time for brain tumors, psychiatric and neurologic diseases. This includes the development of new methods for obtaining whole-brain metabolites and tools for generating metrics of brain neurotransmitters using 3T and 7T MR scanners, implementation of statistical methods to relate metabolic metrics to clinical outcome or measures, and integrating steady-state 1H metabolic imaging with PET, hyperpolarized 13C and advanced MR imaging parameters in order to elucidate the underlying normal and abnormal biological process.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Monitoring Patients with IDH-Mutant Astrocytoma Using Dynamic and Steady-State Metabolic Imaging
    Department of Defense USAMRAA W81XWH-21-1-0412Sep 1, 2021 - Aug 31, 2024
    Role: Principal Investigator
    Neural mechanisms of speech motor control in Autism Spectrum Disorders
    NIH R01DC019167Aug 2, 2021 - May 31, 2026
    Role: Co-Principal Investigator
    Simultaneous multi-slice GABA-edited MRSI in the developing brain
    NIH R21HD092660Jul 15, 2017 - Jun 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging. Eur J Nucl Med Mol Imaging. 2021 Aug 25. Li Y, Vigneron DB, Xu D. PMID: 34432118.
      View in: PubMed   Mentions:    Fields:    
    2. Denoising of hyperpolarized 13 C MR images of the human brain using patch-based higher-order singular value decomposition. Magn Reson Med. 2021 Jun 25. Kim Y, Chen HY, Autry AW, Villanueva-Meyer J, Chang SM, Li Y, Larson PEZ, Brender JR, Krishna MC, Xu D, Vigneron DB, Gordon JW. PMID: 34173268.
      View in: PubMed   Mentions:    Fields:    
    3. Pilot Study of Hyperpolarized 13C Metabolic Imaging in Pediatric Patients with Diffuse Intrinsic Pontine Glioma and Other CNS Cancers. AJNR Am J Neuroradiol. 2021 01; 42(1):178-184. Autry AW, Park I, Kline C, Chen HY, Gordon JW, Raber S, Hoffman C, Kim Y, Okamoto K, Vigneron DB, Lupo JM, Prados M, Li Y, Xu D, Mueller S. PMID: 33272950.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    4. A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI. Magn Reson Med. 2020 12; 84(6):2943-2952. Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohilger MA, Abraham MR, Xu D, Vigneron DB, Larson PEZ. PMID: 32697867.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    5. Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma. Neuroimage Clin. 2020; 27:102323. Autry AW, Gordon JW, Chen HY, LaFontaine M, Bok R, Van Criekinge M, Slater JB, Carvajal L, Villanueva-Meyer JE, Chang SM, Clarke JL, Lupo JM, Xu D, Larson PEZ, Vigneron DB, Li Y. PMID: 32623139.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    6. Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco. NMR Biomed. 2021 05; 34(5):e4280. Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D. PMID: 32189442.
      View in: PubMed   Mentions: 4     Fields:    
    7. C-13 Hyperpolarized MR Spectroscopy for Metabolic Imaging of Brain Tumors. . 2020 Jan 1; 191-209. Viswanath VP, Li LY, Ronen RS. .
      View in: Publisher Site   Mentions:
    8. Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain. IEEE Trans Med Imaging. 2020 02; 39(2):320-327. Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB. PMID: 31283497.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    9. Comparison between 8- and 32-channel phased-array receive coils for in vivo hyperpolarized 13 C imaging of the human brain. Magn Reson Med. 2019 08; 82(2):833-841. Autry AW, Gordon JW, Carvajal L, Mareyam A, Chen HY, Park I, Mammoli D, Vareth M, Chang SM, Wald LL, Xu D, Vigneron DB, Nelson SJ, Li Y. PMID: 30927300.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    10. Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies. J Magn Reson. 2019 04; 301:73-79. Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW. PMID: 30851668.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Quantitative MRI of the Brain: Principles of Physical Measurement (by Mara Cercignani, Nicholas G. Dowell, Paul S. Tofts). Chapter 12: 1H Spectroscopy of the Brain. 2018. .
    12. Reliable and Reproducible GABA Measurements Using Automated Spectral Prescription at Ultra-High Field. Front Hum Neurosci. 2017; 11:506. Li Y, Bian W, Larson P, Crane JC, Parvathaneni P, Nagarajan S, Nelson SJ. PMID: 29118697.
      View in: PubMed   Mentions:
    13. Comparison between Short and Long Echo Time Magnetic Resonance Spectroscopic Imaging at 3T and 7T for Evaluating Brain Metabolites in Patients with Glioma. ACS Chem Neurosci. 2018 01 17; 9(1):130-137. Li Y, Lafontaine M, Chang S, Nelson SJ. PMID: 29035503.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. Fully automated atlas-based method for prescribing 3D PRESS MR spectroscopic imaging: Toward robust and reproducible metabolite measurements in human brain. Magn Reson Med. 2018 02; 79(2):636-642. Bian W, Li Y, Crane JC, Nelson SJ. PMID: 28470861.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen. Neuro Oncol. 2017 03 01; 19(3):430-439. Nelson SJ, Kadambi AK, Park I, Li Y, Crane J, Olson M, Molinaro A, Roy R, Butowski N, Cha S, Chang S. PMID: 27576874.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    16. Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab. J Neurooncol. 2016 10; 130(1):171-179. Nelson SJ, Li Y, Lupo JM, Olson M, Crane JC, Molinaro A, Roy R, Clarke J, Butowski N, Prados M, Cha S, Chang SM. PMID: 27535746.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    17. Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla. MAGMA. 2016 Jun; 29(3):523-33. Li Y, Jakary A, Gillung E, Eisendrath S, Nelson SJ, Mukherjee P, Luks T. PMID: 26861048.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Association of Diffusion and Anatomic Imaging Parameters with Survival for Patients with Newly Diagnosed Glioblastoma Participating in Two Different Clinical Trials. Transl Oncol. 2015 Dec; 8(6):446-55. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. PMID: 26692525.
      View in: PubMed   Mentions:
    19. Imaging tumor metabolism using in vivo magnetic resonance spectroscopy. Cancer J. 2015 Mar-Apr; 21(2):123-8. Li Y, Park I, Nelson SJ. PMID: 25815853.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    20. NI-61VOLUMETRIC H-1 MR METABOLIC IMAGING FOR DEFINITION OF LESION BURDEN AND PREDICTION OF OUTCOME FOR PATIENTS WITH NEWLY DIAGNOSED GBM. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v151-v152. Nelson NS, Li LY, Prados PM, Butowski BN, Clarke CJ, Chang CS. .
      View in: Publisher Site   Mentions:
    21. Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels. J Magn Reson Imaging. 2015 May; 41(5):1332-41. Li Y, Larson P, Chen AP, Lupo JM, Ozhinsky E, Kelley D, Chang SM, Nelson SJ. PMID: 24935758.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    22. Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging. J Magn Reson. 2013 Apr; 229:187-97. Nelson SJ, Ozhinsky E, Li Y, Park Iw, Crane J. PMID: 23453759.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    23. Survival analysis in patients with newly diagnosed glioblastoma using pre- and postradiotherapy MR spectroscopic imaging. Neuro Oncol. 2013 May; 15(5):607-17. Li Y, Lupo JM, Parvataneni R, Lamborn KR, Cha S, Chang SM, Nelson SJ. PMID: 23393206.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    24. Advances in ultra-high field MRI for the clinical management of patients with brain tumors. Curr Opin Neurol. 2011 Dec; 24(6):605-15. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Lupo JM, Li Y, Hess CP, Nelson SJ. PMID: 22045220.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    25. Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme. Neuro Oncol. 2011 May; 13(5):546-57. Li Y, Lupo JM, Polley MY, Crane JC, Bian W, Cha S, Chang S, Nelson SJ. PMID: 21297128.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    26. Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T. J Magn Reson Imaging. 2008 Aug; 28(2):342-50. Li Y, Srinivasan R, Ratiney H, Lu Y, Chang SM, Nelson SJ. PMID: 18666155.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    27. Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T. Magn Reson Med. 2007 Nov; 58(5):886-92. Li Y, Chen AP, Crane JC, Chang SM, Vigneron DB, Nelson SJ. PMID: 17969114.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    28. Considerations in applying 3D PRESS H-1 brain MRSI with an eight-channel phased-array coil at 3 T. Magn Reson Imaging. 2006 Dec; 24(10):1295-302. Li Y, Osorio JA, Ozturk-Isik E, Chen AP, Xu D, Crane JC, Cha S, Chang S, Berger MS, Vigneron DB, Nelson SJ. PMID: 17145400.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
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