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Young-Wook Jun, PhD

Title(s)Associate Professor, Otolaryngology
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
Phone510-917-9242
ORCID ORCID Icon0000-0003-3182-5366 Additional info
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    Young-Wook Jun, PhD, is an Associate Professor and he is the Director of the Nano-Probing Single Biomolecule Dynamics Laboratory in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his PhD from the Korea Advanced Institute of Science and Technology in Seoul, South Korea, and he completed a postdoctoral from Yonsei University, Seoul, South Korea, followed by a postdoctoral from the University of California, Berkeley.

    Dr. Jun’s research interests include nanoprobing systems to investigate the single molecule dynamics of biomolecules involved in cellular developments such as gene regulation, cell-to-cell communications, and neuron circuit formation. His research on “Nanocrystal-Molecules as Probes for Monitoring the Dynamics of Biomolecular Machineries at the Single Molecule Level” will contribute to a foundation of a new field by providing a comprehensive understanding of the nanocrystal molecules including the fabrication, surface chemistry, scaling laws of magnetic, plasmonic, and charge coupling, and their behaviors in cells.

    Dr. Jun has been invited to speak both national and internationally. He has contributed to over 40 articles, and 5 book chapters.

    Specialty:
    Nano-bio Research, Notch and E-cadherin

    Expertise:
    Nanotechnology, Chemistry, Bioengineering

    Professional Interests:
    Nanotechnology, optical microscopy, single molecule imaging, notch signaling, neural development, angiogenesis

    Education and Training:
    • PhD: Korea Advanced Institute of Science and Technology, Seoul, South Korea – Chemistry
    • Postdoctoral: Yonsei University, Seoul, South Korea – Chemistry
    • Postdoctoral: University of California, Berkeley – Chemistry

    Awards and Honors:
    • 2012 Department of Otolaryngology, UCSF - The Endowed Hemming Fellows
    • 2010 The New Innovator Research Award – UCSF/Sandler Foundation
    • 2005 IUPAC Prize for Young Chemist: The Honorable Mention Award - International Union of Pure and Applied Chemistry (IUPAC)

    Collapse Research 
    Collapse Research Activities and Funding
    Spatiotemporal interrogation of molecular mechanobiololgy at the cell-cell interface with nanotechnology tools
    NIH/NIGMS R35GM134948Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    In situ Investigation of dynamic protein-protein interactions in live cells via Magnetic Co-concentration (MCoC)
    NIH/NCI R21CA224364Jan 1, 2018 - Dec 31, 2019
    Role: Principal Investigator
    Nanomodules for interrogating chemical, spatial, and mechanical dynamics of cell surface receptors
    NIH/NIGMS R01GM126542Sep 15, 2017 - Jul 31, 2021
    Role: Principal Investigator
    Interrogation of mechanotransduction ion channels via nanoruler force microscopy and mechanogenetic nanomodules
    NIH 1R21NS103240-01Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Spatial Mutation of Membrane Protein Assembly Dynamics Using Nano-Actuators
    NIH/NHLBI R21HL123329Sep 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Spatiotemporal Control of Dynamic Notch Signaling with Subcellular Resolution
    NIH/NIGMS R01GM112081Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Small, modular, and monovalent Quantum Dots for single molecule imaging of Notch
    NIH/NIBIB R21EB018044Mar 1, 2014 - Feb 29, 2016
    Role: Principal Investigator
    Single Molecule Imaging of Guided Axonal Development using Plasmon Nanorulers
    NIH/NIBIB R21EB015088Mar 15, 2012 - Feb 28, 2014
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cellulose Nanomaterials in Interfacial Evaporators for Desalination: A "Natural" Choice. Adv Mater. 2020 Jun 14; e2000922. Cao S, Rathi P, Wu X, Ghim D, Jun YS, Singamaneni S. PMID: 32537817.
      View in: PubMed   Mentions:    Fields:    
    2. Small, Clickable, and Monovalent Magnetofluorescent Nanoparticles Enable Mechanogenetic Regulation of Receptors in a Crowded Live-Cell Microenvironment. Nano Lett. 2019 06 12; 19(6):3761-3769. Kwak M, Gu W, Jeong H, Lee H, Lee JU, An M, Kim YH, Lee JH, Cheon J, Jun YW. PMID: 31037941.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Magnetic Nanotweezers for Interrogating Biological Processes in Space and Time. Acc Chem Res. 2018 04 17; 51(4):839-849. Kim JW, Jeong HK, Southard KM, Jun YW, Cheon J. PMID: 29589897.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    4. Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc. 2017 Sep; 12(9):1871-1889. Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner ZJ, Jun YW, Cheon J. PMID: 28817122.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2016 Jun 02; 165(6):1507-1518. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. PMID: 27180907.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    6. Monovalent plasmonic nanoparticles for biological applications. Proceedings of SPIE--the International Society for Optical Engineering. 2016; 9722:972201. View Publication.
    7. In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study. J Vasc Interv Radiol. 2016 Mar; 27(3):426-32.e1. Mabray MC, Lillaney P, Sze CH, Losey AD, Yang J, Kondapavulur S, Liu D, Saeed M, Patel A, Cooke D, Jun YW, El-Sayed I, Wilson M, Hetts SW. PMID: 26706187.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    8. Production and targeting of monovalent quantum dots. J Vis Exp. 2014 Oct 23; (92):e52198. Seo D, Farlow J, Southard K, Jun YW, Gartner ZJ. PMID: 25407345.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia. ACS Nano. 2014 Sep 23; 8(9):9199-208. Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS. PMID: 25166742.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    10. Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology. Methods Enzymol. 2014; 544:271-97. Tajon C, Jun YW, Craik CS. PMID: 24974294.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction. Cancer Discov. 2014 Feb; 4(2):200-15. Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP. PMID: 24362263.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. Formation of targeted monovalent quantum dots by steric exclusion. Nat Methods. 2013 Dec; 10(12):1203-5. Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner ZJ, Jun YW. PMID: 24122039.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    13. Biotite dissolution in brine at varied temperatures and CO2 pressures: its activation energy and potential CO2 intercalation. Langmuir. 2012 Oct 16; 28(41):14633-41. Hu Y, Jun YS. PMID: 22989382.
      View in: PubMed   Mentions: 2     Fields:    
    14. Coupling of optical resonances in a compositionally asymmetric plasmonic nanoparticle dimer. Nano Lett. 2010 Jul 14; 10(7):2655-60. Sheikholeslami S, Jun YW, Jain PK, Alivisatos AP. PMID: 20536212.
      View in: PubMed   Mentions: 19     Fields:    
    15. Hetero-epitaxial anion exchange yields single-crystalline hollow nanoparticles. J Am Chem Soc. 2009 Oct 07; 131(39):13943-5. Park J, Zheng H, Jun YW, Alivisatos AP. PMID: 19788329.
      View in: PubMed   Mentions: 7     Fields:    
    16. Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17735-40. Jun YW, Sheikholeslami S, Hostetter DR, Tajon C, Craik CS, Alivisatos AP. PMID: 19805121.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    17. Observation of single colloidal platinum nanocrystal growth trajectories. Science. 2009 Jun 05; 324(5932):1309-12. Zheng H, Smith RK, Jun YW, Kisielowski C, Dahmen U, Alivisatos AP. PMID: 19498166.
      View in: PubMed   Mentions: 66     Fields:    
    18. Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. Acc Chem Res. 2008 Feb; 41(2):179-89. Jun YW, Seo JW, Cheon J. PMID: 18281944.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    19. Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Angew Chem Int Ed Engl. 2008; 47(28):5122-35. Jun YW, Lee JH, Cheon J. PMID: 18574805.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimals
    20. Highly crystalline anisotropic superstructures via magnetic field induced nanoparticle assembly. Chem Commun (Camb). 2007 Dec 21; (47):5001-3. Park JI, Jun YW, Choi JS, Cheon J. PMID: 18049733.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    21. Hybrid Nanoparticles for Magnetic Resonance Imaging of Target-Specific Viral Gene Delivery. Advanced Materials. 2007; 19(20):3109-12. View Publication.
    22. Two-dimensional nanosheet crystals. Angew Chem Int Ed Engl. 2007; 46(46):8828-31. Seo JW, Jun YW, Park SW, Nah H, Moon T, Park B, Kim JG, Kim YJ, Cheon J. PMID: 17939146.
      View in: PubMed   Mentions: 9     Fields:    
    23. Magnetic nanoparticle assisted molecular MR imaging. Adv Exp Med Biol. 2007; 620:85-106. Jun YW, Jang JT, Cheon J. PMID: 18217337.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    24. Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med. 2007 Jan; 13(1):95-9. Lee JH, Huh YM, Jun YW, Seo JW, Jang JT, Song HT, Kim S, Cho EJ, Yoon HG, Suh JS, Cheon J. PMID: 17187073.
      View in: PubMed   Mentions: 282     Fields:    Translation:HumansAnimalsCells
    25. Biocompatible heterostructured nanoparticles for multimodal biological detection. J Am Chem Soc. 2006 Dec 20; 128(50):15982-3. Choi JS, Jun YW, Yeon SI, Kim HC, Shin JS, Cheon J. PMID: 17165720.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    26. Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma. Angew Chem Int Ed Engl. 2006 Dec 11; 45(48):8160-2. Lee JH, Jun YW, Yeon SI, Shin JS, Cheon J. PMID: 17103471.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    27. Heterostructured magnetic nanoparticles: their versatility and high performance capabilities. Chem Commun (Camb). 2007 Mar 28; (12):1203-14. Jun YW, Choi JS, Cheon J. PMID: 17356759.
      View in: PubMed   Mentions: 11     Fields:    
    28. Shape control of semiconductor and metal oxide nanocrystals through nonhydrolytic colloidal routes. Angew Chem Int Ed Engl. 2006 May 19; 45(21):3414-39. Jun YW, Choi JS, Cheon J. PMID: 16642516.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    29. Cobalt alters the growth of a manganese oxide film. Langmuir. 2006 Feb 28; 22(5):2235-40. Jun YS, Martin ST. PMID: 16489812.
      View in: PubMed   Mentions:    Fields:    
    30. Magnetic superlattices and their nanoscale phase transition effects. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3023-7. Cheon J, Park JI, Choi JS, Jun YW, Kim S, Kim MG, Kim YM, Kim YJ. PMID: 16492783.
      View in: PubMed   Mentions: 7     Fields:    
    31. Selective catalytic activity of ball-shaped Pd@MCM-48 nanocatalysts. Chem Commun (Camb). 2006 Mar 28; (12):1325-7. Lee HY, Ryu S, Kang H, Jun YW, Cheon J. PMID: 16538262.
      View in: PubMed   Mentions:    Fields:    
    32. The concept of delayed nucleation in nanocrystal growth demonstrated for the case of iron oxide nanodisks. J Am Chem Soc. 2006 Feb 08; 128(5):1675-82. Casula MF, Jun YW, Zaziski DJ, Chan EM, Corrias A, Alivisatos AP. PMID: 16448141.
      View in: PubMed   Mentions: 10     Fields:    
    33. In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J Am Chem Soc. 2005 Sep 07; 127(35):12387-91. Huh YM, Jun YW, Song HT, Kim S, Choi JS, Lee JH, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J. PMID: 16131220.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    34. Symmetry-controlled colloidal nanocrystals: nonhydrolytic chemical synthesis and shape determining parameters. J Phys Chem B. 2005 Aug 11; 109(31):14795-806. Jun YW, Lee JH, Choi JS, Cheon J. PMID: 16852873.
      View in: PubMed   Mentions: 1     Fields:    
    35. Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling. J Am Chem Soc. 2005 Jul 20; 127(28):9992-3. Song HT, Choi JS, Huh YM, Kim S, Jun YW, Suh JS, Cheon J. PMID: 16011350.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    36. Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J Am Chem Soc. 2005 Apr 27; 127(16):5732-3. Jun YW, Huh YM, Choi JS, Lee JH, Song HT, Kim S, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J. PMID: 15839639.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    37. In situ one-pot synthesis of 1-dimensional transition metal oxide nanocrystals. J Phys Chem B. 2005 Mar 31; 109(12):5389-91. Seo JW, Jun YW, Ko SJ, Cheon J. PMID: 16851566.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    38. Recent advances in the shape control of inorganic nano-building blocks. Coordination Chemistry Reviews. 2005; 249(17-18):1766-75. View Publication.
    39. Spontaneous one dimensional arrangement of spherical Au nanoparticles with liquid crystal ligands. Chem Commun (Camb). 2005 Feb 14; (6):800-1. In I, Jun YW, Kim YJ, Kim SY. PMID: 15685343.
      View in: PubMed   Mentions: 2     Fields:    
    40. Thiacrownether-mediated Size-controlled Assembly of Gold Nanoparticles. Chemistry Letters. 2004; 33(11):1530-1. View Publication.
    41. Characterization of superparamagnetic "core-shell" nanoparticles and monitoring their anisotropic phase transition to ferromagnetic "solid solution" nanoalloys. J Am Chem Soc. 2004 Jul 28; 126(29):9072-8. Park JI, Kim MG, Jun YW, Lee JS, Lee WR, Cheon J. PMID: 15264840.
      View in: PubMed   Mentions: 1     Fields:    
    42. Surfactant-assisted elimination of a high energy facet as a means of controlling the shapes of TiO2 nanocrystals. J Am Chem Soc. 2003 Dec 24; 125(51):15981-5. Jun YW, Casula MF, Sim JH, Kim SY, Cheon J, Alivisatos AP. PMID: 14677990.
      View in: PubMed   Mentions: 11     Fields:    
    43. Sterically induced shape and crystalline phase control of GaP nanocrystals. J Am Chem Soc. 2002 Nov 20; 124(46):13656-7. Kim YH, Jun YW, Jun BH, Lee SM, Cheon J. PMID: 12431078.
      View in: PubMed   Mentions: 2     Fields:    
    44. Single-crystalline star-shaped nanocrystals and their evolution: programming the geometry of nano-building blocks. J Am Chem Soc. 2002 Sep 25; 124(38):11244-5. Lee SM, Jun YW, Cho SN, Cheon J. PMID: 12236719.
      View in: PubMed   Mentions: 9     Fields:    
    45. Superlattice and magnetism directed by the size and shape of nanocrystals. Chemphyschem. 2002 Jun 17; 3(6):543-7. Park JI, Kang NJ, Jun YW, Oh SJ, Ri HC, Cheon J. PMID: 12465496.
      View in: PubMed   Mentions: 6     Fields:    
    46. Architectural control of magnetic semiconductor nanocrystals. J Am Chem Soc. 2002 Jan 30; 124(4):615-9. Jun YW, Jung YY, Cheon J. PMID: 11804492.
      View in: PubMed   Mentions: 3     Fields:    
    47. Controlled synthesis of multi-armed CdS nanorod architectures using monosurfactant system. J Am Chem Soc. 2001 May 30; 123(21):5150-1. Jun YW, Lee SM, Kang NJ, Cheon J. PMID: 11457367.
      View in: PubMed   Mentions: 6     Fields:    
    48. Size and shape controlled ZnTe nanocrystals with quantum confinement effect. Chemical Communications. 2000; 2001:101-2. View Publication.
    49. Synthesis of Porous Palladium Superlattice Nanoballs and Nanowires. Chemistry of Materials. 2000; 12(12):3530-2. View Publication.
    50. One-step synthesis of size tuned zinc selenide quantum dots via a temperature controlled molecular precursor approach. Chemical Communications. 2000; 2000:1243-4. View Publication.
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