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Yan Li, PhD

Title(s)Assistant Professor, Radiology
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
Phone415-514-2104
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    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley & San FranciscoPh.D.2008Bioengineering
    McGill UniversityMS2004Biochemistry
    Shanghai Jiao Tong UniversityBachelor of Medicine2002Clinical Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Yan Li joined UCSF Radiology and Biomedical Imaging as an Assistant Professor in March 2019. Dr. Li received her medical degree from Shanghai Jiao Tong University in China, Master of Science in Biochemistry from McGill University in Canada, and PhD from the UCSF/UC Berkeley Joint Graduate Program in Bioengineering. Before accepting current position, she worked in the laboratory of Dr. Sarah Nelson as a post-doctoral fellow and later as an assistant research scientist.

    Dr. Yan Li’s research focuses on developing methods for obtaining reliable metabolic information from the brain in order to characterize spatial and temporal heterogeneity and the biologic behavior during disease time for brain tumors, psychiatric and neurologic diseases. This includes the development of new methods for obtaining whole brain metabolites and tools for generating metrics of brain neurotransmitters using 3T and 7T MR scanners, implementation of statistical methods to relate metabolic metrics to clinical outcome or measures, and integrating steady state 1H metabolic imaging with PET, hyperpolarized 13C and advanced MR imaging parameters in order to elucidate the underlying normal and abnormal biological process.

    Collapse Research 
    Collapse Research Activities and Funding
    Simultaneous multi-slice GABA-edited MRSI in the developing brain
    NIH R21HD092660Jul 15, 2017 - Jun 30, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. C-13 Hyperpolarized MR Spectroscopy for Metabolic Imaging of Brain Tumors. . 2020 Jan 1; 191-209. Pavithra Viswanath, Yan Li, Sabrina M. Ronen. .
      View in: Publisher Site   Mentions:
    2. CBMT-36. INITIAL EXPERIENCE WITH HYPERPOLARIZED [2-13C]PYRUVATE MR IMAGING IN PATIENTS WITH IDH-MUTANT GLIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi41-vi41. Adam Autry, Brian Chung, Hsin-Yu Chen, Jeremy Gordon, Marisa Lafontaine, Susan Chang, Javier Villanueva-Meyer, Peder Larson, Daniel Vigneron, Yan Li. .
      View in: Publisher Site   Mentions:
    3. NIMG-33. TUMOR GROWTH AND MRI TRAJECTORIES IN GRADE II AND III GLIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi168-vi168. Tracy Luks, Yan Li, Paula Alcaide-Leon, Marisa Lafontaine, Angela Jakary, Susan Chang, Javier Villanueva-Meyer. .
      View in: Publisher Site   Mentions:
    4. NIMG-57. SERIAL HYPERPOLARIZED 13C PYRUVATE AND 1H METABOLIC IMAGING IN RECURRENT HIGH-GRADE GLIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi174-vi174. Javier Villanueva-Meyer, Adam Autry, Jeremy Gordon, Hsin-Yu Chen, Marisa Lafontaine, Susan Chang, Duan Xu, Peder Larson, Daniel Vigneron, Yan Li. .
      View in: Publisher Site   Mentions:
    5. CBMT-26. SERIAL CHARACTERIZATION OF HYPERPOLARIZED [1-13C]PYRUVATE METABOLISM IN PATIENTS WITH GLIOMA AND THE INFLUENCE OF BEVACIZUMAB. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi38-vi39. Adam Autry, Jeremy Gordon, Hsin-Yu Chen, Marisa Lafontaine, Javier Villanueva-Meyer, Susan Chang, Duan Xu, Peder Larson, Daniel Vigneron, Yan Li. .
      View in: Publisher Site   Mentions:
    6. DIPG-31. FEASIBILITY OF HYPERPOLARIZED 13C METABOLIC IMAGING IN PEDIATRIC PATIENTS WITH DIPG AND OTHER CNS CANCERS. Neuro-Oncology. 2019 Apr 23; 21(Supplement_2):ii75-ii75. Adam Autry, Ilwoo Park, Hsin-Yu Chen, Jeremy Gordon, Cassie Kline-Nunnally, Daniel Vigneron, Janine Lupo, Yan Li, Duan Xu, Sabine Mueller. .
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    7. NIMG-24. DIFFUSION MRI PRECURSORS TO PROGRESSION IN GRADE II AND III GLIOMA. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi181-vi181. Tracy Luks, Yan Li, Marisa Lafontaine, Angela Jakary, Gaurav Inamdar, Michael Wahl, Susan Chang, Sarah Nelson, Javier Villanueva-Meyer. .
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    8. NIMG-66. COMPARISON OF STEADY STATE AND DYNAMIC BRAIN METABOLISM BY USING 1H MRSI AND HYPERPOLARIZED [1-13C]PYRUVATE IMAGING IN PATIENTS WITH GLIOMA. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi190-vi191. Yan Li, Adam Autry, Jeremy Gordon, Jason Crane, Beck Olson, Marisa Lafontaine, Ilwoo Park, Javier Villanueva-Meyer, Daniel Vigneron, Susan Chang, Sarah Nelson. .
      View in: Publisher Site   Mentions:
    9. NIMG-08. REPRODUCIBILITY OF HYPERPOLARIZED C-13 METABOLIC IMAGING IN PATIENTS WITH GLIOMA. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi177-vi177. Adam Autry, Jeremy Gordon, Marisa Lafontaine, Javier Villanueva-Meyer, Daniel Vigneron, Susan Chang, Sarah Nelson, Yan Li. .
      View in: Publisher Site   Mentions:
    10. Quantitative MRI of the Brain: Principles of Physical Measurement (by Mara Cercignani, Nicholas G. Dowell, Paul S. Tofts). Chapter 12: 1H Spectroscopy of the Brain. 2018. Yan Li and Sarah J. Nelson..
    11. Reliable and Reproducible GABA Measurements Using Automated Spectral Prescription at Ultra-High Field. Front Hum Neurosci. 2017; 11:506. Li Y, Bian W, Larson P, Crane JC, Parvathaneni P, Nagarajan S, Nelson SJ. PMID: 29118697.
      View in: PubMed   Mentions:
    12. Comparison between Short and Long Echo Time Magnetic Resonance Spectroscopic Imaging at 3T and 7T for Evaluating Brain Metabolites in Patients with Glioma. ACS Chem Neurosci. 2018 01 17; 9(1):130-137. Li Y, Lafontaine M, Chang S, Nelson SJ. PMID: 29035503.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Fully automated atlas-based method for prescribing 3D PRESS MR spectroscopic imaging: Toward robust and reproducible metabolite measurements in human brain. Magn Reson Med. 2018 02; 79(2):636-642. Bian W, Li Y, Crane JC, Nelson SJ. PMID: 28470861.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen. Neuro Oncol. 2017 03 01; 19(3):430-439. Nelson SJ, Kadambi AK, Park I, Li Y, Crane J, Olson M, Molinaro A, Roy R, Butowski N, Cha S, Chang S. PMID: 27576874.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab. J Neurooncol. 2016 10; 130(1):171-179. Nelson SJ, Li Y, Lupo JM, Olson M, Crane JC, Molinaro A, Roy R, Clarke J, Butowski N, Prados M, Cha S, Chang SM. PMID: 27535746.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla. MAGMA. 2016 Jun; 29(3):523-33. Li Y, Jakary A, Gillung E, Eisendrath S, Nelson SJ, Mukherjee P, Luks T. PMID: 26861048.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    17. Association of Diffusion and Anatomic Imaging Parameters with Survival for Patients with Newly Diagnosed Glioblastoma Participating in Two Different Clinical Trials. Transl Oncol. 2015 Dec; 8(6):446-55. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. PMID: 26692525.
      View in: PubMed   Mentions:
    18. Imaging tumor metabolism using in vivo magnetic resonance spectroscopy. Cancer J. 2015 Mar-Apr; 21(2):123-8. Li Y, Park I, Nelson SJ. PMID: 25815853.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    19. NI-61VOLUMETRIC H-1 MR METABOLIC IMAGING FOR DEFINITION OF LESION BURDEN AND PREDICTION OF OUTCOME FOR PATIENTS WITH NEWLY DIAGNOSED GBM. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v151-v152. Sarah Nelson, Yan Li, Michael Prados, Nicholas Butowski, Jennifer Clarke, Susan Chang. .
      View in: Publisher Site   Mentions:
    20. Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels. J Magn Reson Imaging. 2015 May; 41(5):1332-41. Li Y, Larson P, Chen AP, Lupo JM, Ozhinsky E, Kelley D, Chang SM, Nelson SJ. PMID: 24935758.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging. J Magn Reson. 2013 Apr; 229:187-97. Nelson SJ, Ozhinsky E, Li Y, Park Iw, Crane J. PMID: 23453759.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    22. Survival analysis in patients with newly diagnosed glioblastoma using pre- and postradiotherapy MR spectroscopic imaging. Neuro Oncol. 2013 May; 15(5):607-17. Li Y, Lupo JM, Parvataneni R, Lamborn KR, Cha S, Chang SM, Nelson SJ. PMID: 23393206.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    23. Advances in ultra-high field MRI for the clinical management of patients with brain tumors. Curr Opin Neurol. 2011 Dec; 24(6):605-15. Lupo JM, Li Y, Hess CP, Nelson SJ. PMID: 22045220.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    24. Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme. Neuro Oncol. 2011 May; 13(5):546-57. Li Y, Lupo JM, Polley MY, Crane JC, Bian W, Cha S, Chang S, Nelson SJ. PMID: 21297128.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    25. Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T. J Magn Reson Imaging. 2008 Aug; 28(2):342-50. Li Y, Srinivasan R, Ratiney H, Lu Y, Chang SM, Nelson SJ. PMID: 18666155.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    26. Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T. Magn Reson Med. 2007 Nov; 58(5):886-92. Li Y, Chen AP, Crane JC, Chang SM, Vigneron DB, Nelson SJ. PMID: 17969114.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    27. Considerations in applying 3D PRESS H-1 brain MRSI with an eight-channel phased-array coil at 3 T. Magn Reson Imaging. 2006 Dec; 24(10):1295-302. Li Y, Osorio JA, Ozturk-Isik E, Chen AP, Xu D, Crane JC, Cha S, Chang S, Berger MS, Vigneron DB, Nelson SJ. PMID: 17145400.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
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