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Frank Fan

TitleAssociate Researcher
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-8916
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies Graduate Division

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fan F, Garcia-Rodriguez C, Lou J, Wen W, Conrad F, Zhai W, Smith TJ, Smith LA, Marks JD. A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes. PLoS One. 2017; 12(3):e0174187. PMID: 28323873.
      View in: PubMed
    2. Fan F, Barash JR, Lou J, Conrad F, Marks JD, Arnon SS. Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H. J Infect Dis. 2016 May 15; 213(10):1606-14. PMID: 26936913; PMCID: PMC4837907.
    3. Le Gall M, Crépin R, Neiveyans M, Auclair C, Fan F, Zhou Y, Marks JD, Pèlegrin A, Poul MA. Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5. Mol Cancer Ther. 2015 Nov; 14(11):2595-605. PMID: 26358753.
      View in: PubMed
    4. Fan F, Dong J, Lou J, Wen W, Conrad F, Geren IN, Garcia-Rodriguez C, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD. Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B. Toxins (Basel). 2015 Aug 26; 7(9):3405-23. PMID: 26343720; PMCID: PMC4591640.
    5. Fan F, Geren IN, Dong J, Lou J, Wen W, Conrad F, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD. Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity. PLoS One. 2015; 10(8):e0135306. PMID: 26275214; PMCID: PMC4537209.
    6. Jenko KL, Zhang Y, Kostenko Y, Fan F, Garcia-Rodriguez C, Lou J, Marks JD, Varnum SM. Development of an ELISA microarray assay for the sensitive and simultaneous detection of ten biodefense toxins. Analyst. 2014 Oct 21; 139(20):5093-102. PMID: 25112421.
      View in: PubMed
    7. Galbán S, Jeon YH, Bowman BM, Stevenson J, Sebolt KA, Sharkey LM, Lafferty M, Hoff BA, Butler BL, Wigdal SS, Binkowski BF, Otto P, Zimmerman K, Vidugiris G, Encell LP, Fan F, Wood KV, Galbán CJ, Ross BD, Rehemtulla A. Imaging proteolytic activity in live cells and animal models. PLoS One. 2013; 8(6):e66248. PMID: 23776643; PMCID: PMC3679058.
    8. Feng D, Zhang S, Hu Z, Fan F, Jiang F, Yin R, Xu L. Dynamic investigation of alveolar type II cell function in a long-term survival model of rat lung ischemia-reperfusion injury. Scand J Clin Lab Invest. 2010 Sep; 70(5):364-73. PMID: 20560845.
      View in: PubMed
    9. Fan F, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY. Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol. 2010 Apr; 67(4):488-97. PMID: 20437584; PMCID: PMC3026588.
    10. Dong J, Thompson AA, Fan F, Lou J, Conrad F, Ho M, Pires-Alves M, Wilson BA, Stevens RC, Marks JD. A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region. J Mol Biol. 2010 Apr 09; 397(4):1106-18. PMID: 20138889; PMCID: PMC2903050.
    11. Zhu W, Fan F, Hao Q, Shen F, Hashimoto T, Yang GY, Gasmi M, Bartus RT, Young WL, Chen Y. Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke. J Cereb Blood Flow Metab. 2009 Sep; 29(9):1528-37. PMID: 19513085; PMCID: PMC2763573.
    12. Fan F, Zhu W, Yang M, Zhu Y, Shen F, Hao Q, Young WL, Yang GY, Chen Y. Del-1 gene transfer induces cerebral angiogenesis in mice. Brain Res. 2008 Jul 11; 1219:1-7. PMID: 18534562; PMCID: PMC2553757.
    13. Fan F, Shen F, Chen Y, Hao Q, Liu W, Su H, Young WL, Yang GY. Overexpression of netrin-1 induces neovascularization in the adult mouse brain. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1543-51. PMID: 18461079; PMCID: PMC2581494.
    14. Zhu W, Fan F, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y. Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice. Stroke. 2008 Apr; 39(4):1254-61. PMID: 18309153; PMCID: PMC2553752.
    15. Shen F, Fan F, Su H, Zhu Y, Chen Y, Liu W, Young WL, Yang GY. Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther. 2008; 15(1):30.
    16. Fan F, Ye J, Shen F, Zhu Y, Yeghiazarians Y, Zhu W, Chen Y, Lawton MT, Young WL, Yang GY. Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab. 2008 Jan; 28(1):90-8. PMID: 17519976; PMCID: PMC2581498.
    17. Fan F, Yang GY. Therapeutic angiogenesis for brain ischemia: a brief review. J Neuroimmune Pharmacol. 2007 Sep; 2(3):284-9. PMID: 18040863.
      View in: PubMed
    18. Hao Q, Chen Y, Zhu Y, Fan F, Palmer D, Su H, Young WL, Yang GY. Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1853-60. PMID: 17392691.
      View in: PubMed
    19. Chen Y, Fan F, Poon KY, Achrol AS, Lawton MT, Zhu Y, McCulloch CE, Hashimoto T, Lee C, Barbaro NM, Bollen AW, Yang GY, Young WL. MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. Front Biosci. 2006 Sep 01; 11:3121-8. PMID: 16720380.
      View in: PubMed
    20. Shen F, Su H, Fan F, Chen Y, Zhu Y, Liu W, Young WL, Yang GY. Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke. 2006 Oct; 37(10):2601-6. PMID: 16946160.
      View in: PubMed
    21. Fan F, Shi L, Gu Y, Zhao Y, Xie J, Qiao J, Yang GY, Wang Y, Lu CZ. Pretreatment with PTD-calbindin D 28k alleviates rat brain injury induced by ischemia and reperfusion. J Cereb Blood Flow Metab. 2007 Apr; 27(4):719-28. PMID: 16868556.
      View in: PubMed
    22. Yao JS, Zhai W, Fan F, Lawton MT, Barbaro NM, Young WL, Yang GY. Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells. J Cereb Blood Flow Metab. 2007 Mar; 27(3):510-20. PMID: 16820800.
      View in: PubMed
    23. Li T, Fan F, Luo Y, Xiao B, Lu C. In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. Exp Neurol. 2006 Feb; 197(2):301-8. PMID: 16336964.
      View in: PubMed
    24. Fan F, Lu CZ, Xie J, Zhao YX, Yang GY. Apoptosis inhibition in ischemic brain by intraperitoneal PTD-BIR3-RING (XIAP). Neurochem Int. 2006 Jan; 48(1):50-9. PMID: 16293346.
      View in: PubMed
    25. Xie R, Chen XC, Fan F, Ren HM, Gao L, Xia Y and Li XM. The mutation in exon 8 of CCMI gene and 704 insT in patients with intracranialcavernoushemangioma [Chinese]. Fudan University J. of Medical science. 2005, 3. 2005.
    26. Xie R, Chen XC, Fan F, Xia Y, Gao L, Li XM. . Analysis of CCM1 gene mutations in Chinese patients with intracranial cavernous malformations [Chinese]. Zhonghua Yi Xue Za Zhi. 2005, 85(32): 2254. 2005; 85(32):2254.
    27. Xie R, Chen XC, Fan F, Ren HM, Xia Y, Ji YD, Hu J. . New mutations of the 12th exon of CCM1 gene in Chinese patients with intracranial cavernous angiomas [Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004; 21(3):264.
    28. Xie R, Chen XC, Fan F, Ren HM, Xia Y, Ji YD and Li XM. . A case report for a new samesense mutation of 17th exon of CCM1 gene [Chinese]. Chin J Clin Neurosci. 2004; 12(4):293.
    29. Fan F, Lu CZ and Ren HM. . Signal pathway in neuromuscular junction and myasthenia gravis [Chinese]. Chinese J. Neurology. 2004; 37(5):465.
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