Yen-Sin Ang, PhD

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    Collapse Biography 
    Collapse Education and Training
    Mount Sinai School of MedicinePh.D.
    National University of SingaporeB.Sc.
    Collapse Awards and Honors
    American Heart Association2016Louis N. and Arnold M. Katz Basic Research Prize
    American Heart Association2017  - 2019Scientist Development Grant
    American Heart Association2013  - 2015Postdoctoral Fellowship
    Mount Sinai School of Medicine2012Terry Ann Krulwich Doctoral Dissertation Prize
    University of Edinburgh (declined)2006Darwin Trust Scholarship

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    Collapse Featured Publications

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Britton E, Rogerson C, Mehta S, Li Y, Li X, Fitzgerald RC, Ang Y, Sharrocks AD. Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma. PLoS Genet. 2017 Aug; 13(8):e1006879. PMID: 28859074.
      View in: PubMed
    2. Britton J, Gadeke L, Lovat L, Hamdy S, Hawkey C, McLaughlin J, Ang Y. Research priority setting in Barrett's oesophagus and gastro-oesophageal reflux disease. Lancet Gastroenterol Hepatol. 2017 Aug 31. PMID: 28867477.
      View in: PubMed
    3. Ribeiro AJ, Schwab O, Mandegar MA, Ang Y, Conklin BR, Srivastava D, Pruitt BL. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes. Circ Res. 2017 May 12; 120(10):1572-1583. PMID: 28400398.
      View in: PubMed
    4. Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang Y, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation. 2017 Mar 07; 135(10):978-995. PMID: 27834668.
      View in: PubMed
    5. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang Y, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y, et al. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016 Oct; 22(10):1131-1139. PMID: 27618650.
      View in: PubMed
    6. Ribeiro AJ, Ang Y, Fu JD, Rivas RN, Mohamed TM, Higgs GC, Srivastava D, Pruitt BL. Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12705-10. PMID: 26417073; PMCID: PMC4611612.
    7. Ang Y, Srivastava D. Oxygen: double-edged sword in cardiac function and repair. Circ Res. 2014 Oct 24; 115(10):824-5. PMID: 25342770.
      View in: PubMed
    8. Xu H, Ang Y, Sevilla A, Lemischka IR, Ma'ayan A. Construction and validation of a regulatory network for pluripotency and self-renewal of mouse embryonic stem cells. PLoS Comput Biol. 2014 Aug; 10(8):e1003777. PMID: 25122140; PMCID: PMC4133156.
    9. Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang Y, de Jong PJ, Ivey KN, Srivastava D. microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife. 2013 Nov 19; 2:e01323. PMID: 24252873; PMCID: PMC3833424.
    10. Lee DF, Su J, Ang Y, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell. 2012 Aug 03; 11(2):179-94. PMID: 22862944; PMCID: PMC3413175.
    11. Fidalgo M, Shekar PC, Ang Y, Fujiwara Y, Orkin SH, Wang J. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells. 2011 Nov; 29(11):1705-16. PMID: 21915945; PMCID: PMC3272666.
    12. Tsai SY, Bouwman BA, Ang Y, Kim SJ, Lee DF, Lemischka IR, Rendl M. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells. 2011 Jun; 29(6):964-71. PMID: 21563278.
      View in: PubMed
    13. Ang Y, Gaspar-Maia A, Lemischka IR, Bernstein E. Stem cells and reprogramming: breaking the epigenetic barrier? Trends Pharmacol Sci. 2011 Jul; 32(7):394-401. PMID: 21621281; PMCID: PMC3128683.
    14. Carvajal-Vergara X, Sevilla A, D'Souza SL, Ang Y, Schaniel C, Lee DF, Yang L, Kaplan AD, Adler ED, Rozov R, Ge Y, Cohen N, Edelmann LJ, Chang B, Waghray A, Su J, Pardo S, Lichtenbelt KD, Tartaglia M, Gelb BD, Lemischka IR. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature. 2010 Jun 10; 465(7299):808-12. PMID: 20535210; PMCID: PMC2885001.
    15. Tsai SY, Clavel C, Kim S, Ang Y, Grisanti L, Lee DF, Kelley K, Rendl M. Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells. 2010 Feb; 28(2):221-8. PMID: 20014278.
      View in: PubMed
    16. Schaniel C, Ang Y, Ratnakumar K, Cormier C, James T, Bernstein E, Lemischka IR, Paddison PJ. Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells. 2009 Dec; 27(12):2979-91. PMID: 19785031.
      View in: PubMed
    17. Tam WL, Lim CY, Han J, Zhang J, Ang Y, Ng HH, Yang H, Lim B. T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells. 2008 Aug; 26(8):2019-31. PMID: 18467660; PMCID: PMC2692055.
    18. Tay YM, Tam WL, Ang Y, Gaughwin PM, Yang H, Wang W, Liu R, George J, Ng HH, Perera RJ, Lufkin T, Rigoutsos I, Thomson AM, Lim B. MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells. 2008 Jan; 26(1):17-29. PMID: 17916804.
      View in: PubMed
    19. Tam WL, Ang Y, Lim B. The molecular basis of ageing in stem cells. Mech Ageing Dev. 2007 Jan; 128(1):137-48. PMID: 17134742.
      View in: PubMed
    20. Miranda KC, Huynh T, Tay Y, Ang Y, Tam WL, Thomson AM, Lim B, Rigoutsos I. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell. 2006 Sep 22; 126(6):1203-17. PMID: 16990141.
      View in: PubMed
    21. Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang Y, Lim B, Robson P, Ng HH. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol. 2005 Jul; 25(14):6031-46. PMID: 15988017; PMCID: PMC1168830.
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